{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:03:36Z","timestamp":1793261016844,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cellsig.2021.110153","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T15:12:02Z","timestamp":1632496322000},"page":"110153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Maintaining blood retinal barrier homeostasis to attenuate retinal ischemia-reperfusion injury by targeting the KEAP1\/NRF2\/ARE pathway with lycopene"],"prefix":"10.1016","volume":"88","author":[{"given":"Hao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xielan","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongde","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangxuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2021.110153_bb0005","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fimmu.2016.00444","article-title":"Cellular stress response and immune signaling in retinal ischemia-reperfusion injury","volume":"7","author":"Minhas","year":"2016","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110153_bb0010","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4093\/dmj.2018.0182","article-title":"Pathophysiology of diabetic retinopathy: the old and the new","volume":"42","author":"Kusuhara","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.cellsig.2021.110153_bb0015","doi-asserted-by":"crossref","first-page":"25792","DOI":"10.1038\/srep25792","article-title":"Association between systemic oxidative stress and visual field damage in open-angle glaucoma","volume":"6","author":"Tanito","year":"2016","journal-title":"Sci. Rep."},{"issue":"Suppl 1","key":"10.1016\/j.cellsig.2021.110153_bb0020","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S0039-6257(99)00044-2","article-title":"Neuroprotection in relation to retinal ischemia and relevance to glaucoma","volume":"43","author":"Osborne","year":"1999","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12035-012-8344-z","article-title":"Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation","volume":"47","author":"Sanderson","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2021.110153_bb0035","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110153_bb0040","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.cellsig.2021.110153_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2015.00117","article-title":"Use of mesothelial cells and biological matrices for tissue engineering of simple epithelium surrogates","volume":"3","author":"Lachaud","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110153_bb0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00146764","article-title":"The blood-retinal barriers","volume":"41","author":"Cunha-Vaz","year":"1976","journal-title":"Doc. Ophthalmol."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110153_bb0055","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.preteyeres.2008.09.003","article-title":"Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management","volume":"27","author":"Kaur","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0060","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/jcbfm.2013.230","article-title":"Ischemia-reperfusion injury induces occludin phosphorylation\/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner","volume":"34","author":"Muthusamy","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110153_bb0065","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/08820539909069543","article-title":"Molecular mechanisms of vascular permeability in diabetic retinopathy","volume":"14","author":"Antonetti","year":"1999","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.cellsig.2021.110153_bb0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12974-015-0452-z","article-title":"Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion","volume":"12","author":"Cho","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2021.110153_bb0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.cellsig.2021.110153_bb0080","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1007\/s12035-016-0111-0","article-title":"Nrf2-a promising therapeutic target for defensing against oxidative stress in stroke","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110153_bb0085","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/ars.2016.6795","article-title":"Nuclear factor (erythroid-derived 2)-like 2 and thioredoxin-1 in atherosclerosis and ischemia\/reperfusion injury in the heart","volume":"26","author":"Jakobs","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cellsig.2021.110153_bb0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0065-2571(02)00038-9","article-title":"Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis","volume":"43","author":"Talalay","year":"2003","journal-title":"Adv. Enzym. Regul."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110153_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","article-title":"Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution","volume":"16","author":"Taguchi","year":"2011","journal-title":"Genes Cells"},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2010.01.013","article-title":"Nrf2 the rescue: effects of the antioxidative\/electrophilic response on the liver","volume":"244","author":"Klaassen","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110153_bb0105","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1089\/ars.2010.3221","article-title":"Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway","volume":"13","author":"Hayes","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.cellsig.2021.110153_bb0110","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1074\/jbc.R111.271999","article-title":"Signal transduction by mitochondrial oxidants","volume":"287","author":"Finkel","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.cellsig.2021.110153_bb0115","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1016\/S0021-9258(18)77351-1","article-title":"Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants","volume":"265","author":"Rushmore","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2021.110153_bb0120","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.freeradbiomed.2020.01.185","article-title":"Natural ingredients-derived antioxidants attenuate H(2)O(2)-induced oxidative stress and have chondroprotective effects on human osteoarthritic chondrocytes via Keap1\/Nrf2 pathway","volume":"152","author":"Yang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2021.110153_bb0125","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10557-009-6206-3","article-title":"Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells","volume":"23","author":"Tang","year":"2009","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.cellsig.2021.110153_bb0130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2018.07.010","article-title":"Lycopene treatment inhibits activation of Jak1\/Stat3 and Wnt\/beta-catenin signaling and attenuates hyperproliferation in gastric epithelial cells","volume":"70","author":"Park","year":"2019","journal-title":"Nutr. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2021.110153_bb0135","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.nutres.2012.03.011","article-title":"Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects","volume":"32","author":"Xaplanteris","year":"2012","journal-title":"Nutr. Res."},{"issue":"12","key":"10.1016\/j.cellsig.2021.110153_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114387","article-title":"Protection against chemotaxis in the anti-inflammatory effect of bioactives from tomato ketchup","volume":"9","author":"Hazewindus","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2021.110153_bb0145","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.2147\/DDDT.S194753","article-title":"Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening","volume":"13","author":"Li","year":"2019","journal-title":"Drug. Des. Devel. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110153_bb0150","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000495466","article-title":"Anti-inflammatory effect of lycopene on experimental spinal cord ischemia injury via Cyclooxygenase-2 suppression","volume":"26","author":"Hua","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.cellsig.2021.110153_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.05.082","article-title":"Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism","volume":"124","author":"Zhao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"13","key":"10.1016\/j.cellsig.2021.110153_bb0160","article-title":"Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina","volume":"52","author":"Ogishima","year":"2011","journal-title":"Invest. Opthalmol. Visual Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00109-020-02017-3","article-title":"2,3,5,6-tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation","volume":"99","author":"Huang","year":"2021","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"6","key":"10.1016\/j.cellsig.2021.110153_bb0170","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1101\/gad.1383706","article-title":"The notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis","volume":"20","author":"Shen","year":"2006","journal-title":"Genes Dev."},{"issue":"3\u20134","key":"10.1016\/j.cellsig.2021.110153_bb0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.brainresbull.2011.07.014","article-title":"Quercetin protects oligodendrocyte precursor cells from oxygen\/glucose deprivation injury in vitro via the activation of the PI3K\/Akt signaling pathway","volume":"86","author":"Wang","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.cellsig.2021.110153_bb0180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2017.07.025","article-title":"Retinal metabolism: a comparative look at energetics in the retina","volume":"1672","author":"Country","year":"2017","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0185","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0300-9572(87)90012-8","article-title":"Mechanisms of ischemic cerebral injury","volume":"15","author":"Kaplan","year":"1987","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2021.110153_bb0195","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2021.110153_bb0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-0102(02)00196-7","article-title":"Cell permeable ROS scavengers, tiron and tempol, rescue PC12 cell death caused by pyrogallol or hypoxia\/reoxygenation","volume":"45","author":"Yamada","year":"2003","journal-title":"Neurosci. Res."},{"issue":"9","key":"10.1016\/j.cellsig.2021.110153_bb0210","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0215","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J. Pathol."},{"key":"10.1016\/j.cellsig.2021.110153_bb0220","series-title":"Electroretinography, Atlas of Inherited Retinal Diseases","first-page":"17","author":"Tsang","year":"2018"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0225","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0306-3623(97)00359-5","article-title":"The b-wave of the electroretinogram as an index of retinal ischemia","volume":"30","author":"Block","year":"1998","journal-title":"Gen. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2021.110153_bb0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10633-016-9534-1","article-title":"Differentiation of murine models of \u201cnegative ERG\u201d by single and repetitive light stimuli","volume":"132","author":"Tanimoto","year":"2016","journal-title":"Doc. Ophthalmol."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0235","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41433-020-0984-z","article-title":"Early structural and functional neurovascular changes in the retina in the prediabetic stage","volume":"35","author":"Ratra","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.cellsig.2021.110153_bb0240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.visres.2017.05.009","article-title":"The inner blood-retinal barrier: cellular basis and development","volume":"139","author":"D\u00edaz-Cor\u00e1nguez","year":"2017","journal-title":"Vis. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010211","article-title":"Tight junctions of the outer blood retina barrier","volume":"21","author":"Naylor","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0250","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/CIRCULATIONAHA.116.014411","article-title":"Diabetes-induced Jagged1 overexpression in endothelial cells causes retinal capillary regression in a murine model of diabetes mellitus","volume":"134","author":"Yoon","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.cellsig.2021.110153_bb0255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1167\/iovs.06-0510","article-title":"Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes","volume":"48","author":"Zheng","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2021.110153_bb0260","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.2337\/db19-0471","article-title":"Pericyte bridges in homeostasis and hyperglycemia","volume":"69","author":"Corliss","year":"2020","journal-title":"Diabetes"},{"issue":"7823","key":"10.1016\/j.cellsig.2021.110153_bb0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41586-020-2589-x","article-title":"Interpericyte tunnelling nanotubes regulate neurovascular coupling","volume":"585","author":"Alarcon-Martinez","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cellsig.2021.110153_bb0270","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3233\/JAD-2010-100219","article-title":"A review of string vessels or collapsed, empty basement membrane tubes","volume":"21","author":"Brown","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.cellsig.2021.110153_bb0275","article-title":"Multimodal fundus imaging of sodium iodate-treated mice informs RPE susceptibility and origins of increased fundus autofluorescence","volume":"58","author":"Zhao","year":"2017","journal-title":"Invest. Opthalmol. Visual Sci."},{"key":"10.1016\/j.cellsig.2021.110153_bb0280","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.freeradbiomed.2019.10.414","article-title":"Inhibition of the Keap1-Nrf2 protein-protein interaction protects retinal cells and ameliorates retinal ischemia-reperfusion injury","volume":"146","author":"Hui","year":"2020","journal-title":"Free Radic. Biol. Med."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821002424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656821002424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:02:25Z","timestamp":1760266945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656821002424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":56,"alternative-id":["S0898656821002424"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110153","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maintaining blood retinal barrier homeostasis to attenuate retinal ischemia-reperfusion injury by targeting the KEAP1\/NRF2\/ARE pathway with lycopene","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2021.110153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110153"}}