{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:46:26Z","timestamp":1793850386255,"version":"4.6.1"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020\\u202FM671562"],"award-info":[{"award-number":["2020\\u202FM671562"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171038"],"award-info":[{"award-number":["82171038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101101"],"award-info":[{"award-number":["82101101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018557","name":"Science and Technology Project of Nantong City","doi-asserted-by":"publisher","award":["MS22022020"],"award-info":[{"award-number":["MS22022020"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2020Z318"],"award-info":[{"award-number":["2020Z318"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cellsig.2025.111623","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:32:59Z","timestamp":1737545579000},"page":"111623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["METTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1\/NRF2 pathways"],"prefix":"10.1016","volume":"127","author":[{"given":"Lihua","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9459","key":"10.1016\/j.cellsig.2025.111623_bb0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(05)70803-5","article-title":"Age-related cataract","volume":"365","author":"Asbell","year":"2005","journal-title":"Lancet"},{"issue":"10094","key":"10.1016\/j.cellsig.2025.111623_bb0010","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","article-title":"Cataracts","volume":"390","author":"Liu","year":"2017","journal-title":"Lancet"},{"issue":"10374","key":"10.1016\/j.cellsig.2025.111623_bb0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0140-6736(22)01839-6","article-title":"Cataracts","volume":"401","author":"Cicinelli","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/ICU.0000000000001009","article-title":"Oxidative stress and antioxidants in cataract development","volume":"35","author":"Lee","year":"2024","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1134\/S0006297922020031","article-title":"Biochemistry of eye lens in the norm and in cataractogenesis","volume":"87","author":"Muranov","year":"2022","journal-title":"Biochemistry (Mosc)"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexmp.2017.02.006","article-title":"Expression of DNA repair genes in lens cortex of age-related cortical cataract","volume":"102","author":"Wang","year":"2017","journal-title":"Exp. Mol. Pathol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/15672018113106660062","volume":"11","author":"Babizhayev","year":"2014","journal-title":"Curr. Drug Deliv."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0040","first-page":"400","article-title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line","volume":"40","author":"Carper","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2025.111623_bb0045","first-page":"143","article-title":"Free radicals and aging of anterior segment tissues of the eye: a hypothesis","volume":"27","author":"Green","year":"1995","journal-title":"Ophthalmic Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2016.09.020","article-title":"Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure","volume":"1863","author":"Brennan","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.cellsig.2025.111623_bb0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.toxlet.2018.02.001","article-title":"D-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions","volume":"289","author":"Xu","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cellsig.2025.111623_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102102","article-title":"Connexin hemichannels regulate redox potential via metabolite exchange and protect lens against cellular oxidative damage","volume":"46","author":"Quan","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111623_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119450","article-title":"Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells","volume":"1870","author":"Wu","year":"2023","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111623_bb0070","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.3390\/ijms24043916","article-title":"DNA damage and repair in eye diseases","volume":"24","author":"Sohn","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0075","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1167\/iovs.12-10940","article-title":"The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu eye study","volume":"54","author":"Su","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111623_bb0080","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ophtha.2011.11.004","article-title":"Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract","volume":"119","author":"Zhang","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.cellsig.2025.111623_bb0085","first-page":"1754","article-title":"Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens","volume":"16","author":"Zhang","year":"2010","journal-title":"Mol. Vis."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111623_bb0090","first-page":"1838","article-title":"Long non-coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR-4728-5p\/OGG1 axis","volume":"46","author":"Zhou","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111623_bb0095","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/tx010072j","article-title":"Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model","volume":"14","author":"Luo","year":"2001","journal-title":"Chem. Res. Toxicol."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111623_bb0100","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.3390\/ijms22094542","article-title":"NEIL1 and NEIL2 are recruited as potential backup for OGG1 upon OGG1 depletion or inhibition by TH5487","volume":"22","author":"Hanna","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"33","key":"10.1016\/j.cellsig.2025.111623_bb0105","doi-asserted-by":"crossref","first-page":"E3090","DOI":"10.1073\/pnas.1304231110","article-title":"Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins","volume":"110","author":"Hegde","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.cellsig.2025.111623_bb0110","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1074\/jbc.M110.198796","article-title":"Preferential repair of oxidized base damage in the transcribed genes of mammalian cells","volume":"286","author":"Banerjee","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2019.10.118","article-title":"Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson\u2019s disease mice model","volume":"521","author":"Xue","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0120","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neurobiolaging.2014.09.026","article-title":"Loss of NEIL1 causes defects in olfactory function in mice","volume":"36","author":"Canugovi","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cellsig.2025.111623_bb0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.dnarep.2016.10.010","article-title":"Enhanced sensitivity of Neil1(\u2212\/\u2212) mice to chronic UVB exposure","volume":"48","author":"Calkins","year":"2016","journal-title":"DNA Repair (Amst)"},{"issue":"41","key":"10.1016\/j.cellsig.2025.111623_bb0130","doi-asserted-by":"crossref","first-page":"24636","DOI":"10.1074\/jbc.M115.658146","article-title":"Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation","volume":"290","author":"Chakraborty","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111623_bb0135","doi-asserted-by":"crossref","first-page":"10469","DOI":"10.1096\/fj.201802291R","article-title":"A variant in a microRNA binding site in NEIL2 3\u2019UTR confers susceptibility to age-related cataracts","volume":"33","author":"Kang","year":"2019","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0140","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s10571-016-0447-z","article-title":"The role of DNA methylation in Lens development and cataract formation","volume":"37","author":"Wang","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2025.111623_bb0145","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fcell.2020.00850","article-title":"CircRNA is a rising star in researches of ocular diseases","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0150","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/antiox12020510","article-title":"m6A modification-association with oxidative stress and implications on eye diseases","volume":"12","author":"Ni","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0155","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s12964-023-01385-w","article-title":"The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing","volume":"21","author":"Wen","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Sign. Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111623_bb0165","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/febs.13614","article-title":"N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases","volume":"283","author":"Maity","year":"2016","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111623_bb0170","doi-asserted-by":"crossref","first-page":"304","DOI":"10.31083\/j.fbl2711304","article-title":"N6-Methyladenosine-modification-related ophthalmic diseases and potential therapeutic strategies","volume":"27","author":"Chen","year":"2022","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0175","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14491","article-title":"Methyltransferase METTL3-mediated maturation of miR-4654 facilitates high glucose-induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2","volume":"103","author":"Guo","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.cellsig.2025.111623_bb0180","article-title":"METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p\/EIF4EBP1","volume":"11","author":"Li","year":"2023","journal-title":"PeerJ"},{"issue":"7646","key":"10.1016\/j.cellsig.2025.111623_bb0185","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature21671","article-title":"RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response","volume":"543","author":"Xiang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2025.111623_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105731","article-title":"Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells","volume":"122","author":"Kong","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.848","article-title":"YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation","volume":"12","author":"Huang","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111623_bb0200","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","article-title":"Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors","volume":"11","author":"Singh","year":"2016","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0014-4835(90)90110-G","article-title":"Late onset hereditary cataract of the Emory mouse. A model for human senile cataract","volume":"50","author":"Kuck","year":"1990","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111623_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.02.034","article-title":"Endoribonucleolytic cleavage of m(6)A-containing RNAs by RNase P\/MRP complex","volume":"74","author":"Park","year":"2019","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2025.111623_bb0215","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1177\/112067210801800501","article-title":"Oxidative stress intensity in lens and aqueous depending on age-related cataract type and brunescense","volume":"18","author":"Zoric","year":"2008","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.cellsig.2025.111623_bb0220","article-title":"The role of oxidative damage in cataract etiopathogenesis","volume":"15","author":"Atalay","year":"2023","journal-title":"Ther. Adv. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33071-0","article-title":"MicroRNA binding mediated functional sequence variant in 3\u2019-UTR of DNA repair gene XPC in age-related cataract","volume":"8","author":"Zou","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cellsig.2025.111623_bb0230","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/02713683.2014.957778","article-title":"Altered DNA methylation and expression profiles of 8-Oxoguanine DNA glycosylase 1 in Lens tissue from age-related cataract patients","volume":"40","author":"Wang","year":"2015","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.cellsig.2025.111623_bb0235","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13148-016-0229-y","article-title":"Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation","volume":"8","author":"Wang","year":"2016","journal-title":"Clin. Epigenetics"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0240","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1073\/pnas.062053799","article-title":"Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA","volume":"99","author":"Hazra","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0245","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1038\/s41467-021-24431-y","article-title":"DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"49","key":"10.1016\/j.cellsig.2025.111623_bb0250","doi-asserted-by":"crossref","first-page":"40544","DOI":"10.1074\/jbc.M508772200","article-title":"Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes","volume":"280","author":"Hu","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.cellsig.2025.111623_bb0255","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1073\/pnas.1620932114","article-title":"NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice","volume":"114","author":"Vartanian","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2025.111623_bb0260","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5053975","article-title":"Nei endonuclease VIII-Like1 (NEIL1) inhibits apoptosis of human colorectal cancer cells","volume":"2020","author":"Xue","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113654","article-title":"NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1","volume":"43","author":"Cao","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2025.111623_bb0270","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2019.05.037","article-title":"NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress","volume":"141","author":"Yang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2025.111623_bb0275","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.colsurfb.2013.07.068","article-title":"Natural antioxidant biomolecules promises future nanomedicine based therapy for cataract","volume":"112","author":"Sunkireddy","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"10","key":"10.1016\/j.cellsig.2025.111623_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103142","article-title":"Vitamin C and the Lens: new insights into delaying the onset of cataract","volume":"12","author":"Lim","year":"2020","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.cellsig.2025.111623_bb0285","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.3390\/nu12123651","article-title":"The protective effects of flavonoids in cataract formation through the activation of Nrf2 and the inhibition of MMP-9","volume":"12","author":"Hilliard","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.cellsig.2025.111623_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108912","article-title":"Melatonin counteracts oxidative damage in lens by regulation of Nrf2 and NLRP3 inflammasome activity","volume":"215","author":"Lledo","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.cellsig.2025.111623_bb0295","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.freeradbiomed.2019.01.016","article-title":"Redox regulation by NRF2 in aging and disease","volume":"134","author":"Schmidlin","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.cellsig.2025.111623_bb0300","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.18240\/ijo.2021.08.19","article-title":"Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress","volume":"14","author":"Cai","year":"2021","journal-title":"Int. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111623_bb0305","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111623_bb0310","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0315","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111623_bb0320","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.molcel.2015.07.021","article-title":"Organelle-specific initiation of autophagy","volume":"59","author":"Sica","year":"2015","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111623_bb0325","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","article-title":"Activation of the human mitochondrial transcription factor a gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0330","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2025.111623_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.893806","article-title":"Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor a","volume":"10","author":"Sharma","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"9\u201310","key":"10.1016\/j.cellsig.2025.111623_bb0340","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bbagrm.2012.03.002","article-title":"Mitochondrial transcription factor a regulates mitochondrial transcription initiation, DNA packaging, and genome copy number","volume":"1819","author":"Campbell","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2025.111623_bb0345","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0350","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111623_bb0355","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.embor.7400488","article-title":"Separate fusion of outer and inner mitochondrial membranes","volume":"6","author":"Malka","year":"2005","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111623_bb0360","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0968-0004(00)88977-X","article-title":"The RNA polymerase II holoenzyme and its implications for gene regulation","volume":"20","author":"Koleske","year":"1995","journal-title":"Trends Biochem. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111623_bb0365","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","article-title":"New insights into the function and regulation of mitochondrial fission","volume":"1833","author":"Otera","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.cellsig.2025.111623_bb0370","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1091\/mbc.12.8.2245","article-title":"Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells","volume":"12","author":"Smirnova","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0375","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbamcr.2012.05.002","article-title":"Recent advances into the understanding of mitochondrial fission","volume":"1833","author":"Elgass","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0380","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"issue":"7859","key":"10.1016\/j.cellsig.2025.111623_bb0385","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0390","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1073\/pnas.0507444103","article-title":"The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase","volume":"103","author":"Vartanian","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"15","key":"10.1016\/j.cellsig.2025.111623_bb0395","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1111\/febs.16784","article-title":"Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells","volume":"290","author":"Zhang","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.cellsig.2025.111623_bb0400","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49044","article-title":"NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress","volume":"8","author":"Han","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0405","article-title":"Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission","volume":"18","author":"Wang","year":"2023","journal-title":"Open Med. (Wars)"},{"key":"10.1016\/j.cellsig.2025.111623_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101626","article-title":"Metformin alleviates lead-induced mitochondrial fragmentation via AMPK\/Nrf2 activation in SH-SY5Y cells","volume":"36","author":"Yang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2025.111623_bb0415","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.freeradbiomed.2021.12.001","article-title":"Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury","volume":"179","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2025.111623_bb0420","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"1","author":"Holmstrom","year":"2016","journal-title":"Curr. Opin. Toxicol."},{"issue":"10","key":"10.1016\/j.cellsig.2025.111623_bb0425","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.61.10.13","article-title":"Identification and characterization of N6-Methyladenosine CircRNAs and methyltransferases in the Lens epithelium cells from age-related cataract","volume":"61","author":"Li","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111623_bb0430","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2025.111623_bb0435","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-052521-035330","article-title":"The proteins of mRNA modification: writers, readers, and erasers","volume":"92","author":"Flamand","year":"2023","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111623_bb0440","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","article-title":"Dynamic regulation and functions of mRNA m6A modification","volume":"22","author":"Wang","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2025.111623_bb0445","unstructured":"Qi S, Kumar A, Chen S, Zhou S, Parihar M, Villalobos C, et al. Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing. Res. Sq. n.d. [Preprint]. rs.3.rs-3150186."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111623_bb0450","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cellsig.2025.111623_bb0455","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111623_bb0460","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tig.2019.12.007","article-title":"Molecular mechanisms driving mRNA degradation by m(6)A modification","volume":"36","author":"Lee","year":"2020","journal-title":"Trends Genet."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:42:54Z","timestamp":1778546574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825000361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":92,"alternative-id":["S0898656825000361"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111623","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1\/NRF2 pathways","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111623"}}