{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:41:13Z","timestamp":1792190473786,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["02-408-2501-2337"],"award-info":[{"award-number":["02-408-2501-2337"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360549"],"award-info":[{"award-number":["82360549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB25520"],"award-info":[{"award-number":["20242BAB25520"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cellsig.2025.112154","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:53:11Z","timestamp":1759211591000},"page":"112154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ROCK2 promotes renal cell carcinoma progression by functioning as an RNA-binding protein regulating the PAI-1\/NLRP3 axis and senescence escape"],"prefix":"10.1016","volume":"136","author":[{"given":"Zhengdong","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunlong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.112154_bb0005","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal cell carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO classification of Tumours of the urinary system and male genital organs-part a: renal, penile, and testicular Tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. Urol."},{"issue":"9669","key":"10.1016\/j.cellsig.2025.112154_bb0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(09)60229-4","article-title":"Renal cell carcinoma","volume":"373","author":"Rini","year":"2009","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.15586\/jkcvhl.2017.64","article-title":"Maslinic acid inhibits proliferation of renal cell carcinoma cell lines and suppresses angiogenesis of endothelial cells","volume":"4","author":"Thakor","year":"2017","journal-title":"J. Kidney Cancer VHL"},{"issue":"5","key":"10.1016\/j.cellsig.2025.112154_bb0025","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1007\/s13577-023-00947-x","article-title":"ROCK2-RNA interaction map reveals multiple biological mechanisms underlying tumor progression in renal cell carcinoma","volume":"36","author":"Hong","year":"2023","journal-title":"Hum. Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2025.112154_bb0030","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1073\/pnas.80.10.2956","article-title":"Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells","volume":"80","author":"Loskutoff","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2025.112154_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.622473","article-title":"Targeting PAI-1 in cardiovascular disease: structural insights into PAI-1 functionality and inhibition","volume":"7","author":"Sillen","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112154_bb0040","first-page":"642","article-title":"Structure and functions of plasminogen\/plasmin system","volume":"40","author":"A\u012dsina","year":"2014","journal-title":"Bioorg. Khim."},{"issue":"7","key":"10.1016\/j.cellsig.2025.112154_bb0045","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41419-018-0808-2","article-title":"Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance","volume":"9","author":"Che","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13046-023-02714-0","article-title":"Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells","volume":"42","author":"Wei","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0055","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12964-019-0373-z","article-title":"Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling","volume":"17","author":"Wei","year":"2019","journal-title":"Cell Commun. Signal."},{"issue":"18 Pt 2","key":"10.1016\/j.cellsig.2025.112154_bb0060","article-title":"The von Hippel-Lindau tumor suppressor gene and kidney cancer","volume":"10","author":"Kaelin","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112154_bb0065","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2025.112154_bb0070","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/onc.2016.272","article-title":"Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma","volume":"36","author":"Thompson","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12964-023-01235-9","article-title":"Divergent functions of NLRP3 inflammasomes in cancer: a review","volume":"21","author":"Shadab","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112154_bb0080","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112154_bb0085","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/nn.4421","article-title":"An interferon-\u03b2-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage","volume":"19","author":"Inoue","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cellsig.2025.112154_bb0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fcimb.2013.00077","article-title":"Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection","volume":"3","author":"Malireddi","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.cellsig.2025.112154_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ebiom.2017.03.020","article-title":"Mitochondria in cell senescence: is Mitophagy the weakest link?","volume":"21","author":"Korolchuk","year":"2017","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.cellsig.2025.112154_bb0100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41419-024-06797-1","article-title":"The miR-30-5p\/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics","volume":"15","author":"Tak","year":"2024","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112154_bb0105","first-page":"77","article-title":"Therapeutic challenges in renal cell carcinoma","volume":"3","author":"Penticuff","year":"2015","journal-title":"Am. J. Clin. Exp. Urol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112154_bb0110","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1158\/1078-0432.CCR-23-1892","article-title":"Management of renal cell carcinoma: promising biomarkers and the challenges to reach the clinic","volume":"30","author":"Lyskj\u00e6r","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112154_bb0115","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.21873\/invivo.13285","article-title":"Combined immunotherapy and tyrosine kinase inhibitor treatment for metastatic renal cell carcinoma with unknown primary origin: a report of two cases and literature review","volume":"37","author":"Chen","year":"2023","journal-title":"In Vivo"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12943-022-01656-z","article-title":"Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition","volume":"21","author":"Daly","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112154_bb0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4143\/crt.2009.41.4.187","article-title":"Significance of cellular senescence in aging and cancer","volume":"41","author":"Grimes","year":"2009","journal-title":"Cancer Res. Treat."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112154_bb0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2025.112154_bb0140","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/ijc.27316","article-title":"Cellular senescence and tumor suppressor gene p16","volume":"130","author":"Rayess","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2025.112154_bb0145","first-page":"448","article-title":"The regulation of cellular senescence in cancer","volume":"15","author":"Zhang","year":"2025"},{"key":"10.1016\/j.cellsig.2025.112154_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2025.112045","article-title":"Exosomal dynamics: bridging the gap between cellular senescence and cancer therapy","volume":"225","author":"Aswani","year":"2025","journal-title":"Mech. Ageing Dev."},{"issue":"7501","key":"10.1016\/j.cellsig.2025.112154_bb0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cellsig.2025.112154_bb0160","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/carcin\/bgh296","article-title":"Senescence and immortalization: role of telomeres and telomerase","volume":"26","author":"Shay","year":"2004","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.cellsig.2025.112154_bb0165","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2006.05.052","article-title":"A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation","volume":"126","author":"Narita","year":"2006","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2025.112154_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082134","article-title":"Senescence and Cancer: a review of clinical implications of senescence and Senotherapies","volume":"12","author":"Wyld","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"7051","key":"10.1016\/j.cellsig.2025.112154_bb0175","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","article-title":"Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis","volume":"436","author":"Chen","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112154_bb0180","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/s41467-020-14987-6","article-title":"Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours","volume":"11","author":"Brenner","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112154_bb0185","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1161\/ATVBAHA.121.316414","article-title":"Endothelial METTL3 (methyltransferase-like 3) inhibits fibrinolysis by promoting PAI-1 (plasminogen activator Inhibitor-1) expression through enhancing Jun proto-oncogene N6-Methyladenosine modification","volume":"41","author":"Bai","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112154_bb0190","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5582\/bst.2022.01449","article-title":"How do RNA binding proteins trigger liquid-liquid phase separation in human health and diseases?","volume":"16","author":"Huai","year":"2022","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.cellsig.2025.112154_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.840256","article-title":"Emerging roles for phase separation of RNA-binding proteins in cellular pathology of ALS","volume":"10","author":"Milicevic","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2025.112154_bb0200","article-title":"Specific protein-RNA interactions are mostly preserved in biomolecular condensates","volume":"10","author":"de Vries","year":"2024"},{"issue":"19","key":"10.1016\/j.cellsig.2025.112154_bb0205","doi-asserted-by":"crossref","first-page":"10659","DOI":"10.1021\/jacs.3c00932","article-title":"Mass Spectrometry of RNA-Binding Proteins during Liquid\u2013Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures","volume":"145","author":"Sahin","year":"2023","journal-title":"J. Am. Chem. Soc."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825005698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:32:51Z","timestamp":1781677971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825005698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S0898656825005698"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112154","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROCK2 promotes renal cell carcinoma progression by functioning as an RNA-binding protein regulating the PAI-1\/NLRP3 axis and senescence escape","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112154"}}