{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:09:45Z","timestamp":1785906585851,"version":"3.56.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019155","name":"Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.cellsig.2024.111111","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T16:52:06Z","timestamp":1708620726000},"page":"111111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer"],"prefix":"10.1016","volume":"117","author":[{"given":"Hong","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2024.111111_bb0005","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111111_bb0010","first-page":"86","article-title":"A review of cancer immunotherapy toxicity","volume":"70","author":"Kennedy","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111111_bb0015","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41423-020-0488-6","article-title":"The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"19","key":"10.1016\/j.cellsig.2024.111111_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21196983","article-title":"What role does COA6 play in cytochrome C oxidase biogenesis: a Metallochaperone or thiol oxidoreductase, or both?","volume":"21","author":"Maghool","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111111_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/biom12010125","article-title":"The role of COA6 in the mitochondrial copper delivery pathway to cytochrome c oxidase","volume":"12","author":"Swaminathan","year":"2022","journal-title":"Biomolecules."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111111_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.11.054","article-title":"COA6 is structurally tuned to function as a thiol-disulfide oxidoreductase in copper delivery to mitochondrial cytochrome c oxidase","volume":"29","author":"Soma","year":"2019","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2024.111111_bb0035","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41591-018-0101-z","article-title":"Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer","volume":"24","author":"Kim","year":"2018","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111111_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065705","article-title":"High expression of COA6 is related to unfavorable prognosis and enhanced oxidative phosphorylation in lung adenocarcinoma","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111111_bb0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jtho.2022.11.006","article-title":"A Clinician\u2019s guide to bioinformatics for next-generation sequencing","volume":"18","author":"Larson","year":"2023","journal-title":"J. Thora. Oncol.\u202f: Offi. Public. Intern. Assoc. Study of Lung Cancer."},{"key":"10.1016\/j.cellsig.2024.111111_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.111012","article-title":"Bioinformatics analysis of CMTM family in pan-cancer and preliminary exploration of CMTM6 in bladder cancer","volume":"115","author":"Xu","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2024.111111_bb0055","doi-asserted-by":"crossref","first-page":"1111319","DOI":"10.3389\/fimmu.2023.1111319","article-title":"Identification of a glutamine metabolism reprogramming signature for predicting prognosis, immunotherapy efficacy, and drug candidates in bladder cancer","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2024.111111_bb0060","first-page":"0284","article-title":"Exercise prescription: pioneering the \u201cthird pole\u201d for clinical health management","volume":"6","author":"Luo","year":"2023","journal-title":"Research (Wash D C)."},{"key":"10.1016\/j.cellsig.2024.111111_bb0065","doi-asserted-by":"crossref","first-page":"1053137","DOI":"10.3389\/fphar.2022.1053137","article-title":"Exercise-induced IL-15 acted as a positive prognostic implication and tumor-suppressed role in pan-cancer","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2024.111111_bb0070","first-page":"0247","article-title":"Remodeling tumor immune microenvironment by using polymer-lipid-manganese dioxide nanoparticles with radiation therapy to boost immune response of castration-resistant prostate Cancer","volume":"6","author":"Zetrini","year":"2023","journal-title":"Research (Wash D C)."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111111_bb0075","doi-asserted-by":"crossref","first-page":"400","DOI":"10.5847\/wjem.j.1920-8642.2022.076","article-title":"Incidence and outcomes of secondary infections in septic patients with cancer","volume":"13","author":"Qu","year":"2022","journal-title":"World J Emerg Med"},{"key":"10.1016\/j.cellsig.2024.111111_bb0080","doi-asserted-by":"crossref","first-page":"1301157","DOI":"10.3389\/fimmu.2023.1301157","article-title":"Integration of multi-omics and clinical treatment data reveals bladder cancer therapeutic vulnerability gene combinations and prognostic risks","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111111_bb0085","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nchembio.72","article-title":"Mechanisms for copper acquisition, distribution and regulation","volume":"4","author":"Kim","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111111_bb0090","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.122.009082","article-title":"Predicting risk or adjusting for risk?","volume":"15","author":"Normand","year":"2022","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.cellsig.2024.111111_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104935","article-title":"Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models","volume":"183","author":"Tharappel","year":"2020","journal-title":"Antivir. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111111_bb0100","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259314","article-title":"Castanospermine suppresses CD44 ectodomain cleavage as revealed by transmembrane bioluminescent sensors","volume":"135","author":"Noda","year":"2022","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111111_bb0105","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1038\/s41467-023-38410-y","article-title":"Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models","volume":"14","author":"Costa-Machado","year":"2023","journal-title":"Nat. Commun."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824000792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824000792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:33:20Z","timestamp":1776717200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824000792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":21,"alternative-id":["S0898656824000792"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111111","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111111"}}