{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:13:04Z","timestamp":1778548384163,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB665"],"award-info":[{"award-number":["2023AFB665"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFD448"],"award-info":[{"award-number":["2024AFD448"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042024YXB017"],"award-info":[{"award-number":["2042024YXB017"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cellsig.2025.111814","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T17:52:11Z","timestamp":1745171531000},"page":"111814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["NR2F2 and its contribution to lymph node metastasis in oral squamous cell carcinoma"],"prefix":"10.1016","volume":"132","author":[{"given":"Xuan-Hao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian-Nian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Rui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Rui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Wen","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Lin","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2025.111814_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2025.111814_bb0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.oraloncology.2019.02.001","article-title":"Survival outcomes after treatment of cancer of the oral cavity (1985-2015)","volume":"90","author":"Zanoni","year":"2019","journal-title":"Oral Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111814_bb0015","first-page":"203","article-title":"Cancer survival statistics in China 2019\u20132021: a multicenter, population-based study","volume":"4","author":"Zeng","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111814_bb0020","article-title":"Lymph node metastasis in oral squamous cell carcinoma: where we are and where we are going","volume":"3","author":"Cao","year":"2023","journal-title":"Clin. Transl. Discov."},{"issue":"31","key":"10.1016\/j.cellsig.2025.111814_bb0025","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1200\/JCO.2016.71.1176","article-title":"Metastatic lymph node burden and survival in oral cavity cancer","volume":"35","author":"Ho","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0030","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/JS9.0000000000001953","article-title":"Frequency of lymph node metastases at different neck levels in patients with oral squamous cell carcinoma: a systematic review and meta-analysis","volume":"111","author":"Yu","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cellsig.2025.111814_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106989","article-title":"Nanotheranostics in cancer lymph node metastasis: the long road ahead","volume":"198","author":"Zhou","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12951-024-02408-5","article-title":"Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives","volume":"22","author":"Cai","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0045","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/00220345221130013","article-title":"Preliminary extracellular vesicle profiling in drainage fluid after neck dissection in OSCC","volume":"102","author":"Wang","year":"2023","journal-title":"J. Dent. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111814_bb0050","article-title":"Neoadjuvant immunotherapy: new horizon for lymph node preservation","volume":"5","author":"Zhong","year":"2024","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.cellsig.2025.111814_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216740","article-title":"Seizing the fate of lymph nodes in immunotherapy: to preserve or not?","volume":"588","author":"Xu","year":"2024","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.cellsig.2025.111814_bb0060","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41568-021-00366-w","article-title":"Cancer stem cell-immune cell crosstalk in tumour progression","volume":"21","author":"Bayik","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"19","key":"10.1016\/j.cellsig.2025.111814_bb0065","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1158\/0008-5472.CAN-20-1079","article-title":"Cancer cell CD44 mediates macrophage\/monocyte-driven regulation of head and neck cancer stem cells","volume":"80","author":"Gomez","year":"2020","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111814_bb0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s13402-021-00591-3","article-title":"Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications","volume":"44","author":"Patni","year":"2021","journal-title":"Cell. Oncol. (Dordr)"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0075","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1038\/s41467-021-27619-4","article-title":"Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing","volume":"12","author":"Kurten","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0080","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/s41467-023-37379-y","article-title":"Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis","volume":"14","author":"Quah","year":"2023","journal-title":"Nat. Commun."},{"issue":"6476","key":"10.1016\/j.cellsig.2025.111814_bb0085","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111814_bb0090","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae243","article-title":"irGSEA: the integration of single-cell rank-based gene set enrichment analysis","volume":"25","author":"Fan","year":"2024","journal-title":"Brief. Bioinform."},{"issue":"43","key":"10.1016\/j.cellsig.2025.111814_bb0095","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111814_bb0100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111814_bb0105","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","article-title":"Extending support for mouse data in the molecular signatures database (MSigDB)","volume":"20","author":"Castanza","year":"2023","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111814_bb0110","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41571-019-0293-2","article-title":"Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update","volume":"17","author":"Clara","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"35","key":"10.1016\/j.cellsig.2025.111814_bb0115","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1038\/s41388-024-03112-2","article-title":"NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2\/VEGFA axis","volume":"43","author":"Wang","year":"2024","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111814_bb0120","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2023.11875","article-title":"COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1","volume":"25","author":"Tian","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0125","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","article-title":"Machine learning identifies stemness features associated with oncogenic dedifferentiation","volume":"173","author":"Malta","year":"2018","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.cellsig.2025.111814_bb0130","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.stem.2021.04.011","article-title":"CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance","volume":"28","author":"Wang","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.730","article-title":"Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA sequencing","volume":"12","author":"Jiang","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0140","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.canlet.2014.12.013","article-title":"Cancer stem cells, lymphangiogenesis, and lymphatic metastasis","volume":"357","author":"Li","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/aps.2014.86","article-title":"The role of the orphan nuclear receptor COUP-TFII in tumorigenesis","volume":"36","author":"Xu","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111814_bb0150","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/bjc.2014.373","article-title":"COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1","volume":"111","author":"Bao","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0155","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1186\/s12885-020-07107-6","article-title":"NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells","volume":"20","author":"Xia","year":"2020","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0160","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s13238-016-0340-z","article-title":"miR-27b inhibits gastric cancer metastasis by targeting NR2F2","volume":"8","author":"Feng","year":"2017","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jcp.28963","article-title":"The molecular markers of cancer stem cells in head and neck tumors","volume":"235","author":"Yu","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0170","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41392-023-01576-4","article-title":"Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions","volume":"8","author":"Ji","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.111814_bb0175","article-title":"Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma","volume":"13","author":"Liu","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111814_bb0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0022034515613507","article-title":"The role of Wnt signaling in squamous cell carcinoma","volume":"95","author":"Shiah","year":"2016","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111814_bb0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41420-022-00899-5","article-title":"FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111814_bb0190","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10585-024-10317-y","article-title":"Lymph nodes in oral squamous cell carcinoma: a comprehensive anatomical perspective","volume":"41","author":"Wang","year":"2024","journal-title":"Clin. Exp. Metastasis"},{"issue":"9","key":"10.1016\/j.cellsig.2025.111814_bb0195","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1158\/1078-0432.CCR-16-1469","article-title":"Biomarker and tumor responses of oral cavity squamous cell carcinoma to trametinib: a phase II neoadjuvant window-of-opportunity clinical trial","volume":"23","author":"Uppaluri","year":"2017","journal-title":"Clin. Cancer Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682500227X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682500227X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:42:32Z","timestamp":1778546552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865682500227X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S089865682500227X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111814","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NR2F2 and its contribution to lymph node metastasis in oral squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111814"}}