{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:06:54Z","timestamp":1777874814368,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872507"],"award-info":[{"award-number":["81872507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Nn10py2017-01"],"award-info":[{"award-number":["Nn10py2017-01"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cellsig.2021.110014","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T15:08:32Z","timestamp":1619017712000},"page":"110014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein"],"prefix":"10.1016","volume":"84","author":[{"given":"Meiyin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2021.110014_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer: a review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.cellsig.2021.110014_bb0010","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fpubh.2016.00146","article-title":"Increase of incidence and mortality of ovarian cancer during 2003-2012 in Jiangsu Province, China","volume":"4","author":"Teng","year":"2016","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cellsig.2021.110014_bb0015","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2021.110014_bb0020","first-page":"937","article-title":"Diagnosis and management of ovarian cancer","volume":"93","author":"Doubeni","year":"2016","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.cellsig.2021.110014_bb0025","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrc2696","article-title":"Emerging roles of E2Fs in cancer: an exit from cell cycle control","volume":"9","author":"Chen","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2021.110014_bb0030","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41568-019-0143-7","article-title":"The broken cycle: E2F dysfunction in cancer","volume":"19","author":"Kent","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2021.110014_bb0035","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3748\/wjg.v19.i21.3189","article-title":"E2F transcription factors and digestive system malignancies: how much do we know?","volume":"19","author":"Xanthoulis","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0040","doi-asserted-by":"crossref","first-page":"32628","DOI":"10.18632\/oncotarget.8701","article-title":"Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer","volume":"7","author":"Hong","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.cellsig.2021.110014_bb0045","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1128\/MCB.00737-14","article-title":"The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer","volume":"34","author":"Hollern","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fonc.2019.00161","article-title":"E2F2\/5\/8 serve as potential prognostic biomarkers and targets for human ovarian cancer","volume":"9","author":"Zhou","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0055","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1074\/jbc.271.14.8144","article-title":"Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein","volume":"271","author":"Ma","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2021.110014_bb0060","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.3390\/ijms140510015","article-title":"Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis","volume":"14","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2021.110014_bb0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/path.2889","article-title":"Role of RNA binding protein HuR in ductal carcinoma in situ of the breast","volume":"224","author":"Heinonen","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059095","article-title":"High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer","volume":"8","author":"Miyata","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2021.110014_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4143\/crt.2009.41.2.87","article-title":"Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer","volume":"41","author":"Lim","year":"2009","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.cellsig.2021.110014_bb0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12013-020-00939-w","article-title":"HuR promotes ovarian cancer cell proliferation by regulating TIMM44 mRNA stability","volume":"78","author":"Yu","year":"2020","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2021.110014_bb0085","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s13238-015-0202-0","article-title":"An intriguing RNA species--perspectives of circularized RNA","volume":"6","author":"Shen","year":"2015","journal-title":"Protein Cell."},{"key":"10.1016\/j.cellsig.2021.110014_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.omtn.2019.02.005","article-title":"Circular RNAs in cancer","volume":"16","author":"Bach","year":"2019","journal-title":"Mol. Ther. Nucleic Acids."},{"key":"10.1016\/j.cellsig.2021.110014_bb0095","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"Jama."},{"key":"10.1016\/j.cellsig.2021.110014_bb0100","series-title":"In: th, editor. Guide for the Care and Use of Laboratory Animals","article-title":"The National Academies Collection: Reports funded by National Institutes of Health","author":"C. National Research Council Committee for the Update of the Guide for the, A. Use of Laboratory","year":"2011"},{"key":"10.1016\/j.cellsig.2021.110014_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkl151","article-title":"Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing","volume":"34","author":"Suzuki","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cellsig.2021.110014_bb0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/bmb.2006.49403401050","article-title":"The effect of actinomycin D on RNA metabolism in human cells","volume":"34","author":"Szeberenyi","year":"2006","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.cellsig.2021.110014_bb0115","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1261\/rna.043687.113","article-title":"circBase: a database for circular RNAs","volume":"20","author":"Gla\u017ear","year":"2014","journal-title":"Rna."},{"key":"10.1016\/j.cellsig.2021.110014_bb0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4939-7562-4_4","article-title":"Analysis of circular RNAs using the web tool CircInteractome","volume":"1724","author":"Panda","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0125","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3892\/ol.2021.12619","article-title":"Effect of eukaryotic translation initiation factor 4A3 in malignant tumors","volume":"21","author":"Zhu","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cellsig.2021.110014_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102370","article-title":"Absence of BRCA\/FMR1 correlations in women with ovarian cancers","volume":"9","author":"Gleicher","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2021.110014_bb0135","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/15476286.2017.1279788","article-title":"Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1","volume":"14","author":"Abdelmohsen","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/1471-2105-12-489","article-title":"Predicting RNA-protein interactions using only sequence information","volume":"12","author":"Muppirala","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cellsig.2021.110014_bb0145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1758834014544891","article-title":"Neoadjuvant chemotherapy in advanced ovarian cancer: latest results and place in therapy","volume":"6","author":"Sato","year":"2014","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.trecan.2016.12.005","article-title":"Tumor-host cell interactions in ovarian cancer: pathways to therapy failure","volume":"3","author":"Pogge von Strandmann","year":"2017","journal-title":"Trends Cancer."},{"key":"10.1016\/j.cellsig.2021.110014_bb0155","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/14737159.2017.1326820","article-title":"The role of biomarkers in the management of epithelial ovarian cancer","volume":"17","author":"Yang","year":"2017","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.cellsig.2021.110014_bb0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12935-020-01367-9","article-title":"The emerging roles of circular RNAs in ovarian cancer","volume":"20","author":"Yang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2021.110014_bb0165","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases","volume":"14","author":"Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0170","first-page":"2150","article-title":"E2F2 induces MCM4, CCNE2 and WHSC1 upregulation in ovarian cancer and predicts poor overall survival","volume":"21","author":"Xie","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2021.110014_bb0175","doi-asserted-by":"crossref","first-page":"11677","DOI":"10.1038\/s41598-019-47871-5","article-title":"Matrix metalloproteinase expressions play important role in prediction of ovarian cancer outcome","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2021.110014_bb0180","doi-asserted-by":"crossref","first-page":"56081","DOI":"10.18632\/oncotarget.9760","article-title":"Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer","volume":"8","author":"Anderson","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.cellsig.2021.110014_bb0185","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/emboj.2011.359","article-title":"miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA","volume":"30","author":"Hansen","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2021.110014_bb0190","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/15476286.2016.1207036","article-title":"Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4\/LPS pathway","volume":"13","author":"Ng","year":"2016","journal-title":"RNA Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0195","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s42003-020-0933-1","article-title":"Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis","volume":"3","author":"Wu","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0200","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1007\/s00018-008-8252-6","article-title":"Diverse molecular functions of Hu proteins","volume":"65","author":"Hinman","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2021.110014_bb0205","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2021.110014_bb0210","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1002\/jcp.29589","article-title":"CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR","volume":"235","author":"Liu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.cellsig.2021.110014_bb0215","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1111\/jcmm.14925","article-title":"circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646","volume":"24","author":"Zang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2021.110014_bb0220","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1172\/JCI130379","article-title":"HuR\/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis","volume":"130","author":"Palomo-Irigoyen","year":"2020","journal-title":"J. Clin. Invest."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:23:56Z","timestamp":1777580636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656821001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":44,"alternative-id":["S0898656821001030"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110014","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110014"}}