{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:11:40Z","timestamp":1786378300651,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101767"],"award-info":[{"award-number":["82101767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271707"],"award-info":[{"award-number":["82271707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cellsig.2025.111946","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:10:19Z","timestamp":1750209019000},"page":"111946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The role of FAK signaling in early placental development and trophoblast lineage specification in human pregnancy"],"prefix":"10.1016","volume":"134","author":[{"given":"Hong-Xiu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cen","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Long","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.111946_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.semcdb.2022.03.039","article-title":"Human placental development and function","volume":"131","author":"Cindrova-Davies","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111946_bb0010","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/humupd\/dmae007","article-title":"TGF\u03b2 signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy","volume":"30","author":"Horvat Mercnik","year":"2024","journal-title":"Hum. Reprod. Update"},{"issue":"31","key":"10.1016\/j.cellsig.2025.111946_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci. Immunol."},{"issue":"22","key":"10.1016\/j.cellsig.2025.111946_bb0020","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.cellsig.2025.111946_bb0025","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/cbdd.13808","article-title":"Focal adhesion kinase-an emerging viable target in cancer and development of focal adhesion kinase inhibitors","volume":"97","author":"Chauhan","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111946_bb0030","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1071\/RD18296","article-title":"Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development","volume":"31","author":"Dai","year":"2019","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.cellsig.2025.111946_bb0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tox.2017.05.008","article-title":"Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8\/SVneo cells by down-regulating MMP2 through inhibition of FAK\/SRC\/PI3K\/AKT pathway","volume":"386","author":"Wang","year":"2017","journal-title":"Toxicol"},{"issue":"9","key":"10.1016\/j.cellsig.2025.111946_bb0040","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.placenta.2012.06.007","article-title":"Focal adhesion kinase signaling is necessary for the Cyclosporin A-enhanced migration and invasion of human trophoblast cells","volume":"33","author":"Tang","year":"2012","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.cellsig.2025.111946_bb0045","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.placenta.2008.07.011","article-title":"PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1\/2 and inhibiting FAK activation","volume":"29","author":"Daoud","year":"2008","journal-title":"Placenta"},{"issue":"Pt 1","key":"10.1016\/j.cellsig.2025.111946_bb0050","article-title":"TBX3 reciprocally controls key trophoblast lineage decisions in villi during human placenta development in the first trimester","volume":"263","author":"Yi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2025.111946_bb0060","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1093\/nar\/gkad109","article-title":"Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization","volume":"51","author":"Yu","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0065","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/15476286.2018.1559688","article-title":"Molecular network of miR-1343 regulates the pluripotency of porcine pluripotent stem cells via repressing OTX2 expression","volume":"16","author":"Xie","year":"2019","journal-title":"RNA Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-022-01221-6","article-title":"Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.cellsig.2025.111946_bb0075","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nm.4123","article-title":"Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy","volume":"22","author":"Jiang","year":"2016","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.cellsig.2025.111946_bb0080","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1158\/1535-7163.MCT-16-0366","article-title":"Oncogenic receptor tyrosine kinases directly phosphorylate focal adhesion kinase (FAK) as a resistance mechanism to FAK-kinase inhibitors","volume":"15","author":"Marlowe","year":"2016","journal-title":"Mol. Cancer Ther."},{"issue":"10","key":"10.1016\/j.cellsig.2025.111946_bb0085","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1210\/endo.142.10.8448","article-title":"PPAR gamma\/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation","volume":"142","author":"Tarrade","year":"2001","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2025.111946_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mce.2010.10.013","article-title":"Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line","volume":"332","author":"Delidaki","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111946_bb0100","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2025.111946_bb0105","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00204-023-03664-4","article-title":"27-hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K\/AKT\/mTOR signaling pathway","volume":"98","author":"Zhao","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111946_bb0110","article-title":"Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: a pilot study","volume":"12","author":"Ji","year":"2024","journal-title":"Phys. Rep."},{"issue":"Pt 8","key":"10.1016\/j.cellsig.2025.111946_bb0115","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/jcs.00373","article-title":"Focal adhesion kinase: the first ten years","volume":"116","author":"Parsons","year":"2003","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111946_bb0120","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.cellsig.2025.111946_bb0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2741\/4236","article-title":"Targeting FAK in human cancer: from finding to first clinical trials","volume":"19","author":"Golubovskaya","year":"2014","journal-title":"Front. Biosci. (Landmark Ed)."},{"issue":"3","key":"10.1016\/j.cellsig.2025.111946_bb0130","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/aji.12436","article-title":"Cell signaling pathways involved during invasion and syncytialization of trophoblast cells","volume":"75","author":"Gupta","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.cellsig.2025.111946_bb0135","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1095\/biolreprod.105.044206","article-title":"Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11\/14 (p38 MAP kinase) activation","volume":"73","author":"Johnstone","year":"2005","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111946_bb0140","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/biolre\/ioae064","article-title":"HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway\u2020","volume":"111","author":"Li","year":"2024","journal-title":"Biol. Reprod."},{"issue":"Pt 2","key":"10.1016\/j.cellsig.2025.111946_bb0145","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.2005.089326","article-title":"ERK1\/2 and p38 regulate trophoblasts differentiation in human term placenta","volume":"566","author":"Daoud","year":"2005","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0150","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1038\/s41598-023-34435-x","article-title":"Mitochondrial citrate metabolism and efflux regulate BeWo differentiation","volume":"13","author":"Mahr","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2025.111946_bb0155","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.stem.2024.07.003","article-title":"Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells","volume":"31","author":"Yu","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cellsig.2025.111946_bb0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-031-37936-9_6","article-title":"Trophoblast syncytialization: a metabolic crossroads","volume":"71","author":"Podini\u0107","year":"2024","journal-title":"Results Probl. Cell Differ."},{"issue":"1","key":"10.1016\/j.cellsig.2025.111946_bb0165","doi-asserted-by":"crossref","first-page":"8474","DOI":"10.1038\/s41598-017-09163-8","article-title":"Down-regulation of PDK4 is critical for the switch of carbohydrate catabolism during syncytialization of human placental trophoblasts","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.cellsig.2025.111946_bb0170","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pharmthera.2013.12.003","article-title":"The role of FAK in tumor metabolism and therapy","volume":"142","author":"Zhang","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2025.111946_bb0175","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ceb.2020.08.010","article-title":"Progress in deciphering trophoblast cell differentiation during human placentation","volume":"67","author":"Xiao","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.111946_bb0180","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/biolre\/ioaa126","article-title":"Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase\/protein kinase B\/matrix metallopeptidase 2 pathway\u2020","volume":"103","author":"Li","year":"2020","journal-title":"Biol. Reprod."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825003614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825003614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T22:41:07Z","timestamp":1756248067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825003614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":36,"alternative-id":["S0898656825003614"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111946","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of FAK signaling in early placental development and trophoblast lineage specification in human pregnancy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.111946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111946"}}