{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:14:06Z","timestamp":1792588446391,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1305400"],"award-info":[{"award-number":["2022YFA1305400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272962"],"award-info":[{"award-number":["82272962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972549"],"award-info":[{"award-number":["81972549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cellsig.2024.111546","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T11:32:57Z","timestamp":1733139177000},"page":"111546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Hypoxia regulates small extracellular vesicle biogenesis and cargo sorting through HIF-1\u03b1\/HRS signaling pathway in head and neck squamous cell carcinoma"],"prefix":"10.1016","volume":"127","author":[{"given":"Yiman","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41368-021-00131-7","article-title":"Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma. Int","volume":"13","author":"Elmusrati","year":"2021","journal-title":"J. Oral Sci."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111546_bb0010","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.trecan.2018.10.002","article-title":"The multiple layers of the tumor environment","volume":"4","author":"Laplane","year":"2018","journal-title":"Trends Cancer"},{"issue":"12","key":"10.1016\/j.cellsig.2024.111546_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126234","article-title":"Tumor-Derived Exosomes (TEX) and their role in immuno-oncology","volume":"22","author":"Whiteside","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0020","doi-asserted-by":"crossref","DOI":"10.1172\/JCI81136","article-title":"Exosomes and tumor-mediated immune suppression","volume":"126","author":"Whiteside","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0025","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0030","doi-asserted-by":"crossref","unstructured":"van Niel G, Carter DRF, Clayton A, Lambert DW, Raposo G, Vader P. Challenges and directions in studying cell-cell communication by extracellular vesicles. Nat. Rev. Mol. Cell Biol. May 2022;23(5):369\u2013382. doi:https:\/\/doi.org\/10.1038\/s41580-022-00460-3.","DOI":"10.1038\/s41580-022-00460-3"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","article-title":"Exosomes: key players in cancer and potential therapeutic strategy","volume":"5","author":"Dai","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-021-01440-5","article-title":"Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications","volume":"21","author":"He","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2024.111546_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcell.2019.00004","article-title":"Hypoxia-modified Cancer cell metabolism","volume":"7","author":"Al Tameemi","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111546_bb0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.20517\/cdr.2022.38","article-title":"Exosome secretion from hypoxic cancer cells reshapes the tumor microenvironment and mediates drug resistance","volume":"5","author":"To KKW","year":"2022","journal-title":"Cancer Drug Res."},{"key":"10.1016\/j.cellsig.2024.111546_bb0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2407-12-421","article-title":"Hypoxic enhancement of exosome release by breast cancer cells","volume":"12","author":"King","year":"2012","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111546_bb0060","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/mc.22124","article-title":"Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules","volume":"54","author":"Ramteke","year":"2015","journal-title":"Mol. Carcinog."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111546_bb0065","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s10620-018-5380-1","article-title":"Exosomal miR-155 derived from hepatocellular carcinoma cells under hypoxia promotes angiogenesis in endothelial cells","volume":"64","author":"Matsuura","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cellsig.2024.111546_bb0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13578-019-0325-8","article-title":"Colon cancer cells secrete exosomes to promote self-proliferation by shortening mitosis duration and activation of STAT3 in a hypoxic environment","volume":"9","author":"Ren","year":"2019","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0075","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/jcb.29328","article-title":"Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival","volume":"121","author":"Patton","year":"2020","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111546_bb0080","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1158\/1541-7786.MCR-19-0725","article-title":"Hypoxic Cancer-secreted Exosomal miR-182-5p promotes glioblastoma angiogenesis by targeting Kruppel-like factor 2 and 4","volume":"18","author":"Li","year":"2020","journal-title":"Mol. Cancer Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111546_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12310","article-title":"Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1\u03b1","volume":"12","author":"Wang","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"28","key":"10.1016\/j.cellsig.2024.111546_bb0090","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1038\/s41388-018-0189-0","article-title":"Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3\/Rab proteins","volume":"37","author":"Dorayappan","year":"2018","journal-title":"Oncogene"},{"issue":"31","key":"10.1016\/j.cellsig.2024.111546_bb0095","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1410041111","article-title":"Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00893-3","article-title":"Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment","volume":"13","author":"Wang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2023.09.034","article-title":"Hypoxic regulation of extracellular vesicles: implications for cancer therapy","volume":"363","author":"Yoo","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.cellsig.2024.111546_bb0110","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2014.05.004","article-title":"Biogenesis and secretion of exosomes","volume":"29","author":"Kowal","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111546_bb0120","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0130","doi-asserted-by":"crossref","unstructured":"Henne WM, Buchkovich NJ, Emr SD. The ESCRT pathway. Dev. Cell Jul 19 2011;21(1):77\u201391. doi:https:\/\/doi.org\/10.1016\/j.devcel.2011.05.015.","DOI":"10.1016\/j.devcel.2011.05.015"},{"issue":"6","key":"10.1016\/j.cellsig.2024.111546_bb0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/10409238.2010.502516","article-title":"The ESCRT complexes","volume":"45","author":"Hurley","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"Pt 24","key":"10.1016\/j.cellsig.2024.111546_bb0140","first-page":"5553","article-title":"Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles","volume":"126","author":"Colombo","year":"2013","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111546_bb0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1158\/2326-6066.CIR-22-0277","article-title":"HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti\u2013PD-1 treatment efficacy","volume":"11","author":"Xiao","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2024.111546_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113352","article-title":"HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111546_bb0155","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41588-018-0318-2","article-title":"Molecular landmarks of tumor hypoxia across cancer types","volume":"51","author":"Bhandari","year":"2019","journal-title":"Nat. Genet."},{"issue":"7290","key":"10.1016\/j.cellsig.2024.111546_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/nature08849","article-title":"Molecular mechanism of multivesicular body biogenesis by ESCRT complexes","volume":"464","author":"Wollert","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0165","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell Vesicles"},{"issue":"7718","key":"10.1016\/j.cellsig.2024.111546_bb0170","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0175","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1038\/s41467-021-25202-5","article-title":"Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.cellsig.2024.111546_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109180","article-title":"Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity","volume":"35","author":"Gonzalez-Franquesa","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0185","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111546_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2022.01.002","article-title":"ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression","volume":"57","author":"Zhang","year":"2022","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.cellsig.2024.111546_bb0195","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nprot.2006.98","article-title":"Chromatin immunoprecipitation and microarray-based analysis of protein location","volume":"1","author":"Lee","year":"2006","journal-title":"Nat. Protoc."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0200","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.devcel.2011.08.019","article-title":"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis","volume":"21","author":"van Niel","year":"2011","journal-title":"Dev. Cell"},{"issue":"5867","key":"10.1016\/j.cellsig.2024.111546_bb0205","doi-asserted-by":"crossref","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0210","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41580-019-0177-4","article-title":"The many functions of ESCRTs","volume":"21","author":"Vietri","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0215","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1016\/j.csbj.2022.08.016","article-title":"Rab GTPases: the principal players in crafting the regulatory landscape of endosomal trafficking","volume":"20","author":"Zhang","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cellsig.2024.111546_bb0220","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-065X.2008.00607.x","article-title":"The yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance","volume":"222","author":"Allavena","year":"2008","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0225","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2024.111546_bb0230","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.7150\/jca.69278","article-title":"Tumor-derived exosomes in hypoxic microenvironment: release mechanism, biological function and clinical application","volume":"13","author":"Qian","year":"2022","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0235","article-title":"Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells","volume":"8","author":"Panigrahi","year":"2018","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2024.111546_bb0240","article-title":"Tumor exosomes reprogrammed by low pH are efficient targeting vehicles for smart drug delivery and personalized therapy against their homologous tumor","volume":"8","author":"Gong","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"37","key":"10.1016\/j.cellsig.2024.111546_bb0245","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/onc.2014.66","article-title":"Exosomal HIF1\u03b1 supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes","volume":"33","author":"Aga","year":"2014","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.cellsig.2024.111546_bb0250","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1158\/0008-5472.CAN-15-1625","article-title":"Exosomes derived from hypoxic Oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a Prometastatic phenotype","volume":"76","author":"Li","year":"2016","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0255","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tem.2018.02.002","article-title":"Mitochondria and hypoxia: metabolic crosstalk in cell-fate decisions","volume":"29","author":"Bargiela","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"issue":"7986","key":"10.1016\/j.cellsig.2024.111546_bb0260","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","article-title":"The power and potential of mitochondria transfer","volume":"623","author":"Borcherding","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cellsig.2024.111546_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2022.02.016","article-title":"Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue","volume":"34","author":"Rosina","year":"2022","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.cellsig.2024.111546_bb0270","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006049","article-title":"PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness","volume":"220","author":"Rabas","year":"2021","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0275","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","article-title":"Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells","volume":"17","author":"Saha","year":"2022","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2024.111546_bb0280","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13045-020-00893-3","article-title":"Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment","volume":"13","author":"Wang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2024.111546_bb0285","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fonc.2020.00188","article-title":"Tumor-associated macrophages: recent insights and therapies","volume":"10","author":"Zhou","year":"2020","journal-title":"Front. Oncol."},{"issue":"16","key":"10.1016\/j.cellsig.2024.111546_bb0290","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1158\/0008-5472.CAN-17-3841","article-title":"Hypoxic tumor-derived Exosomal miR-301a mediates M2 macrophage polarization via PTEN\/PI3K\u03b3 to promote pancreatic Cancer metastasis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.cellsig.2024.111546_bb0295","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ymthe.2017.11.016","article-title":"Hypoxic lung-cancer-derived extracellular vesicle MicroRNA-103a increases the oncogenic effects of macrophages by targeting PTEN","volume":"26","author":"Hsu","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cellsig.2024.111546_bb0300","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12876-016-0440-5","article-title":"Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C","volume":"16","author":"El-Derany","year":"2016","journal-title":"BMC Gastroenterol."},{"issue":"3","key":"10.1016\/j.cellsig.2024.111546_bb0305","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdiacomp.2007.10.006","article-title":"Influence of vitamin E supplementation on endothelial complications in type 2 diabetes mellitus patients who underwent coronary artery bypass graft","volume":"23","author":"Hamdy","year":"2009","journal-title":"J. Diabetes Complicat."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824005217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824005217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:41:40Z","timestamp":1745840500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824005217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":61,"alternative-id":["S0898656824005217"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111546","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia regulates small extracellular vesicle biogenesis and cargo sorting through HIF-1\u03b1\/HRS signaling pathway in head and neck squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111546"}}