{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:27:29Z","timestamp":1782930449758,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770505"],"award-info":[{"award-number":["81770505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.cellsig.2022.110410","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T22:54:39Z","timestamp":1658012079000},"page":"110410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy"],"prefix":"10.1016","volume":"98","author":[{"given":"Wanlin","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cellsig.2022.110410_bb0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/jamacardio.2019.0295","article-title":"Burden of cardiovascular diseases in China, 1990-2016: findings from the 2016 global burden of disease study","volume":"4","author":"Liu","year":"2019","journal-title":"JAMA Cardiol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110410_bb0010","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pcad.2016.04.003","article-title":"Coronary atherosclerosis: pathophysiologic basis for diagnosis and management","volume":"58","author":"Boudoulas","year":"2016","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"41","key":"10.1016\/j.cellsig.2022.110410_bb0015","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1093\/eurheartj\/eht351","article-title":"Endothelial dysfunction over the course of coronary artery disease","volume":"34","author":"Guti\u00e9rrez","year":"2013","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110410_bb0020","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.2353\/ajpath.2010.100129","article-title":"Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration","volume":"177","author":"Goh","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110410_bb0025","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1161\/01.RES.0000250758.63358.91","article-title":"Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton","volume":"99","author":"Cazes","year":"2006","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110410_bb0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3945\/ajcn.112.043687","article-title":"Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes","volume":"97","author":"Jonker","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110410_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrendo.2018.35","article-title":"Obesity: ANGPTL4 - the link binding obesity and glucose intolerance","volume":"14","author":"Morris","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110410_bb0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ccr.2011.01.018","article-title":"Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(\u2212):H2O2 ratio and confers anoikis resistance to tumors","volume":"19","author":"Zhu","year":"2011","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.cellsig.2022.110410_bb0045","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1194\/jlr.C200010-JLR200","article-title":"Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase","volume":"43","author":"Yoshida","year":"2002","journal-title":"J. Lipid Res."},{"issue":"12","key":"10.1016\/j.cellsig.2022.110410_bb0050","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJMoa1510926","article-title":"Inactivating variants in ANGPTL4 and risk of coronary artery disease","volume":"374","author":"Dewey","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2022.110410_bb0055","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.1038\/ncomms12313","article-title":"ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression","volume":"7","author":"Aryal","year":"2016","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110410_bb0060","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/ATVBAHA.113.301698","article-title":"Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development","volume":"33","author":"Georgiadi","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110410_bb0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12944-021-01580-z","article-title":"Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity","volume":"20","author":"Sun","year":"2021","journal-title":"Lipids Health Dis."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110410_bb0070","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and mitophagy in cardiovascular disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2022.110410_bb0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-981-15-4272-5_18","article-title":"Autophagy, hyperlipidemia, and atherosclerosis","volume":"1207","author":"Miao","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110410_bb0080","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbrc.2010.03.026","article-title":"The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells","volume":"394","author":"Zhang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110410_bb0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/15548627.2017.1395114","article-title":"Endothelial autophagic flux hampers atherosclerotic lesion development","volume":"14","author":"Kheloufi","year":"2018","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.cellsig.2022.110410_bb0090","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.abb.2007.01.013","article-title":"Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron","volume":"462","author":"Kurz","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110410_bb0095","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/EBC20170022","article-title":"Autophagy in health and disease: focus on the cardiovascular system","volume":"61","author":"Mialet-Perez","year":"2017","journal-title":"Essays Biochem."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110410_bb0100","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.molmed.2019.05.010","article-title":"ANGPTL4 in metabolic and cardiovascular disease","volume":"25","author":"Aryal","year":"2019","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110410_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020431","article-title":"Angiopoietin-like proteins in angiogenesis, inflammation and Cancer","volume":"19","author":"Carbone","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2022.110410_bb0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.expneurol.2015.05.020","article-title":"Angiopoietin-like 4: a double-edged sword in atherosclerosis and ischemic stroke?","volume":"272","author":"Xu","year":"2015","journal-title":"Exp. Neurol."},{"issue":"47","key":"10.1016\/j.cellsig.2022.110410_bb0115","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1093\/eurheartj\/eht153","article-title":"Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke","volume":"34","author":"Bouleti","year":"2013","journal-title":"Eur. Heart J."},{"issue":"17","key":"10.1016\/j.cellsig.2022.110410_bb0120","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1038\/onc.2013.174","article-title":"ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis","volume":"33","author":"Okochi-Takada","year":"2014","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110410_bb0125","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41418-019-0287-8","article-title":"Autophagy in endothelial cells and tumor angiogenesis","volume":"26","author":"Schaaf","year":"2019","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110410_bb0130","first-page":"459","article-title":"Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells","volume":"4","author":"Xie","year":"2011","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2022.110410_bb0135","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/cvr\/cvx064","article-title":"ULK1 prevents cardiac dysfunction in obesity through autophagy-meditated regulation of lipid metabolism","volume":"113","author":"An","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110410_bb0140","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1074\/jbc.RA118.005932","article-title":"Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition","volume":"294","author":"Gutgsell","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110410_bb0145","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911222","article-title":"ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a","volume":"12","author":"Jung","year":"2020","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110410_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085808","article-title":"Angiopoietin-like 4 confers resistance to hypoxia\/serum deprivation-induced apoptosis through PI3K\/Akt and ERK1\/2 signaling pathways in mesenchymal stem cells","volume":"9","author":"Hou","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.cellsig.2022.110410_bb0155","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1161\/ATVBAHA.111.224899","article-title":"Autophagy in atherosclerosis: a potential drug target for plaque stabilization","volume":"31","author":"Schrijvers","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110410_bb0160","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.metabol.2008.06.016","article-title":"Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study","volume":"57","author":"Folsom","year":"2008","journal-title":"Metabolism"},{"issue":"12","key":"10.1016\/j.cellsig.2022.110410_bb0165","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1056\/NEJMoa1507652","article-title":"Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease","volume":"374","author":"Stitziel","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110410_bb0170","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/ATVBAHA.110.212209","article-title":"The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk","volume":"30","author":"Smart-Halajko","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110410_bb0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/CIRCULATIONAHA.111.049072","article-title":"Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4","volume":"125","author":"Galaup","year":"2012","journal-title":"Circulation"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822001723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822001723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T19:12:07Z","timestamp":1746558727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656822001723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":35,"alternative-id":["S0898656822001723"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110410","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110410"}}