{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:34:37Z","timestamp":1783006477258,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ7580"],"award-info":[{"award-number":["2024JJ7580"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ50243"],"award-info":[{"award-number":["2023JJ50243"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cellsig.2024.111585","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:27:50Z","timestamp":1735648070000},"page":"111585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination"],"prefix":"10.1016","volume":"127","author":[{"given":"Longhui","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengsheng","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinkuan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangning","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2024.111585_bb0005","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41571-023-00825-3","article-title":"Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy","volume":"20","author":"Singal","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0010","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","article-title":"Global epidemiology and genetics of hepatocellular carcinoma","volume":"164","author":"Toh","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2024.111585_bb0015","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41419-022-04632-z","article-title":"Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer","volume":"13","author":"Jiang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2024.111585_bb0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13045-023-01498-2","article-title":"Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics","volume":"16","author":"Jin","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13046-023-02732-y","article-title":"METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression","volume":"42","author":"Wei","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111585_bb0035","first-page":"14","article-title":"Revisiting the Warburg effect with focus on lactate","author":"Kocianova","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cellsig.2024.111585_bb0040","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1016\/j.cell.2024.06.026","article-title":"100 years of the Warburg effect: a cancer metabolism endeavor","volume":"187","author":"Fendt","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2024.111585_bb0045","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.apsb.2023.12.003","article-title":"Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer","volume":"14","author":"Liao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cellsig.2024.111585_bb0050","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1038\/s41388-018-0137-z","article-title":"USP27-mediated cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis","volume":"37","author":"Dong","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2024.111585_bb0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00018-021-04118-9","article-title":"Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression","volume":"79","author":"Zou","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2024.111585_bb0060","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00018-024-05114-5","article-title":"KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3\/Akt\/mTOR pathway","volume":"81","author":"Zhang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2024.111585_bb0065","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255146","article-title":"CTCF shapes chromatin structure and gene expression in health and disease","volume":"23","author":"Dehingia","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2024.111585_bb0070","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.csbj.2022.05.044","article-title":"CTCF: a misguided jack-of-all-trades in cancer cells","volume":"20","author":"Segueni","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cellsig.2024.111585_bb0075","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00109-022-02248-6","article-title":"TGF-beta1\/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a","volume":"100","author":"Yang","year":"2022","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.cellsig.2024.111585_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.733595","article-title":"Identification of glycolysis-related lncRNAs and the novel lncRNA WAC-AS1 promotes glycolysis and tumor progression in hepatocellular carcinoma","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1443","article-title":"Cullin-associated and neddylation-dissociated 1 regulate reprogramming of lipid metabolism through SKP1-Cullin-1-F-box(FBXO11) -mediated heterogeneous nuclear ribonucleoprotein A2\/B1 ubiquitination and promote hepatocellular carcinoma","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cellsig.2024.111585_bb0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","article-title":"FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner","volume":"41","author":"Huang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111585_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120322","article-title":"Ubiquitination regulation of aerobic glycolysis in cancer","volume":"292","author":"Xie","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2024.111585_bb0100","article-title":"N4-Acetylcytidine drives glycolysis addiction in gastric Cancer via NAT10\/SEPT9\/HIF-1alpha positive feedback loop","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cellsig.2024.111585_bb0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/j.gastro.2020.03.008","article-title":"CPEB4 increases expression of PFKFB3 to induce glycolysis and activate mouse and human hepatic stellate cells, promoting liver fibrosis","volume":"159","author":"Mejias","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2024.111585_bb0110","first-page":"13","article-title":"Role of PFKFB3 and PFKFB4 in cancer: genetic basis, impact on disease development\/progression, and potential as therapeutic targets","author":"Kotowski","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cellsig.2024.111585_bb0115","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1038\/s41388-022-02391-x","article-title":"PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma","volume":"41","author":"Thirusangu","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2024.111585_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13059-020-02152-7","article-title":"Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation","volume":"21","author":"Fang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.067","article-title":"A WIZ\/Cohesin\/CTCF complex anchors DNA loops to define gene expression and cell identity","volume":"31","author":"Justice","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2024.111585_bb0130","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1093\/nar\/gkab520","article-title":"CTCF as a regulator of alternative splicing: new tricks for an old player","volume":"49","author":"Alharbi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cellsig.2024.111585_bb0135","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41556-021-00722-w","article-title":"CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells","volume":"23","author":"Soochit","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2024.111585_bb0140","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.tplants.2018.09.004","article-title":"Protein language: post-translational modifications talking to each other","volume":"23","author":"Vu","year":"2018","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.cellsig.2024.111585_bb0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41467-023-35795-8","article-title":"Control of protein stability by post-translational modifications","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2024.111585_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13046-023-02805-y","article-title":"Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application","volume":"42","author":"Gao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2024.111585_bb0155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12943-024-02005-y","article-title":"Drug resistance mechanisms and treatment strategies mediated by ubiquitin-specific proteases (USPs) in cancers: new directions and therapeutic options","volume":"23","author":"Gao","year":"2024","journal-title":"Mol. Cancer"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824005618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656824005618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:30:08Z","timestamp":1762317008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656824005618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":31,"alternative-id":["S0898656824005618"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111585","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2024.111585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111585"}}