{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:08:30Z","timestamp":1771650510334,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202201011143"],"award-info":[{"award-number":["202201011143"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J0278"],"award-info":[{"award-number":["2024A03J0278"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110232"],"award-info":[{"award-number":["2023A1515110232"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["20231064"],"award-info":[{"award-number":["20231064"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cellsig.2025.112206","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T23:01:43Z","timestamp":1762038103000},"page":"112206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["PYGM downregulates necroptosis signaling to attenuate sodium iodate\u2013induced RPE cell degeneration"],"prefix":"10.1016","volume":"137","author":[{"given":"Yaqi","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huini","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haocheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengjie","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2025.112206_bb0005","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.cellsig.2025.112206_bb0010","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2025.112206_bb0015","first-page":"513","article-title":"The diagnosis and treatment of age-related macular degeneration","volume":"117","author":"Stahl","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.cellsig.2025.112206_bb0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/path.4266","article-title":"Mechanisms of age-related macular degeneration and therapeutic opportunities","volume":"232","author":"van Lookeren Campagne","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0030","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s12276-023-01046-5","article-title":"Mitochondria-associated programmed cell death as a therapeutic target for age-related disease","volume":"55","author":"Nguyen","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellsig.2025.112206_bb0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s44280-024-00056-w","article-title":"Ellagic acid supplementation ameliorates cisplatin-induced liver injury in mice by inhibiting the NF-\u03baB pathway and activating the Nrf2\/HO-1 pathway","volume":"2","author":"Zhang","year":"2024","journal-title":"One Health Adv."},{"key":"10.1016\/j.cellsig.2025.112206_bb0040","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1073\/pnas.1901179116","article-title":"Targeting RIPK1 for the treatment of human diseases","volume":"116","author":"Degterev","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2921\u20132931","key":"10.1016\/j.cellsig.2025.112206_bb0045","article-title":"RIP1-Mediated Necroptosis Facilitates Oxidative Stress\u2013Induced Melanocyte Death, Offering Insight into Vitiligo","volume":"141","author":"Li","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2025.112206_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102840","article-title":"Comparative mechanistic study of RPE cell death induced by different oxidative stresses","volume":"65","author":"Tong","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cellsig.2025.112206_bb0065","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jare.2023.06.004","article-title":"Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation","volume":"60","author":"Yang","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12929-019-0531-z","article-title":"Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death","volume":"26","author":"Chan","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0075","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1167\/iovs.66.1.63","article-title":"CAMK2D and complement factor I-involved calcium\/calmodulin signaling modulates sodium iodate-induced mouse retinal degeneration","volume":"66","author":"Xu","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0080","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41419-021-03520-2","article-title":"Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.112206_bb0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13578-022-00879-3","article-title":"Melatonin inhibits NaIO(3)-induced ARPE-19 cell apoptosis via suppression of HIF-1alpha\/BNIP3-LC3B\/mitophagy signaling","volume":"12","author":"Wang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0090","article-title":"Continuous exposure to non-lethal doses of sodium iodate induces retinal pigment epithelial cell dysfunction","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112206_bb0095","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/thno.78370","article-title":"3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2025.112206_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13512","article-title":"Necroptosis contributes to chronic inflammation and fibrosis in aging liver","volume":"20","author":"Mohammed","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2025.112206_bb0105","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.7150\/thno.33139","article-title":"Embryonic stem cells modulate the Cancer-permissive microenvironment of human uveal melanoma","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2025.112206_bb0110","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.exer.2005.08.002","article-title":"Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration","volume":"82","author":"Enzmann","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0115","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1167\/iovs.08-2898","article-title":"Decreased visual function after patchy loss of retinal pigment epithelium induced by low-dose sodium iodate","volume":"50","author":"Franco","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0120","doi-asserted-by":"crossref","DOI":"10.21037\/aes-21-25","article-title":"Comparison between sodium iodate and lipid peroxide murine models of age-related macular degeneration for drug evaluation-a narrative review","volume":"7","author":"Kim","year":"2022","journal-title":"Ann. Eye Sci"},{"key":"10.1016\/j.cellsig.2025.112206_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23062918","article-title":"Sodium-iodate injection can replicate retinal degenerative disease stages in pigmented mice and rats: non-invasive follow-up using OCT and ERG","volume":"23","author":"Koster","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0130","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/15476286.2021.1974208","article-title":"MustSeq, an alternative approach for multiplexible strand-specific 3\u2032 end sequencing of mRNA transcriptome confers high efficiency and practicality","volume":"18","author":"Mai","year":"2021","journal-title":"RNA Biol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0135","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cellsig.2025.112206_bb0140","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0145","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cellsig.2025.112206_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13030579","article-title":"Insights into the correlation and immune crosstalk between COVID-19 and Sjogren\u2019s syndrome Keratoconjunctivitis sicca via weighted gene Coexpression network analysis and machine learning","volume":"13","author":"Cheng","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2025.112206_bb0155","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12864-019-5686-1","article-title":"aFold - using polynomial uncertainty modelling for differential gene expression estimation from RNA sequencing data","volume":"20","author":"Yang","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cellsig.2025.112206_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0165","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-Related Macular Degeneration: A Review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"Jama"},{"key":"10.1016\/j.cellsig.2025.112206_bb0170","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1167\/iovs.16-19355","article-title":"A swine model of selective geographic atrophy of outer retinal layers mimicking atrophic AMD: a phase I escalating dose of subretinal sodium iodate","volume":"57","author":"Mones","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0175","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.18-24245","article-title":"An acute injury model for the phenotypic characteristics of geographic atrophy","volume":"59","author":"Bhutto","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0180","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/iovs.64.12.15","article-title":"Kallistatin deficiency induces the oxidative stress-related epithelial-mesenchymal transition of retinal pigment epithelial cells: a novel protagonist in age-related macular degeneration","volume":"64","author":"Shen","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2025.112206_bb0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13024-024-00739-3","article-title":"Urolithin a promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration","volume":"19","author":"Jimenez-Loygorri","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.cellsig.2025.112206_bb0190","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2025.112206_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101201","article-title":"Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors","volume":"24","author":"Brown","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s44280-023-00023-x","article-title":"Lactobacillus intestinalis\/lactobacillus rhamnosus protects against AFB1-induced liver damage: involvement of intestinal mucosal barrier","volume":"1","author":"Chen","year":"2023","journal-title":"One Health Adv."},{"key":"10.1016\/j.cellsig.2025.112206_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100858","article-title":"Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration","volume":"79","author":"Kaarniranta","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0210","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1080\/15548627.2022.2109286","article-title":"Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity","volume":"19","author":"Datta","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2025.112206_bb0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s44280-024-00048-w","article-title":"Comparison of the recovery characteristics for canine corneal ulcer treated with corneoconjunctival transposition or conjunctival autografts","volume":"2","author":"Wang","year":"2024","journal-title":"One Health Adv."},{"key":"10.1016\/j.cellsig.2025.112206_bb0220","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajpath.2019.10.012","article-title":"Necroptosis in the pathophysiology of disease","volume":"190","author":"Khoury","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cellsig.2025.112206_bb0225","doi-asserted-by":"crossref","first-page":"16054","DOI":"10.1038\/cddiscovery.2016.54","article-title":"Retinal pigment epithelial cell necroptosis in response to sodium iodate","volume":"2","author":"Hanus","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.112206_bb0230","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exer.2018.11.026","article-title":"Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease","volume":"180","author":"Jang","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153296","article-title":"Polystyrene microplastics induced oxidative stress, inflammation and necroptosis via NF-kappaB and RIP1\/RIP3\/MLKL pathway in chicken kidney","volume":"478","author":"Meng","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.cellsig.2025.112206_bb0240","article-title":"Unveiling the interplay of MAPK\/NF-kappaB\/MLKL axis in brain health: Omega-3 as a promising candidates against copper neurotoxicity","volume":"370","author":"Wang","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.cellsig.2025.112206_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153688","article-title":"A new insight into fluoride induces cardiotoxicity in chickens: involving the regulation of PERK\/IRE1\/ATF6 pathway and heat shock proteins","volume":"501","author":"Hou","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.cellsig.2025.112206_bb0250","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.1021\/acs.jafc.5c00224","article-title":"Quercetin alleviates Pyroptosis and necroptosis triggered on by DEHP exposure in Bursa of Fabricius in chicken by the ROS\/MAPK\/NF-kappaB pathway","volume":"73","author":"Huang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cellsig.2025.112206_bb0255","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkp896","article-title":"KEGG for representation and analysis of molecular networks involving diseases and drugs","volume":"38","author":"Kanehisa","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cellsig.2025.112206_bb0260","first-page":"771","article-title":"RIP1\/RIP3-regulated necroptosis as a target for multifaceted disease therapy (review)","volume":"44","author":"Liu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cellsig.2025.112206_bb0265","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ophtha.2018.09.013","article-title":"Retinopathy associated with Biallelic mutations in PYGM (McArdle disease)","volume":"126","author":"Mahroo","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.cellsig.2025.112206_bb0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-022-04504-2","article-title":"Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells","volume":"478","author":"Hytti","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cellsig.2025.112206_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2025.102233","article-title":"Nuclear functional role of metabolic enzymes and related metabolites: focus on gene expression regulation","volume":"100","author":"Todisco","year":"2025","journal-title":"Mol Metab"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:21:09Z","timestamp":1769858469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825006217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":55,"alternative-id":["S0898656825006217"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112206","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PYGM downregulates necroptosis signaling to attenuate sodium iodate\u2013induced RPE cell degeneration","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112206"}}