{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:37:56Z","timestamp":1776829076252,"version":"3.51.2"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20252BAC240484"],"award-info":[{"award-number":["20252BAC240484"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.cellsig.2026.112385","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:41:50Z","timestamp":1768894910000},"page":"112385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NR4A1 attenuates neuroinflammation after spinal cord injury by modulating microglial polarization via negatively regulating the VAV1 pathway"],"prefix":"10.1016","volume":"141","author":[{"given":"Ning","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenJie","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LingLi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KaiYun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LuoLong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanLong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QiHua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cellsig.2026.112385_bb0005","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","article-title":"Spinal cord repair: advances in biology and technology","volume":"25","author":"Courtine","year":"2019","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112385_bb0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10143-018-1008-3","article-title":"Recent update on basic mechanisms of spinal cord injury","volume":"43","author":"Quadri","year":"2020","journal-title":"Neurosurg. Rev."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112385_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112385_bb0020","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.2174\/1570159X21666230502111013","article-title":"OL-FS13 alleviates cerebral ischemia-reperfusion injury by inhibiting miR-21-3p expression","volume":"21","author":"Liu","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cellsig.2026.112385_bb0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2022.02.017","article-title":"Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats","volume":"598","author":"Zhao","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112385_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102429","article-title":"Peptide OM-LV20 protects astrocytes against oxidative stress via the \u2018PAC1R\/JNK\/TPH1\u2019 axis","volume":"298","author":"Yin","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-023-02739-4","article-title":"A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328\/IKK\u03b2\/NF-\u03baB axis","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2026.112385_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117306","article-title":"Epigenetic modifications of inflammation in spinal cord injury","volume":"179","author":"Lu","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"17","key":"10.1016\/j.cellsig.2026.112385_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172692","article-title":"Inflammation: a target for treatment in spinal cord injury","volume":"11","author":"Freyermuth-Trujillo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112385_bb0050","doi-asserted-by":"crossref","first-page":"tkac054","DOI":"10.1093\/burnst\/tkac054","article-title":"Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications","volume":"11","author":"Jin","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.cellsig.2026.112385_bb0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","article-title":"Microglia and central nervous system-associated macrophages-from origin to disease modulation","volume":"39","author":"Prinz","year":"2021","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112385_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112418","article-title":"NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia\/macrophages and mice models of spinal cord injury","volume":"398","author":"Ji","year":"2021","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112385_bb0065","first-page":"1809","article-title":"Poly(ADP-ribose) polymerase family member 14 promotes functional recovery after spinal cord injury through regulating microglia M1\/M2 polarization via STAT1\/6 pathway","volume":"18","author":"Xu","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112385_bb0070","doi-asserted-by":"crossref","first-page":"858","DOI":"10.4103\/NRR.NRR-D-23-01925","article-title":"Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model","volume":"20","author":"Ding","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112385_bb0075","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.4049\/jimmunol.1600638","article-title":"The nuclear receptor Nr4a1 acts as a microglia rheostat and serves as a therapeutic target in autoimmune-driven central nervous system inflammation","volume":"198","author":"Rothe","year":"2017","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112385_bb0080","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jnc.13907","article-title":"Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death","volume":"140","author":"Liu","year":"2017","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112385_bb0085","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.4103\/1673-5374.339492","article-title":"NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis","volume":"17","author":"Yu","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"16","key":"10.1016\/j.cellsig.2026.112385_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168606","article-title":"A time-course study of the expression level of synaptic plasticity-associated genes in un-lesioned spinal cord and brain areas in a rat model of spinal cord injury: a bioinformatic approach","volume":"22","author":"Baldassarro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112385_bb0095","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.it.2024.06.004","article-title":"VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases","volume":"45","author":"Neurath","year":"2024","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12868-022-00737-5","article-title":"Identification of hub genes in the subacute spinal cord injury in rats","volume":"23","author":"Yan","year":"2022","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.cellsig.2026.112385_bb0105","doi-asserted-by":"crossref","first-page":"1068359","DOI":"10.3389\/fimmu.2023.1068359","article-title":"Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112385_bb0110","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.4103\/1673-5374.371368","article-title":"Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia\/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation","volume":"18","author":"Qiu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cellsig.2026.112385_bb0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2017.07.022","article-title":"Proteomic analysis of the effects of Nur77 on lipopolysaccharide-induced microglial activation","volume":"659","author":"Chen","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112385_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108935","article-title":"Inhibition of CD44 suppresses the formation of fibrotic scar after spinal cord injury via the JAK2\/STAT3 signaling pathway","volume":"27","author":"Guo","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.cellsig.2026.112385_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.729524","article-title":"Fascin-1 is highly expressed specifically in microglia after spinal cord injury and regulates microglial migration","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112385_bb0130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112385_bb0135","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1007\/s12031-020-01509-8","article-title":"Therapeutic effects of minocycline Pretreatment in the locomotor and sensory complications of spinal cord injury in an animal model","volume":"70","author":"Afshary","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.cellsig.2026.112385_bb0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbi.2024.12.152","article-title":"Nuclear receptor 4A1 facilitates complete Freund\u2019s adjuvant-induced inflammatory pain in rats by promoting ferroptosis in spinal glial cells","volume":"125","author":"Deng","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112385_bb0145","doi-asserted-by":"crossref","first-page":"8349","DOI":"10.1080\/21655979.2022.2053804","article-title":"Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)\/AMP-activated protein kinase (AMPK) signaling","volume":"13","author":"Zheng","year":"2022","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0150","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-019-1591-4","article-title":"NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB\/Nr4a1\/NF-\u03baB pathway after intracerebral hemorrhage in mice","volume":"16","author":"Wu","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112385_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.766","article-title":"Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology","volume":"9","author":"Katsuki","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112385_bb0160","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1007\/s12035-025-04878-6","article-title":"Whole transcriptome RNA-Seq reveals drivers of pathological dysfunction in a transgenic model of Alzheimer\u2019s disease","volume":"62","author":"Potemkin","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112385_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910601","article-title":"Transcriptomic profiling of primary microglia: effects of miR-19a-3p and miR-19b-3p on microglia activation","volume":"25","author":"Sahebdel","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112385_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.911414","article-title":"Molecular structure, expression and role of TAFA4 and its receptor FPR1 in the spinal cord","volume":"10","author":"Zhu","year":"2022","journal-title":"Front. Cell Develop. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0175","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41467-019-08446-0","article-title":"Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury","volume":"10","author":"Bellver-Landete","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112385_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112385_bb0185","doi-asserted-by":"crossref","first-page":"171","DOI":"10.31083\/j.jin2309171","article-title":"Research Progress on treating spinal cord injury by modulating the phenotype of microglia","volume":"23","author":"Yu","year":"2024","journal-title":"J. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12035-024-04280-8","article-title":"HPGD: an intermediate player in microglial polarization and multiple sclerosis regulated by Nr4a1","volume":"62","author":"Sun","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2026.112385_bb0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbi.2017.09.015","article-title":"Nr4a1 plays a crucial modulatory role in Th1\/Th17 cell responses and CNS autoimmunity","volume":"68","author":"Wang","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbrc.2019.08.008","article-title":"NR4A1 regulates cerebral ischemia-induced brain injury by regulating neuroinflammation through interaction with NF-\u03baB\/p65","volume":"518","author":"Zhang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112385_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002199","article-title":"Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization","volume":"21","author":"Liu","year":"2023","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13018-016-0437-3","article-title":"Identification of molecular pathway changes after spinal cord injury by microarray analysis","volume":"11","author":"Zhang","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"issue":"8\u20139","key":"10.1016\/j.cellsig.2026.112385_bb0215","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.molimm.2009.01.014","article-title":"Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia","volume":"46","author":"Shah","year":"2009","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112385_bb0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00018-024-05203-5","article-title":"Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation","volume":"81","author":"Marrocco","year":"2024","journal-title":"Cell. Mole. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112385_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100527","article-title":"Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression","volume":"296","author":"Du","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112385_bb0230","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.4049\/jimmunol.1300157","article-title":"Atreya I: a key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6","volume":"192","author":"Zenker","year":"2014","journal-title":"J. Immunol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826000355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826000355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:39:30Z","timestamp":1776825570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826000355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":46,"alternative-id":["S0898656826000355"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112385","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NR4A1 attenuates neuroinflammation after spinal cord injury by modulating microglial polarization via negatively regulating the VAV1 pathway","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112385"}}