{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:54:49Z","timestamp":1768406089439,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.cellsig.2023.110916","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:41:40Z","timestamp":1696624900000},"page":"110916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Glycation of fibronectin impairs angiopoietin-1\/Tie-2 signaling through uncoupling Tie-2-\u03b15\u03b21 integrin crosstalk"],"prefix":"10.1016","volume":"112","author":[{"given":"Tangting","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangshuang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcan","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youkun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2023.110916_bb0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2023.110916_bb0010","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.canlet.2014.09.035","article-title":"Targeting the Angiopoietin-2\/Tie-2 axis in conjunction with VEGF signal interference","volume":"380","author":"Biel","year":"2016","journal-title":"Cancer Lett."},{"issue":"6535","key":"10.1016\/j.cellsig.2023.110916_bb0015","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/376070a0","article-title":"Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation","volume":"376","author":"Sato","year":"1995","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2023.110916_bb0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmed.2012.10.010","article-title":"Orchestral actions of angiopoietin-1 in vascular regeneration","volume":"19","author":"Koh","year":"2013","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2023.110916_bb0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10456-009-9147-3","article-title":"The role of the angiopoietins in vascular morphogenesis","volume":"12","author":"Thomas","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cellsig.2023.110916_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/836759","article-title":"Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1\/Tie-2 signaling in diabetes","volume":"2012","author":"Chen","year":"2012","journal-title":"Exp. Diabetes Res."},{"issue":"1","key":"10.1016\/j.cellsig.2023.110916_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/aps.2010.183","article-title":"Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition","volume":"32","author":"Tuo","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"issue":"13","key":"10.1016\/j.cellsig.2023.110916_bb0040","first-page":"5255","article-title":"Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies","volume":"61","author":"Taverna","year":"2001","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2023.110916_bb0045","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.119.4.1093","article-title":"Embryonic mesodermal defects in alpha 5 integrin-deficient mice","volume":"119","author":"Yang","year":"1993","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.cellsig.2023.110916_bb0050","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1182\/blood.V90.8.3073","article-title":"Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells","volume":"90","author":"George","year":"1997","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.cellsig.2023.110916_bb0055","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1083\/jcb.200507082","article-title":"Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1","volume":"170","author":"Cascone","year":"2005","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2023.110916_bb0060","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.cellsig.2023.110916_bb0065","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","article-title":"The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality","volume":"28","author":"Chaudhuri","year":"2018","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.cellsig.2023.110916_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.08.004","article-title":"Glycation-induced modification of tissue-specific ECM proteins: a pathophysiological mechanism in degenerative diseases","volume":"1863","author":"Bansode","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"6","key":"10.1016\/j.cellsig.2023.110916_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.174","article-title":"Glycation of vitronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2-\u03b1v\u03b23 integrin cross-talk","volume":"6","author":"Wang","year":"2015","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.cellsig.2023.110916_bb0080","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.2337\/db09-0320","article-title":"Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes","volume":"58","author":"Duran-Jimenez","year":"2009","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.cellsig.2023.110916_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193280","article-title":"Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal M\u00fcller cells","volume":"13","author":"Thompson","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cellsig.2023.110916_bb0090","doi-asserted-by":"crossref","first-page":"H1277","DOI":"10.1152\/ajpheart.00168.2002","article-title":"Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy","volume":"284","author":"Herrmann","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"12","key":"10.1016\/j.cellsig.2023.110916_bb0095","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.RES.0000022161.42655.98","article-title":"Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells","volume":"90","author":"Chen","year":"2002","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2023.110916_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12347","article-title":"Nonenzymatic glycation interferes with fibronectin-integrin interactions in vascular smooth muscle cells","volume":"24","author":"Dhar","year":"2017","journal-title":"Microcirculation"},{"issue":"16","key":"10.1016\/j.cellsig.2023.110916_bb0105","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1111\/jcmm.15552","article-title":"Glycation of fibronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2-c-Src crosstalk","volume":"24","author":"Chen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2023.110916_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.871968","article-title":"Modification of fibronectin by non-enzymatic glycation impairs K+ channel function in rat cerebral artery smooth muscle cells","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.cellsig.2023.110916_bb0115","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.bpj.2014.10.041","article-title":"Early events in cell spreading as a model for quantitative analysis of biomechanical events","volume":"107","author":"Wolfenson","year":"2014","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.cellsig.2023.110916_bb0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1515\/cclm-2012-0818","article-title":"Site-specific AGE modifications in the extracellular matrix: a role for glyoxal in protein damage in diabetes","volume":"52","author":"Voziyan","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cellsig.2023.110916_bb0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.matbio.2016.07.003","article-title":"Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly","volume":"59","author":"Pastino","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cellsig.2023.110916_bb0130","first-page":"1509","article-title":"Advanced glycation of the Arg-Gly-asp (RGD) tripeptide motif modulates retinal microvascular endothelial cell dysfunction","volume":"15","author":"McDonald","year":"2009","journal-title":"Mol. Vis."},{"issue":"2","key":"10.1016\/j.cellsig.2023.110916_bb0135","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12013-008-9040-5","article-title":"Integrin and growth factor receptor alliance in angiogenesis","volume":"53","author":"Somanath","year":"2009","journal-title":"Cell Biochem. Biophys."},{"issue":"Pt4","key":"10.1016\/j.cellsig.2023.110916_bb0140","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1242\/jcs.111.4.469","article-title":"The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration","volume":"111","author":"Woodard","year":"1998","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2023.110916_bb0145","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/emboj\/18.4.882","article-title":"Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2","volume":"18","author":"Soldi","year":"1999","journal-title":"EMBO J."},{"issue":"1\u20133","key":"10.1016\/j.cellsig.2023.110916_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-4889(01)00161-6","article-title":"The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase\/Akt pathway in intestinal epithelial cells","volume":"1542","author":"Lee","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.cellsig.2023.110916_bb0155","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.153.4.881","article-title":"Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts","volume":"153","author":"Beningo","year":"2001","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2023.110916_bb0160","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/emboj\/21.8.1957","article-title":"The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins","volume":"21","author":"Baron","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2023.110916_bb0165","doi-asserted-by":"crossref","first-page":"6198495","DOI":"10.1155\/2019\/6198495","article-title":"Advanced glycation end-products and hyperglycemia increase angiopoietin-2 production by impairing angiopoietin-1-Tie-2 system","volume":"2019","author":"Puddu","year":"2019","journal-title":"J. Diabetes Res."},{"issue":"14","key":"10.1016\/j.cellsig.2023.110916_bb0170","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1073\/pnas.1236929100","article-title":"Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice","volume":"100","author":"Tamarat","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cellsig.2023.110916_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017752","article-title":"Collagen cross-linking is associated with cardiac remodeling in hypertrophic obstructive cardiomyopathy","volume":"10","author":"Bi","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cellsig.2023.110916_bb0180","article-title":"Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen","volume":"17","author":"Romanowicz","year":"2022","journal-title":"Bone Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2023.110916_bb0185","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/HYPERTENSIONAHA.110.155556","article-title":"Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner","volume":"56","author":"Ahmad","year":"2010","journal-title":"Hypertension"},{"issue":"203","key":"10.1016\/j.cellsig.2023.110916_bb0190","doi-asserted-by":"crossref","first-page":"203ra127","DOI":"10.1126\/scitranslmed.3006666","article-title":"Angiopoietin-1 guides directional angiogenesis through integrin \u03b1v\u03b25 signaling for recovery of ischemic retinopathy","volume":"5","author":"Lee","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2023.110916_bb0195","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1161\/01.RES.0000158285.57191.60","article-title":"Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins","volume":"96","author":"Dallabrida","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2023.110916_bb0200","doi-asserted-by":"crossref","first-page":"14105","DOI":"10.1038\/ncomms14105","article-title":"Fibronectin-guided migration of carcinoma collectives","volume":"8","author":"Gopal","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656823003315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656823003315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:14:32Z","timestamp":1760267672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656823003315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":40,"alternative-id":["S0898656823003315"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2023.110916","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycation of fibronectin impairs angiopoietin-1\/Tie-2 signaling through uncoupling Tie-2-\u03b15\u03b21 integrin crosstalk","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2023.110916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110916"}}