{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:36:29Z","timestamp":1790872589438,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005329","name":"Guizhou Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["QKHJCMS[2025]366"],"award-info":[{"award-number":["QKHJCMS[2025]366"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010844","name":"Hanshan Normal University","doi-asserted-by":"publisher","award":["QD2023312"],"award-info":[{"award-number":["QD2023312"]}],"id":[{"id":"10.13039\/501100010844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.cellsig.2025.112243","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:29:59Z","timestamp":1763346599000},"page":"112243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Immunomodulatory effects of ononin alleviates arthritis through modulation of macrophage polarization and JAK\/STAT3 signaling"],"prefix":"10.1016","volume":"138","author":[{"given":"Guowei","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Yuzhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4196\/kjpp.24.079","article-title":"Retinoic acid ameliorates rheumatoid arthritis by attenuating inflammation and modulating macrophage polarization through MKP-1\/MAPK signaling pathway","volume":"29","author":"Xin","year":"2025","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122867","article-title":"Macrophage corpses for immunoregulation and targeted drug delivery in treatment of collagen-induced arthritis mice","volume":"314","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.cellsig.2025.112243_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119147","article-title":"Soufeng sanjie formula alleviates osteoarthritis by inhibiting macrophage M1 polarization and modulating intestinal metabolites","volume":"339","author":"Fan","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"Pt 3","key":"10.1016\/j.cellsig.2025.112243_bb0020","article-title":"Wutou decoction attenuates rheumatoid arthritis in rats through SIRT1-mediated deacetylation of the HMGB1\/NF-\u03baB pathway","volume":"337","author":"Shen","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122943","article-title":"Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis","volume":"315","author":"Wu","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13075-025-03473-3","article-title":"Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2","volume":"27","author":"Zhou","year":"2025","journal-title":"Arthritis. Res. Ther."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112243_bb0035","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.3892\/mmr.2017.7719","article-title":"Regulation of M1-type and M2-type macrophage polarization in RAW264.7 cells by Galectin-9","volume":"16","author":"Lv","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112243_bb0040","doi-asserted-by":"crossref","first-page":"858","DOI":"10.4103\/NRR.NRR-D-23-01925","article-title":"Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model","volume":"20","author":"Ding","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2025.112243_bb0045","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.4103\/NRR.NRR-D-23-01256","article-title":"Pharmacological targeting cGAS\/STING\/NF-\u03baB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury","volume":"20","author":"Fan","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cellsig.2025.112243_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102181","article-title":"Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1\/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells","volume":"51","author":"Xin","year":"2025","journal-title":"Transl. Oncol."},{"issue":"9","key":"10.1016\/j.cellsig.2025.112243_bb0055","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4103\/NRR.NRR-D-23-01772","article-title":"High-dose dexamethasone regulates microglial polarization via the GR\/JAK1\/STAT3 signaling pathway after traumatic brain injury","volume":"20","author":"Yang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cellsig.2025.112243_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113715","article-title":"Macrophage polarization in sepsis: Emerging role and clinical application prospect","volume":"144","author":"Hou","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156813","article-title":"The role of macrophages in chronic pain","volume":"185","author":"Tang","year":"2025","journal-title":"Cytokine"},{"key":"10.1016\/j.cellsig.2025.112243_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113706","article-title":"Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-\u03baB pathway","volume":"144","author":"Xiong","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101939","article-title":"Scorpion venom polypeptide governs alveolar macrophage M1\/M2 polarization to alleviate pulmonary fibrosis","volume":"79","author":"Xu","year":"2022","journal-title":"Tissue Cell"},{"key":"10.1016\/j.cellsig.2025.112243_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112243_bb0085","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1111\/cns.14333","article-title":"Ultrasound reduces inflammation by modulating M1\/M2 polarization of microglia through STAT1\/STAT6\/PPAR\u03b3 signaling pathways","volume":"29","author":"Hsu","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0090","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1038\/s41467-023-43219-w","article-title":"RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis","volume":"14","author":"Han","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.cellsig.2025.112243_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11495","article-title":"Adipose-derived stem cell-secreted exosomes enhance angiogenesis by promoting macrophage M2 polarization in type 2 diabetic mice with limb ischemia via the JAK\/STAT6 pathway","volume":"8","author":"Wang","year":"2022","journal-title":"Heliyon"},{"issue":"7","key":"10.1016\/j.cellsig.2025.112243_bb0100","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41419-018-0744-1","article-title":"M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia","volume":"9","author":"Sheng","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2025.112243_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117375","article-title":"Ononin ameliorates depression-like behaviors by regulating BDNF-TrkB-CREB signaling in vitro and in vivo","volume":"320","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0110","first-page":"0553","article-title":"Ononin inhibits tumor bone metastasis and osteoclastogenesis by targeting mitogen-activated protein kinase pathway in breast cancer","volume":"7","author":"Ganesan","year":"2024","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.cellsig.2025.112243_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111959","article-title":"Ononin triggers ferroptosis-mediated disruption in the triple negative breast cancer both in vitro and in vivo","volume":"132","author":"Gong","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112243_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030758","article-title":"Anti-invasive and anti-migratory effects of ononin on human osteosarcoma cells by limiting the MMP2\/9 and EGFR-Erk1\/2 pathway","volume":"15","author":"Gong","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.cellsig.2025.112243_bb0125","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/acs.jnatprod.1c00008","article-title":"Anti-angiogenesis function of ononin via suppressing the MEK\/Erk signaling pathway","volume":"84","author":"Gong","year":"2021","journal-title":"J. Nat. Prod."},{"issue":"9","key":"10.1016\/j.cellsig.2025.112243_bb0130","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s11427-023-2499-2","article-title":"Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K\/Akt\/mTOR pathway","volume":"67","author":"Ganesan","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cellsig.2025.112243_bb0135","doi-asserted-by":"crossref","first-page":"5122448","DOI":"10.1155\/2022\/5122448","article-title":"Antitumor effects of ononin by modulation of apoptosis in non-small-cell lung cancer through inhibiting PI3K\/Akt\/mTOR pathway","volume":"2022","author":"Gong","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12906-022-03504-5","article-title":"Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1\u03b2-induced osteoarthritis by downregulating the MAPK and NF-\u03baB pathways","volume":"22","author":"Xu","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112243_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.776","article-title":"Ononin alleviates DSS-induced colitis through inhibiting NLRP3 inflammasome via triggering mitophagy","volume":"11","author":"Yu","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13619-024-00205-x","article-title":"Beyond resorption: osteoclasts as drivers of bone formation","volume":"13","author":"Xiang","year":"2024","journal-title":"Cell Regen."},{"issue":"3","key":"10.1016\/j.cellsig.2025.112243_bb0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/08916930701694667","article-title":"Tartrate-resistant acid phosphatase (TRAP) and the osteoclast\/immune cell dichotomy","volume":"41","author":"Hayman","year":"2008","journal-title":"Autoimmunity"},{"issue":"15","key":"10.1016\/j.cellsig.2025.112243_bb0160","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps - myth or reality?","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.cellsig.2025.112243_bb0165","doi-asserted-by":"crossref","first-page":"1352946","DOI":"10.3389\/fimmu.2024.1352946","article-title":"Macrophage polarization: an important role in inflammatory diseases","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112243_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020192","article-title":"Natural compounds regulate macrophage polarization and alleviate inflammation against ALI\/ARDS","volume":"15","author":"Yin","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.cellsig.2025.112243_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113096","article-title":"Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer","volume":"151","author":"Zhou","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0180","doi-asserted-by":"crossref","first-page":"14906","DOI":"10.1038\/s41598-019-51113-z","article-title":"Flavonoid-mediated immunomodulation of human macrophages involves key metabolites and metabolic pathways","volume":"9","author":"Mendes","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2025.112243_bb0185","doi-asserted-by":"crossref","first-page":"1160719","DOI":"10.3389\/fimmu.2023.1160719","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.cellsig.2025.112243_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011197","article-title":"Mangiferin Represses Inflammation in Macrophages Under a Hyperglycemic Environment Through Nrf2 Signaling","volume":"25","author":"Jayasuriya","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2025.112243_bb0195","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tifs.2017.11.003","article-title":"Impact of consumption and cooking manners of vegetable oils on cardiovascular diseases- A critical review","volume":"71","author":"Ganesan","year":"2018","journal-title":"Trends Food Sci. Technol."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112243_bb0200","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00394-024-03391-1","article-title":"Genistein alleviates dextran sulfate sodium-induced colitis in mice through modulation of intestinal microbiota and macrophage polarization","volume":"63","author":"Jia","year":"2024","journal-title":"Eur. J. Nutr."},{"issue":"7","key":"10.1016\/j.cellsig.2025.112243_bb0205","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/bbb\/zbad041","article-title":"8-Prenyl daidzein and 8-prenyl genistein from germinated soybean modulate inflammatory response in activated macrophages","volume":"87","author":"Jheng","year":"2023","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0210","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jid.2024.05.007","article-title":"Orchestration of macrophage polarization dynamics by fibroblast-secreted exosomes during skin wound healing","volume":"145","author":"Chen","year":"2025","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.cellsig.2025.112243_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115268","article-title":"Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction","volume":"476","author":"Zhou","year":"2025","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170666","article-title":"Negative immune regulator TIPE2 promotes M2 macrophage differentiation through the activation of PI3K-AKT signaling pathway","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.cellsig.2025.112243_bb0225","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.4049\/jimmunol.1201168","article-title":"SOCS3 deficiency promotes M1 macrophage polarization and inflammation","volume":"189","author":"Qin","year":"2012","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112243_bb0230","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/flgastro-2023-102400","article-title":"JAK inhibitors for inflammatory bowel disease: recent advances","volume":"15","author":"Honap","year":"2024","journal-title":"Front. Gastroent."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112243_bb0235","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/rheumatology\/kead448","article-title":"Differential properties of Janus kinase inhibitors in the treatment of immune-mediated inflammatory diseases","volume":"63","author":"Taylor","year":"2024","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.cellsig.2025.112243_bb0240","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/13543784.2023.2199919","article-title":"JAK inhibitors for rheumatoid arthritis","volume":"32","author":"Kubo","year":"2023","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"4","key":"10.1016\/j.cellsig.2025.112243_bb0245","doi-asserted-by":"crossref","first-page":"103276","DOI":"10.1016\/j.autrev.2023.103276","article-title":"JAK inhibitors and autoimmune rheumatic diseases","volume":"22","author":"Benucci","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cellsig.2025.112243_bb0250","doi-asserted-by":"crossref","first-page":"607725","DOI":"10.3389\/fmed.2020.607725","article-title":"JAK inhibitors and modulation of B cell immune responses in rheumatoid arthritis","volume":"7","author":"Moura","year":"2020","journal-title":"Front. Med. (Lausanne)"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825006588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T01:12:18Z","timestamp":1766106738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825006588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"alternative-id":["S0898656825006588"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112243","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory effects of ononin alleviates arthritis through modulation of macrophage polarization and JAK\/STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112243"}}