{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:29:14Z","timestamp":1783524554140,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cellsig.2025.111840","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T12:01:43Z","timestamp":1745841703000},"page":"111840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy"],"prefix":"10.1016","volume":"132","author":[{"given":"Lini","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41584-020-00523-9","article-title":"Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines","volume":"17","author":"Arden","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"24","key":"10.1016\/j.cellsig.2025.111840_bb0010","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1016\/j.cell.2021.11.003","article-title":"Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations","volume":"184","author":"Boer","year":"2021","journal-title":"Cell"},{"issue":"7743","key":"10.1016\/j.cellsig.2025.111840_bb0015","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","article-title":"The CH25H-CYP7B1-RORalpha axis of cholesterol metabolism regulates osteoarthritis","volume":"566","author":"Choi","year":"2019","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.cellsig.2025.111840_bb0020","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41584-020-00518-6","article-title":"Emerging pharmaceutical therapies for osteoarthritis","volume":"16","author":"Latourte","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"35","key":"10.1016\/j.cellsig.2025.111840_bb0025","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1073\/pnas.1703856114","article-title":"Knee osteoarthritis has doubled in prevalence since the mid-20th century","volume":"114","author":"Wallace","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0030","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/ard.2008.089748","article-title":"Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study","volume":"68","author":"Lohmander","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111840_bb0035","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","article-title":"Therapeutic options for targeting inflammatory osteoarthritis pain","volume":"15","author":"Conaghan","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"issue":"469","key":"10.1016\/j.cellsig.2025.111840_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8800","article-title":"Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis","volume":"10","author":"Geiger","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111840_bb0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joca.2011.12.003","article-title":"Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?","volume":"20","author":"van der Kraan","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111840_bb0050","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10237-011-0340-0","article-title":"Mechanics of chondrocyte hypertrophy","volume":"11","author":"van Donkelaar","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biocel.2007.06.009","article-title":"Endochondral ossification: how cartilage is converted into bone in the developing skeleton","volume":"40","author":"Mackie","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2025.111840_bb0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41413-019-0046-y","article-title":"Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin beta1-SMAD1 interaction","volume":"7","author":"Lian","year":"2019","journal-title":"Bone Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.matbio.2007.01.006","article-title":"Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis","volume":"26","author":"Tchetina","year":"2007","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0070","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11914-014-0192-5","article-title":"Osteoblast-chondrocyte interactions in osteoarthritis","volume":"12","author":"Findlay","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.cellsig.2025.111840_bb0075","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3389\/fphys.2018.00706","article-title":"Role of the inflammation-autophagy-senescence integrative network in osteoarthritis","volume":"9","author":"Vinatier","year":"2018","journal-title":"Front. Physiol."},{"issue":"22","key":"10.1016\/j.cellsig.2025.111840_bb0080","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111840_bb0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"issue":"43","key":"10.1016\/j.cellsig.2025.111840_bb0090","doi-asserted-by":"crossref","first-page":"25992","DOI":"10.1074\/jbc.270.43.25992","article-title":"Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop","volume":"270","author":"Becerra","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111840_bb0095","first-page":"102","article-title":"Pigment epithelium-derived factor in lipid metabolic disorders","volume":"41","author":"Huang","year":"2018","journal-title":"Biom. J."},{"key":"10.1016\/j.cellsig.2025.111840_bb0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bone.2015.04.008","article-title":"The effect of SERPINF1 in-frame mutations in osteogenesis imperfecta type VI","volume":"76","author":"Al-Jallad","year":"2015","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00223-016-0201-z","article-title":"Novel mutations in SERPINF1 result in rare osteogenesis imperfecta type VI","volume":"100","author":"Wang","year":"2017","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0110","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.bbrc.2018.07.015","article-title":"The role of lncRNA XIST\/miR-211 axis in modulating the proliferation and apoptosis of osteoarthritis chondrocytes through CXCR4 and MAPK signaling","volume":"503","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0115","article-title":"From the low-density lipoprotein receptor-related protein 1 to neuropathic pain: a potentially novel target","volume":"6","author":"Garcia-Fernandez","year":"2021","journal-title":"Pain Rep."},{"key":"10.1016\/j.cellsig.2025.111840_bb0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-2094-7-16","article-title":"Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells","volume":"7","author":"Tanabe","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2025.111840_bb0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2009.06.081","article-title":"Inflammatory cytokines stimulate the chemokines CCL2\/MCP-1 and CCL7\/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]","volume":"1287","author":"Thompson","year":"2009","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111840_bb0130","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.joca.2018.07.012","article-title":"Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis","volume":"26","author":"Fisch","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111840_bb0135","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/art.22711","article-title":"Global analyses of gene expression in early experimental osteoarthritis","volume":"56","author":"Appleton","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111840_bb0140","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0145","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"issue":"24","key":"10.1016\/j.cellsig.2025.111840_bb0150","first-page":"4245","article-title":"Characterization of human primary chondrocytes of osteoarthritic cartilage at varying severity","volume":"124","author":"Yin","year":"2011","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0155","doi-asserted-by":"crossref","first-page":"20692","DOI":"10.1038\/s41598-023-46965-5","article-title":"Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats","volume":"13","author":"Scanu","year":"2023","journal-title":"Sci. Rep."},{"issue":"Suppl. 3","key":"10.1016\/j.cellsig.2025.111840_bb0160","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111840_bb0165","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/cge.14172","article-title":"Novel BMP1, CRTAP, and SERPINF1 variants causing autosomal recessive osteogenesis imperfecta","volume":"102","author":"Kuptanon","year":"2022","journal-title":"Clin. Genet."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jbm4.10044","article-title":"Whole-exome sequencing identifies an Intronic cryptic splice site in SERPINF1 causing osteogenesis imperfecta type VI","volume":"2","author":"Jin","year":"2018","journal-title":"JBMR Plus"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111840_bb0175","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000369108","article-title":"Novel deletion of SERPINF1 causes autosomal recessive osteogenesis imperfecta Type VI in two Brazilian families","volume":"5","author":"Minillo","year":"2014","journal-title":"Mol. Syndromol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0180","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00438-019-01558-8","article-title":"Insufficient evidence for a role of SERPINF1 in otosclerosis","volume":"294","author":"Valgaeren","year":"2019","journal-title":"Mol. Gen. Genomics."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111840_bb0185","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/156652410791065345","article-title":"The pathophysiological role of PEDF in bone diseases","volume":"10","author":"Broadhead","year":"2010","journal-title":"Curr. Mol. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111840_bb0190","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ajhg.2011.01.015","article-title":"Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta","volume":"88","author":"Becker","year":"2011","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0195","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/gutjnl-2014-307138","article-title":"Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats","volume":"64","author":"Mejias","year":"2015","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0200","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrc3484","article-title":"The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential","volume":"13","author":"Becerra","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2011.09.003","article-title":"Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1\/2 and induction of Bcl-2","volume":"72","author":"Sanchez","year":"2012","journal-title":"Neurosci. Res."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111840_bb0210","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db10-0845","article-title":"Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase","volume":"60","author":"Borg","year":"2011","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.cellsig.2025.111840_bb0215","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/jbmr.2173","article-title":"A novel IFITM5 mutation in severe atypical osteogenesis imperfecta type VI impairs osteoblast production of pigment epithelium-derived factor","volume":"29","author":"Farber","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0220","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/jbmr.2002.17.1.30","article-title":"Osteogenesis imperfecta type VI: a form of brittle bone disease with a mineralization defect","volume":"17","author":"Glorieux","year":"2002","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111840_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072358","article-title":"The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression","volume":"21","author":"Rim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111840_bb0230","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.joca.2015.07.008","article-title":"Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration","volume":"24","author":"Ashraf","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111840_bb0235","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.joca.2015.03.015","article-title":"Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes","volume":"23","author":"Piva","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"11","key":"10.1016\/j.cellsig.2025.111840_bb0240","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.joca.2015.01.008","article-title":"Aging-related inflammation in osteoarthritis","volume":"23","author":"Greene","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111840_bb0245","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111840_bb0250","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.4049\/jimmunol.174.9.5781","article-title":"NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments","volume":"174","author":"Pulai","year":"2005","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cellsig.2025.111840_bb0255","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4049\/jimmunol.1800486","article-title":"Activation of NF-kappaB in synovium versus cartilage from patients with advanced knee osteoarthritis: a potential contributor to inflammatory aspects of disease progression","volume":"201","author":"Ahmed","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111840_bb0260","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.cellsig.2025.111840_bb0265","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-kappaB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"issue":"9","key":"10.1016\/j.cellsig.2025.111840_bb0270","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cellsig.2025.111840_bb0275","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.111840_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-kappaB-NLRP3-GSDMD and AMPK-PGC-1alpha axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cellsig.2025.111840_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153296","article-title":"Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-kappaB and RIP1\/RIP3\/MLKL pathway in chicken kidney","volume":"478","author":"Meng","year":"2022","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.cellsig.2025.111840_bb0290","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/acs.est.1c00515","article-title":"ROS-induced hepatotoxicity under Cypermethrin: involvement of the crosstalk between Nrf2\/Keap1 and NF-kappaB\/ikappaB-alpha pathways regulated by proteasome","volume":"55","author":"Zhao","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"20","key":"10.1016\/j.cellsig.2025.111840_bb0295","doi-asserted-by":"crossref","first-page":"18111","DOI":"10.1074\/jbc.M200750200","article-title":"CXCR4\/CCR5 down-modulation and chemotaxis are regulated by the proteasome pathway","volume":"277","author":"Fernandis","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111840_bb0300","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10555-010-9256-x","article-title":"CXCL12 \/ CXCR4 \/ CXCR7 chemokine axis and cancer progression","volume":"29","author":"Sun","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.cellsig.2025.111840_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.123235","article-title":"Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway","volume":"371","author":"Wang","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.cellsig.2025.111840_bb0310","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13578-019-0315-x","article-title":"CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-kappaB signaling pathways","volume":"9","author":"Tian","year":"2019","journal-title":"Cell Biosci."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825002530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825002530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:18:11Z","timestamp":1769689091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825002530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"alternative-id":["S0898656825002530"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111840","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111840"}}