{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:26:16Z","timestamp":1792517176625,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cellsig.2023.110754","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T21:13:07Z","timestamp":1686604387000},"page":"110754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions"],"prefix":"10.1016","volume":"109","author":[{"given":"Yue","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongying","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2023.110754_bb0005","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1200\/JCO.2017.73.0119","article-title":"Adult glioblastoma","volume":"35","author":"Alexander","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0010","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/jama.2013.280319","article-title":"Glioblastoma and other malignant gliomas: a clinical review","volume":"310","author":"Omuro","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.cellsig.2023.110754_bb0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI89587","article-title":"Overcoming therapeutic resistance in glioblastoma: the way forward","volume":"127","author":"Osuka","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2023.110754_bb0020","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nec.2020.08.007","article-title":"Radiosurgery for glioblastoma","volume":"32","author":"Bunevicius","year":"2021","journal-title":"Neurosurg. Clin. N. Am."},{"key":"10.1016\/j.cellsig.2023.110754_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.canlet.2020.01.027","article-title":"Glioblastoma precision therapy: from the bench to the clinic","volume":"475","author":"Zhou","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2023.110754_bb0030","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41582-018-0025-8","article-title":"Multidimensional communication in the microenvirons of glioblastoma","volume":"14","author":"Broekman","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0035","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1200\/JCO.2012.41.9242","article-title":"Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies","volume":"30","author":"Bottsford-Miller","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0040","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nrclinonc.2012.120","article-title":"Cancer prevention by targeting angiogenesis","volume":"9","author":"Albini","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/PPO.0b013e3182431c6f","article-title":"Antiangiogenic therapy for glioblastoma","volume":"18","author":"Gerstner","year":"2012","journal-title":"Cancer J."},{"key":"10.1016\/j.cellsig.2023.110754_bb0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrclinonc.2009.94","article-title":"Adverse effects of anticancer agents that target the VEGF pathway","volume":"6","author":"Chen","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0055","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccr.2009.02.007","article-title":"Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited","volume":"15","author":"Loges","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0060","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1200\/JCO.2015.62.3637","article-title":"Can we predict bevacizumab responders in patients with glioblastoma?","volume":"33","author":"Mayer","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0065","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/PPO.0000000000000326","article-title":"Bevacizumab and glioblastoma: past, present, and future directions","volume":"24","author":"Kim","year":"2018","journal-title":"Cancer J."},{"key":"10.1016\/j.cellsig.2023.110754_bb0070","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11060-017-2477-x","article-title":"The role of bevacizumab in the treatment of glioblastoma","volume":"133","author":"Diaz","year":"2017","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ph13120470","article-title":"Update on chemotherapeutic approaches and management of bevacizumab usage for glioblastoma","volume":"13","author":"Funakoshi","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.cellsig.2023.110754_bb0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/neuonc\/nop027","article-title":"Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice","volume":"12","author":"de Groot","year":"2010","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.cellsig.2023.110754_bb0085","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/neuonc\/now030","article-title":"Novel MET\/TIE2\/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models","volume":"18","author":"Piao","year":"2016","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.cellsig.2023.110754_bb0090","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1158\/2159-8290.CD-20-0057","article-title":"Tumor microenvironment is critical for the maintenance of cellular states found in primary glioblastomas","volume":"10","author":"Pine","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cellsig.2023.110754_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2013.02.021","article-title":"Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth","volume":"153","author":"Cheng","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10571-020-00975-3","article-title":"Glioma pericytes promote angiogenesis by producing periostin","volume":"42","author":"Bernardes","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s42003-019-0560-x","article-title":"Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping","volume":"2","author":"Lane","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0110","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0115","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41571-018-0036-9","article-title":"Extracellular vesicles in cancer - implications for future improvements in cancer care","volume":"15","author":"Xu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-019-0967-5","article-title":"The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy","volume":"18","author":"Huang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2023.110754_bb0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.21037\/sci.2017.08.08","article-title":"Extracellular vesicles as regulators of tumor fate: crosstalk among cancer stem cells, tumor cells and mesenchymal stem cells","volume":"4","author":"Lindoso","year":"2017","journal-title":"Stem Cell Investig."},{"key":"10.1016\/j.cellsig.2023.110754_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcdb.2015.02.011","article-title":"Extracellular vesicles in the biology of brain tumour stem cells--implications for inter-cellular communication, therapy and biomarker development","volume":"40","author":"Nakano","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13287-019-1467-7","article-title":"Autofluorescence of NADH is a new biomarker for sorting and characterizing cancer stem cells in human glioma","volume":"10","author":"Yuan","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.cellsig.2023.110754_bb0140","first-page":"792","article-title":"ERBB3, IGF1R, and TGFBR2 expression correlate with PDGFR expression in glioblastoma and participate in PDGFR inhibitor resistance of glioblastoma cells","volume":"8","author":"Song","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellsig.2023.110754_bb0145","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ccell.2020.04.001","article-title":"The glioma stem cell model in the era of single-cell genomics","volume":"37","author":"Suva","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0150","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13046-020-01724-6","article-title":"Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas","volume":"39","author":"Mudassar","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2023.110754_bb0155","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah6816","article-title":"Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance","volume":"10","author":"Shi","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cellsig.2023.110754_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2013.02.021","article-title":"Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth","volume":"153","author":"Cheng","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0165","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ccell.2020.10.011","article-title":"Molecular subsets in renal cancer determine outcome to checkpoint and angiogenesis blockade","volume":"38","author":"Motzer","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0170","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2017.10.002","article-title":"Targeting glioma stem cell-derived pericytes disrupts the blood-tumor barrier and improves chemotherapeutic efficacy","volume":"21","author":"Zhou","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0175","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s11060-014-1652-6","article-title":"Single agent vinorelbine in pediatric patients with progressive optic pathway glioma","volume":"121","author":"Cappellano","year":"2015","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0180","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.critrevonc.2006.01.004","article-title":"Angiogenesis in malignant glioma--a target for antitumor therapy?","volume":"59","author":"Tuettenberg","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0185","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00401-012-1066-5","article-title":"Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited","volume":"124","author":"Plate","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0190","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.ajpath.2017.01.010","article-title":"Hypoxia-mediated mechanisms associated with antiangiogenic treatment resistance in glioblastomas","volume":"187","author":"Mahase","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212608","article-title":"Hypoxia: the cornerstone of glioblastoma","volume":"22","author":"Domenech","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2023.110754_bb0200","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2016.03.004","article-title":"Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA","volume":"29","author":"Qu","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0205","first-page":"1","article-title":"Extracellular vesicles and their role in glioblastoma","author":"Whitehead","year":"2019","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.cellsig.2023.110754_bb0210","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.celrep.2016.10.052","article-title":"Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies","volume":"17","author":"Bowman","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2023.110754_bb0215","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccr.2006.11.020","article-title":"A perivascular niche for brain tumor stem cells","volume":"11","author":"Calabrese","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0225","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/glia.23520","article-title":"Astrocytes, the rising stars of the glioblastoma microenvironment","volume":"67","author":"Brandao","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.cellsig.2023.110754_bb0230","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1158\/0008-5472.CAN-16-2524","article-title":"Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587","volume":"77","author":"Figueroa","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2023.110754_bb0235","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2023.110754_bb0240","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-3-319-69194-7_7","article-title":"Glioblastoma stem cells and their microenvironment","volume":"1041","author":"Sattiraju","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cellsig.2023.110754_bb0245","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1517\/14728222.2012.714774","article-title":"Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells","volume":"16","author":"Bao","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.cellsig.2023.110754_bb0250","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/ijc.29521","article-title":"Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells","volume":"137","author":"de Vrij","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2023.110754_bb0255","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2013.02.021","article-title":"Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth","volume":"153","author":"Cheng","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2023.110754_bb0260","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11060-017-2477-x","article-title":"The role of bevacizumab in the treatment of glioblastoma","volume":"133","author":"Diaz","year":"2017","journal-title":"J. Neuro-Oncol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656823001687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656823001687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:14:23Z","timestamp":1760267663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656823001687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"alternative-id":["S0898656823001687"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2023.110754","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2023.110754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110754"}}