{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:06:19Z","timestamp":1792843579509,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cellsig.2025.111658","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T21:31:28Z","timestamp":1739482288000},"page":"111658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["LAMP3 exacerbates autophagy-mediated neuronal damage through NF-kB in microglia"],"prefix":"10.1016","volume":"129","author":[{"given":"Kejuan","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruile","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.111658_bb0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1468-1331.2000.00137.x","article-title":"European stroke initiative (EUSI) recommendations for stroke management. The European stroke initiative writing committee","volume":"7","author":"Hacke","year":"2000","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0010","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/1871527311312050015","article-title":"Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities","volume":"12","author":"Rodrigo","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.cellsig.2025.111658_bb0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2013.12.013","article-title":"Ischemia\/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition","volume":"88","author":"Duehrkop","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.06.019","article-title":"Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke","volume":"382","author":"Pei","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cellsig.2025.111658_bb0025","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jns.2019.03.015","article-title":"The progress of neuronal autophagy in cerebral ischemia stroke: mechanisms, roles and research methods","volume":"400","author":"Hou","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.cellsig.2025.111658_bb0030","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41419-019-1777-9","article-title":"Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke","volume":"10","author":"Xu","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.111658_bb0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-019-1464-x","article-title":"LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke","volume":"16","author":"Zhang","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2025.111658_bb0040","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.neuron.2023.04.006","article-title":"Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration","volume":"111","author":"Festa","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.cellsig.2025.111658_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106547","article-title":"Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation\/reoxygenation","volume":"84","author":"Fu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0050","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1080\/15548627.2020.1840796","article-title":"Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons","volume":"17","author":"Zhang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111658_bb0055","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1080\/15548627.2023.2235196","article-title":"LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles","volume":"19","author":"Qiao","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111658_bb0060","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2021.1995150","article-title":"LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization","volume":"18","author":"Tanaka","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111658_bb0065","doi-asserted-by":"crossref","DOI":"10.1080\/08916934.2023.2259125","article-title":"MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy","volume":"56","author":"Lu","year":"2023","journal-title":"Autoimmunity"},{"key":"10.1016\/j.cellsig.2025.111658_bb0070","article-title":"Quantification of ferroptosis pathway status revealed heterogeneity in breast cancer patients with distinct immune microenvironment","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0075","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1602\/neurorx.2.3.396","article-title":"Rodent models of focal stroke: size, mechanism, and purpose","volume":"2","author":"Carmichael","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.cellsig.2025.111658_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: a disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2025.111658_bb0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2007.04.006","article-title":"Autophagy and NF-kappaB: fight for fate","volume":"18","author":"Xiao","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cellsig.2025.111658_bb0090","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1080\/15548627.2018.1491489","article-title":"The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain","volume":"14","author":"Issa","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.111658_bb0095","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.18632\/aging.103307","article-title":"Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia\/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1\u03b1","volume":"12","author":"Huang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cellsig.2025.111658_bb0100","first-page":"367","article-title":"Expression of LAMP3 and its correlation with clinicopathologic characteristics and prognosis in hepatocellular carcinoma","volume":"11","author":"Gui","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0105","first-page":"714","article-title":"LAMP3 is a potent uterine corpus endometrial carcinoma prognostic biomarker associated with immune behavior","volume":"16","author":"Fu","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cellsig.2025.111658_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71669-5","article-title":"LAMP3 induces apoptosis and autoantigen release in Sj\u00f6gren\u2019s syndrome patients","volume":"10","author":"Tanaka","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.111658_bb0115","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/cac2.12486","volume":"43","author":"Qu","year":"2023","journal-title":"Cancer Commun. (Lond)."},{"key":"10.1016\/j.cellsig.2025.111658_bb0120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejcb.2015.01.003","article-title":"Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition","volume":"94","author":"Dominguez-Bautista","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0125","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1158\/1078-0432.CCR-13-0526","article-title":"Hypoxic activation of the PERK\/eIF2\u03b1 arm of the unfolded protein response promotes metastasis through induction of LAMP3","volume":"19","author":"Mujcic","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2025.111658_bb0130","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.mce.2017.10.010","article-title":"LAMP3 regulates hepatic lipid metabolism through activating PI3K\/Akt pathway","volume":"470","author":"Liao","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0135","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01456-22","article-title":"Upregulation of ATF4-LAMP3 Axis by ORF45 facilitates lytic replication of Kaposi\u2019s sarcoma-associated herpesvirus","volume":"96","author":"Sun","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1530\/ERC-13-0183","article-title":"LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy","volume":"21","author":"Nagelkerke","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.cellsig.2025.111658_bb0145","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11325-013-0930-4","article-title":"Autophagy and hippocampal neuronal injury","volume":"18","author":"Li","year":"2014","journal-title":"Sleep Breath."},{"key":"10.1016\/j.cellsig.2025.111658_bb0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2019.04.002","article-title":"TIGAR alleviates ischemia\/reperfusion-induced autophagy and ischemic brain injury","volume":"137","author":"Zhang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2025.111658_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108761","article-title":"Review of the effects and mechanisms of microglial autophagy in ischemic stroke","volume":"108","author":"Hu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0160","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41392-021-00778-y","article-title":"Targeting lysosomes in human disease: from basic research to clinical applications","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.111658_bb0165","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/art.42540","article-title":"Lysosome-associated membrane protein 3 induces lysosome-dependent cell death by impairing Autophagic caspase 8 degradation in the salivary glands of individuals with Sjogren\u2019s disease","volume":"75","author":"Nakamura","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0170","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.stem.2023.02.010","article-title":"Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis","volume":"30","author":"Chua","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cellsig.2025.111658_bb0175","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1007\/s00210-023-02524-3","article-title":"USP22 knockdown protects against cerebral ischemia\/reperfusion injury via destabilizing PTEN protein and activating the mTOR\/TFEB pathway","volume":"396","author":"Li","year":"2023","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.cellsig.2025.111658_bb0180","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.111658_bb0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13041-022-00899-7","article-title":"The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke","volume":"15","author":"Hou","year":"2022","journal-title":"Mol. Brain"},{"key":"10.1016\/j.cellsig.2025.111658_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cellimm.2016.09.013","article-title":"Vitamin D(3) regulates LAMP3 expression in monocyte derived dendritic cells","volume":"311","author":"Malaguarnera","year":"2017","journal-title":"Cell. Immunol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825000713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T22:43:27Z","timestamp":1740523407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825000713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":38,"alternative-id":["S0898656825000713"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111658","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LAMP3 exacerbates autophagy-mediated neuronal damage through NF-kB in microglia","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111658"}}