{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:55:44Z","timestamp":1793476544794,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cellsig.2024.111468","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:17:31Z","timestamp":1728605851000},"page":"111468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation"],"prefix":"10.1016","volume":"124","author":[{"given":"Jingyi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2024.111468_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"15","key":"10.1016\/j.cellsig.2024.111468_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13153739","article-title":"Precision medicine and triple-negative breast Cancer: current landscape and future directions","volume":"13","author":"Hossain","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.cellsig.2024.111468_bb0015","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrclinonc.2016.66","article-title":"Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease","volume":"13","author":"Bianchini","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111468_bb0020","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111468_bb0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.cellsig.2024.111468_bb0030","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma","volume":"8","author":"Pavlides","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cellsig.2024.111468_bb0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-030-34025-4_3","article-title":"Lactate and lactate transporters as key players in the maintenance of the Warburg effect","volume":"1219","author":"Pereira-Nunes","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111468_bb0040","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/pr.119.018762","article-title":"Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease","volume":"72","author":"Felmlee","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cellsig.2024.111468_bb0045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/1471-2407-11-235","article-title":"Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer","volume":"11","author":"Robey","year":"2011","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111468_bb0050","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","article-title":"Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-\u03baB\/IL-8 pathway that drives tumor angiogenesis","volume":"71","author":"V\u00e9gran","year":"2011","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111468_bb0055","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2174\/1568009616666151222150543","article-title":"Lactate transporters and pH regulation: potential therapeutic targets in glioblastomas","volume":"16","author":"Miranda-Gon\u00e7alves","year":"2016","journal-title":"Curr. Cancer Drug Targets"},{"issue":"9","key":"10.1016\/j.cellsig.2024.111468_bb0060","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/hep.32348","article-title":"Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack","volume":"77","author":"Fang","year":"2023","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111468_bb0070","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/15384101.2018.1444305","article-title":"Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK\/STAT3 signaling pathway in breast cancer","volume":"17","author":"Mu","year":"2018","journal-title":"Cell Cycle"},{"issue":"8","key":"10.1016\/j.cellsig.2024.111468_bb0075","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41419-021-03990-4","article-title":"Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-\u03baB pathway in HNSCC","volume":"12","author":"Chang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2024.111468_bb0080","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cmet.2016.12.018","article-title":"Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments","volume":"25","author":"Angelin","year":"2017","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111468_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.111846","article-title":"Lactic acid promotes macrophage polarization through MCT-HIF1\u03b1 signaling in gastric cancer","volume":"388","author":"Zhang","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"7851","key":"10.1016\/j.cellsig.2024.111468_bb0090","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"issue":"7779","key":"10.1016\/j.cellsig.2024.111468_bb0095","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Natures"},{"key":"10.1016\/j.cellsig.2024.111468_bb0100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/bs.apcsb.2020.05.001","article-title":"Catalytic activity regulation through post-translational modification: the expanding universe of protein diversity","volume":"122","author":"Kokkinidis","year":"2020","journal-title":"Adv. Protein Chem. Struct. Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111468_bb0105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1515\/BC.2008.048","article-title":"Role of histone modifications in defining chromatin structure and function","volume":"389","author":"Gelato","year":"2008","journal-title":"Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41467-023-35795-8","article-title":"Control of protein stability by post-translational modifications","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111468_bb0115","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s42255-022-00710-w","article-title":"Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma","volume":"5","author":"Yang","year":"2023","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"issue":"48","key":"10.1016\/j.cellsig.2024.111468_bb0130","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"Irizarry-Caro","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111468_bb0135","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111468_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110986","article-title":"Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-\u03b2 signaling in regulatory T cells","volume":"39","author":"Gu","year":"2022","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111468_bb0145","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","article-title":"Histone Lactylation boosts reparative gene activation post-myocardial infarction","volume":"131","author":"Wang","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2024.111468_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.949252","article-title":"The role and mechanism of histone lactylation in health and diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Genet."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111468_bb0155","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.cell.2024.04.002","article-title":"Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis","volume":"187","author":"Zong","year":"2024","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111468_bb0160","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1093\/nar\/gkad1193","article-title":"Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A","volume":"52","author":"Gu","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41392-024-01812-5","article-title":"A positive feedback inhibition of isocitrate dehydrogenase 3\u03b2 on paired-box gene 6 promotes Alzheimer-like pathology","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111468_bb0170","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.immuni.2024.04.006","article-title":"Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma","volume":"57","author":"De Leo","year":"2024","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.cellsig.2024.111468_bb0175","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","article-title":"Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy","volume":"16","author":"Chen","year":"2024","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111468_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad295","article-title":"Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals","volume":"11","author":"Li","year":"2024","journal-title":"Natl. Sci. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111468_bb0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cmet.2023.12.023","article-title":"Augmentation of scleral glycolysis promotes myopia through histone lactylation","volume":"36","author":"Lin","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0190","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15548627.2023.2249762","article-title":"Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer","volume":"20","author":"Li","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2024.111468_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106270","article-title":"Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells","volume":"181","author":"Pan","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111468_bb0200","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","article-title":"Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis","volume":"35","author":"Rho","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2024.111468_bb0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.rinim.2015.10.001","article-title":"Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells","volume":"5","author":"Puck","year":"2015","journal-title":"Res. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2009.07.006","article-title":"Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence","volume":"447","author":"Bustos","year":"2009","journal-title":"Gene"},{"issue":"15","key":"10.1016\/j.cellsig.2024.111468_bb0215","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1128\/MCB.00019-15","article-title":"Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells","volume":"35","author":"Sassano","year":"2015","journal-title":"Mol. Cell. Biol."},{"issue":"51","key":"10.1016\/j.cellsig.2024.111468_bb0220","doi-asserted-by":"crossref","first-page":"40333","DOI":"10.1074\/jbc.M110.151076","article-title":"Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells","volume":"285","author":"Katsoulidis","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2024.111468_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2019.03.004","article-title":"SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT\/GSK-3\u03b2\/\u03b2-catenin pathway","volume":"59","author":"Wan","year":"2019","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111468_bb0230","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41416-020-0873-z","article-title":"Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription","volume":"123","author":"Wan","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111468_bb0235","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.molcel.2023.02.004","article-title":"SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology","volume":"83","author":"Huang","year":"2023","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111468_bb0245","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13059-022-02707-w","article-title":"GoPeaks: histone modification peak calling for CUT&Tag","volume":"23","author":"Yashar","year":"2022","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2024.111468_bb0250","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nprot.2018.015","article-title":"Targeted in situ genome-wide profiling with high efficiency for low cell numbers","volume":"13","author":"Skene","year":"2018","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111468_bb0255","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi6696","article-title":"Class I histone deacetylases (HDAC1-3) are histone lysine delactylases","volume":"8","author":"Moreno-Yruela","year":"2022","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111468_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111468_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030548","article-title":"Lactate activates germline and cleavage embryo genes in mouse embryonic stem cells","volume":"11","author":"Tian","year":"2022","journal-title":"Cells"}],"updated-by":[{"DOI":"10.1016\/j.cellsig.2026.112942","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000}}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824004418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824004418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T21:41:31Z","timestamp":1734644491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824004418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":52,"alternative-id":["S0898656824004418"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111468","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111468"}}