{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:18:05Z","timestamp":1787980685135,"version":"build-2784847793"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","award":["52"],"award-info":[{"award-number":["52"]}],"id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360139"],"award-info":[{"award-number":["82360139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cellsig.2026.112421","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:56:34Z","timestamp":1770479794000},"page":"112421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mechanism study of LncRNA PRINS targeting TFAM to regulate mitochondrial dysfunction in human renal tubular epithelial cells under ischemia-reperfusion"],"prefix":"10.1016","volume":"142","author":[{"given":"Xuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songmin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhuyati","family":"Wulasihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqian","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulaer","family":"Adeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamasha","family":"Yernaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulibiya","family":"Tuohetiyaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulidure","family":"Nurelibieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112421_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1324996","article-title":"Regulated necrosis role in inflammation and repair in acute kidney injury","volume":"14","author":"Guerrero-Mauvecin","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112421_bb0010","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1053\/j.ajkd.2023.10.009","article-title":"Epidemiology and clinical outcomes of community-acquired acute kidney injury in the emergency department: a multisite retrospective cohort study","volume":"83","author":"Ehmann","year":"2024","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112421_bb0015","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.kint.2022.02.033","article-title":"Harmonization of epidemiology of acute kidney injury and acute kidney disease produces comparable findings across four geographic populations","volume":"101","author":"Sawhney","year":"2022","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112421_bb0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00134-025-07821-4","article-title":"Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness","volume":"51","author":"G\u00f3mez","year":"2025","journal-title":"Intensive Care Med."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112421_bb0025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00134-025-08015-8","article-title":"Preventing acute kidney injury and its longer-term impact in the critically ill","volume":"51","author":"Zarbock","year":"2025","journal-title":"Intensive Care Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112421_bb0030","doi-asserted-by":"crossref","first-page":"F367","DOI":"10.1152\/ajprenal.00571.2013","article-title":"Mitochondrial dysfunction in the pathophysiology of renal diseases","volume":"306","author":"Che","year":"2014","journal-title":"Am. J. Physiol.-Renal Physiol."},{"key":"10.1016\/j.cellsig.2026.112421_bb0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-physiol-042222-025000","article-title":"Mitochondrial Dysfunction in Kidney Tubulopathies[J]","volume":"86","author":"Hoogstraten","year":"2024","journal-title":"Annu. Rev. Physiol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112421_bb0040","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00134-025-07909-x","article-title":"Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery","volume":"51","author":"Oyaert","year":"2025","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.kint.2025.03.025","article-title":"Single-cell analysis of proximal tubular cells with different DNA content reveals functional heterogeneity in the acute kidney injury to chronic kidney disease transition","volume":"108","author":"Li","year":"2025","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112421_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202412233","article-title":"SREBP1c-mediated transcriptional repression of YME1L1 contributes to acute kidney injury by inducing mitochondrial dysfunction in tubular epithelial cells","volume":"12","author":"Xin","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41419-025-07438-x","article-title":"Tubular CD44 plays a key role in aggravating AKI through NF-\u03baB p65-mediated mitochondrial dysfunction","volume":"16","author":"Huang","year":"2025","journal-title":"Cell Death Dis."},{"issue":"43","key":"10.1016\/j.cellsig.2026.112421_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404753","article-title":"Mitochondrial dysfunction-evoked DHODH acetylation is involved in renal cell Ferroptosis during cisplatin-induced acute kidney injury","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112421_bb0065","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112421_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155591","article-title":"Long journey on the role of long non-coding RNA (lncRNA) in acute kidney injury (AKI)","volume":"263","author":"Alsaab","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.cellsig.2026.112421_bb0075","article-title":"An update of long-noncoding RNAs in acute kidney injury","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Physiol."},{"issue":"25","key":"10.1016\/j.cellsig.2026.112421_bb0080","doi-asserted-by":"crossref","first-page":"24159","DOI":"10.1074\/jbc.M501704200","article-title":"Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS *","volume":"280","author":"Sonkoly","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0085","article-title":"TFF3-dependent resistance of human colorectal adenocarcinoma cells HT-29\/B6 to apoptosis is mediated by miR-491-5p regulation of lncRNA PRINS","volume":"3","author":"Hanisch","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112421_bb0090","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hon.2554","article-title":"Circulating exosomal long noncoding RNA PRINS\u2014first findings in monoclonal gammopathies","volume":"36","author":"Sedlarikova","year":"2018","journal-title":"Hematol. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112421_bb0095","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3390\/diagnostics10100762","article-title":"PRINS lncRNA is a new biomarker candidate for HPV infection and prognosis of head and neck squamous cell carcinomas","volume":"10","author":"Kopczy\u0144ska","year":"2020","journal-title":"Diagnostics"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112421_bb0100","first-page":"3203","article-title":"LncRNA PRINS is involved in the development of nephropathy in patients with diabetes via interaction with Smad7","volume":"17","author":"Jiao","year":"2019","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0105","article-title":"RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1\u03b1 and LncRNA PRINS","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112421_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107044","article-title":"CRISPR\/Cas9 based knockout of lncRNA MALAT1 attenuates TGF-\u03b21 induced Smad 2\/3 mediated fibrosis during AKI-to-CKD transition","volume":"207","author":"Puri","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.cellsig.2026.112421_bb0115","article-title":"LncRNA-gm33782 exacerbates renal inflammation and injury in AKI by activating M1 macrophage polarization through Ccl5\/NF-\u03baB signaling","volume":"161","author":"Zhi","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112421_bb0120","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.7150\/thno.101229","article-title":"An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4","volume":"14","author":"He","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112421_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1216094","article-title":"Advances in the study of B cells in renal ischemia-reperfusion injury","volume":"14","author":"Fan","year":"2023","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112421_bb0130","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112421_bb0135","article-title":"Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release","volume":"297","author":"L","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0140","first-page":"1","article-title":"The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0145","first-page":"1","article-title":"Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/s13072-017-0149-x","article-title":"Long noncoding RNAs coordinate functions between mitochondria and the nucleus","volume":"10","author":"Dong","year":"2017","journal-title":"Epigenetics Chromatin"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112421_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07107-5","article-title":"LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease","volume":"15","author":"Lv","year":"2024","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112421_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07231-2","article-title":"Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis","volume":"15","author":"Su","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112421_bb0165","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2022.11.003","article-title":"Mitochondrial permeability transition pore-dependent necrosis","volume":"174","author":"Robichaux","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11010-020-03926-0","article-title":"Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies","volume":"476","author":"Cui","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cellsig.2026.112421_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112421_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28808","article-title":"Mitochondrial complex I subunit MT-ND1 mutations affect disease progression","volume":"10","author":"Lin","year":"2024","journal-title":"Heliyon"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112421_bb0185","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/jcmm.17735","article-title":"NDUFV1 attenuates renal ischemia-reperfusion injury by improving mitochondrial homeostasis","volume":"27","author":"Li","year":"2023","journal-title":"J. Cell. Mol. Med."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112421_bb0190","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/jcmm.17735","article-title":"NDUFV1 attenuates renal ischemia-reperfusion injury by improving mitochondrial homeostasis","volume":"27","author":"Li","year":"2023","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0195","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cellsig.2026.112421_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122941","article-title":"Mitochondrial fragmentation in early differentiation of human MB135 myoblasts: role of mitochondrial ROS production in the absence of depolarization","volume":"354","author":"Chernyavskij","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112421_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145706","article-title":"Mitochondrial transcription factor a as a guardian of mitochondrial integrity and emerging therapeutic target in human diseases: a review","volume":"319","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112421_bb0210","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1016\/j.ymthe.2023.08.014","article-title":"AMPK activation coupling SENP1-Sirt3 axis protects against acute kidney injury","volume":"31","author":"Zhu","year":"2023","journal-title":"Mol. Ther."},{"issue":"17","key":"10.1016\/j.cellsig.2026.112421_bb0215","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.7150\/thno.115661","article-title":"The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112421_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102707","article-title":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","volume":"62","author":"Zhu","year":"2023","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.cellsig.2026.112421_bb0225","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.molcel.2024.07.020","article-title":"OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response","volume":"84","author":"Liang","year":"2024","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112421_bb0230","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1007\/s12035-023-03841-7","article-title":"The protective mechanism of TFAM on mitochondrial DNA and its role in neurodegenerative diseases","volume":"61","author":"Song","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"14","key":"10.1016\/j.cellsig.2026.112421_bb0235","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1016\/j.cell.2024.05.017","article-title":"MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels","volume":"187","author":"T\u00e1bara","year":"2024","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0240","article-title":"Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X-PGC1\u03b1-NRF2 signaling pathway","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med. (Camb., Mass.)."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112421_bb0245","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112421_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156426","article-title":"Chaihuang yishen granule ameliorates mitochondrial homeostasis by upregulating PRDX5\/TFAM axis to inhibit renal fibrosis in CKD","volume":"139","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112421_bb0255","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.freeradbiomed.2024.04.242","article-title":"Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma","volume":"220","author":"Dong","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05575-9","article-title":"PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation","volume":"14","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112421_bb0265","doi-asserted-by":"crossref","first-page":"11973","DOI":"10.2147\/IJN.S488532","article-title":"Targeted delivery and ROS-responsive release of lutein Nanoassemblies inhibit myocardial ischemia-reperfusion injury by improving mitochondrial function","volume":"19","author":"Shi","year":"2024","journal-title":"Int. J. Nanomedicine"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112421_bb0270","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/CIRCRESAHA.123.323596","article-title":"Mitochondrial CypD acetylation promotes endothelial dysfunction and hypertension","volume":"134","author":"Dikalova","year":"2024","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0275","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-07725-7","article-title":"Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia\/reperfusion injury through the mitochondrial pathway","volume":"16","author":"Sun","year":"2025","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112421_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11071356","article-title":"Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease","volume":"11","author":"Fontecha-Barriuso","year":"2022","journal-title":"Antioxidants"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112421_bb0285","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-022-01705-7","article-title":"LncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942\/TNS1 axis and is positively regulated by the m6A reader YTHDC2","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"23","key":"10.1016\/j.cellsig.2026.112421_bb0295","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1038\/s44318-024-00270-7","article-title":"The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer\u2019s disease","volume":"43","author":"Xiong","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2026.112421_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101925","article-title":"Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy","volume":"78","author":"Kumar","year":"2024","journal-title":"Mitochondrion"},{"issue":"13","key":"10.1016\/j.cellsig.2026.112421_bb0305","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1042\/CS20240242","article-title":"DY131 Activates ERR\u03b3\/TFAM axis to Protect against Metabolic Disorders and Acute Kidney Injury","volume":"vol. 138","author":"Gong","year":"2024","journal-title":"Clin. Sci. (London, England: 1979)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0310","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-022-03782-0","article-title":"GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury","volume":"20","author":"Lv","year":"2022","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112421_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-03793-2","article-title":"LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.cellsig.2026.112421_bb0320","article-title":"HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis","volume":"93","author":"Sato","year":"2025","journal-title":"Mol. Metaboli."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826000719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826000719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:38:11Z","timestamp":1785292691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826000719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":64,"alternative-id":["S0898656826000719"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112421","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism study of LncRNA PRINS targeting TFAM to regulate mitochondrial dysfunction in human renal tubular epithelial cells under ischemia-reperfusion","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112421","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112421"}}