{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:21:55Z","timestamp":1773930115958,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024103","name":"M\u00f8re og Romsdal Fylkeskommune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"National Autonomous University of Mexico Directorate General of Academic Staff Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cellsig.2025.112318","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T16:16:44Z","timestamp":1765988204000},"page":"112318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The LPA2 receptor PDZ domain affects canonical Wnt signaling in colon cancer cells"],"prefix":"10.1016","volume":"139","author":[{"given":"M. Cristina","family":"Casta\u00f1eda-Patl\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos Mart\u00ednez-","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"Morquecho-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Brise\u00f1o-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Helivier","family":"Sol\u00eds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"Romero-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Adolfo","family":"Garc\u00eda-S\u00e1inz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Robles-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cellsig.2025.112318_bb0005","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1021\/cr200273u","article-title":"Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors","volume":"111","author":"Blaho","year":"2011","journal-title":"Chem. Rev."},{"issue":"15","key":"10.1016\/j.cellsig.2025.112318_bb0010","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1111\/bph.12678","article-title":"Lysophospholipid receptor nomenclature review: IUPHAR Review 8: lysophospholipid receptor nomenclature","volume":"171","author":"Kihara","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112318_bb0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/excr.1999.4702","article-title":"Bioactive lysophospholipids and their G protein-coupled receptors","volume":"253","author":"Moolenaar","year":"1999","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.cellsig.2025.112318_bb0020","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.3390\/ijms24087031","article-title":"Hypoxia increases ATX expression by histone crotonylation in a HIF-2\u03b1-dependent manner","volume":"24","author":"Qu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112318_bb0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112318_bb0030","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0026-895X(24)12687-9","article-title":"Lysophosphatidic acid receptors","volume":"58","author":"Contos","year":"2000","journal-title":"Mol. Pharmacol."},{"issue":"1\u20134","key":"10.1016\/j.cellsig.2025.112318_bb0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-6980(01)00107-1","article-title":"Physiological responses to lysophosphatidic acid and related glycero-phospholipids","volume":"64","author":"Tigyi","year":"2001","journal-title":"Prostagland. Other Lipid Mediat."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112318_bb0040","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.7150\/jca.41841","article-title":"Lysophosphatidic acid receptors: biochemical and clinical implications in different diseases","volume":"11","author":"Xiang","year":"2020","journal-title":"J. Cancer"},{"issue":"15","key":"10.1016\/j.cellsig.2025.112318_bb0045","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1096\/fasebj.12.15.1589","article-title":"Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate","volume":"12","author":"Goetzl","year":"1998","journal-title":"FASEB J."},{"issue":"36","key":"10.1016\/j.cellsig.2025.112318_bb0050","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.3748\/wjg.15.4547","article-title":"Effects of lysophosphatidic acid on human colon cancer cells and its mechanisms of action","volume":"15","author":"Sun","year":"2009","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112318_bb0055","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.biocel.2010.09.021","article-title":"Colorectal cancer cells \u2013 proliferation, survival, and invasion by lysophosphatidic acid","volume":"42","author":"Lee","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2025.112318_bb0060","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/labinvest.3700146","article-title":"Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer","volume":"84","author":"Shida","year":"2004","journal-title":"Lab. Investig."},{"issue":"1","key":"10.1016\/j.cellsig.2025.112318_bb0065","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.bbrc.2016.12.088","article-title":"Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells","volume":"483","author":"Takahashi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.cellsig.2025.112318_bb0070","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2025.112318_bb0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2010","journal-title":"J. Hematol. Oncol."},{"issue":"17","key":"10.1016\/j.cellsig.2025.112318_bb0080","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.0501535102","article-title":"G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the \u03b2-catenin pathway","volume":"102","author":"Yang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.cellsig.2025.112318_bb0085","first-page":"1706","article-title":"Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA11","volume":"63","author":"Shida","year":"2003","journal-title":"Cancer Res."},{"issue":"21","key":"10.1016\/j.cellsig.2025.112318_bb0090","doi-asserted-by":"crossref","first-page":"15541","DOI":"10.1074\/jbc.M700702200","article-title":"Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Kr\u00fcppel-like factor 5","volume":"282","author":"Zhang","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112318_bb0095","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cellsig.2015.02.005","article-title":"Kr\u00fcppel-like factor 5 incorporates into the \u03b2-catenin\/TCF complex in response to LPA in colon cancer cells","volume":"27","author":"Guo","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.112318_bb0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cellsig.2017.03.023","article-title":"Dvl stability is positively regulated by PKC\u03b6-mediated phosphorylation upon Wnt stimulation","volume":"35","author":"Vel\u00e1zquez","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2025.112318_bb0105","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3390\/cells13221870","article-title":"Structural and functional insights into dishevelled-mediated Wnt signaling","volume":"13","author":"Wang","year":"2024","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.cellsig.2025.112318_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112704","article-title":"Dishevelled localization and function are differentially regulated by structurally distinct sterols","volume":"28","author":"Sengupta","year":"2025","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.cellsig.2025.112318_bb0115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1194\/jlr.S091744","article-title":"Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential","volume":"60","author":"Tigyi","year":"2019","journal-title":"J. Lipid Res."},{"issue":"19","key":"10.1016\/j.cellsig.2025.112318_bb0120","doi-asserted-by":"crossref","first-page":"19358","DOI":"10.1074\/jbc.M414561200","article-title":"Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho Guanine nucleotide Exchange Factors (RhoGEFs)","volume":"280","author":"Yamada","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.112318_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.111930","article-title":"Lysophosphatidic acid receptor LPA1 trafficking and interaction with Rab proteins, as evidenced by F\u00f6rster resonance energy transfer","volume":"570","author":"Mart\u00ednez-Morales","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"issue":"12","key":"10.1016\/j.cellsig.2025.112318_bb0130","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.3390\/ijms25126491","article-title":"Lysophosphatidic acid receptor 3 (LPA3): Signaling and phosphorylation sites","volume":"25","author":"Sol\u00eds","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2025.112318_bb0135","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jemt.20376","article-title":"FRET and colocalization analyzer--a method to validate measurements of sensitized emission FRET acquired by confocal microscopy and available as an ImageJ Plug-in","volume":"69","author":"Hachet-Haas","year":"2006","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.cellsig.2025.112318_bb0140","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejphar.2017.09.013","article-title":"A549 cells as a model to study endogenous LPA1 receptor signaling and regulation","volume":"815","author":"Carmona-Rosas","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2025.112318_bb0145","first-page":"192","article-title":"LPA receptor signaling: pharmacology, physiology, and pathophysiology","volume":"55(7):1","author":"Yung","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cellsig.2025.112318_bb0150","article-title":"Canonical and Non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells","volume":"109636","author":"Flores-Hern\u00e1ndez","year":"2020","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.cellsig.2025.112318_bb0155","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1128\/MCB.00828-15","article-title":"GSK3\u03b2 is positively regulated by PKC\u03b6-mediated phosphorylation induced by Wnt agonists","volume":"36","author":"Tejeda-Mu\u00f1oz","year":"2016","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2025.112318_bb0160","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1074\/jbc.273.2.685","article-title":"Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase","volume":"273","author":"Daaka","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.cellsig.2025.112318_bb0165","doi-asserted-by":"crossref","first-page":"18677","DOI":"10.1074\/jbc.273.30.18677","article-title":"G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization","volume":"273","author":"Lefkowitz","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"5402","key":"10.1016\/j.cellsig.2025.112318_bb0170","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.283.5402.655","article-title":"Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes","volume":"283","author":"Luttrell","year":"1999","journal-title":"Science"},{"issue":"45","key":"10.1016\/j.cellsig.2025.112318_bb0175","doi-asserted-by":"crossref","first-page":"32248","DOI":"10.1074\/jbc.274.45.32248","article-title":"Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization","volume":"274","author":"Oakley","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.cellsig.2025.112318_bb0180","doi-asserted-by":"crossref","first-page":"23120","DOI":"10.1074\/jbc.M002581200","article-title":"The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits","volume":"275","author":"Laporte","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"549","key":"10.1016\/j.cellsig.2025.112318_bb0185","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav1646","article-title":"Arrestins and G proteins in cellular signaling: The coin has two sides","volume":"11","author":"Gurevich","year":"2018","journal-title":"Sci. Signal."},{"issue":"22","key":"10.1016\/j.cellsig.2025.112318_bb0190","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1007\/s00018-019-03272-5","article-title":"Plethora of functions packed into 45 kDa arrestins: biological implications and possible therapeutic strategies","volume":"76","author":"Gurevich","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2025.112318_bb0195","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fphar.2019.00125","article-title":"GPCR signaling regulation: the role of GRKs and arrestins","volume":"10","author":"Gurevich","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"25","key":"10.1016\/j.cellsig.2025.112318_bb0200","doi-asserted-by":"crossref","first-page":"14139","DOI":"10.1073\/pnas.1918736117","article-title":"Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor","volume":"117","author":"Kaya","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2025.112318_bb0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1139\/cjpp-2020-0449","article-title":"Effect of casein kinase 1a inhibition on autophagy flux and the AKT\/phospho-\u03b2-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line","volume":"99","author":"Behrouj","year":"2021","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cellsig.2025.112318_bb0210","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/onc.2011.294","article-title":"A Rac1\/PAK1 cascade controls \u03b2-catenin activation in colon cancer cells","volume":"31","author":"Zhu","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2025.112318_bb0215","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bbamcr.2007.11.013","article-title":"A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation","volume":"1783","author":"Shano","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cellsig.2025.112318_bb0220","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/5584_2018_288","article-title":"Polyphosphoinositide-binding domains: insights from peripheral membrane and lipid-transfer proteins","volume":"1111","author":"Pemberton","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cellsig.2025.112318_bb0225","series-title":"Lipid-mediated Protein Signaling, Advances in Experimental Medicine and Biology","first-page":"41","article-title":"Phosphoinositides and PDZ domain scaffolds","volume":"vol. 991","author":"Wawrzyniak","year":"2025"},{"issue":"8","key":"10.1016\/j.cellsig.2025.112318_bb0230","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbalip.2006.04.003","article-title":"The prevalence and significance of PDZ domain-phosphoinositide interactions","volume":"1761","author":"Zimmermann","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"748","key":"10.1016\/j.cellsig.2025.112318_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abo2820","article-title":"PI(4,5)P2-stimulated positive feedback drives the recruitment of dishevelled to Frizzled in Wnt-\u03b2-catenin signaling","volume":"15","author":"Mahoney","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2025.112318_bb0240","doi-asserted-by":"crossref","first-page":"22544","DOI":"10.1074\/jbc.M109.014399","article-title":"Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl","volume":"284","author":"Qin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2025.112318_bb0245","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1038\/ncomms12101","article-title":"Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling","volume":"7","author":"Egea-Jimenez","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825007338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656825007338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:24:34Z","timestamp":1773919474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656825007338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"alternative-id":["S0898656825007338"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112318","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The LPA2 receptor PDZ domain affects canonical Wnt signaling in colon cancer cells","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2025.112318","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112318"}}