{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:14:43Z","timestamp":1788221683603,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200707"],"award-info":[{"award-number":["82200707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20212BAB206027"],"award-info":[{"award-number":["20212BAB206027"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20232BAB206056"],"award-info":[{"award-number":["20232BAB206056"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cellsig.2026.112475","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:43:00Z","timestamp":1772984580000},"page":"112475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mild hypothermia alleviates ferroptosis in kidney ischemia-reperfusion injury via the glycolysis-lactate-HMGB1 lactylation axis"],"prefix":"10.1016","volume":"143","author":[{"given":"Biqi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cellsig.2026.112475_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084332","article-title":"Ischemia-reperfusion injury in kidney transplantation: mechanisms and potential therapeutic targets","volume":"25","author":"Lasorsa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112475_bb0010","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41591-023-02376-7","article-title":"Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial","volume":"29","author":"Hosgood","year":"2023","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112475_bb0015","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112475_bb0020","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.7150\/ijbs.85674","article-title":"Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases","volume":"19","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112475_bb0025","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s10157-024-02491-w","article-title":"Targeting ferroptosis for treating kidney disease","volume":"28","author":"Mishima","year":"2024","journal-title":"Clin. Exp. Nephrol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112475_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14050613","article-title":"The ferroptosis-mitochondrial axis in depression: unraveling the feedforward loop of oxidative stress, metabolic homeostasis dysregulation, and neuroinflammation","volume":"14","author":"Liu","year":"2025","journal-title":"Antioxidants"},{"issue":"11\u221212","key":"10.1016\/j.cellsig.2026.112475_bb0035","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s10495-025-02192-z","article-title":"The impact of lipid metabolism on ferroptosis in myocardial ischemia-reperfusion injury","volume":"30","author":"Li","year":"2025","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112475_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01463-5","article-title":"Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells","volume":"9","author":"Cheng","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cellsig.2026.112475_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107841","article-title":"Lactate in ferroptosis regulation: a new perspective on tumor progression and therapy","volume":"218","author":"Wu","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"41","key":"10.1016\/j.cellsig.2026.112475_bb0050","article-title":"Lactylation of HMGB1 at K177 drives nuclear export of TIAR to promote hypoxia-induced stress granule formation","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112475_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112475_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.501","article-title":"Therapeutic strategies for ischemia reperfusion injury in emergency medicine","volume":"7","author":"Naito","year":"2020","journal-title":"Acute Med. Surg."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112475_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.010326","article-title":"Hypothermia for reduction of myocardial reperfusion injury in acute myocardial infarction: closing the translational gap","volume":"14","author":"El Farissi","year":"2021","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112475_bb0070","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1093\/cvr\/cvad028","article-title":"Mild hypothermia attenuates ischaemia\/reperfusion injury: insights from serial non-invasive pressure-volume loops","volume":"119","author":"Berg","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cellsig.2026.112475_bb0075","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1681\/ASN.0000000000000024","article-title":"Tubular epithelial cell HMGB1 promotes AKI-CKD transition by sensitizing cycling tubular cells to oxidative stress: a rationale for targeting HMGB1 during AKI recovery","volume":"34","author":"Zhao","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112475_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105867","article-title":"Liraglutide protects against lethal renal ischemia-reperfusion injury by inhibiting high-mobility group box 1 nuclear-cytoplasmic translocation and release","volume":"173","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112475_bb0085","first-page":"2101","article-title":"TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats","volume":"20","author":"Zhong","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112475_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-52140-9","article-title":"Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39","volume":"15","author":"Kawamura","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112475_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061337","article-title":"Hypothermia mitigates renal fibrosis through the upregulation of PGC-1\u03b1 after ischemia-reperfusion injury","volume":"13","author":"Kim","year":"2025","journal-title":"Biomedicines"},{"issue":"16","key":"10.1016\/j.cellsig.2026.112475_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169229","article-title":"Mild therapeutic hypothermia protects from acute and chronic renal ischemia-reperfusion injury in mice by mitigated mitochondrial dysfunction and modulation of local and systemic inflammation","volume":"23","author":"Schleef","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112475_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103360","article-title":"Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1","volume":"77","author":"Deng","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112475_bb0110","article-title":"The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cellsig.2026.112475_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1435139","article-title":"Targeting ferroptosis: a new therapeutic opportunity for kidney diseases","volume":"15","author":"Long","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112475_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109757","article-title":"Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia\/reperfusion","volume":"116","author":"Zhao","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"17","key":"10.1016\/j.cellsig.2026.112475_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710108","article-title":"Hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury","volume":"23","author":"Eskla","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112475_bb0130","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S2213-2600(24)00117-6","article-title":"Hypothermia for expanded criteria organ donors in kidney transplantation in France (HYPOREME): a multicentre, randomised controlled trial","volume":"12","author":"HYPOREME Trial Group","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.cellsig.2026.112475_bb0135","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2025.02.020","article-title":"TIMP2-mediated mitochondrial fragmentation and glycolytic reprogramming drive renal fibrogenesis following ischemia-reperfusion injury","volume":"232","author":"Pang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112475_bb0140","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ajt.2025.01.037","article-title":"High mobility group box-1 protein-mediated class II major histocompatibility complex transactivator superenhancers are critical for dendritic cell-trained immunity in acute-to-chronic progression of allograft rejection","volume":"25","author":"Sun","year":"2025","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.cellsig.2026.112475_bb0145","article-title":"High mobility group box 1 contributes to the acute rejection of liver allografts by activating dendritic cells","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:51:55Z","timestamp":1775602315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826001269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"alternative-id":["S0898656826001269"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112475","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mild hypothermia alleviates ferroptosis in kidney ischemia-reperfusion injury via the glycolysis-lactate-HMGB1 lactylation axis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112475"}}