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Clin. Invest."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112166_bb0380","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neo.2014.11.008","article-title":"Inactivation of SAG\/RBX2\/ROC2 E3 ubiquitin ligase triggers senescence and inhibits Kras-induced immortalization","volume":"17","author":"Tan","year":"2015","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112166_bb0385","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.emboj.7600486","article-title":"Enhanced Mdm2 activity inhibits PRB function via ubiquitin-dependent degradation","volume":"24","author":"Uchida","year":"2005","journal-title":"EMBO J."},{"issue":"47","key":"10.1016\/j.cellsig.2025.112166_bb0390","doi-asserted-by":"crossref","first-page":"28200","DOI":"10.1074\/jbc.M115.655597","article-title":"A novel retinoblastoma protein (Rb) E3 ubiquitin ligase (Nrbe3) promotes Rb degradation and is transcriptionally regulated by E2F1 transcription factor","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112166_bb0395","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1073\/pnas.94.6.2221","article-title":"Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the PRB tumor suppressor protein","volume":"94","author":"Campanero","year":"1997","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.cellsig.2025.112166_bb0400","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.18632\/aging.101038","article-title":"Sirt6 delays cellular senescence by promoting P27KIP1 ubiquitin-proteasome degradation","volume":"8","author":"Zhao","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"38","key":"10.1016\/j.cellsig.2025.112166_bb0405","doi-asserted-by":"crossref","first-page":"33447","DOI":"10.1074\/jbc.M111.225565","article-title":"Ww domain-containing E3 ubiquitin protein ligase 1 (Wwp1) delays cellular senescence by promoting P27<SUP>KIP1<\/SUP> degradation in human diploid fibroblasts","volume":"286","author":"Cao","year":"2011","journal-title":"J. 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Invest. 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Int."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112166_bb0530","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3109\/02656736.2013.798873","article-title":"Stress proteins in aging and life span","volume":"29","author":"Murshid","year":"2013","journal-title":"Int. J. Hyperth."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112166_bb0535","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.freeradbiomed.2007.03.034","article-title":"Trends in oxidative aging theories","volume":"43","author":"Muller","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112166_bb0540","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tem.2008.12.005","article-title":"Hsps and aging","volume":"20","author":"Tower","year":"2009","journal-title":"Trends Endocrinol. 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Cell Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112166_bb0555","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1379\/CSC-99r.1","article-title":"Heat shock proteins in Cancer: diagnostic, prognostic, predictive, and treatment implications","volume":"10","author":"Ciocca","year":"2005","journal-title":"Cell Stress Chaperones"},{"issue":"2","key":"10.1016\/j.cellsig.2025.112166_bib789","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/MCB.01041-08","article-title":"Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells","volume":"29","author":"Gabai","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"52","key":"10.1016\/j.cellsig.2025.112166_bb0565","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1073\/pnas.1516131112","article-title":"Exogenous HSP70 delays senescence and improves cognitive function in aging mice","volume":"112","author":"Bobkova","year":"2015","journal-title":"Proc. Natl. Acad. Sci. 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Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2025.112166_bb0585","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/s12276-023-01059-0","article-title":"ALKBH5 facilitates CYP1B1 MRNA degradation via M6A demethylation to alleviate Msc senescence and osteoarthritis progression","volume":"55","author":"Ye","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112166_bb0590","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated M<SUP>6<\/SUP>a modification of Atg7 regulates autophagy-GATA4 Axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112166_bb0595","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-024-05691-w","article-title":"METTL3-mediated M6a modification of SIRT1 mRNAAffects the progression of diabetic cataracts through cellular autophagy and senescence","volume":"22","author":"Dong","year":"2024","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112166_bb0600","article-title":"METTL3-mediated M6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing","volume":"21","author":"Wang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112166_bb0605","doi-asserted-by":"crossref","first-page":"950","DOI":"10.7150\/ijbs.80461","article-title":"CD73\/NT5E-mediated ubiquitination of Aurka regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence","volume":"19","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112166_bb0610","first-page":"333","article-title":"Japan idiopathic Pulm fibrosis, dietary fat and meat intake and idiopathic pulmonary fibrosis: a case-control study in Japan","volume":"10","author":"Miyake","year":"2006","journal-title":"Int. J. Tuberculosis Lung Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112166_bb0615","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1308","article-title":"Inflammasome activation and metabolic Remodelling in P16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-Polyubiquitin-dependent degradation of SGK1","volume":"13","author":"Gu","year":"2023","journal-title":"Clin. Transl. 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Oncol."},{"issue":"4","key":"10.1016\/j.cellsig.2025.112166_bb0635","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1532-5415.1997.tb05175.x","article-title":"Aging and Cancer: the double-edged sword of replicative senescence","volume":"45","author":"Campisi","year":"1997","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.cellsig.2025.112166_bb0640","doi-asserted-by":"crossref","DOI":"10.1002\/path.6164","article-title":"Escape from senescence: molecular basis and therapeutic ramifications","author":"Evangelou","year":"2023","journal-title":"J. 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