{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:04:50Z","timestamp":1786986290081,"version":"build-2736575974"},"reference-count":215,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.cellsig.2024.111343","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T21:12:37Z","timestamp":1723151557000},"page":"111343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Glaucoma and the ocular renin-angiotensin-aldosterone system: Update on molecular signalling and treatment perspectives"],"prefix":"10.1016","volume":"122","author":[{"given":"Francesco","family":"Buonfiglio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Gericke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0005","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. Health"},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0015","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0020","doi-asserted-by":"crossref","first-page":"13762","DOI":"10.1038\/s41598-021-92971-w","article-title":"Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2024.111343_bb0025","series-title":"Role of Proteoglycans in the Trabecular Meshwork\u2606, Reference Module in Neuroscience and Biobehavioral Psychology","author":"Acott","year":"2017"},{"key":"10.1016\/j.cellsig.2024.111343_bb0030","series-title":"Progress in Brain Research","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/bs.pbr.2020.07.010","article-title":"Chapter 2 - links between obstructive sleep apnea and glaucoma neurodegeneration","author":"Cesareo","year":"2020"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(03)00143-0","article-title":"Glaucoma clinical trials and what they mean for our patients","volume":"136","author":"Lichter","year":"2003","journal-title":"Am. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0040","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0161-6420(02)01974-7","article-title":"Blindness in patients with treated open-angle glaucoma","volume":"110","author":"Chen","year":"2003","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0002-9394(01)00912-6","article-title":"Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma","volume":"132","author":"Kwon","year":"2001","journal-title":"Am. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136632","article-title":"Blindness and Glaucoma: a multicenter data review from 7 academic eye clinics","volume":"10","author":"Rossetti","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0055","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3390\/ph16091193","article-title":"Immunomodulatory and antioxidant drugs in Glaucoma treatment","volume":"16","author":"Buonfiglio","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/1470320314549791","article-title":"Expression of classical components of the renin-angiotensin system in the human eye","volume":"16","author":"White","year":"2015","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0065","first-page":"1008","article-title":"Angiotensin levels in the eye","volume":"35","author":"Danser","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0070","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000081633","article-title":"Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues","volume":"36","author":"Savaskan","year":"2004","journal-title":"Ophthalmic Res."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0075","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1172\/JCI118623","article-title":"Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH\/NADPH oxidase activation. Contribution to alterations of vasomotor tone","volume":"97","author":"Rajagopalan","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1042\/CS20100389","article-title":"Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence","volume":"120","author":"Willis","year":"2011","journal-title":"Clin. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0085","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.HYP.36.6.1099","article-title":"Retinal neovascularization is prevented by blockade of the renin-angiotensin system","volume":"36","author":"Moravski","year":"2000","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0090","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1097\/01.ASN.0000090747.59919.D2","article-title":"Role of oxidative stress in endothelial dysfunction and enhanced responses to angiotensin II of afferent arterioles from rabbits infused with angiotensin II","volume":"14","author":"Wang","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00396","article-title":"Angiotensin II-induced endothelial dysfunction is temporally linked with increases in interleukin-6 and vascular macrophage accumulation","volume":"5","author":"Gomolak","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10557-011-6351-3","article-title":"Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of rho-BH4-eNOS-NO pathway","volume":"26","author":"Zhang","year":"2012","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0105","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3390\/antiox10081238","article-title":"Angiotensin II induces oxidative stress and endothelial dysfunction in mouse ophthalmic arteries via involvement of AT1 receptors and NOX2","volume":"10","author":"Birk","year":"2021","journal-title":"Antioxidants"},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2024.111343_bb0110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0303-7207(00)00406-8","article-title":"Control of renin secretion from adrenal gland in transgenic Ren-2 and normal rats","volume":"173","author":"Rong","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2024.111343_bb0115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0303-7207(02)00217-4","article-title":"Characterisation of a thymic renin\u2013angiotensin system in the transgenic m (Ren-2) 27 rat","volume":"194","author":"Wilkinson-Berka","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0120","article-title":"Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction","volume":"2012","author":"Kurihara","year":"2012","journal-title":"Int. J. Inflamm."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joco.2016.09.009","article-title":"Therapeutic targets of renin-angiotensin system in ocular disorders","volume":"29","author":"Choudhary","year":"2017","journal-title":"J. Curr. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0130","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s42003-020-01483-2","article-title":"Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models","volume":"3","author":"Nagai","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0135","first-page":"4252031","article-title":"Renin-angiotensin system inhibitor usage and age-related macular degeneration among hypertensive patients: results from the National Health and nutrition examination survey, 2005-2008","volume":"2020","author":"Ren","year":"2020","journal-title":"J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0140","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5935\/0004-2749.20200052","article-title":"Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma","volume":"83","author":"Seki","year":"2020","journal-title":"Arq. Bras. Oftalmol."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9123838","article-title":"Evaluation of systemic renin and angiotensin II levels in Normal tension Glaucoma","volume":"9","author":"Jeon","year":"2020","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0150","first-page":"772","article-title":"Inhibition of renin-angiotensin system prevents neurodegeneration in a mouse model of Normal tension Glaucoma","volume":"120","author":"Semba","year":"2016","journal-title":"Nippon Ganka Gakkai Zasshi"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0155","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.122.322003","article-title":"Maintenance of enteral ACE2 prevents diabetic retinopathy in type 1 diabetes","volume":"132","author":"Prasad","year":"2023","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032334","article-title":"Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduces vascular injury and increases regulatory T-cells: studies in rodents with diabetic and Neovascular retinopathy","volume":"24","author":"Jerome","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22789","article-title":"Role of the renin-angiotensin system in the development of cataract formation in angiotensin-II-induced experimental rats","volume":"35","author":"Choudhary","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0170","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1177\/1120672120962401","article-title":"Therapeutic effects of various renin angiotensin modulators on hyperglycemia-induced cataract formation in Sprague Dawley rats","volume":"31","author":"Shree","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168809","article-title":"Involvement of renin-angiotensin system in retinopathy of prematurity - a possible target for therapeutic intervention","volume":"11","author":"Nath","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.18097\/pbmc20236902097","article-title":"Enalaprilat as a new means of preventing the development of retinopathy of prematurity","volume":"69","author":"Katargina","year":"2023","journal-title":"Biomed. Khim."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0185","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1111\/bcp.15213","article-title":"Eplerenone repurposing in management of chorioretinopathy: mechanism, nanomedicine-based delivery applications and future trends","volume":"88","author":"Abdelhakeem","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107788","article-title":"Aldosterone as a mediator of severity in retinal vascular disease: evidence and potential mechanisms","volume":"188","author":"Allingham","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0195","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1167\/iovs.14-13883","article-title":"Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice","volume":"55","author":"Qiu","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0200","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00417-007-0730-2","article-title":"Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats","volume":"246","author":"Miyazaki","year":"2008","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0205","doi-asserted-by":"crossref","first-page":"31912","DOI":"10.1038\/srep31912","article-title":"AAV8-mediated angiotensin-converting enzyme 2 gene delivery prevents experimental autoimmune uveitis by regulating MAPK, NF-\u03baB and STAT3 pathways","volume":"6","author":"Qiu","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141137","article-title":"Losartan treatment protects retinal ganglion cells and alters scleral remodeling in experimental Glaucoma","volume":"10","author":"Quigley","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0215","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41419-022-04762-4","article-title":"Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma","volume":"13","author":"Jeon","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0220","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1167\/iovs.12-11427","article-title":"Antiglaucomatous effects of the activation of intrinsic angiotensin-converting enzyme 2","volume":"54","author":"Foureaux","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2024.111343_bb0225","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/WNO.0000000000000289","article-title":"The morphological difference between glaucoma and other optic neuropathies","volume":"35","author":"Burgoyne","year":"2015","journal-title":"J. Neuroophthalmol."},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0230","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/jech.57.9.752","article-title":"Primary open angle glaucoma. The need for a consensus case definition","volume":"57","author":"Kroese","year":"2003","journal-title":"J. Epidemiol. Community Health"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0235","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of glaucoma: clinical and experimental concepts","volume":"40","author":"Casson","year":"2012","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0240","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0245","series-title":"Acute Closed Angle Glaucoma, StatPearls, StatPearls Publishing Copyright \u00a9 2022","author":"Khazaeni","year":"2022"},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0250","doi-asserted-by":"crossref","first-page":"C174","DOI":"10.12968\/hmed.2019.80.12.C174","article-title":"Acute angle closure glaucoma","volume":"80","author":"Flores-S\u00e1nchez","year":"2019","journal-title":"Br. J. Hosp. Med. (Lond.)"},{"issue":"13","key":"10.1016\/j.cellsig.2024.111343_bb0255","first-page":"225","article-title":"The diagnosis and treatment of Glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0260","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s12325-017-0513-z","article-title":"Targeting Schlemm's canal in the medical therapy of Glaucoma: current and future considerations","volume":"34","author":"Andr\u00e9s-Guerrero","year":"2017","journal-title":"Adv. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2005.02.008","article-title":"Morphological changes in glaucomatous eyes and the role of TGF\u03b22 for the pathogenesis of the disease","volume":"81","author":"L\u00fctjen-Drecoll","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0270","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/ceo.14027","article-title":"Pathogenesis of glaucoma: extracellular matrix dysfunction in the trabecular meshwork-a review","volume":"50","author":"Keller","year":"2022","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102967","article-title":"Oxidative stress in the eye and its role in the pathophysiology of ocular diseases","volume":"68","author":"B\u00f6hm","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0280","doi-asserted-by":"crossref","first-page":"9736047","DOI":"10.1155\/2019\/9736047","article-title":"Elevated intraocular pressure causes abnormal reactivity of mouse retinal arterioles","volume":"2019","author":"Gericke","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0285","doi-asserted-by":"crossref","first-page":"e57557","DOI":"10.1371\/journal.pone.0057557","article-title":"Enhanced Insight into the Autoimmune Component of Glaucoma: IgG Autoantibody Accumulation and Pro-Inflammatory Conditions in Human Glaucomatous Retina","volume":"8","author":"Gramlich","year":"2013","journal-title":"PLoS One"},{"issue":"46","key":"10.1016\/j.cellsig.2024.111343_bb0290","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1523\/JNEUROSCI.3200-08.2008","article-title":"Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived Fas-ligand","volume":"28","author":"Martin","year":"2008","journal-title":"J. Neurosci."},{"issue":"9\u201310","key":"10.1016\/j.cellsig.2024.111343_bb0295","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/1120672103013009-1003","article-title":"Analysis of autoantibody repertoires in sera of patients with Glaucoma","volume":"13","author":"Joachim","year":"2003","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0300","first-page":"573","article-title":"Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens, Graefe's archive for","volume":"246","author":"Joachim","year":"2008","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0305","first-page":"817","article-title":"Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens, Graefe's archive for","volume":"243","author":"Joachim","year":"2005","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"1327137","key":"10.1016\/j.cellsig.2024.111343_bb0310","first-page":"13","article-title":"Complex autoantibody repertoires in patients with glaucoma","volume":"10","author":"Grus","year":"2004","journal-title":"Mol. Vis."},{"issue":"13","key":"10.1016\/j.cellsig.2024.111343_bb0315","first-page":"1285","article-title":"Serum autoantibodies in glaucoma patients from Germany and the United States: further implications for autoimmune mechanisms in the neurodegenerative processes of glaucoma","volume":"46","author":"Grus","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0320","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0002-9394(99)80084-1","article-title":"Anti-Ro\/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma","volume":"125","author":"Wax","year":"1998","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0325","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0161-6420(00)00525-X","article-title":"Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States","volume":"108","author":"Wax","year":"2001","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0330","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/02713680701375183","article-title":"Antibodies to \u03b1 B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor","volume":"32","author":"Joachim","year":"2007","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.cellsig.2024.111343_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12886-015-0044-9","article-title":"Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway","volume":"15","author":"Bell","year":"2015","journal-title":"BMC Ophthalmol."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0340","article-title":"Intraocular Pressure-induced endothelial dysfunction of retinal blood vessels is persistent, but does not trigger retinal ganglion cell loss","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0345","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ophtha.2012.11.043","article-title":"How does glaucoma look?: patient perception of visual field loss","volume":"120","author":"Crabb","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.cellsig.2024.111343_bb0350","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajo.2021.03.030","article-title":"Screening for open-angle Glaucoma and its effect on blindness","volume":"228","author":"Aspberg","year":"2021","journal-title":"Am. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0355","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0039-6257(98)00049-6","article-title":"Ophthalmoscopic evaluation of the optic nerve head","volume":"43","author":"Jonas","year":"1999","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0360","doi-asserted-by":"crossref","first-page":"P41","DOI":"10.1016\/j.ophtha.2015.10.053","article-title":"Primary open-angle Glaucoma preferred practice pattern(\u00ae) guidelines","volume":"123","author":"Prum","year":"2016","journal-title":"Ophthalmology"},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0365","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/cns.12187","article-title":"Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models","volume":"20","author":"Tan","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cellsig.2024.111343_bb0370","article-title":"Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis","volume":"10","author":"Li","year":"2021","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0375","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1177\/11206721211008783","article-title":"Netarsudil: a new ophthalmic drug in the treatment of chronic primary open angle glaucoma and ocular hypertension","volume":"31","author":"Batra","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0380","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-158-4-201302190-00008","article-title":"Comparative effectiveness of treatments for open-angle Glaucoma: a systematic review for the U.S. preventive services task force","volume":"158","author":"Boland","year":"2013","journal-title":"Ann. Intern. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0385","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3390\/antiox12071465","article-title":"Oxidative stress: a suitable therapeutic target for optic nerve diseases?","volume":"12","author":"Buonfiglio","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.cellsig.2024.111343_bb0390","article-title":"The renin-angiotensin-aldosterone system in vascular inflammation and remodeling","volume":"2014","author":"Pacurari","year":"2014","journal-title":"Int. J. Inf. Secur."},{"issue":"11\u221212","key":"10.1016\/j.cellsig.2024.111343_bb0395","first-page":"1965","article-title":"In vitro studies on the conversion of the biosynthetic precursor of renin, clinical and experimental hypertension","volume":"4","author":"Lund","year":"1982","journal-title":"Part A: Theory Pract."},{"issue":"11\u201312","key":"10.1016\/j.cellsig.2024.111343_bb0400","first-page":"1939","article-title":"Biosynthesis of Preprorenin. Studies using whole tissue, a cell-free system, and E. Coli containing cDna inserted at the PstI site of plasmid pBR322, clinical and experimental hypertension","volume":"4","author":"Catanzaro","year":"1982","journal-title":"Part A: Theory Pract."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0405","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0014-5793(98)01145-4","article-title":"Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus","volume":"436","author":"Streatfeild-James","year":"1998","journal-title":"FEBS Lett."},{"issue":"11\u201312","key":"10.1016\/j.cellsig.2024.111343_bb0410","first-page":"1973","article-title":"The nature of renin precursor and inactive renin, clinical and experimental hypertension","volume":"4","author":"Dzau","year":"1982","journal-title":"Part A: Theory Pract."},{"issue":"51","key":"10.1016\/j.cellsig.2024.111343_bb0415","doi-asserted-by":"crossref","first-page":"32497","DOI":"10.1016\/S0021-9258(18)31662-4","article-title":"Functional expression of the human angiotensinogen gene in transgenic mice","volume":"269","author":"Yang","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.cellsig.2024.111343_bb0420","doi-asserted-by":"crossref","first-page":"11617","DOI":"10.1016\/S0021-9258(19)50246-0","article-title":"Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes","volume":"268","author":"Fukamizu","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"33","key":"10.1016\/j.cellsig.2024.111343_bb0425","doi-asserted-by":"crossref","first-page":"24539","DOI":"10.1016\/S0021-9258(19)74498-6","article-title":"Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors","volume":"268","author":"Mukoyama","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0430","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.HYP.24.1.63","article-title":"Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension","volume":"24","author":"Bonnardeaux","year":"1994","journal-title":"Hypertension"},{"issue":"6323","key":"10.1016\/j.cellsig.2024.111343_bb0435","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","article-title":"Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor","volume":"351","author":"Murphy","year":"1991","journal-title":"Nature"},{"issue":"6323","key":"10.1016\/j.cellsig.2024.111343_bb0440","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/351230a0","article-title":"Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor","volume":"351","author":"Sasaki","year":"1991","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0445","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.80.5.607","article-title":"Angiotensin II signal transduction in vascular smooth muscle","volume":"80","author":"Berk","year":"1997","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0450","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.0000159937.05502.d1","article-title":"Angiotensin II and aldosterone regulate gene transcription via functional Mineralocortocoid receptors in human coronary artery smooth muscle cells","volume":"96","author":"Jaffe","year":"2005","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0455","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11906-018-0845-3","article-title":"Dimerization of AT(2) and mas receptors in control of blood pressure","volume":"20","author":"Patel","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0460","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/HYPERTENSIONAHA.116.08814","article-title":"Evidence for Heterodimerization and functional interaction of the angiotensin type 2 receptor and the receptor MAS","volume":"69","author":"Leonhardt","year":"2017","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0465","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/CIRCRESAHA.108.184911","article-title":"Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart","volume":"103","author":"Mercure","year":"2008","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0470","doi-asserted-by":"crossref","first-page":"H1560","DOI":"10.1152\/ajpheart.00941.2004","article-title":"Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor","volume":"289","author":"Tallant","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0475","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1-7) through receptor mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"issue":"14","key":"10.1016\/j.cellsig.2024.111343_bb0480","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0485","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/expphysiol.2012.067165","article-title":"Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats","volume":"98","author":"Lo","year":"2013","journal-title":"Exp. Physiol."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0490","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme\u2013related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0495","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BJ20040634","article-title":"Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism","volume":"383","author":"Rice","year":"2004","journal-title":"Biochem. J."},{"issue":"17","key":"10.1016\/j.cellsig.2024.111343_bb0500","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0505","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/HYPERTENSIONAHA.110.167957","article-title":"Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats","volume":"57","author":"Gonzalez","year":"2011","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0510","doi-asserted-by":"crossref","first-page":"17402","DOI":"10.1038\/s41598-021-96892-6","article-title":"Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis","volume":"11","author":"Amari","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0515","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12964-020-0531-3","article-title":"The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers","volume":"18","author":"Wang","year":"2020","journal-title":"Cell Communicat. Signal."},{"issue":"5964","key":"10.1016\/j.cellsig.2024.111343_bb0520","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1179802","article-title":"Requirement of Prorenin receptor and vacuolar H+-ATPase\u2013mediated acidification for Wnt signaling","volume":"327","author":"Cruciat","year":"2010","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0525","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI0214276","article-title":"Pivotal role of the renin\/prorenin receptor in angiotensin II production and cellular responses to renin","volume":"109","author":"Nguyen","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0530","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/hr.2014.46","article-title":"Serum soluble (pro)renin receptor levels in patients with essential hypertension","volume":"37","author":"Morimoto","year":"2014","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0535","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1210\/jcem-68-1-160","article-title":"Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy","volume":"68","author":"Danser","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0540","first-page":"1749","article-title":"Ocular renin-angiotensin: immunohistochemical evidence for the presence of prorenin in eye tissue","volume":"29","author":"Sramek","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0545","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3109\/02713689309020401","article-title":"Ocular renin angiotensin: EM immunocytochemical localization of prorenin","volume":"12","author":"Wallow","year":"1993","journal-title":"Curr. Eye Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0550","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/bjo.80.2.159","article-title":"Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system","volume":"80","author":"Wagner","year":"1996","journal-title":"Br. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0555","first-page":"876","article-title":"Angiotensin-converting enzyme in bovine, feline, and human ocular tissues","volume":"29","author":"Ferrari-Dileo","year":"1988","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0560","doi-asserted-by":"crossref","first-page":"F396","DOI":"10.1152\/ajprenal.00576.2009","article-title":"Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli","volume":"299","author":"Milenkovic","year":"2010","journal-title":"American J. Physiol.-Renal Physiol."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0565","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00417-015-2952-z","article-title":"The expression of mas-receptor of the renin\u2013angiotensin system in the human eye","volume":"253","author":"Vaajanen","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0570","series-title":"Angiotensin I Converting Enzyme Activity in the Choroid Plexus and in the Retina, Central Actions of Angiotensin and Related Hormones","first-page":"23","author":"Igic","year":"1977"},{"key":"10.1016\/j.cellsig.2024.111343_bb0575","doi-asserted-by":"crossref","first-page":"107680","DOI":"10.1016\/j.exer.2019.05.020","article-title":"The renin-angiotensin-aldosterone system and its therapeutic targets","volume":"186","author":"Mirabito Colafella","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0580","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3109\/02713689409047011","article-title":"Renin mRNA is synthesized locally in rat ocular tissues","volume":"13","author":"Brandt","year":"1994","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.cellsig.2024.111343_bb0585","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1874364101509010028","article-title":"Angiotensin(1-7) and ACE2, \"the hot spots\" of renin-angiotensin system, detected in the human aqueous humor","volume":"9","author":"Holappa","year":"2015","journal-title":"Open Ophthalmol J"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0590","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/02713680490517944","article-title":"Identification of angiotensin converting enzyme 2 in the rodent retina","volume":"29","author":"Tikellis","year":"2004","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0595","doi-asserted-by":"crossref","first-page":"44266","DOI":"10.1038\/srep44266","article-title":"Pathologic roles of receptor-associated Prorenin system in idiopathic Epiretinal membrane","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2024.111343_bb0600","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1007\/s00125-012-2702-2","article-title":"(pro) renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy","volume":"55","author":"Kanda","year":"2012","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0605","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/bjophthalmol-2012-302680","article-title":"Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy","volume":"97","author":"Kanda","year":"2013","journal-title":"Br. J. Ophthalmol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0610","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.2353\/ajpath.2008.080457","article-title":"(pro) renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system","volume":"173","author":"Satofuka","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0615","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2337\/db08-0254","article-title":"(pro) renin receptor\u2013mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation","volume":"58","author":"Satofuka","year":"2009","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0620","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.HYP.0000215838.48170.0b","article-title":"Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension","volume":"47","author":"Ichihara","year":"2006","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0625","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/sj.ki.5000011","article-title":"Renin increases mesangial cell transforming growth factor-\u03b21 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms","volume":"69","author":"Huang","year":"2006","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0630","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41598-017-18314-w","article-title":"(pro) renin receptor is involved in mesangial fibrosis and matrix expansion","volume":"8","author":"Narumi","year":"2018","journal-title":"Sci. Rep."},{"issue":"1\u20133","key":"10.1016\/j.cellsig.2024.111343_bb0635","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2008.12.050","article-title":"Inhibition of renin\/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release","volume":"606","author":"He","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0640","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1042\/CS20201047","article-title":"Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor","volume":"135","author":"Fu","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0645","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.3390\/jcm9082336","article-title":"Receptor-associated Prorenin system in the trabecular meshwork of patients with primary open-angle Glaucoma and Neovascular Glaucoma","volume":"9","author":"Ishizuka","year":"2020","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0650","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049624","article-title":"Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel","volume":"7","author":"Barro-Soria","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0655","doi-asserted-by":"crossref","first-page":"F785","DOI":"10.1152\/ajprenal.00372.2004","article-title":"Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways","volume":"288","author":"Fellner","year":"2005","journal-title":"American J. Physiol.-Renal Physiol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0660","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.diabres.2007.09.023","article-title":"The eyes in diabetes and diabetes through the eyes","volume":"78","author":"Harman-Boehm","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0665","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s001250051539","article-title":"Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes","volume":"43","author":"Gilbert","year":"2000","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0670","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s001250100556","article-title":"The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats","volume":"44","author":"Nagisa","year":"2001","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0675","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.ajpath.2011.02.006","article-title":"Angiotensin II\u2013induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1\u2013mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration","volume":"178","author":"Pons","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0680","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1167\/iovs.06-1473","article-title":"Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-\u03baB pathway","volume":"48","author":"Nagai","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111343_bb0685","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1007\/s11064-013-1058-4","article-title":"Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats","volume":"38","author":"Ola","year":"2013","journal-title":"Neurochem. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0690","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1161\/01.RES.0000043501.47934.FA","article-title":"Superoxide mediates the actions of angiotensin II in the central nervous system","volume":"91","author":"Zimmerman","year":"2002","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0695","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/CS20120212","article-title":"Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy","volume":"124","author":"Wilkinson-Berka","year":"2013","journal-title":"Clin. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0700","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.RES.74.6.1141","article-title":"Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells","volume":"74","author":"Griendling","year":"1994","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0705","first-page":"R1076","article-title":"Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons","volume":"302","author":"Wang","year":"2012","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cellsig.2024.111343_bb0710","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fendo.2012.00164","article-title":"How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?","volume":"3","author":"Guimond","year":"2012","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0715","first-page":"R144","article-title":"Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats","volume":"295","author":"Lee","year":"2008","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cellsig.2024.111343_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107770","article-title":"Angiotensin receptor expression revealed by reporter mice and beneficial effects of AT2R agonist in retinal cells","volume":"187","author":"Verma","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0725","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bbadis.2016.03.013","article-title":"Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia","volume":"1862","author":"Mateos","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0730","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0092-8674(86)90785-3","article-title":"Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains","volume":"45","author":"Young","year":"1986","journal-title":"Cell"},{"issue":"1\u20133","key":"10.1016\/j.cellsig.2024.111343_bb0735","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0167-0115(98)00134-7","article-title":"Angiotensin-(1\u20137): a bioactive fragment of the renin\u2013angiotensin system","volume":"78","author":"Ferrario","year":"1998","journal-title":"Regul. Pept."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0740","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/j.1476-5381.2012.01905.x","article-title":"Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1\/2- and NF-\u03baB-dependent pathways","volume":"166","author":"El-Hashim","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0745","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fphar.2019.00146","article-title":"Participation of G\u03b1i-adenylate cyclase and ERK1\/2 in mas receptor signaling pathways","volume":"10","author":"Burghi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0750","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fphar.2019.00146","article-title":"Participation of G\u03b1(i)-adenylate cyclase and ERK1\/2 in mas receptor signaling pathways","volume":"10","author":"Burghi","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0755","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2009.08.112","article-title":"Chronic angiotensin-(1-7) administration improves vascular remodeling after angioplasty through the regulation of the TGF-beta\/Smad signaling pathway in rabbits","volume":"389","author":"Zeng","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0760","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00109-018-1704-z","article-title":"Pre-treatment with angiotensin-(1\u20137) inhibits tumor growth via autophagy by downregulating PI3K\/Akt\/mTOR signaling in human nasopharyngeal carcinoma xenografts","volume":"96","author":"Lin","year":"2018","journal-title":"J. Mol. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0765","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1167\/iovs.07-1399","article-title":"Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye","volume":"49","author":"Vaajanen","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"37","key":"10.1016\/j.cellsig.2024.111343_bb0770","doi-asserted-by":"crossref","first-page":"18578","DOI":"10.1073\/pnas.1903172116","article-title":"Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist","volume":"116","author":"Fuller","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6099","key":"10.1016\/j.cellsig.2024.111343_bb0775","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/325075a0","article-title":"Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor","volume":"325","author":"Green","year":"1987","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0780","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1096\/fj.09-154344","article-title":"The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in M\u00fcller glial cells","volume":"24","author":"Zhao","year":"2010","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0785","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI61427","article-title":"Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy","volume":"122","author":"Zhao","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb0790","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/CIRCRESAHA.108.174235","article-title":"Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion","volume":"102","author":"Caprio","year":"2008","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0795","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/CIRCRESAHA.115.308269","article-title":"Endothelial mineralocorticoid receptor mediates diet-induced aortic stiffness in females","volume":"118","author":"Jia","year":"2016","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0800","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/HYPERTENSIONAHA.111.188136","article-title":"Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy","volume":"59","author":"Deliyanti","year":"2012","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0805","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/CIRCRESAHA.108.176008","article-title":"Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology","volume":"104","author":"Wilkinson-Berka","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2024.111343_bb0810","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajo.2023.03.014","article-title":"A systematic review and Meta-analysis of systemic antihypertensive medications with intraocular pressure and Glaucoma","volume":"255","author":"Leung","year":"2023","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0815","doi-asserted-by":"crossref","first-page":"16224","DOI":"10.1038\/s41598-023-43420-3","article-title":"Effect of antihypertensive medications on the risk of open-angle glaucoma","volume":"13","author":"Lee","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2024.111343_bb0820","series-title":"Expression and Function of Angiotensins in the Regulation of Intraocular Pressure-an Experimental Study","author":"Vaajanen","year":"2009"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0825","first-page":"147","article-title":"Angiotensin binding sites in rabbit anterior uvea and human ciliary epithelial cells","volume":"31","author":"Lin","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0830","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/bjo.86.6.676","article-title":"Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium","volume":"86","author":"Cullinane","year":"2002","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0835","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1167\/iovs.04-0860","article-title":"Expression of acute-phase response proteins in retinal M\u00fcller cells in diabetes","volume":"46","author":"Gerhardinger","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0840","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.preteyeres.2010.03.003","article-title":"The renin\u2013angiotensin system in retinal health and disease: its influence on neurons, glia and the vasculature","volume":"29","author":"Fletcher","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0845","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1167\/iovs.17-22416","article-title":"The role of angiotensin II\/AT1 receptor signaling in regulating retinal microglial activation","volume":"59","author":"Phipps","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0850","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/01.hjh.0000220410.69116.f8","article-title":"Role of the angiotensin II type 1 receptor in the pathogenesis of diabetic retinopathy: effects of blood pressure control and beyond","volume":"24","author":"Clermont","year":"2006","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0855","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.exer.2004.11.012","article-title":"Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes","volume":"80","author":"Wang","year":"2005","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0860","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/exer.2000.0866","article-title":"Effect of Oral losartan potassium administration on intraocular pressure in normotensive and glaucomatous human subjects","volume":"71","author":"Costagliola","year":"2000","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0865","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/112067219500500104","article-title":"Effect of oral captopril (SQ 14225) on intraocular pressure in man","volume":"5","author":"Costagliola","year":"1995","journal-title":"Eur. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0870","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jop.1990.6.1","article-title":"Prostaglandins mediate the ocular hypotensive action of the angiotensin converting enzyme inhibitor MK-422 (Enalaprilat) in African Green monkeys","volume":"6","author":"Lotti","year":"1990","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2024.111343_bb0875","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2014.02.021","article-title":"Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats","volume":"730","author":"Agarwal","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0880","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00005344-200008000-00005","article-title":"Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of Glaucoma","volume":"36","author":"Shah","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb0885","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1139\/Y10-026","article-title":"Oculohypotensive effect of perindopril in acute and chronic models of glaucoma in rabbits","volume":"88","author":"Mehta","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb0890","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1177\/112067219400400407","article-title":"Individual measurements of angiotensin II concentrations in aqueous humor of the eye","volume":"4","author":"Osusky","year":"1994","journal-title":"Eur. J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb0895","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1167\/iovs.03-0088","article-title":"Relationship between ciliary blood flow and aqueous production in rabbits","volume":"44","author":"Reitsamer","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0900","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1167\/iovs.09-3678","article-title":"Neuroprotective effects of angiotensin II type 1 receptor blocker in a rat model of chronic Glaucoma","volume":"50","author":"Yang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"14","key":"10.1016\/j.cellsig.2024.111343_bb0905","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/01.CIR.0000160867.23556.7D","article-title":"G-protein-coupled receptor mas is a physiological antagonist of the angiotensin II type 1 receptor","volume":"111","author":"Kostenis","year":"2005","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb0910","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00417-015-2952-z","article-title":"The expression of mas-receptor of the renin-angiotensin system in the human eye","volume":"253","author":"Vaajanen","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb0915","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/jop.2014.0114","article-title":"Novel potential treatment modalities for ocular hypertension: focus on angiotensin and bradykinin system axes","volume":"31","author":"Sharif","year":"2015","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2024.111343_bb0920","doi-asserted-by":"crossref","DOI":"10.1177\/09636897231162526","article-title":"Elevated angiotensin-II levels contribute to the pathogenesis of open-angle Glaucoma via inducing the expression of fibrosis-related genes in trabecular meshwork cells through a ROS\/NOX4\/SMAD3 Axis","volume":"32","author":"Li","year":"2023","journal-title":"Cell Transplant."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0925","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/tvst.7.2.20","article-title":"Inhibitory effects of angiotensin II receptor blockade on human Tenon fibroblast migration and reactive oxygen species production in cell culture","volume":"7","author":"Kim","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.cellsig.2024.111343_bb0930","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2020.03.016","article-title":"The antioxidant activity and neuroprotective mechanism of isoliquiritigenin","volume":"152","author":"Shi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2024.111343_bb0935","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108146","article-title":"Isoliquiritigenin protects against angiotensin II-induced fibrogenesis by inhibiting NF-\u03baB\/PPAR\u03b3 inflammatory pathway in human Tenon's capsule fibroblasts","volume":"199","author":"Ye","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111343_bb0940","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1167\/iovs.14-15301","article-title":"Angiotensin II as a Morphogenic cytokine stimulating Fibrogenesis of human Tenon's capsule fibroblasts","volume":"56","author":"Shi","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2024.111343_bb0945","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.omtn.2019.05.012","article-title":"Suppression of choroidal neovascularization and fibrosis by a novel RNAi therapeutic agent against (pro)renin receptor","volume":"17","author":"Liu","year":"2019","journal-title":"Mol. Therapy - Nucleic Acids"},{"key":"10.1016\/j.cellsig.2024.111343_bb0950","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.omtn.2017.01.001","article-title":"A novel single-Strand RNAi therapeutic agent targeting the (pro)renin receptor suppresses ocular inflammation","volume":"7","author":"Kanda","year":"2017","journal-title":"Mol. Therapy - Nucleic Acids"},{"issue":"13","key":"10.1016\/j.cellsig.2024.111343_bb0955","first-page":"6295","article-title":"Suppression of ocular inflammation by a combination of renin inhibitor and prorenin receptor blocker","volume":"55","author":"Li","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb0960","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189696","article-title":"Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy","volume":"12","author":"Hase","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0965","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s41232-016-0027-0","article-title":"Receptor-associated prorenin system contributes to development of inflammation and angiogenesis in proliferative diabetic retinopathy","volume":"36","author":"Kanda","year":"2016","journal-title":"Inflammat. Regenerat."},{"issue":"13","key":"10.1016\/j.cellsig.2024.111343_bb0970","first-page":"2191","article-title":"Role of Prorenin and Prorenin receptor in ocular inflammation","volume":"55","author":"Verma","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0975","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2353\/ajpath.2008.080757","article-title":"Prorenin and the (pro)renin receptor in ocular pathology","volume":"173","author":"Wilkinson-Berka","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb0980","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1167\/iovs.05-1458","article-title":"Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of Prorenin","volume":"47","author":"Satofuka","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0985","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1167\/iovs.06-0534","article-title":"Role of Nonproteolytically activated Prorenin in pathologic, but not physiologic, retinal neovascularization","volume":"48","author":"Satofuka","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb0990","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/hr.2010.136","article-title":"Aliskiren binds to renin and prorenin bound to (pro) renin receptor in vitro","volume":"33","author":"Biswas","year":"2010","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb0995","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10384-012-0204-x","article-title":"Renin\u2013angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells","volume":"57","author":"Ozawa","year":"2013","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2024.111343_bb1000","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fncel.2018.00116","article-title":"Microglial activation is modulated by captopril: in vitro and in vivo studies","volume":"12","author":"Asraf","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111343_bb1005","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","article-title":"Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt\/\u03b2-catenin signaling in hypertension","volume":"55","author":"Bhat","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb1010","doi-asserted-by":"crossref","first-page":"e1333","DOI":"10.1038\/cddis.2014.296","article-title":"Renin\u2013angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma","volume":"5","author":"Semba","year":"2014","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111343_bb1015","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.3390\/jcm9123838","article-title":"Evaluation of systemic renin and angiotensin II levels in Normal tension Glaucoma","volume":"9","author":"Jeon","year":"2020","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb1020","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3390\/ph16040556","article-title":"Angiotensin II-related activation of scleral fibroblasts and their role on retinal ganglion cell death in Glaucoma","volume":"16","author":"Oh","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111343_bb1025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41467-018-08125-6","article-title":"Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.cellsig.2024.111343_bb1030","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.1038\/cddis.2013.240","article-title":"Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma","volume":"4","author":"Nitta","year":"2013","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb1035","doi-asserted-by":"crossref","DOI":"10.1177\/1470320318795001","article-title":"Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival","volume":"19","author":"Takasago","year":"2018","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111343_bb1040","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/02713683.2022.2029907","article-title":"Compromised blood flow in the optic nerve head after systemic Administration of Aldosterone in rats: a possible rat model of retinal ganglion cell loss","volume":"47","author":"Wada","year":"2022","journal-title":"Curr. Eye Res."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb1045","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3390\/antiox11040610","article-title":"The retinal renin-angiotensin-aldosterone system: implications for Glaucoma","volume":"11","author":"Hirooka","year":"2022","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111343_bb1050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242090","article-title":"The association of primary aldosteronism with glaucoma-related fundus abnormalities","volume":"15","author":"Ohshima","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111343_bb1055","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10384-018-0595-4","article-title":"Gene expression changes in the retina after systemic administration of aldosterone","volume":"62","author":"Ono","year":"2018","journal-title":"Jpn. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111343_bb1060","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/dom.14915","volume":"25","author":"Rossing","year":"2023","journal-title":"Diabetes Obes. Metab."},{"issue":"10220","key":"10.1016\/j.cellsig.2024.111343_bb1065","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(19)32981-2","article-title":"Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial","volume":"395","author":"Lotery","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.cellsig.2024.111343_bb1070","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41433-020-0802-7","article-title":"Lack of efficacy of eplerenone for treatment of active central serous chorioretinopathy","volume":"34","author":"Sadda","year":"2020","journal-title":"Eye"},{"issue":"10","key":"10.1016\/j.cellsig.2024.111343_bb1075","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.4103\/IJO.IJO_175_23","article-title":"Possible dose-dependent effect of eplerenone on intraocular pressure","volume":"71","author":"Sadat Razavi","year":"2023","journal-title":"Indian J. Ophthalmol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824003115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824003115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:29:15Z","timestamp":1730744955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824003115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":215,"alternative-id":["S0898656824003115"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111343","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glaucoma and the ocular renin-angiotensin-aldosterone system: Update on molecular signalling and treatment perspectives","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111343","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111343"}}