{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:15:39Z","timestamp":1769883339163,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022MH073"],"award-info":[{"award-number":["ZR2022MH073"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["QDFY+X202101012"],"award-info":[{"award-number":["QDFY+X202101012"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012270","name":"Shaanxi Key Science and Technology Innovation Team Project","doi-asserted-by":"publisher","award":["202204051002030"],"award-info":[{"award-number":["202204051002030"]}],"id":[{"id":"10.13039\/501100012270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672662"],"award-info":[{"award-number":["81672662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020758","name":"Science and Technology Innovation Team of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cellsig.2025.111614","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:34:03Z","timestamp":1737430443000},"page":"111614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["KGF impedes TRIM21-enhanced stabilization of keratin 10 mediating differentiation in hypopharyngeal cancer"],"prefix":"10.1016","volume":"127","author":[{"given":"Fangyu","family":"Chai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.cellsig.2025.111614_bb0005","doi-asserted-by":"crossref","first-page":"13230","DOI":"10.1074\/jbc.273.21.13230","article-title":"Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)","volume":"273","author":"Igarashi","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111614_bb0010","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.cellsig.2009.04.004","article-title":"Novel phosphotyrosine targets of FGFR2IIIb signaling","volume":"21","author":"Luo","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.111614_bb0015","article-title":"FGFR2b is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation","author":"Aure","year":"2023","journal-title":"Res. Sq."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111614_bb0020","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00018-022-04327-w","article-title":"Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice","volume":"79","author":"Ahmadvand","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111614_bb0025","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/S0022-5347(01)66930-1","article-title":"Keratinocyte growth factor causes proliferation of urothelium in vivo","volume":"154","author":"Yi","year":"1995","journal-title":"J. Urol."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111614_bb0030","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1073\/pnas.96.11.6267","article-title":"Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas","volume":"96","author":"Miralles","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111614_bb0035","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1053\/gast.2001.24029","article-title":"Keratinocyte growth factor promotes goblet cell differentiation through regulation of goblet cell silencer inhibitor","volume":"120","author":"Iwakiri","year":"2001","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111614_bb0040","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1073\/pnas.062321799","article-title":"Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation","volume":"99","author":"Elghazi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.cellsig.2025.111614_bb0045","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41419-018-0509-x","article-title":"Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCdelta and PKCalpha","volume":"9","author":"Rosato","year":"2018","journal-title":"Cell Death Dis."},{"issue":"22","key":"10.1016\/j.cellsig.2025.111614_bb0050","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1242\/dev.00788","article-title":"A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning","volume":"130","author":"Petiot","year":"2003","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.cellsig.2025.111614_bb0055","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/sj.emboj.7601583","article-title":"The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development","volume":"26","author":"Grose","year":"2007","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0060","first-page":"307","article-title":"Expression of keratinocyte growth factor receptor correlates with expansive growth and early stage of gastric cancer","volume":"28","author":"Matsunobu","year":"2006","journal-title":"Int. J. Oncol."},{"issue":"51","key":"10.1016\/j.cellsig.2025.111614_bb0065","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1038\/sj.onc.1203186","article-title":"Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer","volume":"18","author":"Ricol","year":"1999","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.cellsig.2025.111614_bb0070","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1158\/0008-5472.CAN-10-1489","article-title":"GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling","volume":"70","author":"Bai","year":"2010","journal-title":"Cancer Res."},{"issue":"23","key":"10.1016\/j.cellsig.2025.111614_bb0075","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1158\/1078-0432.CCR-10-0531","article-title":"Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts","volume":"16","author":"Zhao","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111614_bb0080","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pros.20093","article-title":"Restoration of fibroblast growth factor receptor2 suppresses growth and tumorigenicity of malignant human prostate carcinoma PC-3 cells","volume":"61","author":"Yasumoto","year":"2004","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0085","first-page":"247","article-title":"Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer","volume":"13","author":"Yoshino","year":"2005","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/path.1617","article-title":"Expression of keratinocyte growth factor\/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumour proliferative activity and patient prognosis","volume":"204","author":"Yamayoshi","year":"2004","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111614_bb0095","first-page":"721","article-title":"Expression and roles of keratinocyte growth factor and its receptor in esophageal cancer cells","volume":"31","author":"Yoshino","year":"2007","journal-title":"Int. J. Oncol."},{"issue":"20","key":"10.1016\/j.cellsig.2025.111614_bb0100","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41388-022-02313-x","article-title":"Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway","volume":"41","author":"Liu","year":"2022","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.cellsig.2025.111614_bb0105","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1172\/JCI68899","article-title":"FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma","volume":"123","author":"Ramsey","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111614_bb0110","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/ijo.2017.3927","article-title":"FGF7\/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1","volume":"50","author":"Huang","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2025.111614_bb0115","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.4049\/jimmunol.1801199","article-title":"FGFR2 promotes expression of PD-L1 in colorectal Cancer via the JAK\/STAT3 signaling pathway","volume":"202","author":"Li","year":"2019","journal-title":"J. Immunol."},{"issue":"15","key":"10.1016\/j.cellsig.2025.111614_bb0120","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1002\/1878-0261.13274","article-title":"FGF7\/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer","volume":"16","author":"Mieczkowski","year":"2022","journal-title":"Mol. Oncol."},{"issue":"25","key":"10.1016\/j.cellsig.2025.111614_bb0125","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1016\/j.cell.2024.10.015","article-title":"Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders","volume":"187","author":"Lu","year":"2024","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.cellsig.2025.111614_bb0130","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.jid.2018.05.016","article-title":"E3 ligase Trim21 Ubiquitylates and stabilizes keratin 17 to induce STAT3 activation in psoriasis","volume":"138","author":"Yang","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41418-021-00867-z","article-title":"TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization","volume":"29","author":"Gao","year":"2022","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/bjd.19057","article-title":"Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-kappaB p65 subunit and promotes inflammation in keratinocytes","volume":"184","author":"Yang","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111614_bb0145","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41419-021-03989-x","article-title":"Induced TRIM21 ISGylation by IFN-beta enhances p62 ubiquitination to prevent its autophagosome targeting","volume":"12","author":"Jin","year":"2021","journal-title":"Cell Death Dis."},{"issue":"14","key":"10.1016\/j.cellsig.2025.111614_bb0150","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1016\/j.molimm.2010.05.004","article-title":"Downregulation of active IKK beta by Ro52-mediated autophagy","volume":"47","author":"Niida","year":"2010","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111614_bb0155","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.chembiol.2023.05.009","article-title":"TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111614_bb0160","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4161\/auto.28145","article-title":"FGF7\/KGF regulates autophagy in keratinocytes: a novel dual role in the induction of both assembly and turnover of autophagosomes","volume":"10","author":"Belleudi","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111614_bb0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12885-015-1065-8","article-title":"The role of HGF\/MET and FGF\/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma","volume":"15","author":"Saito","year":"2015","journal-title":"BMC Cancer"},{"issue":"20","key":"10.1016\/j.cellsig.2025.111614_bb0170","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.18632\/oncotarget.27582","article-title":"PLAC1 is essential for FGF7\/FGFRIIIb-induced Akt-mediated cancer cell proliferation","volume":"11","author":"Roldan","year":"2020","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.cellsig.2025.111614_bb0175","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.acthis.2015.09.003","article-title":"Immunolocalization of FGF7 (KGF) in the regenerating tail of lizard suggests it is involved in the differentiation of the epidermis","volume":"117","author":"Alibardi","year":"2015","journal-title":"Acta Histochem."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111614_bb0180","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.0022-202X.2004.23426.x","article-title":"Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice","volume":"123","author":"Reichelt","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbrc.2014.01.014","article-title":"PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression","volume":"444","author":"Wu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"38","key":"10.1016\/j.cellsig.2025.111614_bb0190","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1038\/sj.onc.1204688","article-title":"Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells","volume":"20","author":"Mehta","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11658-020-00245-6","article-title":"Beyond K48 and K63: non-canonical protein ubiquitination","volume":"26","author":"Tracz","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"12","key":"10.1016\/j.cellsig.2025.111614_bb0200","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/tra.12527","article-title":"MGRN1-mediated ubiquitination of alpha-tubulin regulates microtubule dynamics and intracellular transport","volume":"18","author":"Mukherjee","year":"2017","journal-title":"Traffic"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.1","article-title":"Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation","volume":"5","author":"Srivastava","year":"2014","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.cellsig.2025.111614_bb0210","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1158\/0008-5472.CAN-17-3858","article-title":"Upregulation of E3 ubiquitin ligase CBLC enhances EGFR dysregulation and signaling in lung adenocarcinoma","volume":"78","author":"Hong","year":"2018","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111614_bb0215","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.molcel.2019.11.003","article-title":"Targeting UBE4A revives viperin protein in epithelium to enhance host antiviral defense","volume":"77","author":"Yuan","year":"2020","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111614_bb0220","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1158\/0008-5472.CAN-18-1754","article-title":"Hypermethylation of SHISA3 promotes nasopharyngeal carcinoma metastasis by reducing SGSM1 stability","volume":"79","author":"Zhang","year":"2019","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0225","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12929-020-0625-7","article-title":"TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis","volume":"27","author":"Zhang","year":"2020","journal-title":"J. Biomed. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111614_bb0230","first-page":"186","article-title":"YWHAZ binds to TRIM21 but is not involved in TRIM21-stimulated osteosarcoma cell proliferation","volume":"31","author":"Zeng","year":"2018","journal-title":"Biomed. Environ. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111614_bb0235","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.18632\/aging.102760","article-title":"PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP\/p21 axis","volume":"12","author":"Li","year":"2020","journal-title":"Aging"},{"issue":"30","key":"10.1016\/j.cellsig.2025.111614_bb0240","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/onc.2011.57","article-title":"Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C\/EBPalpha","volume":"30","author":"Grandinetti","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.111614_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.767644","article-title":"Comprehensive analysis of the prognostic values of the TRIM family in hepatocellular carcinoma","volume":"11","author":"Dai","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111614_bb0250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/joim.12375","article-title":"Reduced expression of TRIM21\/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease","volume":"278","author":"Brauner","year":"2015","journal-title":"J. Intern. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111614_bb0255","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/ibd\/izaa229","article-title":"TRIM21 is decreased in colitis-associated Cancer and negatively regulates epithelial carcinogenesis","volume":"27","author":"Zhou","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0260","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41419-020-2350-2","article-title":"SET7\/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21","volume":"11","author":"Si","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.111614_bb0265","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.ijbiomac.2019.10.019","article-title":"Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells","volume":"142","author":"Jin","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111614_bb0270","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41556-019-0455-6","article-title":"BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma","volume":"22","author":"Li","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111614_bb0275","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1158\/0008-5472.CAN-23-2889","article-title":"SPARC stabilizes ApoE to induce cholesterol-dependent invasion and Sorafenib resistance in hepatocellular carcinoma","volume":"84","author":"Wan","year":"2024","journal-title":"Cancer Res."},{"issue":"42","key":"10.1016\/j.cellsig.2025.111614_bb0280","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2406936121","article-title":"TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer","volume":"121","author":"Ye","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0285","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41467-023-36523-y","article-title":"TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111614_bb0290","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12935-024-03367-5","article-title":"NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21","volume":"24","author":"Guo","year":"2024","journal-title":"Cancer Cell Int."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:28:21Z","timestamp":1762316901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825000270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":58,"alternative-id":["S0898656825000270"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111614","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KGF impedes TRIM21-enhanced stabilization of keratin 10 mediating differentiation in hypopharyngeal cancer","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111614"}}