{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:41:49Z","timestamp":1793011309141,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070415"],"award-info":[{"award-number":["82070415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071790"],"award-info":[{"award-number":["82071790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101842"],"award-info":[{"award-number":["82101842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["18SG33"],"award-info":[{"award-number":["18SG33"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["19SG17"],"award-info":[{"award-number":["19SG17"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2019YFA0801502"],"award-info":[{"award-number":["2019YFA0801502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.cellsig.2022.110281","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T02:13:56Z","timestamp":1644459236000},"page":"110281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["PHLPP1 deficiency ameliorates cardiomyocyte death and cardiac dysfunction through inhibiting Mcl-1 degradation"],"prefix":"10.1016","volume":"92","author":[{"given":"Yong","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cellsig.2022.110281_bb0005","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s10495-008-0302-x","article-title":"Role of apoptosis in cardiovascular disease","volume":"14","author":"Lee","year":"2009","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110281_bb0015","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI117504","article-title":"Reperfusion injury induces apoptosis in rabbit cardiomyocytes","volume":"94","author":"Gottlieb","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 3","key":"10.1016\/j.cellsig.2022.110281_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s003950050195","article-title":"Apoptosis and myocardial infarction","volume":"93","author":"Anversa","year":"1998","journal-title":"Basic Res. Cardiol."},{"issue":"20","key":"10.1016\/j.cellsig.2022.110281_bb0025","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJM199511163332015","article-title":"Doxorubicin-induced cardiotoxicity","volume":"333","author":"Silber","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110281_bb0030","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110281_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0008-6363(02)00646-6","article-title":"Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes","volume":"57","author":"Nitobe","year":"2003","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110281_bb0040","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cellsig.2022.110281_bb0045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2017.10.008","article-title":"CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1","volume":"114","author":"Yuan","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10741-016-9532-0","article-title":"Role of cell death in the progression of heart failure","volume":"21","author":"Moe","year":"2016","journal-title":"Heart Fail. Rev."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110281_bb0055","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110281_bb0060","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molcel.2010.01.025","article-title":"The BCL-2 family reunion","volume":"37","author":"Chipuk","year":"2010","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2022.110281_bb0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2011.02.034","article-title":"Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol","volume":"145","author":"Edlich","year":"2011","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2022.110281_bb0070","first-page":"1567","article-title":"Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers","volume":"148","author":"Krajewska","year":"1996","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110281_bb0075","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1182\/blood.V87.6.2470.bloodjournal8762470","article-title":"Frequent expression of the cell death-inducing gene Bax in Reed-Sternberg cells of Hodgkin\u2019s disease","volume":"87","author":"Brousset","year":"1996","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cellsig.2022.110281_bb0080","first-page":"315","article-title":"Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt\u2019s lymphoma cells","volume":"3","author":"Khanna","year":"1996","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110281_bb0085","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1074\/jbc.R111.318675","article-title":"Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling","volume":"287","author":"Warfel","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110281_bb0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2005.03.008","article-title":"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth","volume":"18","author":"Gao","year":"2005","journal-title":"Mol. Cell"},{"issue":"24","key":"10.1016\/j.cellsig.2022.110281_bb0095","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1128\/MCB.05799-11","article-title":"PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth","volume":"31","author":"Liu","year":"2011","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110281_bb0100","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbrc.2013.12.129","article-title":"PHLPP1 regulates contact inhibition by dephosphorylating Mst1 at the inhibitory site","volume":"443","author":"Jung","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.cellsig.2022.110281_bb0105","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1158\/1940-6207.CAPR-14-0233","article-title":"Crucial role of c-Jun phosphorylation at Ser63\/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation","volume":"7","author":"Zhu","year":"2014","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"31","key":"10.1016\/j.cellsig.2022.110281_bb0110","doi-asserted-by":"crossref","first-page":"11772","DOI":"10.1074\/jbc.RA119.007660","article-title":"Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice","volume":"294","author":"Mattson","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2022.110281_bb0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.lfs.2018.08.030","article-title":"Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice","volume":"209","author":"Shao","year":"2018","journal-title":"Life Sci."},{"issue":"22","key":"10.1016\/j.cellsig.2022.110281_bb0120","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1042\/BCJ20190709","article-title":"CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction","volume":"476","author":"Kusuyama","year":"2019","journal-title":"Biochem. J."},{"issue":"7570","key":"10.1016\/j.cellsig.2022.110281_bb0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature15372","article-title":"Epicardial FSTL1 reconstitution regenerates the adult mammalian heart","volume":"525","author":"Wei","year":"2015","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cellsig.2022.110281_bb0130","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.cellsig.2022.110281_bb0135","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1073\/pnas.0608543104","article-title":"Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy","volume":"104","author":"Radke","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110281_bb0140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1139\/cjpp-2017-0742","article-title":"A rapid and efficient method for the isolation of postnatal murine cardiac myocyte and fibroblast cells","volume":"96","author":"Weldrick","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110281_bb0145","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni.2015","article-title":"Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk","volume":"12","author":"Liu","year":"2011","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0150","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41375-018-0176-z","article-title":"The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL","volume":"33","author":"Kampen","year":"2019","journal-title":"Leukemia"},{"issue":"31","key":"10.1016\/j.cellsig.2022.110281_bb0155","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1038\/sj.onc.1207692","article-title":"MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol","volume":"23","author":"Domina","year":"2004","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.cellsig.2022.110281_bb0160","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.RES.86.11.1107","article-title":"Apoptosis and heart failure: a critical review of the literature","volume":"86","author":"Kang","year":"2000","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.cellsig.2022.110281_bb0165","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/eurheartj\/ehaa878","article-title":"The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction","volume":"42","author":"Li","year":"2021","journal-title":"Eur. Heart J."},{"issue":"19","key":"10.1016\/j.cellsig.2022.110281_bb0170","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1161\/01.CIR.0000165128.39715.87","article-title":"Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure","volume":"111","author":"Ding","year":"2005","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.cellsig.2022.110281_bb0175","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jacc.2014.04.068","article-title":"Cardiomyocyte-specific deletion of Gsk3\u03b1 mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure","volume":"64","author":"Ahmad","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110281_bb0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s11626-016-0105-2","article-title":"Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia\/reperfusion injury","volume":"53","author":"Yang","year":"2017","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110281_bb0185","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/FJC.0000000000000733","article-title":"Upregulating MicroRNA-203 alleviates myocardial remodeling and cell apoptosis through downregulating protein tyrosine phosphatase 1B in rats with myocardial infarction","volume":"74","author":"Zhang","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0190","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/j.gastro.2011.10.026","article-title":"The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation","volume":"142","author":"Nitsche","year":"2012","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.cellsig.2022.110281_bb0195","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1053\/j.gastro.2014.02.003","article-title":"PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice","volume":"146","author":"Li","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2022.110281_bb0200","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48609","article-title":"PHLPP1 counter-regulates STAT1-mediated inflammatory signaling","volume":"8","author":"Cohen Katsenelson","year":"2019","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110281_bb0205","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCRESAHA.109.215020","article-title":"PHLPP-1 negatively regulates Akt activity and survival in the heart","volume":"107","author":"Miyamoto","year":"2010","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0210","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/cvr\/cvu243","article-title":"Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy","volume":"105","author":"Moc","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110281_bb0215","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41418-019-0486-3","article-title":"Saga of Mcl-1: regulation from transcription to degradation","volume":"27","author":"Senichkin","year":"2020","journal-title":"Cell Death Differ."},{"issue":"25","key":"10.1016\/j.cellsig.2022.110281_bb0220","doi-asserted-by":"crossref","first-page":"18407","DOI":"10.1074\/jbc.M610010200","article-title":"Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1","volume":"282","author":"Kobayashi","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.cellsig.2022.110281_bb0225","doi-asserted-by":"crossref","first-page":"36353","DOI":"10.18632\/oncotarget.9217","article-title":"DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa\/MCL-1\/CDK2 complex","volume":"7","author":"Nakajima","year":"2016","journal-title":"Oncotarget"},{"issue":"15","key":"10.1016\/j.cellsig.2022.110281_bb0230","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1158\/0008-5472.CAN-08-0579","article-title":"Down-regulation of myeloid cell leukemia-1 through inhibiting Erk\/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer","volume":"68","author":"Ding","year":"2008","journal-title":"Cancer Res."},{"issue":"46","key":"10.1016\/j.cellsig.2022.110281_bb0235","doi-asserted-by":"crossref","first-page":"43730","DOI":"10.1074\/jbc.M207951200","article-title":"Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress","volume":"277","author":"Inoshita","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110281_bb0240","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1128\/MCB.00620-06","article-title":"Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization","volume":"27","author":"Ding","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110281_bb0245","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.molcel.2006.02.009","article-title":"Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1","volume":"21","author":"Maurer","year":"2006","journal-title":"Mol. Cell"},{"issue":"7336","key":"10.1016\/j.cellsig.2022.110281_bb0250","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09779","article-title":"Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7","volume":"471","author":"Wertz","year":"2011","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.cellsig.2022.110281_bb0255","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1128\/MCB.01266-09","article-title":"Ubiquitin-independent degradation of antiapoptotic MCL-1","volume":"30","author":"Stewart","year":"2010","journal-title":"Mol. Cell. Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822000419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822000419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:06:41Z","timestamp":1760267201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656822000419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":51,"alternative-id":["S0898656822000419"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110281","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PHLPP1 deficiency ameliorates cardiomyocyte death and cardiac dysfunction through inhibiting Mcl-1 degradation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110281"}}