{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:03:43Z","timestamp":1782889423785,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730105"],"award-info":[{"award-number":["81730105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.cellsig.2021.110082","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T04:38:09Z","timestamp":1625891889000},"page":"110082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["IL-6\/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation"],"prefix":"10.1016","volume":"86","author":[{"given":"Jie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu-Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qing","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Dong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0005","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI69778","article-title":"Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance","volume":"124","author":"Tian","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0010","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/path.4193","article-title":"Podocyte loss involves MDM2-driven mitotic catastrophe","volume":"230","author":"Mulay","year":"2013","journal-title":"J. Pathol."},{"issue":"18","key":"10.1016\/j.cellsig.2021.110082_bb0015","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99271","article-title":"mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans","volume":"4","author":"Puelles","year":"2019","journal-title":"JCI Insight."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110082_bb0020","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1172\/JCI119163","article-title":"Podocyte loss and progressive glomerular injury in type II diabetes","volume":"99","author":"Pagtalunan","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0025","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1152\/ajprenal.00124.2006","article-title":"Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats","volume":"292","author":"S\u00e1nchez-Lozada","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.cellsig.2021.110082_bb0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.freeradbiomed.2015.02.029","article-title":"Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377","volume":"83","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2021.110082_bb0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bcp.2019.05.016","article-title":"Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1","volume":"166","author":"Li","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110082_bb0040","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00705-013-1759-7","article-title":"Effects of hepatitis B virus X gene on apoptosis and expression of immune molecules of human proximal tubular epithelial cells","volume":"158","author":"Wang","year":"2013","journal-title":"Arch. Virol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000508079","article-title":"Elevated endostatin expression is regulated by the pIgA immune complex and associated with disease severity of IgA nephropathy","volume":"46","author":"Zhai","year":"2021","journal-title":"Kidney Blood Press Res."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0050","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3892\/etm.2021.10052","article-title":"Transforming growth factor-<span>\u03b2<\/span>1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation","volume":"21","author":"Zheng","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cellsig.2021.110082_bb0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cytogfr.2017.03.003","article-title":"IL-6 signaling in diabetic nephropathy: from pathophysiology to therapeutic perspectives","volume":"37","author":"Feigerlov\u00e1","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110082_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057141","article-title":"Early activation of rat skeletal muscle IL-6\/STAT1\/STAT3 dependent gene expression in resistance exercise linked to hypertrophy","volume":"8","author":"Begue","year":"2013","journal-title":"PLoS One."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0065","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbadis.2019.01.020","article-title":"Nrf2 deficiency aggravates angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6\/STAT3-dependent inflammation","volume":"1865","author":"Chen","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.cellsig.2021.110082_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.658431","article-title":"Gestational and breastfeeding low-protein intake on blood pressure, kidney structure, and renal function in male rat offspring in adulthood","volume":"12","author":"Lamana","year":"2021","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20110340","article-title":"IL-6\/IL-6 receptor system and its role in physiological and pathological conditions","volume":"122","author":"Mihara","year":"2012","journal-title":"Clin. Sci. (Lond)."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1681\/ASN.2014111147","article-title":"IL-6 trans-signaling drives murine crescentic GN","volume":"27","author":"Braun","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0085","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1681\/ASN.2007070744","article-title":"IL-6\/IL-6R axis plays a critical role in acute kidney injury","volume":"19","author":"Nechemia-Arbely","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110082_bb0090","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-3083.1994.tb03448.x","article-title":"Interleukin-6 and interleukin-6 receptor are expressed by cultured glomerular epithelial cells","volume":"40","author":"Moutabarrik","year":"1994","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0095","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/s41467-017-01885-7","article-title":"Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis","volume":"8","author":"Henique","year":"2017","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110082_bb0100","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2174\/1871520617666170327155124","article-title":"The cross-talk between tristetraprolin and cytokines in cancer","volume":"17","author":"Guo","year":"2017","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0105","first-page":"1203","article-title":"Effects of tristetraprolin on doxorubicin (adriamycin)-induced experimental kidney injury through inhibiting IL-13\/STAT6 signal pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0110","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1038\/s41598-017-01027-5","article-title":"MiRNA-29c regulates the expression of inflammatory cytokines in diabetic nephropathy by targeting tristetraprolin","volume":"7","author":"Guo","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2021.110082_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141471","article-title":"The expression of tristetraprolin and its relationship with urinary proteins in patients with diabetic nephropathy","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One."},{"key":"10.1016\/j.cellsig.2021.110082_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.metabol.2018.03.020","article-title":"Lacking ketohexokinase-a exacerbates renal injury in streptozotocin-induced diabetic mice","volume":"85","author":"Doke","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.cellsig.2021.110082_bb0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnutbio.2019.05.017","article-title":"Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase","volume":"71","author":"Hayasaki","year":"2019","journal-title":"J. Nutr. Biochem."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110082_bb0130","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1681\/ASN.2013080901","article-title":"Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy","volume":"25","author":"Lanaspa","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110082_bb0135","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1681\/ASN.2016111215","article-title":"MicroRNA-92a mediates endothelial dysfunction in CKD","volume":"28","author":"Shang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.cellsig.2021.110082_bb0140","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/CIRCRESAHA.109.197491","article-title":"Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17\/92 pathway","volume":"104","author":"Brock","year":"2009","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.cellsig.2021.110082_bb0145","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1101\/gad.11.8.973","article-title":"Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development","volume":"11","author":"Yan","year":"1997","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0150","first-page":"3258","article-title":"Cell proliferation is induced in renal cell carcinoma through miR-92a-3p upregulation by targeting FBXW7","volume":"19","author":"Zeng","year":"2020","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0155","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2008060576","article-title":"Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells","volume":"20","author":"Cirillo","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/157339908783502370","article-title":"Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy","volume":"4","author":"Ziyadeh","year":"2008","journal-title":"Curr. Diabetes Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0165","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.humpath.2013.10.030","article-title":"Claudin 1 and nephrin label cellular crescents in diabetic glomerulosclerosis","volume":"45","author":"Gaut","year":"2014","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/jcmm.13314","article-title":"The classic signalling and trans-signalling of interleukin-6 are both injurious in podocyte under high glucose exposure","volume":"22","author":"Lei","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0175","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1159\/000189470","article-title":"Platelet-derived growth factor, interleukin (IL)-1 beta, IL-6R and tumor necrosis factor-alpha in IgA nephropathy An immunohistochemical study","volume":"74","author":"Taniguchi","year":"1996","journal-title":"Nephron"},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0180","first-page":"44","article-title":"Maslinic acid, a natural triterpene from","volume":"273","author":"Reyes-Zurita","year":"2009"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0185","doi-asserted-by":"crossref","first-page":"F712","DOI":"10.1152\/ajprenal.00433.2009","article-title":"Dietary fructose causes tubulointerstitial injury in the normal rat kidney","volume":"298","author":"Nakayama","year":"2010","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0190","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrd.2018.45","article-title":"Interleukin-6: designing specific therapeutics for a complex cytokine","volume":"17","author":"Garbers","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.cellsig.2021.110082_bb0195","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S1470-2045(14)70319-5","article-title":"Siltuximab for multicentric Castleman&apos;s disease: a randomised, double-blind, placebo-controlled trial","volume":"15","author":"van Rhee","year":"2014","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110082_bb0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/art.39944","article-title":"Sarilumab and nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis and inadequate response or intolerance to tumor necrosis factor inhibitors","volume":"69","author":"Fleischmann","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110082_bb0205","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1158\/1078-0432.CCR-09-2581","article-title":"Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma","volume":"16","author":"Puchalski","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0210","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.cellsig.2021.110082_bb0215","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1182\/blood-2004-12-4602","article-title":"Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease","volume":"106","author":"Nishimoto","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0220","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1613849","article-title":"Trial of tocilizumab in giant-cell arteritis","volume":"377","author":"Stone","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"10038","key":"10.1016\/j.cellsig.2021.110082_bb0225","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/S0140-6736(16)00232-4","article-title":"Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial","volume":"387","author":"Khanna","year":"2016","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.cellsig.2021.110082_bb0230","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1212\/WNL.0000000000000317","article-title":"Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study","volume":"82","author":"Araki","year":"2014","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0235","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.krcp.2016.09.003","article-title":"The role of local IL6\/JAK2\/STAT3 signaling in high glucose-induced podocyte hypertrophy","volume":"35","author":"Jo","year":"2016","journal-title":"Kidney Res. Clin. Pract."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/10715760500467935","article-title":"Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages","volume":"40","author":"M\u00e1rquez Mart\u00edn","year":"2006","journal-title":"Free Radic. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110082_bb0245","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1248\/bpb.30.2075","article-title":"Maslinic acid reduces blood glucose in KK-ay mice","volume":"30","author":"Liu","year":"2007","journal-title":"Biol. Pharm. Bull."},{"issue":"8","key":"10.1016\/j.cellsig.2021.110082_bb0250","doi-asserted-by":"crossref","first-page":"11538","DOI":"10.3390\/molecules190811538","article-title":"Maslinic acid, a natural phytoalexin-type triterpene from olives\u2013a promising nutraceutical?","volume":"19","author":"Lozano-Mena","year":"2014","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.cellsig.2021.110082_bb0255","doi-asserted-by":"crossref","first-page":"11791","DOI":"10.1096\/fj.201900413RRR","article-title":"Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1\/AMPK signaling pathway","volume":"33","author":"Liou","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2021.110082_bb0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.micpath.2018.04.002","article-title":"Maslinic acid protects against lipopolysaccharide\/<span><span>d<\/span><\/span>-galactosamine-induced acute liver injury in mice","volume":"119","author":"Wang","year":"2018","journal-title":"Microb. Pathog."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110082_bb0265","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/0886022X.2013.867799","article-title":"Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function","volume":"36","author":"Mkhwanazi","year":"2014","journal-title":"Ren. Fail."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0270","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/0886022X.2019.1623818","article-title":"Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid","volume":"41","author":"Mkhwanazi","year":"2019","journal-title":"Ren. Fail."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0275","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.3892\/ol.2017.6073","article-title":"Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated janus kinase\/signal transducer and activator of transcription 3 signaling pathway","volume":"13","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110082_bb0280","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41419-020-2630-x","article-title":"RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease","volume":"11","author":"Guo","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110082_bb0285","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0002-9440(10)65739-2","article-title":"Cell cycle regulation and differentiation in the human podocyte lineage","volume":"153","author":"Nagata","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110082_bb0290","doi-asserted-by":"crossref","first-page":"F515","DOI":"10.1152\/ajprenal.2000.278.4.F515","article-title":"Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis","volume":"278","author":"Shankland","year":"2000","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110082_bb0295","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1523-1755.2000.00149.x","article-title":"Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies","volume":"58","author":"Barisoni","year":"2000","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110082_bb0300","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2337\/db14-0411","article-title":"Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway","volume":"64","author":"Marek","year":"2015","journal-title":"Diabetes"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821001716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T02:11:46Z","timestamp":1718763106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656821001716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":60,"alternative-id":["S0898656821001716"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110082","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-6\/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110082"}}