{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:08:32Z","timestamp":1788667712450,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"am","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["KJ2021ZD0036"],"award-info":[{"award-number":["KJ2021ZD0036"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["2022e07020069"],"award-info":[{"award-number":["2022e07020069"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.cellsig.2024.111137","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:49:34Z","timestamp":1710132574000},"page":"111137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma"],"prefix":"10.1016","volume":"118","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10145","key":"10.1016\/j.cellsig.2024.111137_bb0005","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(18)30990-5","article-title":"Primary brain tumours in adults","volume":"392","author":"Lapointe","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0010","doi-asserted-by":"crossref","first-page":"15017","DOI":"10.1038\/nrdp.2015.17","article-title":"Glioma","volume":"16","author":"Weller","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111137_bb0015","doi-asserted-by":"crossref","first-page":"e13060","DOI":"10.1111\/bpa.13060","article-title":"The 2021 WHO classification of tumors of the central nervous system: an update on pediatric low-grade gliomas and glioneuronal tumors","volume":"32","author":"Bale","year":"2022","journal-title":"Brain Pathol."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111137_bb0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12020-016-1216-y","article-title":"Insights into the relationships between diabetes, prediabetes, and cancer","volume":"56","author":"Scappaticcio","year":"2017","journal-title":"Endocrine."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111137_bb0025","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.cellsig.2024.111137_bb0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11060-011-0676-4","article-title":"Type 2 diabetes mellitus and obesity are independent risk factors for poor outcome in patients with high-grade glioma","volume":"106","author":"Chambless","year":"2012","journal-title":"J. Neuro-Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111137_bb0035","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1038\/oncsis.2017.2","article-title":"Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway","volume":"6","author":"Vasconcelos-Dos-Santos","year":"2017","journal-title":"Oncogenesis"},{"issue":"10","key":"10.1016\/j.cellsig.2024.111137_bb0040","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/s41401-023-01109-3","article-title":"Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10","volume":"44","author":"Liang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111137_bb0045","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41419-018-0799-z","article-title":"A novel small-molecule activator of Sirtuin-1 induces autophagic cell death\/mitophagy as a potential therapeutic strategy in glioblastoma","volume":"9","author":"Yao","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0050","doi-asserted-by":"crossref","first-page":"101270","DOI":"10.1016\/j.tranon.2021.101270","article-title":"miR-376a inhibits glioma proliferation and angiogenesis by regulating YAP1\/VEGF signalling via targeting of SIRT1","volume":"15","author":"Deng","year":"2022","journal-title":"Transl. Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111137_bb0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.64.3.16","article-title":"SIRT1 inhibits high glucose-induced TXNIP\/NLRP3 Inflammasome activation and cataract formation","volume":"64","author":"Lian","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Pt 4","key":"10.1016\/j.cellsig.2024.111137_bb0060","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1042\/bst0290395","article-title":"HMG1 and 2: architectural DNA-binding proteins","volume":"29","author":"Thomas","year":"2001","journal-title":"Biochem. Soc. Trans."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111137_bb0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111137_bb0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a therapeutic target in inflammatory diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111137_bb0075","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/cells9071664","article-title":"High mobility group box 1 in human Cancer","volume":"9","author":"Rapoport","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.cellsig.2024.111137_bb0080","first-page":"659","article-title":"High mobility group box 1 promotes the epithelial-to-mesenchymal transition in prostate cancer PC3 cells via the RAGE\/NF-\u03baB signaling pathway","volume":"53","author":"Zhang","year":"2018","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111137_bb0085","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-018-0626-6","article-title":"HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2024.111137_bb0090","doi-asserted-by":"crossref","first-page":"104253","DOI":"10.1016\/j.phrs.2019.104253","article-title":"Natural products as a potential modulator of microglial polarization in neurodegenerative diseases","volume":"145","author":"Jin","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0095","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-018-1151-3","article-title":"Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1\/NF-\u03baB pathway following experimental traumatic brain injury","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2024.111137_bb0100","doi-asserted-by":"crossref","first-page":"105779","DOI":"10.1016\/j.intimp.2019.105779","article-title":"SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: a possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury","volume":"75","author":"Le","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"22","key":"10.1016\/j.cellsig.2024.111137_bb0105","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","article-title":"Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF-\u03baB and TNF-\u03b1\/TNFR1\/NF-\u03baB pathways","volume":"177","author":"Xu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2024.111137_bb0110","doi-asserted-by":"crossref","first-page":"109254","DOI":"10.1016\/j.neuropharm.2022.109254","article-title":"Melatonin attenuates bone cancer pain via the SIRT1\/HMGB1 pathway","volume":"220","author":"Yang","year":"2022","journal-title":"Neuropharmacology."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111137_bb0115","first-page":"786","article-title":"A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8,21) acute myeloid leukemia","volume":"21","author":"Zhou","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111137_bb0120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/neup.12625","article-title":"Formation of new lymphatic vessels in glioma: An immunohistochemical analysis","volume":"40","author":"Meng","year":"2020","journal-title":"Neuropathology"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111137_bb0125","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/nm.4418","article-title":"Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma","volume":"23","author":"Mai","year":"2017","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11060-015-1815-0","article-title":"Impact of glycemia on survival of glioblastoma patients treated with radiation and temozolomide","volume":"124","author":"Tieu","year":"2015","journal-title":"J. Neuro-Oncol."},{"issue":"3191","key":"10.1016\/j.cellsig.2024.111137_bb0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"WARBURG O","year":"1956","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111137_bb0140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1158\/1541-7786.MCR-05-0061","article-title":"Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes","volume":"4","author":"Jelluma","year":"2006","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1194\/jlr.R046797","article-title":"The ketogenic diet for the treatment of malignant glioma","volume":"56","author":"Woolf","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cellsig.2024.111137_bb0150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.arr.2018.02.004","article-title":"Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming","volume":"43","author":"Ong","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"33","key":"10.1016\/j.cellsig.2024.111137_bb0155","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1021\/acs.jafc.5b02876","article-title":"Sirtuin 1 (SIRT1) deacetylase activity and NAD+\/NADH ratio are imperative for capsaicin-mediated programmed cell death","volume":"63","author":"Lee","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111137_bb0160","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/15384101.2020.1743911","article-title":"Metformin activates AMPK\/SIRT1\/NF-\u03baB pathway and induces mitochondrial dysfunction to drive caspase3\/GSDME-mediated cancer cell pyroptosis","volume":"19","author":"Zheng","year":"2020","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111137_bb0165","first-page":"5343","article-title":"Sirtuin 1 knockdown inhibits glioma cell proliferation and potentiates temozolomide toxicity via facilitation of reactive oxygen species generation","volume":"17","author":"Chen","year":"2019","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111137_bb0170","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1002\/jcb.27966","article-title":"Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression","volume":"120","author":"Lei","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111137_bb0175","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cmet.2011.04.008","article-title":"High-mobility group box 1 is essential for mitochondrial quality control","volume":"13","author":"Tang","year":"2011","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111137_bb0180","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111137_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/leu.2010.225","article-title":"HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells","volume":"25","author":"Liu","year":"2011","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.cellsig.2024.111137_bb0190","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/onc.2012.49","article-title":"Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1","volume":"32","author":"van Beijnum","year":"2013","journal-title":"Oncogene."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824001050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824001050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:46:46Z","timestamp":1778633206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824001050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S0898656824001050"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111137","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111137"}}