{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:06:00Z","timestamp":1772571960650,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014902","name":"Jiamusi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.cellsig.2025.111624","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:13:21Z","timestamp":1738023201000},"page":"111624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["mTOR\/p70S6K signaling pathway promotes fibrillin-1 expression in AKI-to-CKD transition post CA\/CPR"],"prefix":"10.1016","volume":"128","author":[{"given":"Xiaohui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.111624_bb0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40620-020-00918-7","article-title":"Severe acute kidney injury in critically ill COVID-19 patients","volume":"34","author":"Pi\u00f1eiro","year":"2021","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0010","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00134-021-06454-7","article-title":"Acute kidney injury in the critically ill: an updated review on pathophysiology and management","volume":"47","author":"Pickkers","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.cellsig.2025.111624_bb0015","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2460\/javma.252.10.1257","article-title":"Characterization of subclinical bacteriuria, bacterial cystitis, and pyelonephritis in dogs with chronic kidney disease","volume":"252","author":"Foster","year":"2018","journal-title":"Javma"},{"key":"10.1016\/j.cellsig.2025.111624_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.817","article-title":"Kidney damage from nonsteroidal anti-inflammatory drugs\u2014myth or truth? Review of selected literature","volume":"9","author":"Dro\u017cd\u017cal","year":"2021","journal-title":"Pharmacology Res Perspec"},{"key":"10.1016\/j.cellsig.2025.111624_bb0025","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.3390\/ijms222011253","article-title":"The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential","volume":"22","author":"Zhang","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.cellsig.2025.111624_bb0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10238-021-00715-x","article-title":"Kidney disease and COVID-19 disease severity\u2014systematic review and meta-analysis","volume":"22","author":"Singh","year":"2021","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.cellsig.2025.111624_bb0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","article-title":"SARS-CoV-2 pathogenesis","volume":"20","author":"Lamers","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-020-02112-0","article-title":"The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation","volume":"21","author":"Kant","year":"2020","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0045","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2353\/ajpath.2007.060497","article-title":"Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and mammalian target of rapamycin","volume":"170","author":"Schaefer","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.repc.2019.09.008","article-title":"S\u00edndrome de Marfan revisitada \u2013 da gen\u00e9tica \u00e0 cl\u00ednica","volume":"39","author":"Coelho","year":"2020","journal-title":"Rev. Port. Cardiol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0055","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/deaa100","article-title":"Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause","volume":"35","author":"Ouni","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cellsig.2025.111624_bb0060","article-title":"Fibrillin-1\u2013enriched microenvironment drives endothelial injury and vascular rarefaction in chronic kidney disease","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cellsig.2025.111624_bb0065","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/CIRCULATIONAHA.120.051685","article-title":"Cardiac and kidney benefits of Empagliflozin in heart failure across the spectrum of kidney function","volume":"143","author":"Zannad","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.cellsig.2025.111624_bb0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.kint.2019.06.022","article-title":"The acute kidney injury to chronic kidney disease transition in a mouse model of acute cardiorenal syndrome emphasizes the role of inflammation","volume":"97","author":"Matsushita","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2025.111624_bb0075","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3390\/ijms22041743","article-title":"The role of mTOR signaling as a therapeutic target in cancer","volume":"22","author":"Popova","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.cellsig.2025.111624_bb0080","article-title":"Two decades of a protooncogene HPIP\/PBXIP1: uncovering the tale from germ cell to cancer","volume":"1876","author":"Khumukcham","year":"2021","journal-title":"Biochim. et Biophys. Acta (BBA) - Rev. Cancer."},{"key":"10.1016\/j.cellsig.2025.111624_bb0085","doi-asserted-by":"crossref","first-page":"11119","DOI":"10.1074\/jbc.RA118.002191","article-title":"Protein kinase C\u03b1 drives fibroblast activation and kidney fibrosis by stimulating autophagic flux","volume":"293","author":"Xue","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.111624_bb0090","doi-asserted-by":"crossref","first-page":"12503","DOI":"10.1039\/D1FO02719K","article-title":"Isorhamnetin, the xanthine oxidase inhibitor fromSophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.cellsig.2025.111624_bb0095","doi-asserted-by":"crossref","first-page":"F629","DOI":"10.1152\/ajprenal.00573.2016","article-title":"Determination of renal function and injury using near-infrared fluorimetry in experimental cardiorenal syndrome","volume":"312","author":"Ikeda","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0100","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2460\/javma.240.5.540","article-title":"Small animal cardiopulmonary resuscitation requires a continuum of care: proposal for a chain of survival for veterinary patients","volume":"240","author":"Boller","year":"2012","journal-title":"Javma"},{"key":"10.1016\/j.cellsig.2025.111624_bb0105","first-page":"306","article-title":"Evaluation of fetal hypermethylated RASSF1A in pre-eclampsia and its relationship with placental protein-13, pregnancy associated plasma protein-a and urine protein","volume":"6","author":"Saraswathy","year":"2016","journal-title":"Pregnancy Hypertens. Int. J. Women\u2019s Cardiovasc. Health."},{"key":"10.1016\/j.cellsig.2025.111624_bb0110","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/clinchem\/28.6.1359","article-title":"Immunoturbidimetry of albumin and immunoglobulin G in urine","volume":"28","author":"Teppo","year":"1982","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cellsig.2025.111624_bb0115","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.apsb.2019.04.003","article-title":"Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3","volume":"9","author":"Xiao","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cellsig.2025.111624_bb0120","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1111\/jcmm.14313","article-title":"The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis","volume":"23","author":"Xue","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2025.111624_bb0125","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1681\/ASN.0000000000000024","article-title":"Tubular epithelial cell HMGB1 promotes AKI-CKD transition by sensitizing cycling tubular cells to oxidative stress: a rationale for targeting HMGB1 during AKI recovery","volume":"34","author":"Zhao","year":"2023","journal-title":"JASN"},{"key":"10.1016\/j.cellsig.2025.111624_bb0130","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.2015.119","article-title":"Rictor\/mTORC2 signaling mediates TGF\u03b21-induced fibroblast activation and kidney fibrosis","volume":"88","author":"Li","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2025.111624_bb0135","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1681\/ASN.2012050476","article-title":"Rheb\/mTORC1 signaling promotes kidney fibroblast activation and fibrosis","volume":"24","author":"Jiang","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1379","article-title":"Understanding the mTOR signaling pathway via mathematical modeling","volume":"9","author":"Sulaimanov","year":"2017","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.cellsig.2025.111624_bb0145","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2215\/CJN.11290821","article-title":"Drug-induced acute kidney injury","volume":"17","author":"Perazella","year":"2022","journal-title":"CJASN"},{"key":"10.1016\/j.cellsig.2025.111624_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cellsig.2025.111624_bb0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/15548627.2022.2072054","article-title":"Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis","volume":"19","author":"Livingston","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111624_bb0160","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.7150\/ijbs.56748","article-title":"The role of fibrinogen-like proteins in cancer","volume":"17","author":"Yu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2025.111624_bb0165","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1080\/15548627.2022.2038994","article-title":"Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions","volume":"18","author":"Zhou","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111624_bb0170","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1089\/end.2019.0546","article-title":"Postoperative renal function in patients undergoing unilateral nephrectomy: development of a prediction model using preoperative risk factors and 51Cr-EDTA clearance","volume":"34","author":"Andrade","year":"2020","journal-title":"J. Endourol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0175","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7150\/ijbs.39024","article-title":"Ruxolitinib alleviates renal interstitial fibrosis in UUO mice","volume":"16","author":"Bai","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2025.111624_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127624","article-title":"PP2A-mTOR-p70S6K\/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury","volume":"424","author":"Chen","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cellsig.2025.111624_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118284","article-title":"Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR\/p70S6K signaling pathway","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2025.111624_bb0190","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1136\/gutjnl-2021-326350","article-title":"PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma","volume":"71","author":"Lu","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.cellsig.2025.111624_bb0195","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/S2665-9913(23)00302-8","article-title":"Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial","volume":"6","author":"Redl","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.cellsig.2025.111624_bb0200","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1200\/JCO.23.02266","article-title":"Phase II trial of nab-sirolimus in patients with advanced malignant perivascular epithelioid cell tumors (AMPECT): long-term efficacy and safety update","volume":"42","author":"Wagner","year":"2024","journal-title":"JCO"},{"key":"10.1016\/j.cellsig.2025.111624_bb0205","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.21.01728","article-title":"Nab-Sirolimus for patients with malignant perivascular epithelioid cell tumors","volume":"39","author":"Wagner","year":"2021","journal-title":"JCO"},{"key":"10.1016\/j.cellsig.2025.111624_bb0210","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1016\/S2666-7568(23)00258-1","article-title":"Targeting ageing with rapamycin and its derivatives in humans: a systematic review","volume":"5","author":"Lee","year":"2024","journal-title":"Lancet Healthy Longevity."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T18:28:56Z","timestamp":1740508136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":42,"alternative-id":["S0898656825000373"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111624","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mTOR\/p70S6K signaling pathway promotes fibrillin-1 expression in AKI-to-CKD transition post CA\/CPR","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111624"}}