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Res."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110121_bb1155","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Murai","year":"2009","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110121_bb1160","doi-asserted-by":"crossref","first-page":"24249","DOI":"10.1038\/srep24249","article-title":"Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. 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Biochem."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110121_bb1190","doi-asserted-by":"crossref","DOI":"10.3390\/v13020145","article-title":"The role of ubiquitination in NF-?B signaling during virus infection","volume":"13","author":"Song","year":"2021","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110121_bb1195","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/MCB.23.3.1061-1074.2003","article-title":"Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis","volume":"23","author":"Bayon","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110121_bb1200","first-page":"229","article-title":"Effect of all-trans retinoic acid on airway inflammation in asthmatic rats and its mechanism","volume":"24","author":"Fang","year":"2004","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Scie. = hua zhong ke ji da xue xue bao. yi xue ying De wen ban = huazhong keji daxue xuebao Yixue Yingdewen ban"},{"issue":"4","key":"10.1016\/j.cellsig.2021.110121_bb1205","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.4049\/jimmunol.181.4.2277","article-title":"Retinoic acid increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression","volume":"181","author":"Xiao","year":"2008","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.cellsig.2021.110121_bb1210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-pharmtox-010919-023711","article-title":"(Inverse) agonists of retinoic acid-related orphan receptor ?: regulation of immune responses inflammation, and autoimmune disease","volume":"60","author":"Jetten","year":"2020","journal-title":"Ann. Rev. Pharmacol. 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