{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:51:20Z","timestamp":1783569080867,"version":"3.55.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.cellsig.2022.110550","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T14:22:27Z","timestamp":1669904547000},"page":"110550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The role of acetaldehyde dehydrogenase 2 in the pathogenesis of liver diseases"],"prefix":"10.1016","volume":"102","author":[{"given":"Yin-cui","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-song","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-xian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Shuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2022.110550_bb0005","article-title":"Human pluripotent stem cell-derived hepatocyte-like cells and organoids for liver disease and therapy","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2022.110550_bb0010","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.actbio.2021.06.012","article-title":"Artificial cells for the treatment of liver diseases","volume":"130","author":"Zou","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cellsig.2022.110550_bb0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin. Liver. Dis."},{"key":"10.1016\/j.cellsig.2022.110550_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2022.110550_bb0025","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00203-020-01909-9","article-title":"Cross talk between alcohol-induced oxidative stress and HCV replication","volume":"202","author":"Sobhanimonfared","year":"2020","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0030","doi-asserted-by":"crossref","first-page":"G930","DOI":"10.1152\/ajpgi.00021.2016","article-title":"Role of apoptotic hepatocytes in HCV dissemination: regulation by acetaldehyde","volume":"310","author":"Ganesan","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.omtm.2019.08.004","article-title":"Gene therapy correction of aldehyde dehydrogenase 2 deficiency","volume":"15","author":"Matsumura","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.cellsig.2022.110550_bb0040","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1073\/pnas.1908137116","article-title":"Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking","volume":"116","author":"Guillot","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2022.110550_bb0045","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2019.06.018","article-title":"ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles","volume":"71","author":"Seo","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0050","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/hep.22010","article-title":"Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease","volume":"46","author":"Zakhari","year":"2007","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0055","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3389\/fonc.2020.01141","article-title":"Methylation-induced silencing of ALDH2 facilitates lung adenocarcinoma bone metastasis by activating the MAPK pathway","volume":"10","author":"Yang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0060","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.bbadis.2019.03.015","article-title":"Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagy","volume":"1865","author":"Pang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.cellsig.2022.110550_bb0065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1081\/DMR-120034001","article-title":"Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism","volume":"36","author":"Vasiliou","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.cellsig.2022.110550_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1265\/jjh.71.55","article-title":"Fundamental Properties of Aldehyde Dehydrogenase 2 (ALDH2) and the Importance of the ALDH2 Polymorphism","volume":"71","author":"Matsumoto","year":"2016","journal-title":"Nihon Eiseigaku Zasshi."},{"key":"10.1016\/j.cellsig.2022.110550_bb0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-981-13-6260-6_3","article-title":"ALDH2 and Cardiovascular Disease","volume":"1193","author":"Chen","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0080","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7150\/ijbs.42300","article-title":"Aldehyde dehydrogenase, liver disease and cancer","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2022.110550_bb0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s10930-018-9768-8","article-title":"Alcohol metabolic inefficiency: structural characterization of polymorphism-induced ALDH2 dysfunctionality and allosteric site identification for design of potential wildtype reactivators","volume":"37","author":"Adeniji","year":"2018","journal-title":"Protein J."},{"key":"10.1016\/j.cellsig.2022.110550_bb0090","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.apsb.2021.02.008","article-title":"The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment","volume":"11","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cellsig.2022.110550_bb0095","doi-asserted-by":"crossref","first-page":"30550","DOI":"10.1074\/jbc.M502345200","article-title":"Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase \u201cAsian\u201d variant","volume":"280","author":"Larson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2022.110550_bb0100","doi-asserted-by":"crossref","first-page":"9088","DOI":"10.1073\/pnas.1510757112","article-title":"ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis","volume":"112","author":"Jin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2022.110550_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.lfs.2016.01.028","article-title":"ALDH2 gene polymorphism in different types of cancers and its clinical significance","volume":"147","author":"Li","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2022.110550_bb0110","doi-asserted-by":"crossref","first-page":"18950","DOI":"10.1038\/s41598-019-55427-w","article-title":"Effect of ALDH2 on sleep disturbances in patients with Parkinson\u2019s disease","volume":"9","author":"Lin","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2022.110550_bb0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.81.1.258","article-title":"Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals","volume":"81","author":"Yoshida","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2022.110550_bb0120","first-page":"90","article-title":"Role of ALDH2 in hepatic disorders: gene polymorphism and disease pathogenesis","volume":"9","author":"Wang","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"Electronic address EEE, European Association for the Study of the L. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma","volume":"69","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104501","article-title":"Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease","volume":"150","author":"Hu","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2022.110550_bb0140","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0140-6736(15)00122-1","article-title":"Alcohol use disorders","volume":"387","author":"Connor","year":"2016","journal-title":"Lancet."},{"key":"10.1016\/j.cellsig.2022.110550_bb0145","first-page":"307","article-title":"Practice guideline committee of the American Association for the Study of Liver D, Practice Parameters Committee of the American College of G. Alcoholic liver disease","volume":"51","author":"O\u2019Shea","year":"2010","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-0035-1550054","article-title":"Liver fibrosis in alcoholic liver disease","volume":"35","author":"Bataller","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.cellsig.2022.110550_bb0155","first-page":"25","article-title":"Relationship between drinking, smoking, and dietary habits and the body mass index of Japanese alcoholic men","volume":"45","author":"Hosokawa","year":"2010","journal-title":"Nihon Arukoru Yakubutsu Igakkai Zasshi."},{"key":"10.1016\/j.cellsig.2022.110550_bb0160","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/acer.12069","article-title":"Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men","volume":"37","author":"Yokoyama","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.cellsig.2022.110550_bb0165","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cvr\/cvq192","article-title":"Mitochondrial aldehyde dehydrogenase and cardiac diseases","volume":"88","author":"Chen","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellsig.2022.110550_bb0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yjmcc.2015.03.004","article-title":"Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt\/Nrf2\/heme oxygenase-1 pathway","volume":"82","author":"Yeh","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0175","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/gutjnl-2018-316221","article-title":"Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids","volume":"68","author":"Gao","year":"2019","journal-title":"Gut."},{"key":"10.1016\/j.cellsig.2022.110550_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.111070","article-title":"Hepatic injury and inflammation alter ethanol metabolism and drinking behavior","volume":"136","author":"Ren","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0185","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3892\/mmr.2020.11312","article-title":"Pretreatment with the ALDH2 activator Alda1 protects rat livers from ischemia\/reperfusion injury by inducing autophagy","volume":"22","author":"Liu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cellsig.2022.110550_bb0190","first-page":"8","article-title":"Hepatitis C virus-infected apoptotic hepatocytes program macrophages and hepatic stellate cells for liver inflammation and fibrosis development: role of ethanol as a second hit","author":"Ganesan","year":"2018","journal-title":"Biomolecules."},{"key":"10.1016\/j.cellsig.2022.110550_bb0195","doi-asserted-by":"crossref","first-page":"G566","DOI":"10.1152\/ajpgi.00183.2015","article-title":"Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells","volume":"309","author":"Ganesan","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0200","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/hep.28380","article-title":"Retinoid regulation of antiviral innate immunity in hepatocytes","volume":"63","author":"Cho","year":"2016","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22105332","article-title":"Role of PEG35, mitochondrial ALDH2, and glutathione in cold fatty liver graft preservation: an IGL-2 approach","volume":"22","author":"Bardallo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2022.110550_bb0210","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10096-019-03746-1","article-title":"Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies","volume":"39","author":"Ebrahimzadeh Leylabadlo","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.cellsig.2022.110550_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s43440-019-00020-1","article-title":"New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis","volume":"72","author":"Pydyn","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cellsig.2022.110550_bb0220","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0225","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030","volume":"69","author":"Estes","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0230","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0235","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0028-1091981","article-title":"Mechanisms of disease progression in nonalcoholic fatty liver disease","volume":"28","author":"Jou","year":"2008","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.cellsig.2022.110550_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2016.17","article-title":"The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease","volume":"6","author":"Oniki","year":"2016","journal-title":"Nutr. Diabetes."},{"key":"10.1016\/j.cellsig.2022.110550_bb0245","first-page":"10","article-title":"Aldehyde dehydrogenase mutation exacerbated high-fat-diet-induced nonalcoholic fatty liver disease with gut microbiota remodeling in male mice","author":"Yang","year":"2021","journal-title":"Biology (Basel)."},{"key":"10.1016\/j.cellsig.2022.110550_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101205","article-title":"Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1","volume":"24","author":"Chen","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0255","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/MCB.20.8.2818-2826.2000","article-title":"The DNA binding protein BTEB mediates acetaldehyde-induced, jun N-terminal kinase-dependent alphaI(I) collagen gene expression in rat hepatic stellate cells","volume":"20","author":"Chen","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mam.2007.10.001","article-title":"Alcohol induced hepatic fibrosis: role of acetaldehyde","volume":"29","author":"Mello","year":"2008","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.cellsig.2022.110550_bb0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/hep.510310117","article-title":"Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells","volume":"31","author":"Galli","year":"2000","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0270","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/hep.21107","article-title":"Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium","volume":"43","author":"Purohit","year":"2006","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0275","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1172\/JCI1413","article-title":"HNE interacts directly with JNK isoforms in human hepatic stellate cells","volume":"102","author":"Parola","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2022.110550_bb0280","first-page":"417","article-title":"Fertility preservation opportunities for cancer patients in Malaysia","volume":"76","author":"Abdul Karim","year":"2021","journal-title":"Med J Malaysia"},{"key":"10.1016\/j.cellsig.2022.110550_bb0285","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/hep.27036","article-title":"Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice","volume":"60","author":"Kwon","year":"2014","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0290","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1111\/jcmm.13677","article-title":"Aldehyde dehydrogenase 2 activation ameliorates CCl4 -induced chronic liver fibrosis in mice by up-regulating Nrf2\/HO-1 antioxidant pathway","volume":"22","author":"Ma","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2022.110550_bb0295","doi-asserted-by":"crossref","first-page":"12190","DOI":"10.3748\/wjg.v21.i42.12190","article-title":"Research progress and prospects of markers for liver cancer stem cells","volume":"21","author":"Zhu","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0300","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13046-019-1480-9","article-title":"Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis","volume":"38","author":"Yang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2022.110550_bb0305","first-page":"22","article-title":"Liver transplantation for hepatocellular carcinoma","volume":"2","author":"Byam","year":"2013","journal-title":"Hepatobil. Surg. Nutr."},{"key":"10.1016\/j.cellsig.2022.110550_bb0310","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/hep.29006","article-title":"Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice","volume":"65","author":"Hou","year":"2017","journal-title":"Hepatology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0315","first-page":"5319","article-title":"ALDH2 is a prognostic biomarker and related with immune infiltrates in HCC","volume":"11","author":"Yao","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellsig.2022.110550_bb0320","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology."},{"key":"10.1016\/j.cellsig.2022.110550_bb0325","first-page":"1","article-title":"Liver extracellular vesicles in health and disease","author":"Royo","year":"2012","journal-title":"J Extracell Vesicles."},{"key":"10.1016\/j.cellsig.2022.110550_bb0330","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/folmed-2017-0094","article-title":"A role of cytokine gene polymorphisms in cognitive functioning","volume":"60","author":"Trenova","year":"2018","journal-title":"Folia Med. (Plovdiv)."},{"key":"10.1016\/j.cellsig.2022.110550_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104621","article-title":"ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease","volume":"150","author":"Singh","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.cellsig.2022.110550_bb0340","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pharmthera.2012.02.003","article-title":"Stress management at the ER: regulators of ER stress-induced apoptosis","volume":"134","author":"Gorman","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2022.110550_bb0345","doi-asserted-by":"crossref","first-page":"13854","DOI":"10.1016\/S0021-9258(17)36725-X","article-title":"Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase","volume":"269","author":"Farres","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2022.110550_bb0350","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0006-291X(84)91072-6","article-title":"Human aldehyde dehydrogenase: catalytic activity in oriental liver","volume":"118","author":"Ferencz-Biro","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2022.110550_bb0355","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","article-title":"Carcinogenicity of alcoholic beverages","volume":"8","author":"Baan","year":"2007","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00017.2013","article-title":"Targeting aldehyde dehydrogenase 2: new therapeutic opportunities","volume":"94","author":"Chen","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2022.110550_bb0365","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s42255-021-00357-z","article-title":"Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication","volume":"3","author":"Jin","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cellsig.2022.110550_bb0370","doi-asserted-by":"crossref","first-page":"16227","DOI":"10.1038\/s41598-020-73263-1","article-title":"ALDH2 genotype modulates the association between alcohol consumption and AST\/ALT ratio among middle-aged Japanese men: a genome-wide G x E interaction analysis","volume":"10","author":"Sutoh","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2022.110550_bb0375","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.2147\/DMSO.S290491","article-title":"The association and interaction of aldehyde dehydrogenase 2 polymorphisms with food group intake and probability of having non-alcoholic fatty liver disease","volume":"13","author":"Hao","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.cellsig.2022.110550_bb0380","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23855","article-title":"Association between aldehyde dehydrogenase 2 gene rs671 G>A polymorphism and alcoholic liver cirrhosis in southern Chinese Hakka population","volume":"35","author":"Zeng","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.cellsig.2022.110550_bb0385","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1440-1746.2011.06948.x","article-title":"Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study","volume":"27","author":"Tomoda","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108329","article-title":"6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes","volume":"686","author":"Kitakaze","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2022.110550_bb0395","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2022.110550_bb0400","article-title":"The Nrf2 pathway in liver diseases","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0405","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","article-title":"Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors","volume":"11","author":"Singh","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0410","doi-asserted-by":"crossref","first-page":"3453926","DOI":"10.1155\/2016\/3453926","article-title":"Naturally occurring Nrf2 activators: potential in treatment of liver injury","volume":"2016","author":"Jadeja","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cellsig.2022.110550_bb0415","doi-asserted-by":"crossref","first-page":"20059","DOI":"10.1074\/jbc.R700016200","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"Schindler","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2022.110550_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101954","article-title":"SRRM1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by regulating the JAK\/STAT signaling pathway","volume":"79","author":"Song","year":"2022","journal-title":"Tissue Cell"},{"key":"10.1016\/j.cellsig.2022.110550_bb0425","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4014\/jmb.1907.07003","article-title":"A Review on structure, modifications and structure-activity relation of quercetin and its derivatives","volume":"30","author":"Magar","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.cellsig.2022.110550_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126482","article-title":"Interactions between trans-resveratrol and CpLIP2 lipase\/acyltransferase: Evidenced by fluorescence and in silico","volume":"318","author":"Nguyen","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.cellsig.2022.110550_bb0435","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/jb\/mvaa001","article-title":"Quercetin attenuates high glucose-induced injury in human retinal pigment epithelial cell line ARPE-19 by up-regulation of miR-29b","volume":"167","author":"Wang","year":"2020","journal-title":"J. Biochem."},{"key":"10.1016\/j.cellsig.2022.110550_bb0440","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41591-018-0209-1","article-title":"Treatment of a metabolic liver disease by in vivo genome base editing in adult mice","volume":"24","author":"Villiger","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2022.110550_bb0445","doi-asserted-by":"crossref","first-page":"1979883","DOI":"10.1080\/19490976.2021.1979883","article-title":"High alcohol-producing Klebsiella pneumoniae causes fatty liver disease through 2,3-butanediol fermentation pathway in vivo","volume":"13","author":"Li","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.cellsig.2022.110550_bb0450","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1186\/s12885-016-2820-1","article-title":"Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma","volume":"16","author":"Flahaut","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cellsig.2022.110550_bb0455","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1124\/pr.120.019554","article-title":"RNA drugs and RNA targets for small molecules: principles, progress, and challenges","volume":"72","author":"Yu","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2022.110550_bb0460","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1615\/CritRevEukaryotGeneExpr.2022041749","article-title":"miR-671-5p promotes cell proliferation, invasion, and migration in hepatocellular carcinoma through targeting ALDH2","volume":"32","author":"Chen","year":"2022","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.cellsig.2022.110550_bb0465","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cellsig.2022.110550_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114458","article-title":"A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells","volume":"189","author":"Luo","year":"2021","journal-title":"Biochem. Pharmacol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822003126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822003126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:09:16Z","timestamp":1760267356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656822003126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":94,"alternative-id":["S0898656822003126"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110550","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of acetaldehyde dehydrogenase 2 in the pathogenesis of liver diseases","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110550"}}