{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:17:29Z","timestamp":1778548649775,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2023KJ023"],"award-info":[{"award-number":["2023KJ023"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cellsig.2024.111553","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T03:01:16Z","timestamp":1733454076000},"page":"111553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["LLGL2 targets the Hedgehog signaling pathway to influence malignant progression of endometrial cancer"],"prefix":"10.1016","volume":"127","author":[{"given":"Hua","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2022","key":"10.1016\/j.cellsig.2024.111553_bb0005","first-page":"7","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2024.111553_bb0010","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.3390\/ijms24076462","article-title":"New strategies for endometrial cancer detection and management","volume":"24","author":"Paleari","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2024.111553_bb0015","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(22)00323-3","article-title":"Endometrial cancer","volume":"399","author":"Crosbie","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2024.111553_bb0020","first-page":"258","article-title":"Current recommendations and recent progress in endometrial cancer","volume":"69","author":"Brooks","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2024.111553_bb0025","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.semcancer.2012.02.012","article-title":"Cell polarity proteins and cancer","volume":"22","author":"Ellenbroek","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cellsig.2024.111553_bb0030","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/sj.onc.1208520","article-title":"Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer","volume":"24","author":"Schimanski","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2024.111553_bb0035","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7150\/ijbs.11243","article-title":"Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development","volume":"11","author":"Cao","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2024.111553_bb0040","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1101\/gad.1211604","article-title":"Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors","volume":"18","author":"Bilder","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cellsig.2024.111553_bb0045","first-page":"1","article-title":"SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p","volume":"23","author":"Zhang","year":"2022","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.cellsig.2024.111553_bb0050","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-019-1126-2","article-title":"LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer","volume":"569","author":"Saito","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2024.111553_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.683629","article-title":"LLGL2 increases Ca2+ influx and exerts oncogenic activities via PI3K\/AKT signaling pathway in hepatocellular carcinoma","volume":"11","author":"Leng","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2024.111553_bb0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40659-024-00499-w","article-title":"Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer","volume":"57","author":"Hong","year":"2024","journal-title":"Biol. Res."},{"key":"10.1016\/j.cellsig.2024.111553_bb0065","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1038\/s41467-019-10739-3","article-title":"TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2024.111553_bb0070","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/ijms24021321","article-title":"Emerging roles of Hedgehog signaling in cancer immunity","volume":"24","author":"Giammona","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2024.111553_bb0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3892\/ijmm.2021.4939","article-title":"Sonic Hedgehog signaling pathway in gynecological and genitourinary cancer (review)","volume":"47","author":"Kotulak-Chrz\u0105szcz","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cellsig.2024.111553_bb0080","first-page":"11131","article-title":"Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog\/Gli pathway","volume":"15","author":"Hu","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cellsig.2024.111553_bb0085","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.3892\/or.2020.7798","article-title":"The hedgehog signaling pathway promotes chemotherapy resistance via multidrug resistance protein 1 in ovarian cancer","volume":"44","author":"Zhang","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellsig.2024.111553_bb0090","first-page":"2797","article-title":"SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer","volume":"9","author":"Jin","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111553_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208221","article-title":"Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer","volume":"13","author":"Polychronidou","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2024.111553_bb0100","article-title":"Endometrial cancer: improving management among increasing incidence rates","volume":"103","author":"null eBioMedicine","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cellsig.2024.111553_bb0105","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1016\/j.jmb.2018.06.003","article-title":"Context-specific mechanisms of cell polarity regulation","volume":"430","author":"Allam","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cellsig.2024.111553_bb0110","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202308069","article-title":"Cell polarity changes in cancer initiation and progression","volume":"223","author":"Peglion","year":"2024","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111553_bb0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s10120-013-0324-0","article-title":"Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression","volume":"17","author":"Nam","year":"2014","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.cellsig.2024.111553_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000720","article-title":"Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis","volume":"5","author":"Reischauer","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cellsig.2024.111553_bb0125","first-page":"103","article-title":"Reinterpreting polarity and cancer: the changing landscape from tumor suppression to tumor promotion","volume":"2018","author":"Saito","year":"1869","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.cellsig.2024.111553_bb0130","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/neuonc\/noac001","article-title":"The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells","volume":"24","author":"Kundu","year":"2022","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.cellsig.2024.111553_bb0135","doi-asserted-by":"crossref","first-page":"8201","DOI":"10.1158\/0008-5472.CAN-07-6567","article-title":"The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer","volume":"68","author":"Nolan","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111553_bb0140","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/biom11030405","article-title":"SCRIB is involved in the progression of ovarian carcinomas in association with the factors linked to epithelial-to-mesenchymal transition and predicts shorter survival of diagnosed patients","volume":"11","author":"Hussein","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.cellsig.2024.111553_bb0145","first-page":"610","article-title":"The HIPPO pathway in gynecological malignancies","volume":"10","author":"Wang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111553_bb0150","first-page":"143","article-title":"Signalling pathways in endometrial cancer","volume":"18","author":"Markowska","year":"2014","journal-title":"Contemp Oncol (Pozn)"},{"key":"10.1016\/j.cellsig.2024.111553_bb0155","doi-asserted-by":"crossref","first-page":"487","DOI":"10.26502\/jcsct.5079089","article-title":"The role of Hedgehog pathway in female cancers","volume":"4","author":"Garcia","year":"2020","journal-title":"J. Cancer Sci. Clin. Ther."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682400528X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682400528X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:00:12Z","timestamp":1778547612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865682400528X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":31,"alternative-id":["S089865682400528X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111553","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LLGL2 targets the Hedgehog signaling pathway to influence malignant progression of endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111553","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111553"}}