{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:19:53Z","timestamp":1788232793216,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.cellsig.2024.111303","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T15:23:01Z","timestamp":1721056981000},"page":"111303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction\u2013associated steatotic liver disease"],"prefix":"10.1016","volume":"121","author":[{"given":"Shuowen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2024.111303_bb0005","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0010","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/jhep.2003.50161","article-title":"Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome","volume":"37","author":"Marchesini","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2024.111303_bb0015","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4254\/wjh.v7.i6.846","article-title":"Non-alcoholic fatty liver disease: the diagnosis and management","volume":"7","author":"Abd El-Kader","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0020","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2024.111303_bb0025","doi-asserted-by":"crossref","first-page":"E584","DOI":"10.1152\/ajpendo.00272.2010","article-title":"Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?","volume":"299","author":"Hodson","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2024.111303_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12876-017-0592-y","article-title":"Non alcoholic fatty liver disease and eNOS dysfunction in humans","volume":"17","author":"Persico","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900043","article-title":"Mitochondria-mediated pathogenesis and therapeutics for non-alcoholic fatty liver disease","volume":"63","author":"Li","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.cellsig.2024.111303_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biocel.2017.12.019","article-title":"Mitochondria in non-alcoholic fatty liver disease","volume":"95","author":"Simoes","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0045","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2024.111303_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2024.111303_bb0060","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2024.111303_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1158\/2159-8290.CD-18-0959","article-title":"The biology of m(6)A RNA methylation in Normal and malignant hematopoiesis","volume":"9","author":"Vu","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cellsig.2024.111303_bb0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"18","author":"Zhao","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-020-00385-4","article-title":"RNA N6-methyladenosine: a promising molecular target in metabolic diseases","volume":"10","author":"Li","year":"2020","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cellsig.2024.111303_bb0080","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2217\/epi-2019-0009","article-title":"Comprehensive analysis of differences of N(6)-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers","volume":"11","author":"Luo","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.cellsig.2024.111303_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101058","article-title":"The m(6)a methyltransferase METTL3 modifies PGC-1alpha mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes","volume":"297","author":"Zhang","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2024.111303_bb0090","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41422-020-00394-5","article-title":"Active RNA interference in mitochondria","volume":"31","author":"Gao","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.cellsig.2024.111303_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470942390.mo150182","article-title":"Analysis of mitochondrial respiratory chain Supercomplexes using blue native polyacrylamide gel electrophoresis (BN-PAGE)","volume":"6","author":"Jha","year":"2016","journal-title":"Curr Protoc Mouse Biol"},{"key":"10.1016\/j.cellsig.2024.111303_bb0100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nsmb.3206","article-title":"Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis","volume":"23","author":"Gao","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0105","doi-asserted-by":"crossref","first-page":"1023482","DOI":"10.3389\/fnmol.2022.1023482","article-title":"Chronic exercise remodels the lysine acetylome in the mouse hippocampus","volume":"15","author":"Qian","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cellsig.2024.111303_bb0110","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12035-016-0303-7","article-title":"LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1","volume":"55","author":"Azkona","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.cellsig.2024.111303_bb0115","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m(6)a decoration: writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.cellsig.2024.111303_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13622","article-title":"Mitochondria, oxidative stress and nonalcoholic fatty liver disease: a complex relationship","volume":"52","author":"Karkucinska-Wieckowska","year":"2022","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2024.111303_bb0125","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1172\/JCI120846","article-title":"Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2024.111303_bb0130","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2024.111303_bb0170","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2024.111303_bb0135","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jhep.2020.04.009","article-title":"Epitranscriptomics in liver disease: basic concepts and therapeutic potential","volume":"73","author":"Zhao","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2024.111303_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2020.153087","article-title":"METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway","volume":"216","author":"Hou","year":"2020","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.cellsig.2024.111303_bb0145","first-page":"3197","article-title":"METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway","volume":"19","author":"Liang","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cellsig.2024.111303_bb0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2024.111303_bb0155","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2024.111303_bb0160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"issue":"426\u201340","key":"10.1016\/j.cellsig.2024.111303_bb0165","article-title":"Landscape and regulation of m(6)A and m(6)Am Methylome across human and mouse tissues","volume":"77","author":"Liu","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2024.111303_bb0180","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.5858\/arpa.2017-0285-RS","article-title":"Succinate dehydrogenase complex: An updated review","volume":"142","author":"Rasheed","year":"2018","journal-title":"Arch. Pathol. Lab. Med."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824002717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824002717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:29:32Z","timestamp":1762316972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824002717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":35,"alternative-id":["S0898656824002717"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111303","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction\u2013associated steatotic liver disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111303"}}