{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T20:07:08Z","timestamp":1783282028022,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085QH311"],"award-info":[{"award-number":["2108085QH311"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cellsig.2022.110436","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T21:50:34Z","timestamp":1659995434000},"page":"110436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["HAO1 negatively regulates liver macrophage activation via the NF-\u03baB pathway in alcohol-associated liver disease"],"prefix":"10.1016","volume":"99","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cellsig.2022.110436_bb0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5009\/gnl16477","article-title":"Pathophysiology and management of alcoholic liver disease: update 2016","volume":"11","author":"Stickel","year":"2017","journal-title":"Gut Liver"},{"issue":"5","key":"10.1016\/j.cellsig.2022.110436_bb0010","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0015","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/hep.28530","article-title":"Alcoholic hepatitis: translational approaches to develop targeted therapies","volume":"64","author":"Mandrekar","year":"2016","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.cellsig.2022.110436_bb0020","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/0016-5085(92)91458-G","article-title":"Immune responses to acetaldehyde-protein adducts: role in alcoholic liver disease","volume":"103","author":"Tuma","year":"1992","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.cellsig.2022.110436_bb0025","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.1002060","article-title":"Adiponectin and heme oxygenase-1 suppress TLR4\/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure","volume":"185","author":"Mandal","year":"2010","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110436_bb0030","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3748\/wjg.v16.i11.1321","article-title":"Alcoholic liver disease and the gut-liver axis","volume":"16","author":"Szabo","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110436_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6336(89)80008-7","article-title":"Peroxisomal oxidases: cytochemical localization and biological relevance","volume":"20","author":"Angermuller","year":"1989","journal-title":"Prog. Histochem. Cytochem."},{"issue":"17","key":"10.1016\/j.cellsig.2022.110436_bb0040","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1074\/jbc.275.17.12590","article-title":"Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases","volume":"275","author":"Jones","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110436_bb0045","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1053\/jhep.2003.50417","article-title":"Oxidative stress-mediated down-regulation of rat hydroxyacid oxidase 1, a liver-specific peroxisomal enzyme","volume":"38","author":"Recalcati","year":"2003","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0050","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1074\/jbc.274.4.2401","article-title":"Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA","volume":"274","author":"Kohler","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2022.110436_bb0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54363","article-title":"Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria","volume":"9","author":"McGregor","year":"2020","journal-title":"eLife"},{"issue":"2","key":"10.1016\/j.cellsig.2022.110436_bb0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40265-020-01463-0","article-title":"Lumasiran: first approval","volume":"81","author":"Scott","year":"2021","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.cellsig.2022.110436_bb0065","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"issue":"47","key":"10.1016\/j.cellsig.2022.110436_bb0070","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1038\/s41388-018-0383-0","article-title":"PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis","volume":"37","author":"Yang","year":"2018","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.cellsig.2022.110436_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070863","article-title":"Kahweol ameliorates the liver inflammation through the inhibition of NF-kappaB and STAT3 activation in primary Kupffer cells and primary hepatocytes","volume":"10","author":"Seo","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.cellsig.2022.110436_bb0080","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Affo","year":"2013","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0085","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1053\/j.gastro.2017.10.048","article-title":"Combination of gene expression signature and model for end-stage liver disease score predicts survival of patients with severe alcoholic hepatitis","volume":"154","author":"Trepo","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110436_bb0095","first-page":"113","article-title":"Current management of alcoholic hepatitis and future therapies","volume":"4","author":"Saberi","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0100","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/alcalc\/agz036","article-title":"Alcoholic hepatitis: a review","volume":"54","author":"Hosseini","year":"2019","journal-title":"Alcohol Alcohol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2302\/kjm.48.184","article-title":"Pathogenesis of alcoholic liver disease: newer mechanisms of injury","volume":"48","author":"Crabb","year":"1999","journal-title":"Keio J. Med."},{"issue":"Suppl","key":"10.1016\/j.cellsig.2022.110436_bb0110","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1046\/j.1440-1746.2000.02179.x","article-title":"Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury","volume":"15","author":"Enomoto","year":"2000","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0115","first-page":"G605","article-title":"Alcoholic liver injury involves activation of Kupffer cells by endotoxin","volume":"275","author":"Thurman","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cellsig.2022.110436_bb0120","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fimmu.2016.00538","article-title":"Critical roles of Kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials","volume":"7","author":"Zeng","year":"2016","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jhep.2015.11.029","article-title":"The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival","volume":"64","author":"Mattu","year":"2016","journal-title":"J. Hepatol."},{"issue":"Pt 9","key":"10.1016\/j.cellsig.2022.110436_bb0130","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1242\/jcs.114.9.1625","article-title":"Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI","volume":"114","author":"Recalcati","year":"2001","journal-title":"J. Cell Sci."},{"issue":"Pt 3","key":"10.1016\/j.cellsig.2022.110436_bb0135","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1042\/bj3630483","article-title":"Sensitive and real-time determination of H2O2 release from intact peroxisomes","volume":"363","author":"Mueller","year":"2002","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110436_bb0140","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00240-018-1089-z","article-title":"Molecular basis of primary hyperoxaluria: clues to innovative treatments","volume":"47","author":"Dindo","year":"2019","journal-title":"Urolithiasis"},{"key":"10.1016\/j.cellsig.2022.110436_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.615308","article-title":"Identification of hub genes associated with development and microenvironment of hepatocellular carcinoma by weighted gene co-expression network analysis and differential gene expression analysis","volume":"11","author":"Bai","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.cellsig.2022.110436_bb0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.ircmb.2017.07.007","article-title":"NF-kappaB and the transcriptional control of inflammation","volume":"335","author":"Mitchell","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"22","key":"10.1016\/j.cellsig.2022.110436_bb0155","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1038\/s41388-019-0702-0","article-title":"NF-kappaB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells","volume":"38","author":"Echizen","year":"2019","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040762","article-title":"Lycopene inhibits reactive oxygen species-mediated NF-kappaB signaling and induces apoptosis in pancreatic cancer cells","volume":"11","author":"Jeong","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cellsig.2022.110436_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110436_bb0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-kappaB in the liver--linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110436_bb0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/hep.510300402","article-title":"Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat","volume":"30","author":"Nanji","year":"1999","journal-title":"Hepatology"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682200198X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682200198X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:07:57Z","timestamp":1760267277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865682200198X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":35,"alternative-id":["S089865682200198X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110436","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HAO1 negatively regulates liver macrophage activation via the NF-\u03baB pathway in alcohol-associated liver disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110436"}}