{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:26:41Z","timestamp":1782476801152,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cellsig.2025.112128","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:20:16Z","timestamp":1757859616000},"page":"112128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated NPM-ALK-induced transforming activity"],"prefix":"10.1016","volume":"136","author":[{"given":"Xin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Korai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Funakoshi-Tago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.112128_bb0005","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","volume":"89","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2025.112128_bb0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/modpathol.3880289","article-title":"Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology","volume":"14","author":"Jaffe","year":"2001","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/123253","article-title":"NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases","volume":"2012","author":"Pearson","year":"2012","journal-title":"J Signal Transduct."},{"key":"10.1016\/j.cellsig.2025.112128_bb0020","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma","volume":"263","author":"Morris","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2025.112128_bb0025","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/MCB.17.4.2312","article-title":"Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis","volume":"17","author":"Bischof","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0030","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.onc.1205152","article-title":"Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death","volume":"21","author":"Zamo","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.112128_bb0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.onc.1209843","article-title":"Oncogenic tyrosine kinase NPM\/ALK induces activation of the MEK\/ERK signaling pathway independently of c-Raf","volume":"26","author":"Marzec","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.112128_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1182\/blood-2011-07-369397","article-title":"Essential role of TAK1 in regulating mantle cell lymphoma survival","volume":"120","author":"Buglio","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2025.112128_bb0045","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1038\/sj.onc.1207048","article-title":"Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase","volume":"22","author":"Turner","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.112128_bb0050","first-page":"2194","article-title":"Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin\/anaplastic lymphoma kinase-mediated lymphomagenesis","volume":"61","author":"Slupianek","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2025.112128_bb0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm1249","article-title":"Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target","author":"Chiarle","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2025.112128_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110985","article-title":"The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis","volume":"114","author":"Korai","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.112128_bb0065","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.pharep.2019.05.021","article-title":"N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties","volume":"71","author":"Uchihara","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cellsig.2025.112128_bb0070","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3390\/ijms19061591","article-title":"Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development","volume":"19","author":"Sgrignani","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2025.112128_bb0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.8272872","article-title":"Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130","volume":"263","author":"L\u00fctticken","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2025.112128_bb0080","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.yexcr.2007.09.018","article-title":"STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells","volume":"314","author":"Onishi","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cellsig.2025.112128_bb0085","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0301-472X(03)00045-6","article-title":"Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway","volume":"31","author":"Wierenga","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0090","doi-asserted-by":"crossref","first-page":"15388","DOI":"10.1038\/s41598-017-15342-4","article-title":"Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112128_bb0095","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfs199","article-title":"JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure","volume":"129","author":"Liu","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cellsig.2025.112128_bb0100","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1128\/MCB.23.11.3918-3928.2003","article-title":"Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3","volume":"23","author":"Xu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0105","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1158\/0008-5472.CAN-12-3175","article-title":"A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation","volume":"73","author":"Zhang","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2025.112128_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2025.112128_bb0115","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1002\/cam4.3510","article-title":"Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation","volume":"9","author":"Sun","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.cellsig.2025.112128_bb0120","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/jid.2012.45","article-title":"Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells","volume":"132","author":"Sakaguchi","year":"2012","journal-title":"J Invest Dermatol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183003","article-title":"Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK","volume":"12","author":"Uchihara","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2025.112128_bb0130","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1073\/pnas.131568898","article-title":"Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis","volume":"98","author":"Bowman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2025.112128_bb0135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1074-7613(00)80145-4","article-title":"Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis","volume":"11","author":"Shirogane","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.cellsig.2025.112128_bb0140","doi-asserted-by":"crossref","first-page":"35556","DOI":"10.1074\/jbc.M112.400911","article-title":"Intracellular interaction of interleukin (IL)-32\u03b1 with protein kinase C\u03b5 (PKC\u03b5) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells","volume":"287","author":"Kang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.112128_bb0145","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/rej.2007.0643","article-title":"Exercise-induced activation of STAT3 signaling is increased with age","volume":"11","author":"Trenerry","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.cellsig.2025.112128_bb0150","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/350512a0","article-title":"A novel cyclin encoded by a bcl1-linked candidate oncogene","volume":"350","author":"Motokura","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2025.112128_bb0155","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.112128_bb0160","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/labinvest.3700348","article-title":"Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3","volume":"85","author":"Marzec","year":"2005","journal-title":"Lab. Investig."},{"key":"10.1016\/j.cellsig.2025.112128_bb0165","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.onc.1205152","article-title":"Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death","volume":"21","author":"Zamo","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.112128_bb0170","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood-2006-04-017434","article-title":"Loss of SHP1 enhances JAK3\/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma","volume":"108","author":"Han","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2025.112128_bb0175","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.3892\/or.2014.3098","article-title":"Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia","volume":"31","author":"Li","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellsig.2025.112128_bb0180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00432-021-03691-7","article-title":"Aberrant expression and genetic alteration of c-MYC in anaplastic large cell lymphoma","volume":"148","author":"Chen","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-023-01721-1","article-title":"Targeting Pim kinases in hematological cancers: molecular and clinical review","volume":"22","author":"Bellon","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2025.112128_bb0190","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1038\/s41467-019-13315-x","article-title":"The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status","volume":"10","author":"Trigg","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.112128_bb0195","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/ncb1618","article-title":"PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation","volume":"9","author":"Zippo","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2025.112128_bb0200","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1073\/pnas.1700682114","article-title":"Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1\/STAT3 mutations","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2025.112128_bb0205","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1186\/s12885-020-07285-3","article-title":"Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma","volume":"20","author":"Khan","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cellsig.2025.112128_bb0210","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1182\/blood-2003-09-3126","article-title":"Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3","volume":"103","author":"Peltola","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cellsig.2025.112128_bb0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41419-025-07535-x","article-title":"Decoy-PROTAC for specific degradation of \"Undruggable\" STAT3 transcription factor","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.112128_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.672267","article-title":"From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation","volume":"9","author":"Cecchini","year":"2021","journal-title":"Front Chem."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:46:09Z","timestamp":1781678769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825005431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S0898656825005431"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112128","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The critical role of the phosphorylation of STAT3 at Y705 in ALCL-associated NPM-ALK-induced transforming activity","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112128"}}