{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:04:47Z","timestamp":1786986287424,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070780"],"award-info":[{"award-number":["82070780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.cellsig.2022.110553","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:18:53Z","timestamp":1670246333000},"page":"110553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["DHCR7 promotes tumorigenesis via activating PI3K\/AKT\/mTOR signalling pathway in bladder cancer"],"prefix":"10.1016","volume":"102","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"DiSanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.euo.2018.08.012","article-title":"High-precision bladder cancer irradiation in the elderly: clinical results for a plan-of-the-day integrated boost technique with image guidance using lipiodol markers","volume":"2","author":"Beulens","year":"2019","journal-title":"Eur. Urol. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.eururo.2019.03.012","article-title":"Diagnostic accuracy and Interobserver agreement for the vesical imaging-reporting and data system for muscle-invasive bladder Cancer: a multireader validation study","volume":"76","author":"Ueno","year":"2019","journal-title":"Eur. Urol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eururo.2021.12.005","article-title":"International bladder cancer group consensus statement on clinical trial design for patients with bacillus calmette-guerin-exposed high-risk non-muscle-invasive bladder cancer","volume":"82","author":"Roumiguie","year":"2022","journal-title":"Eur. Urol."},{"issue":"9","key":"10.1016\/j.cellsig.2022.110553_bb0020","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/RLU.0000000000004301","article-title":"Evaluation of the hybrid tracer Indocyanine green-99mTc-nanocolloid for sentinel node biopsy in bladder cancer-a prospective pilot study","volume":"47","author":"Rietbergen","year":"2022","journal-title":"Clin. Nucl. Med."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110553_bb0025","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s00345-022-04061-9","article-title":"Prognostic implication of TERT promoter mutation and circulating tumor cells in muscle-invasive bladder cancer","volume":"40","author":"Carrasco","year":"2022","journal-title":"World J. Urol."},{"issue":"6","key":"10.1016\/j.cellsig.2022.110553_bb0030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/iju.13955","article-title":"Impact of sex difference on survival of bladder cancer: a population-based registry data in Japan","volume":"26","author":"Nakayama","year":"2019","journal-title":"Int. J. Urol."},{"issue":"10","key":"10.1016\/j.cellsig.2022.110553_bb0035","doi-asserted-by":"crossref","first-page":"18763","DOI":"10.1002\/jcp.28515","article-title":"Prognostic value of differentially methylated gene profiles in bladder cancer","volume":"234","author":"Yang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110553_bb0040","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac072","article-title":"The liver X receptor is selectively modulated to differentially alter female mammary metastasis-associated myeloid cells","volume":"163","author":"Ma","year":"2022","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1158\/1078-0432.CCR-13-0122","article-title":"Molecular pathways: sterols and receptor signaling in cancer","volume":"20","author":"Gabitova","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.cellsig.2022.110553_bb0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s42255-020-0174-0","article-title":"Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities","volume":"2","author":"Huang","year":"2020","journal-title":"Nat Metab."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0055","first-page":"188394","article-title":"Cholesterol metabolism: new functions and therapeutic approaches in cancer. Biochim Biophys Acta rev","volume":"1874","author":"Xu","year":"2020","journal-title":"Cancer."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0060","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/15384101.2018.1558868","article-title":"CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis","volume":"18","author":"Liang","year":"2019","journal-title":"Cell Cycle"},{"issue":"16","key":"10.1016\/j.cellsig.2022.110553_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165845","article-title":"Lipid metabolism and cancer immunotherapy: immunosuppressive myeloid cells at the crossroad","volume":"21","author":"Bleve","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2022.110553_bb0070","doi-asserted-by":"crossref","first-page":"3170950","DOI":"10.1155\/2022\/3170950","article-title":"Silico establishment and validation of novel lipid metabolism-related gene signature in bladder cancer","author":"Sun","year":"2022","journal-title":"Oxid Med Cell Longev."},{"issue":"8","key":"10.1016\/j.cellsig.2022.110553_bb0075","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.7150\/ijbs.32518","article-title":"Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer","volume":"15","author":"Li","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2022.110553_bb0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.plipres.2016.09.003","article-title":"DHCR7: a vital enzyme switch between cholesterol and vitamin D production","volume":"64","author":"Prabhu","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cellsig.2022.110553_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105929","article-title":"Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites","volume":"212","author":"Tuckey","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0090","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41380-021-01074-5","article-title":"Medication effects on developmental sterol biosynthesis","volume":"27","author":"Korade","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"10.1016\/j.cellsig.2022.110553_bb0095","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.coph.2012.07.007","article-title":"Cholesterol epoxide hydrolase and cancer","volume":"12","author":"Silvente-Poirot","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2022.110553_bb0100","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1194\/jlr.M600141-JLR200","article-title":"The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols","volume":"47","author":"Tint","year":"2006","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13058-018-0994-y","article-title":"Vitamin D, DNA methylation, and breast cancer","volume":"20","author":"O\u2019Brien","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cellsig.2022.110553_bb0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fendo.2019.00004","article-title":"Upregulated interleukin 21 receptor enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia","volume":"10","author":"Xu","year":"2019","journal-title":"Front Endocrinol (Lausanne)."},{"key":"10.1016\/j.cellsig.2022.110553_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156965","article-title":"Genetic variants of antioxidant enzymes and environmental exposures as molecular biomarkers associated with the risk and aggressiveness of bladder cancer","volume":"843","author":"Martin-Way","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110553_bb0120","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/s41380-020-0801-x","article-title":"Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis","volume":"25","author":"Genaro-Mattos","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.cellsig.2022.110553_bb0125","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/ije\/dyac031","article-title":"Opium use and risk of bladder cancer: a multi-Centre case-referent study in Iran","volume":"51","author":"Hadji","year":"2022","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110553_bb0130","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.clnu.2022.03.020","article-title":"Tea consumption and risk of bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) study: pooled analysis of 12 international cohort studies","volume":"41","author":"Al-Zalabani","year":"2022","journal-title":"Clin. Nutr."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110553_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/biom11040594","article-title":"The role of androgens and androgen receptor in human bladder cancer","volume":"11","author":"Martinez-Rojo","year":"2021","journal-title":"Biomolecules."},{"key":"10.1016\/j.cellsig.2022.110553_bb0140","article-title":"Epidemiological evidence between variants in matrix Metalloproteinases-2, \u22127, and \u22129 and Cancer risk","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2022.110553_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111144","article-title":"In vitro and in vivo anti-tumor efficacy of krill oil against bladder cancer: involvement of tumor-associated angiogenic vasculature","volume":"156","author":"Kim","year":"2022","journal-title":"Food Res. Int."},{"issue":"11","key":"10.1016\/j.cellsig.2022.110553_bb0150","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/j.apsb.2021.05.027","article-title":"Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K\/AKT\/mTOR and AMPK\/mTOR pathway","volume":"11","author":"Zheng","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cellsig.2022.110553_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106069","article-title":"lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K\/AKT\/mTOR signaling pathway","volume":"140","author":"Yang","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2022.110553_bb0160","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jpp\/rgab036","article-title":"Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K\/AKT\/mTOR and p38MAPK signalling pathways","volume":"73","author":"Acharya","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cellsig.2022.110553_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113680","article-title":"Delicaflavone induces ROS-mediated apoptosis and inhibits PI3K\/AKT\/mTOR and Ras\/MEK\/Erk signaling pathways in colorectal cancer cells","volume":"171","author":"Yao","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.cellsig.2022.110553_bb0170","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41388-020-01634-z","article-title":"KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer","volume":"40","author":"Xiong","year":"2021","journal-title":"ONCOGENE."},{"issue":"3","key":"10.1016\/j.cellsig.2022.110553_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41419-021-03521-1","article-title":"E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2022.110553_bb0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13046-022-02377-3","article-title":"TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K\/AKT pathway in bladder cancer","volume":"41","author":"Chi","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110553_bb0185","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1021\/acsnano.1c10770","article-title":"Photo-enhanced chemotherapy performance in bladder Cancer treatment via albumin coated AIE aggregates","volume":"16","author":"Ding","year":"2022","journal-title":"ACS NANO."},{"key":"10.1016\/j.cellsig.2022.110553_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103749","article-title":"Prospects of targeting PI3K\/AKT\/mTOR pathway in pancreatic cancer","volume":"176","author":"Mortazavi","year":"2022","journal-title":"Crit Rev Oncol Hematol."},{"key":"10.1016\/j.cellsig.2022.110553_bb0195","article-title":"Crosstalk between PI3K\/AKT\/mTOR and WNT\/beta-catenin signaling in GBM - could combination therapy checkmate the collusion?","volume":"95","author":"Daisy","year":"2022","journal-title":"Cell. Signal."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2022.110553_bb0200","first-page":"S60","article-title":"PTEN-PI3K pathway alterations in advanced prostate cancer and clinical implications","volume":"82","author":"Choudhury","year":"2022","journal-title":"PROSTATE."},{"issue":"5","key":"10.1016\/j.cellsig.2022.110553_bb0205","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1007\/s00394-020-02440-9","article-title":"6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K\/Akt\/mTOR pathway","volume":"60","author":"Pei","year":"2021","journal-title":"Eur. J. Nutr."},{"issue":"4","key":"10.1016\/j.cellsig.2022.110553_bb0210","article-title":"Galectin-1 overexpression activates the FAK\/PI3K\/AKT\/mTOR pathway and is correlated with upper urinary urothelial carcinoma progression and survival","volume":"9","author":"Su","year":"2020","journal-title":"CELLS-BASEL"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822003151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656822003151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:09:24Z","timestamp":1760267364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656822003151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"alternative-id":["S0898656822003151"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110553","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DHCR7 promotes tumorigenesis via activating PI3K\/AKT\/mTOR signalling pathway in bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2022.110553","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110553"}}