{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:25Z","timestamp":1791262585098,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cellsig.2025.112078","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:57:47Z","timestamp":1755824267000},"page":"112078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27"],"prefix":"10.1016","volume":"136","author":[{"given":"Miaomiao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanlin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0005","first-page":"26","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol."},{"issue":"7","key":"10.1016\/j.cellsig.2025.112078_bb0010","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317714626","article-title":"Progress in the treatment of advanced gastric cancer","volume":"39","author":"Song","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.cellsig.2025.112078_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.658636","article-title":"5-fluorouracil: a narrative review on the role of regulatory mechanisms in driving resistance to this chemotherapeutic agent","volume":"11","author":"Ghafouri-Fard","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41392-023-01341-7","article-title":"Targeting epigenetic regulators to overcome drug resistance in cancers","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.112078_bb0025","doi-asserted-by":"crossref","first-page":"1153802","DOI":"10.3389\/fendo.2023.1153802","article-title":"N6-methyladenosine with immune infiltration and PD-L1 in hepatocellular carcinoma: novel perspective to personalized diagnosis and treatment","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"11","key":"10.1016\/j.cellsig.2025.112078_bb0030","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.tcb.2014.06.005","article-title":"PRC1 complex diversity: where is it taking us?","volume":"24","author":"Gil","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cellsig.2025.112078_bb0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13148-016-0182-9","article-title":"Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer","volume":"8","author":"Clermont","year":"2016","journal-title":"Clin. Epigenetics"},{"issue":"4","key":"10.1016\/j.cellsig.2025.112078_bb0040","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.18632\/aging.203912","article-title":"Expression profile and prognostic values of Chromobox family members in human glioblastoma","volume":"14","author":"Li","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"14","key":"10.1016\/j.cellsig.2025.112078_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143491","article-title":"The epigenetic regulatory protein CBX2 promotes mTORC1 signalling and inhibits DREAM complex activity to drive breast cancer cell growth","volume":"14","author":"Bilton","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.cellsig.2025.112078_bb0050","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.11776","article-title":"CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP\/\u03b2-catenin pathway","volume":"23","author":"Zeng","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.cellsig.2025.112078_bb0055","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41389-018-0103-1","article-title":"CBX2 identified as driver of anoikis escape and dissemination in high grade serous ovarian cancer","volume":"7","author":"Wheeler","year":"2018","journal-title":"Oncogenesis"},{"issue":"2","key":"10.1016\/j.cellsig.2025.112078_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108170","article-title":"CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness","volume":"301","author":"Li","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.112078_bb0065","doi-asserted-by":"crossref","first-page":"1430891","DOI":"10.3389\/fphar.2024.1430891","article-title":"CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"W1","key":"10.1016\/j.cellsig.2025.112078_bb0070","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"10.1016\/j.cellsig.2025.112078_bb0075","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112078_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11040496","article-title":"A therapeutic strategy for chemotherapy-resistant gastric cancer via destabilization of both \u03b2-catenin and RAS","volume":"11","author":"Ryu","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"50","key":"10.1016\/j.cellsig.2025.112078_bb0085","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/s41388-020-01492-9","article-title":"Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell","volume":"39","author":"Ukai","year":"2020","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.cellsig.2025.112078_bb0090","first-page":"93","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2025.112078_bb0095","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejca.2016.03.081","article-title":"RECIST 1.1-update and clarification: from the RECIST committee","volume":"62","author":"Schwartz","year":"2016","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2025.112078_bb0100","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.celrep.2018.03.078","article-title":"ZRANB1 is an EZH2 deubiquitinase and a potential therapeutic target in breast cancer","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2025.112078_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103207","article-title":"Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer","volume":"73","author":"Dong","year":"2024","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112078_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"22","key":"10.1016\/j.cellsig.2025.112078_bb0115","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","article-title":"Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of Zeste protein","volume":"16","author":"Kuzmichev","year":"2002","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112078_bb0120","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.21873\/anticanres.14306","article-title":"Cell cycle dysregulation is associated with 5-fluorouracil resistance in gastric cancer cells","volume":"40","author":"Kim","year":"2020","journal-title":"Anticancer Res."},{"issue":"1a","key":"10.1016\/j.cellsig.2025.112078_bb0125","first-page":"9","article-title":"Cell cycle perturbation and acquired 5-fluorouracil chemoresistance","volume":"28","author":"Guo","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.cellsig.2025.112078_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101821","article-title":"Epigenetic modifications: key players in cancer heterogeneity and drug resistance","volume":"39","author":"Sadida","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cellsig.2025.112078_bb0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semcancer.2020.11.008","article-title":"Epigenetic modifications of c-MYC: role in cancer cell reprogramming, progression and chemoresistance","volume":"83","author":"Fatma","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-020-01168-8","article-title":"CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2025.112078_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122720","article-title":"Targeting ferroptosis in ovarian cancer: novel strategies to overcome chemotherapy resistance","volume":"349","author":"Kapper","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12935-024-03262-z","article-title":"YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance","volume":"24","author":"Geng","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"18","key":"10.1016\/j.cellsig.2025.112078_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.cellsig.2025.112078_bb0160","article-title":"System X(c) (\u2212)\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2025.112078_bb0165","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2025.112078_bb0170","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2025.112078_bb0175","first-page":"3106","article-title":"SLC7A11\/xCT in cancer: biological functions and therapeutic implications","volume":"10","author":"Lin","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"8","key":"10.1016\/j.cellsig.2025.112078_bb0180","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","article-title":"The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11","volume":"79","author":"Liu","year":"2019","journal-title":"Cancer Res."},{"issue":"7545","key":"10.1016\/j.cellsig.2025.112078_bb0185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13045-020-00937-8","article-title":"EZH2: a novel target for cancer treatment","volume":"13","author":"Duan","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2025.112078_bb0195","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40364-018-0122-2","article-title":"Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential","volume":"6","author":"Gan","year":"2018","journal-title":"Biomark. Res."},{"issue":"21","key":"10.1016\/j.cellsig.2025.112078_bb0200","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1158\/0008-5472.CAN-16-1306","article-title":"Histone H3K27 trimethylation modulates 5-fluorouracil resistance by inhibiting PU.1 binding to the DPYD promoter","volume":"76","author":"Wu","year":"2016","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112078_bb0205","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41588-022-01047-6","article-title":"H3K27me3 conditions chemotolerance in triple-negative breast cancer","volume":"54","author":"Marsolier","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2025.112078_bb0210","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.omtn.2021.12.032","article-title":"CBX2 and EZH2 cooperatively promote the growth and metastasis of lung adenocarcinoma","volume":"27","author":"Hu","year":"2022","journal-title":"Mol. Ther. Nucl. Acids"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0215","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-020-01157-x","article-title":"The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12967-025-06246-3","article-title":"Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112078_bb0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/ol.2021.13165","article-title":"Research progress on SLC7A11 in the regulation of cystine\/cysteine metabolism in tumors","volume":"23","author":"Tang","year":"2022","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0230","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12967-023-04793-1","article-title":"The SOX4\/EZH2\/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury","volume":"22","author":"Yan","year":"2024","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112078_bb0235","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12929-021-00762-2","article-title":"HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression","volume":"28","author":"Liu","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cellsig.2025.112078_bb0240","doi-asserted-by":"crossref","first-page":"1654659","DOI":"10.3389\/fphar.2025.1654659","article-title":"Editorial: post-translational modifications in human cancer: pharmacological insights and therapeutic opportunities","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"42","key":"10.1016\/j.cellsig.2025.112078_bb0245","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2406936121","article-title":"TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer","volume":"121","author":"Ye","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.cellsig.2025.112078_bb0250","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1158\/0008-5472.CAN-23-2889","article-title":"SPARC stabilizes ApoE to induce cholesterol-dependent invasion and Sorafenib resistance in hepatocellular carcinoma","volume":"84","author":"Wan","year":"2024","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.cellsig.2025.112078_bb0255","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.chembiol.2023.05.009","article-title":"TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Chem. Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825004930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825004930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:41:20Z","timestamp":1781678480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825004930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":51,"alternative-id":["S0898656825004930"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112078","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112078"}}