{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:56:10Z","timestamp":1781679370961,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["SZYYB20244800"],"award-info":[{"award-number":["SZYYB20244800"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["2025YLCE0008"],"award-info":[{"award-number":["2025YLCE0008"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cellsig.2025.112142","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:31:58Z","timestamp":1758583918000},"page":"112142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TYROBP facilitates metastatic progression in pancreatic cancer through CTSZ-driven glycolytic rewiring and macrophage recruitment"],"prefix":"10.1016","volume":"136","author":[{"given":"Dingwen","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2024","key":"10.1016\/j.cellsig.2025.112142_bb0005","first-page":"12","article-title":"CA Cancer","volume":"74","author":"Siegel","year":"2024","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.cellsig.2025.112142_bb0010","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41586-025-08735-3","article-title":"Characterization of single neurons reprogrammed by pancreatic cancer","volume":"640","author":"Thiel","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2025.112142_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70878","article-title":"Assessing NODM patients for early PDAC diagnosis: incidence of NODM before PDAC diagnosis and subsequent PDAC risk","volume":"14","author":"Munigala","year":"2025","journal-title":"Cancer Med."},{"key":"10.1016\/j.cellsig.2025.112142_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020515","article-title":"Targeting triple NK cell suppression mechanisms: a comprehensive review of biomarkers in pancreatic cancer therapy","volume":"26","author":"Fanijavadi","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2025.112142_bb0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12943-025-02262-5","article-title":"EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt\/\u03b2-catenin pathway","volume":"24","author":"Fang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2025.112142_bb0030","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2025.2477872","article-title":"Efficacy of anti-LAG3 and anti-PD-1 combination checkpoint inhibitor therapy against head and neck squamous cell carcinoma in a genetically engineered mouse model","volume":"14","author":"Lamenza","year":"2025","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cellsig.2025.112142_bb0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cellsig.2018.07.001","article-title":"Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ\/FAK signaling pathway","volume":"50","author":"Li","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.112142_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.70236","article-title":"A novel lysosome-related gene signature predicts lung Cancer prognosis: a bioinformatics-driven study","volume":"7","author":"Ye","year":"2024","journal-title":"Health Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112142_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1200203","article-title":"TYROBP-positive endothelial cell-derived TWEAK as a promoter of osteosarcoma progression: insights from single-cell omics","volume":"13","author":"Wei","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2025.112142_bb0050","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1038\/s41598-024-61515-3","article-title":"Identification of candidate biomarkers for GBM based on WGCNA","volume":"14","author":"Sun","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112142_bb0055","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1111\/jgh.16783","article-title":"TYROBP promotes the spread of pancreatic cancer by causing M2 TAM polarization","volume":"39","author":"Zhong","year":"2024","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2025.112142_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111949","article-title":"TYROBP overexpression alters macrophage phenotype and enhances pancreatic cancer stemness through STAT3 and PKM2 signaling","volume":"134","author":"Zhong","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.112142_bb0065","article-title":"SP1-Mediated glycolytic reprogramming promotes tumorigenesis and progression in pancreatic cancer","author":"Hang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cellsig.2025.112142_bb0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41392-022-01096-7","article-title":"DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.112142_bb0075","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1136\/gutjnl-2020-322780","article-title":"F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer","volume":"70","author":"Hong","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.cellsig.2025.112142_bb0080","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/glia.22501","article-title":"Siglec-h on activated microglia for recognition and engulfment of glioma cells","volume":"61","author":"Kopatz","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.cellsig.2025.112142_bb0085","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/2211-5463.12993","article-title":"TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma","volume":"10","author":"Wu","year":"2020","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.cellsig.2025.112142_bb0090","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1186\/s12885-021-08456-6","article-title":"Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma","volume":"21","author":"Lu","year":"2021","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.cellsig.2025.112142_bb0095","first-page":"2539","article-title":"SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma","volume":"4","author":"Ishida","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.cellsig.2025.112142_bb0100","article-title":"CIRBP knockdown attenuates Tumourigenesis and improves the Chemosensitivity of pancreatic cancer via the downregulation of DYRK1B","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2025.112142_bb0105","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1038\/s41467-022-35469-x","article-title":"PRDM1\/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.112142_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306298","article-title":"BHLHE40 inhibits ferroptosis in pancreatic cancer cells via upregulating SREBF1","volume":"11","author":"Cao","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cellsig.2025.112142_bb0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chembiol.2023.02.005","article-title":"Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy","volume":"30","author":"Bonazzi","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cellsig.2025.112142_bb0120","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ccell.2023.02.010","article-title":"Dual IKZF2 and CK1\u03b1 degrader targets acute myeloid leukemia cells","volume":"41","author":"Park","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2025.112142_bb0125","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41467-021-21550-4","article-title":"Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.112142_bb0130","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fphys.2020.00275","article-title":"Computational approach to identifying universal macrophage biomarkers","volume":"11","author":"Dang","year":"2020","journal-title":"Front. Physiol."},{"issue":"9","key":"10.1016\/j.cellsig.2025.112142_bb0135","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.ccell.2025.06.020","article-title":"Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer","volume":"43","author":"Chen","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2025.112142_bb0140","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s15010-024-02446-z","article-title":"The role of vitamin D in the prevention and treatment of tuberculosis: a meta-analysis of randomized controlled trials","volume":"53","author":"Meng","year":"2025","journal-title":"Infection"},{"key":"10.1016\/j.cellsig.2025.112142_bb0145","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1097\/JS9.0000000000001307","article-title":"Appropriate thromboprophylaxis strategy for COVID-19 patients on dosage, antiplatelet therapy, outpatient, and postdischarge prophylaxis: a meta-analysis of randomized controlled trials","volume":"110","author":"Meng","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cellsig.2025.112142_bb0150","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.clnu.2023.09.008","article-title":"The role of vitamin D in the prevention and treatment of SARS-CoV-2 infection: a meta-analysis of randomized controlled trials","volume":"42","author":"Meng","year":"2023","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.cellsig.2025.112142_bb0155","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1053\/j.gastro.2025.01.244","article-title":"TREM2 depletion in pancreatic Cancer elicits pathogenic inflammation and accelerates tumor progression via enriching IL-1\u03b2(+) macrophages","volume":"168","author":"Yang","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cellsig.2025.112142_bb0160","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1158\/2326-6066.CIR-20-0111","article-title":"Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the Radioresistance of pancreatic Cancer","volume":"8","author":"Yang","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cellsig.2025.112142_bb0165","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/cas.15671","article-title":"Depletion of tumor-associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin","volume":"114","author":"Kawaguchi","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cellsig.2025.112142_bb0170","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.imbio.2019.03.002","article-title":"Depletion of tumor-associated macrophages enhances the anti-tumor effect of docetaxel in a murine epithelial ovarian cancer","volume":"224","author":"Lu","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.cellsig.2025.112142_bb0175","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/s41467-022-29388-0","article-title":"Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.112142_bb0180","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12967-024-05102-0","article-title":"In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response","volume":"22","author":"Liu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2025.112142_bb0185","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1200\/JCO.21.02616","article-title":"Immunologic strategies in pancreatic Cancer: making cold tumors hot","volume":"40","author":"Ullman","year":"2022","journal-title":"J. Clin. Oncol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:33:06Z","timestamp":1781677986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825005571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"alternative-id":["S0898656825005571"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112142","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TYROBP facilitates metastatic progression in pancreatic cancer through CTSZ-driven glycolytic rewiring and macrophage recruitment","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112142"}}