{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:08:50Z","timestamp":1793304530700,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500873"],"award-info":[{"award-number":["81500873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700993"],"award-info":[{"award-number":["81700993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.cellsig.2021.110042","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T22:05:15Z","timestamp":1620857115000},"page":"110042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["CTRP3 promotes TNF-\u03b1-induced apoptosis and barrier dysfunction in salivary epithelial cells"],"prefix":"10.1016","volume":"85","author":[{"given":"Mei","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Han","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Lan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zeng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellsig.2021.110042_bb0005","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1074\/jbc.M007898200","article-title":"Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development","volume":"276","author":"Maeda","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0010","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/j.2040-4603.2017.tb00770.x","article-title":"C1q\/TNF-related protein 3 (CTRP3) function and regulation","volume":"7","author":"Li","year":"2017","journal-title":"Compr. Physiol."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0015","doi-asserted-by":"crossref","first-page":"G214","DOI":"10.1152\/ajpgi.00102.2013","article-title":"CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism","volume":"305","author":"Peterson","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CBI20090043","article-title":"CTRP3\/cartducin is induced by transforming growth factor-beta1 and promotes vascular smooth muscle cell proliferation","volume":"34","author":"Maeda","year":"2010","journal-title":"Cell Biol. Int."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2021.110042_bb0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11010-007-9506-6","article-title":"CTRP3\/cartducin promotes proliferation and migration of endothelial cells","volume":"304","author":"Akiyama","year":"2007","journal-title":"Mol. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.cellsig.2021.110042_bb0030","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/oby.2008.206","article-title":"Effects of the new C1q\/TNF-related protein (CTRP-3) \u201ccartonectin\u201d on the adipocytic secretion of adipokines","volume":"16","author":"Wolfing","year":"2008","journal-title":"Obesity (Silver Spring)"},{"issue":"25","key":"10.1016\/j.cellsig.2021.110042_bb0035","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1161\/CIRCULATIONAHA.112.099937","article-title":"C1q\/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart","volume":"125","author":"Yi","year":"2012","journal-title":"Circulation."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110042_bb0040","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/ATVBAHA.114.303301","article-title":"Overexpression of c1q\/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro","volume":"34","author":"Zhou","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110042_bb0045","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.prp.2016.08.009","article-title":"Leptin and leptin receptors in salivary glands of primary Sj\u00f6gren's syndrome","volume":"212","author":"Erbasan","year":"2016","journal-title":"Pathol. Res. Pract."},{"issue":"7","key":"10.1016\/j.cellsig.2021.110042_bb0050","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/art.21944","article-title":"Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin","volume":"54","author":"Katsiougiannis","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0055","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/art.27239","article-title":"Activation of AMP-activated protein kinase by adiponectin rescues salivary gland epithelial cells from spontaneous and interferon-gamma-induced apoptosis","volume":"62","author":"Katsiougiannis","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10787-007-1650-9","article-title":"Leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways","volume":"16","author":"Slomiany","year":"2008","journal-title":"Inflammopharmacology."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110042_bb0065","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1373\/clinchem.2008.116939","article-title":"Salivary leptin as a candidate diagnostic marker in salivary gland tumors","volume":"55","author":"Schapher","year":"2009","journal-title":"Clin. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0070","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/cas.12077","article-title":"Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma","volume":"104","author":"Guo","year":"2013","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110042_bb0075","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0080","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/sarh.2003.50019","article-title":"Apoptosis and Sj\u00f6gren syndrome","volume":"33","author":"Manganelli","year":"2003","journal-title":"Semin. Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.cellsig.2021.110042_bb0085","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/ecco-jcc\/jjw053","article-title":"Mechanism of action of anti-TNF therapy in inflammatory bowel disease","volume":"10","author":"Levin","year":"2016","journal-title":"J. Crohns Colitis."},{"issue":"Suppl. 3","key":"10.1016\/j.cellsig.2021.110042_bb0090","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3233\/JAD-132738","article-title":"Apoptosis and oxidative stress in neurodegenerative diseases","volume":"42","author":"Radi","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0095","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/ijms18020367","article-title":"Role of autophagy and apoptosis in non-small-cell lung cancer","volume":"18","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1573397112666160714164149","article-title":"Update on pathogenesis of Sj\u00f6gren's syndrome","volume":"13","author":"Sandhya","year":"2017","journal-title":"Curr. Rheumatol. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0105","first-page":"14","article-title":"One year in review 2018: Sj\u00f6gren's syndrome","volume":"112","author":"Argyropoulou","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2005.02143.x","article-title":"The intriguing biology of the tumor necrosis factor\/tumor necrosis factor receptor superfamily: players, rules and the games","volume":"115","author":"Hehlgans","year":"2005","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.cellsig.2021.110042_bb0115","first-page":"970","article-title":"Salivary cytokine profiles in primary Sj\u00f6gren's syndrome differ from those in non-Sj\u00f6gren sicca in terms of TNF-alpha levels and Th-1\/Th-2 ratios","volume":"29","author":"Kang","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.cellsig.2021.110042_bb0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2013.02.001","article-title":"Sj\u00f6gren's syndrome and the epithelial target: a comprehensive review","volume":"42","author":"Barrera","year":"2013","journal-title":"J. Autoimmun."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110042_bb0125","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/art.27362","article-title":"Disruption of tight junction structure in salivary glands from Sj\u00f6gren's syndrome patients is linked to proinflammatory cytokine exposure","volume":"62","author":"Ewert","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cellsig.2021.110042_bb0130","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1749-6632.2009.04688.x","article-title":"Tumor necrosis factor inhibitors block apoptosis of human epithelial cells of the salivary glands","volume":"1171","author":"Sisto","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cellsig.2021.110042_bb0135","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.3389\/fimmu.2019.02814","article-title":"JAK inhibitors and oxidative stress control","volume":"10","author":"Charras","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110042_bb0140","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000098211","article-title":"Possible involvement of oxidative stress in salivary gland of patients with Sj\u00f6gren's syndrome","volume":"73","author":"Ryo","year":"2006","journal-title":"Pathobiology"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11626-997-0137-8","article-title":"Development and characterization of SV40 immortalized rat submandibular acinar cell lines","volume":"33","author":"Quissell","year":"1997","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"issue":"10","key":"10.1016\/j.cellsig.2021.110042_bb0150","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.cellsig.2015.07.002","article-title":"Claudin-3 is required for modulation of paracellular permeability by TNF-alpha through ERK1\/2\/slug signaling axis in submandibular gland","volume":"27","author":"Mei","year":"2015","journal-title":"Cell. Signal."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2021.110042_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11010-008-9873-7","article-title":"Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland","volume":"319","author":"Mata","year":"2008","journal-title":"Mol. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110042_bb0160","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00109-015-1309-8","article-title":"CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation","volume":"93","author":"Wu","year":"2015","journal-title":"J. Mol. Med (Berl)."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0165","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.oraloncology.2008.05.021","article-title":"Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma","volume":"45","author":"Camisasca","year":"2009","journal-title":"Oral Oncol."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110042_bb0170","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/jcs.165878","article-title":"Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells","volume":"128","author":"Cong","year":"2015","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110042_bb0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3892\/ijmm.2013.1550","article-title":"C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis through the phosphoinositide 3-kinase\/Akt pathway","volume":"33","author":"Hou","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2021.110042_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134006","article-title":"CTRP3 stimulates proliferation and anti-apoptosis of prostate cells through PKC signaling pathways","volume":"10","author":"Hou","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.cellsig.2021.110042_bb0190","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1089\/ars.2011.4489","article-title":"NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts","volume":"16","author":"Coso","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110042_bb0195","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1074\/jbc.M115.679076","article-title":"gamma-secretase activity is required for regulated intramembrane proteolysis of tumor necrosis factor (TNF) receptor 1 and TNF-mediated pro-apoptotic signaling","volume":"291","author":"Chhibber-Goel","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.cellsig.2021.110042_bb0200","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1111\/febs.15260","article-title":"FLIP(L): the pseudo-caspase","volume":"287","author":"Smyth","year":"2020","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110042_bb0205","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/labinvest.2016.141","article-title":"Pathogenic role of endogenous TNF-alpha in the development of Sj\u00f6gren\u2019s-like sialadenitis and secretory dysfunction in non-obese diabetic mice","volume":"97","author":"Zhou","year":"2017","journal-title":"Lab. Investig."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110042_bb0210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.archoralbio.2010.10.014","article-title":"Expression of ghrelin in human salivary glands and its levels in saliva and serum in Chinese obese children and adolescents","volume":"56","author":"Li","year":"2011","journal-title":"Arch. Oral Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110042_bb0215","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1210\/jcem.86.11.7998","article-title":"Identification of leptin in human saliva","volume":"86","author":"Groschl","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110042_bb0220","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbrc.2003.11.035","article-title":"Leptin suppresses porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis","volume":"312","author":"Slomiany","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0225","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbrc.2014.01.163","article-title":"Molecular expression of adiponectin in human saliva","volume":"445","author":"Lin","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12116","article-title":"The physiology of salivary secretion","volume":"70","author":"Proctor","year":"2016","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0235","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1080\/21691401.2019.1666864","article-title":"CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells","volume":"47","author":"Zhang","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.cellsig.2021.110042_bb0240","doi-asserted-by":"crossref","first-page":"109489","DOI":"10.1016\/j.biopha.2019.109489","article-title":"CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling","volume":"120","author":"Meng","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110042_bb0245","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.7150\/ijms.46707","article-title":"Cordycepin attenuates salivary hypofunction through the prevention of oxidative stress in human submandibular gland cells","volume":"17","author":"Jaiboonma","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0250","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.oraloncology.2006.03.006","article-title":"Hydrogen peroxide induced apoptosis in SV-40 transformed human salivary gland acinar cells","volume":"43","author":"Ben-juan","year":"2007","journal-title":"Oral Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0255","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jnutbio.2013.08.011","article-title":"Curcumin prevents leptin-induced tight junction dysfunction in intestinal Caco-2 BBe cells","volume":"25","author":"Kim","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0260","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0092-8674(03)00561-0","article-title":"The TNF receptor 1","volume":"114","author":"Barnhart","year":"2003","journal-title":"Cell."},{"key":"10.1016\/j.cellsig.2021.110042_bb0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2018.04.006","article-title":"Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice","volume":"476","author":"Wei","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0270","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/hep.25726","article-title":"Hepatitis C virus infection enhances TNFalpha-induced cell death via suppression of NF-kappaB","volume":"56","author":"Park","year":"2012","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.cellsig.2021.110042_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186489","article-title":"Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression","volume":"12","author":"Hwang","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0280","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180288","article-title":"hnRNP K plays a protective role in TNF-alpha-induced apoptosis in podocytes","volume":"38","author":"Zhao","year":"2018","journal-title":"Biosci. Rep."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0285","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes","volume":"114","author":"Micheau","year":"2003","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110042_bb0290","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.rdc.2016.03.006","article-title":"Salivary gland pathology in Sj\u00f6gren\u2019s syndrome","volume":"42","author":"Campos","year":"2016","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.cellsig.2021.110042_bb0295","first-page":"2005","article-title":"Salivary resistin reflects local inflammation in Sj\u00f6gren's syndrome","volume":"35","author":"Bostr\u00f6m","year":"2008","journal-title":"J. Rheumatol."},{"issue":"10","key":"10.1016\/j.cellsig.2021.110042_bb0300","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10067-015-3072-1","article-title":"Metabolic syndrome in Sj\u00f6gren's syndrome patients: a relevant concern for clinical monitoring","volume":"35","author":"Augusto","year":"2016","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110042_bb0305","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ijrobp.2008.09.036","article-title":"Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis","volume":"73","author":"Avila","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110042_bb0310","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.3390\/jcm9124095","article-title":"Radiation-induced salivary gland dysfunction: mechanisms, therapeutics and future directions","volume":"9","author":"Jasmer","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110042_bb0315","doi-asserted-by":"crossref","first-page":"12616","DOI":"10.1038\/s41598-020-69352-w","article-title":"Adipocytes protect fibroblasts from radiation-induced damage by adiponectin secretion","volume":"10","author":"Kosmacek","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:46:28Z","timestamp":1784904388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656821001315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":63,"alternative-id":["S0898656821001315"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110042","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CTRP3 promotes TNF-\u03b1-induced apoptosis and barrier dysfunction in salivary epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110042"}}