{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:29:37Z","timestamp":1789586977827,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL128799"],"award-info":[{"award-number":["R01HL128799"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL150059"],"award-info":[{"award-number":["R01HL150059"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cellsig.2022.110245","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T07:54:24Z","timestamp":1641801264000},"page":"110245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["G3bp1 \u2013 microRNA-1 axis regulates cardiomyocyte hypertrophy"],"prefix":"10.1016","volume":"91","author":[{"given":"Saleena","family":"Alikunju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Niranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Mohsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazish","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cellsig.2022.110245_bb0005","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1128\/MCB.16.6.2561","article-title":"A ras-GTPase-activating protein SH3-domain-binding protein","volume":"16","author":"Parker","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110245_bb0010","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1128\/MCB.18.7.3956","article-title":"A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability","volume":"18","author":"Gallouzi","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"22","key":"10.1016\/j.cellsig.2022.110245_bb0015","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1128\/MCB.21.22.7747-7760.2001","article-title":"RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization","volume":"21","author":"Tourriere","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110245_bb0020","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1083\/jcb.200212128","article-title":"The RasGAP-associated endoribonuclease G3BP assembles stress granules","volume":"160","author":"Tourriere","year":"2003","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110245_bb0025","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1083\/jcb.147.7.1431","article-title":"RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules","volume":"147","author":"Kedersha","year":"1999","journal-title":"J. Cell Biol."},{"issue":"Pt 6","key":"10.1016\/j.cellsig.2022.110245_bb0030","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1042\/bst0300963","article-title":"Stress granules: sites of mRNA triage that regulate mRNA stability and translatability","volume":"30","author":"Kedersha","year":"2002","journal-title":"Biochem. Soc. Trans."},{"issue":"12","key":"10.1016\/j.cellsig.2022.110245_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145112","article-title":"GTPase activating protein (Sh3 domain) binding protein 1 regulates the processing of MicroRNA-1 during cardiac hypertrophy","volume":"10","author":"He","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cellsig.2022.110245_bb0040","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","article-title":"MicroRNAs play an essential role in the development of cardiac hypertrophy","volume":"100","author":"Sayed","year":"2007","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110245_bb0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.114.001660","article-title":"Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription","volume":"8","author":"Sayed","year":"2015","journal-title":"Circ. Heart Fail."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110245_bb0050","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physiolgenomics.00144.2007","article-title":"Altered microRNA expression in human heart disease","volume":"31","author":"Ikeda","year":"2007","journal-title":"Physiol. Genomics"},{"issue":"8","key":"10.1016\/j.cellsig.2022.110245_bb0055","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1128\/MCB.01222-08","article-title":"MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes","volume":"29","author":"Ikeda","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110245_bb0060","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89169","article-title":"Myocardial microRNAs associated with reverse remodeling in human heart failure","volume":"2","author":"Sucharov","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.cellsig.2022.110245_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110245_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"issue":"Database issue)","key":"10.1016\/j.cellsig.2022.110245_bb0075","article-title":"KEGG for integration and interpretation of large-scale molecular data sets","volume":"40","author":"Kanehisa","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110245_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011484","article-title":"Glucocorticoid receptor-binding and transcriptome signature in cardiomyocytes","volume":"8","author":"Severinova","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cellsig.2022.110245_bb0085","first-page":"109","article-title":"Methods in Molecular Biology","author":"Graham","year":"1991"},{"issue":"8","key":"10.1016\/j.cellsig.2022.110245_bb0090","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1091\/mbc.e08-02-0159","article-title":"MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths","volume":"19","author":"Sayed","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2022.110245_bb0095","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"Langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2022.110245_bb0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yjmcc.2020.04.007","article-title":"Acute NelfA knockdown restricts compensatory gene expression and precipitates ventricular dysfunction during cardiac hypertrophy","volume":"142","author":"Alikunju","year":"2020","journal-title":"J. Mol. Cell Cardiol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110245_bb0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCULATIONAHA.109.868554","article-title":"Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy","volume":"120","author":"Oceandy","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2022.110245_bb0110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fphys.2020.00389","article-title":"Molecular mechanism of hippo-YAP1\/TAZ pathway in heart development, disease, and regeneration","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Physiol"},{"issue":"2","key":"10.1016\/j.cellsig.2022.110245_bb0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/cvr\/cvv108","article-title":"Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy","volume":"106","author":"Zhong","year":"2015","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110245_bb0120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jacc.2009.02.076","article-title":"ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene","volume":"54","author":"Moulik","year":"2009","journal-title":"J. Am. College Cardiol."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110245_bb0125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/physrev.00006.2010","article-title":"MicroRNAs in development and disease","volume":"91","author":"Sayed","year":"2011","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110245_bb0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/gtc.12023","article-title":"Both G3BP1 and G3BP2 contribute to stress granule formation","volume":"18","author":"Matsuki","year":"2013","journal-title":"Genes Cells"},{"issue":"21","key":"10.1016\/j.cellsig.2022.110245_bb0135","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1128\/MCB.25.21.9520-9531.2005","article-title":"Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1","volume":"25","author":"Lopez de Silanes","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110245_bb0140","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.200502088","article-title":"Stress granules and processing bodies are dynamically linked sites of mRNP remodeling","volume":"169","author":"Kedersha","year":"2005","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110245_bb0145","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1074\/jbc.M112.429449","article-title":"Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy","volume":"288","author":"Sayed","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110245_bb0150","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1083\/jcb.151.6.1257","article-title":"Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules","volume":"151","author":"Kedersha","year":"2000","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110245_bb0155","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1083\/jcb.201801214","article-title":"Phosphorylation of G3BP1-S149 does not influence stress granule assembly","volume":"218","author":"Panas","year":"2019","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110245_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213769","article-title":"Presence and function of stress granules in atrial fibrillation","volume":"14","author":"Dong","year":"2019","journal-title":"PLoS One."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110245_bb0165","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2165\/11537920-000000000-00000","article-title":"Current and future management options for myelodysplastic syndromes","volume":"70","author":"Bryan","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.cellsig.2022.110245_bb0170","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ijbiomac.2021.09.018","article-title":"Genomics-guided targeting of stress granule proteins G3BP1\/2 to inhibit SARS-CoV-2 propagation","volume":"190","author":"Ali","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110245_bb0175","doi-asserted-by":"crossref","first-page":"103562","DOI":"10.1016\/j.isci.2021.103562","article-title":"SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response","volume":"25","author":"Nabeel-Shah","year":"2022","journal-title":"iScience"},{"issue":"19","key":"10.1016\/j.cellsig.2022.110245_bb0180","doi-asserted-by":"crossref","first-page":"8703","DOI":"10.1128\/MCB.25.19.8703-8716.2005","article-title":"Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP","volume":"25","author":"Zekri","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"27","key":"10.1016\/j.cellsig.2022.110245_bb0185","doi-asserted-by":"crossref","first-page":"25717","DOI":"10.1074\/jbc.M414266200","article-title":"An alliance between ras GTPase-activating protein, filamin C, and ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth","volume":"280","author":"Lypowy","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110245_bb0190","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2022.110245_bb0195","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb1050","article-title":"Hippo promotes proliferation arrest and apoptosis in the Salvador\/Warts pathway","volume":"5","author":"Udan","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110245_bb0200","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.cellsig.2022.110245_bb0205","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1016\/j.cub.2006.10.060","article-title":"The Drosophila RASSF homolog antagonizes the hippo pathway","volume":"16","author":"Polesello","year":"2006","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110245_bb0210","first-page":"132","article-title":"ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation","volume":"8","author":"Xiao","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"13","key":"10.1016\/j.cellsig.2022.110245_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136649","article-title":"YAP\/TEAD1 complex is a default repressor of cardiac toll-like receptor genes","volume":"22","author":"Gao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110245_bb0220","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822000055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822000055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:08:07Z","timestamp":1760267287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656822000055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":44,"alternative-id":["S0898656822000055"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110245","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"G3bp1 \u2013 microRNA-1 axis regulates cardiomyocyte hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110245"}}