{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:31:29Z","timestamp":1782160289045,"version":"3.54.5"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220151"],"award-info":[{"award-number":["2023A1515220151"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JJ40005"],"award-info":[{"award-number":["2022JJ40005"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2015JC3131"],"award-info":[{"award-number":["2015JC3131"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2017SK51102"],"award-info":[{"award-number":["2017SK51102"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cellsig.2025.112203","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:06:54Z","timestamp":1761930414000},"page":"112203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cxcl1 as a central regulator of NET formation, cardiomyocyte apoptosis, and fibroblast proliferation in the shared pathogenesis of MR, DCM, and AF"],"prefix":"10.1016","volume":"137","author":[{"given":"Xianjun","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.112203_bb0005","doi-asserted-by":"crossref","first-page":"241","DOI":"10.15171\/jcvtr.2014.019","article-title":"Determinants of atrial electromechanical delay in patients with functional mitral regurgitation and non-ischemic dilated cardiomyopathy","volume":"6","author":"Bengi","year":"2014","journal-title":"J. Cardiovasc. Thorac. Res."},{"key":"10.1016\/j.cellsig.2025.112203_bb0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2967\/jnumed.108.055665","article-title":"Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation","volume":"50","author":"Range","year":"2009","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cellsig.2025.112203_bb0020","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.19102\/icrm.2017.080304","article-title":"Catheter ablation of atrial fibrillation in chronic heart failure: a contemporary review","volume":"8","author":"Matta","year":"2017","journal-title":"J. Innov. Card Rhythm Manag."},{"key":"10.1016\/j.cellsig.2025.112203_bb0025","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbrc.2018.09.092","article-title":"Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression","volume":"506","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2025.112203_bb0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1536\/ihj.17-084","article-title":"Toll-like receptors 2 and 4 predict new-onset atrial fibrillation in acute myocardial infarction patients","volume":"59","author":"Zhang","year":"2018","journal-title":"Int. Heart J."},{"key":"10.1016\/j.cellsig.2025.112203_bb0035","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cyto.a.23169","article-title":"Measurement of NET formation in vitro and in vivo by flow cytometry","volume":"91","author":"Masuda","year":"2017","journal-title":"Cytometry A"},{"key":"10.1016\/j.cellsig.2025.112203_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41392-023-01497-2","article-title":"Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression","volume":"8","author":"He","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2025.112203_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.641973","article-title":"Extracellular HMGB1 contributes to the chronic cardiac allograft vasculopathy\/fibrosis by modulating TGF-beta1 signaling","volume":"12","author":"Zou","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2025.112203_bb0050","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.21037\/atm-22-4595","article-title":"Bioinformatic analysis of potential biomarkers and mechanisms of immune infiltration in mitral regurgitation complicated by atrial fibrillation","volume":"10","author":"Li","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.cellsig.2025.112203_bb0055","article-title":"Identification and verification of atrial fibrillation hub genes caused by primary mitral regurgitation","volume":"102","author":"Yang","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cellsig.2025.112203_bb0060","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12859-020-03560-z","article-title":"Bioinformatics tools for marine biotechnology: a practical tutorial with a metagenomic approach","volume":"21","author":"Liguori","year":"2020","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cellsig.2025.112203_bb0065","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.2147\/CMAR.S282238","article-title":"Expression and bioinformatics-based functional analysis of UAP1 in lung adenocarcinoma","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.cellsig.2025.112203_bb0085","article-title":"CRISPLD1 promotes gastric cancer progression by regulating the Ca(2+)\/PI3K-AKT signaling pathway","volume":"10","author":"Hu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.cellsig.2025.112203_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-020-0784-4","article-title":"CRISPLD1: a novel conserved target in the transition to human heart failure","volume":"115","author":"Khadjeh","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.cellsig.2025.112203_bb0095","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3389\/fimmu.2017.00928","article-title":"Neutrophil extracellular traps and endothelial dysfunction in atherosclerosis and thrombosis","volume":"8","author":"Qi","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2025.112203_bb0100","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40364-023-00463-y","article-title":"Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target","volume":"11","author":"Shang","year":"2023","journal-title":"Biomark. Res."},{"key":"10.1016\/j.cellsig.2025.112203_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.614757","article-title":"High neutrophil to lymphocyte ratio and its gene signatures correlate with diastolic dysfunction in heart failure with preserved ejection fraction","volume":"8","author":"Bai","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cellsig.2025.112203_bb0115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cellsig.2025.112203_bb0120","doi-asserted-by":"crossref","first-page":"31119","DOI":"10.1038\/srep31119","article-title":"Neutrophil extracellular trap formation is increased in psoriasis and induces human beta-defensin-2 production in epidermal keratinocytes","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112203_bb0125","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.1909546117","article-title":"NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture","volume":"117","author":"Thiam","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2025.112203_bb0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10495-016-1326-2","article-title":"NEDD4-1 protects against ischaemia\/reperfusion-induced cardiomyocyte apoptosis via the PI3K\/Akt pathway","volume":"22","author":"Hu","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.cellsig.2025.112203_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13018-020-02150-2","article-title":"Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K\/AKT\/mTOR pathway-mediated apoptosis","volume":"16","author":"Sun","year":"2021","journal-title":"J. Orthop. Surg. Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:20:18Z","timestamp":1769858418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825006187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"alternative-id":["S0898656825006187"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112203","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cxcl1 as a central regulator of NET formation, cardiomyocyte apoptosis, and fibroblast proliferation in the shared pathogenesis of MR, DCM, and AF","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112203"}}