{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:53:15Z","timestamp":1776142395308,"version":"3.50.1"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410313"],"award-info":[{"award-number":["182300410313"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32161143021"],"award-info":[{"award-number":["32161143021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271410"],"award-info":[{"award-number":["81271410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cellsig.2026.112485","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:32:46Z","timestamp":1773419566000},"page":"112485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting TREM2 to disentangle neuroinflammation and \u03b1-Syn pathological propagation in Parkinson's disease"],"prefix":"10.1016","volume":"143","author":[{"given":"Yixu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.cellsig.2026.112485_bb0005","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1097\/MS9.0000000000001142","article-title":"Parkinson\u2019s disease updates: addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment","volume":"85","author":"Prajjwal","year":"2023","journal-title":"Ann. Med. Surg. (Lond.)"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112485_bb0010","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1016\/S2666-7568(24)00094-1","article-title":"Temporal trends in the prevalence of Parkinson\u2019s disease from 1980 to 2023: a systematic review and meta-analysis","volume":"5","author":"Zhu","year":"2024","journal-title":"Lancet Healthy Longev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112485_bb0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/jpm15050172","article-title":"Redefining non-motor symptoms in Parkinson\u2019s disease","volume":"15","author":"Pe\u00f1a-Zelayeta","year":"2025","journal-title":"J Pers Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ibra.12180","article-title":"Progress of non-motor symptoms in early-onset Parkinson\u2019s disease","volume":"11","author":"Zhang","year":"2024","journal-title":"Ibrain"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112485_bb0030","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.32604\/biocell.2024.051518","article-title":"The pathogenesis of parkinson\u2019s disease and crosstalk with other diseases","volume":"48","author":"Liu","year":"2024","journal-title":"Biocell"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112485_bb0035","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11011-021-00689-5","article-title":"Cellular and molecular pathophysiology in the progression of Parkinson\u2019s disease","volume":"36","author":"Zaman","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.cellsig.2026.112485_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40035-019-0165-9","article-title":"The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson\u2019s disease","volume":"8","author":"Pang","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.cellsig.2026.112485_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jare.2024.01.006","article-title":"Current perspectives on microglia-neuron communication in the central nervous system: direct and indirect modes of interaction","volume":"66","author":"Hu","year":"2024","journal-title":"J. Adv. Res."},{"issue":"s1","key":"10.1016\/j.cellsig.2026.112485_bb0050","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.3233\/JPD-223237","article-title":"Microglia in Parkinson\u2019s disease","volume":"12","author":"Stefanova","year":"2022","journal-title":"J. Parkinsons Dis."},{"issue":"Pt 1","key":"10.1016\/j.cellsig.2026.112485_bb0055","article-title":"Role of TREM2 in immune and neurological diseases: structure, function, and implications","volume":"143","author":"Yin","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0060","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/immu.200310033","article-title":"The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44","volume":"33","author":"Allcock","year":"2003","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0065","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/ijms19010318","article-title":"Microglia and aging: the role of the TREM2-DAP12 and CX3CL1-CX3CR1 axes","volume":"19","author":"Mecca","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0070","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-201085","article-title":"Neuropathological Alzheimer\u2019s disease lesions in Nasu-Hakola disease with TREM2 mutation: atypical distribution of neurofibrillary changes","volume":"79","author":"Maderna","year":"2021","journal-title":"J. Alzheimer\u2019s Dis"},{"issue":"17","key":"10.1016\/j.cellsig.2026.112485_bb0075","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3390\/cells14171387","article-title":"TREM2 in neurodegenerative diseases: mechanisms and therapeutic potential","volume":"14","author":"Li","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112485_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.parkreldis.2015.11.026","article-title":"TREM2 rare variant p.R47H is not associated with Parkinson\u2019s disease","volume":"23","author":"Mengel","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112485_bb0085","article-title":"Targeting TREM2 for Parkinson\u2019s disease: where to go?","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112485_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112042","article-title":"Current understanding on TREM-2 molecular biology and physiopathological functions","volume":"134","author":"Bharadwaj","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0095","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1038\/s41598-019-43535-6","article-title":"Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells","volume":"9","author":"Shirotani","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-Beta by microglia","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"issue":"Pt 2","key":"10.1016\/j.cellsig.2026.112485_bb0105","article-title":"TREM2 signaling in Parkinson\u2019s disease: regulation of microglial function and \u03b1-synuclein pathology","volume":"143","author":"Yin","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2026.112485_bb0110","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnagi.2017.00204","article-title":"TREM2\/DAP12 complex regulates inflammatory responses in microglia via the JNK signaling pathway","volume":"9","author":"Zhong","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"Alzheimer genetic analysis group. TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13195-025-01700-2","article-title":"TREM2 risk variants and associated endophenotypes in alzheimer\u2019s disease","volume":"17","author":"Dijkstra","year":"2025","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.cellsig.2026.112485_bb0125","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fncel.2018.00206","article-title":"Microglial TREM2\/DAP12 signaling: a double-edged sword in neural diseases","volume":"12","author":"Konishi","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112485_bb0130","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.3390\/jcm12103589","article-title":"Association between cerebrospinal fluid soluble TREM2, Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"12","author":"Zhou","year":"2023","journal-title":"J. Clin. Med."},{"issue":"6048","key":"10.1016\/j.cellsig.2026.112485_bb0135","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.immuni.2023.12.002","article-title":"Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development","volume":"57","author":"Tagliatti","year":"2024","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112485_bb0145","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s12035-023-03713-0","article-title":"TREM2 deficiency aggravates NLRP3 Inflammasome activation and Pyroptosis in MPTP-induced Parkinson\u2019s disease mice and LPS-induced BV2 cells","volume":"61","author":"Huang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0150","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1359\/JBMR.051016","article-title":"TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function","volume":"21","author":"Humphrey","year":"2006","journal-title":"J. Bone Miner. Res."},{"issue":"219","key":"10.1016\/j.cellsig.2026.112485_bb0155","article-title":"Activation of TREM2 attenuates neuroinflammation via PI3K\/Akt signaling pathway to improve postoperative cognitive dysfunction in mice","author":"Han","year":"2022","journal-title":"Neuropharmacology"},{"issue":"22","key":"10.1016\/j.cellsig.2026.112485_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.09.033","article-title":"TREM2 drives microglia response to amyloid-\u03b2 via SYK-dependent and -independent pathways","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41420-025-02538-1","article-title":"TREM2 deficiency exacerbates cognitive impairment by aggravating \u03b1-Synuclein-induced lysosomal dysfunction in Parkinson\u2019s disease","volume":"11","author":"Zhu","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cellsig.2026.112485_bb0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molimm.2021.12.018","article-title":"Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer\u2019s disease","volume":"142","author":"Ruganzu","year":"2022","journal-title":"Mol. Immunol."},{"issue":"260","key":"10.1016\/j.cellsig.2026.112485_bb0175","article-title":"Modulatory effect of methylsulfonylmethane against BPA\/\u03b3-radiation induced neurodegenerative alterations in rats: influence of TREM-2\/DAP-12\/Syk pathway","author":"Abdel-Rafei","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112485_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2025.106068","article-title":"TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson\u2019s disease models","volume":"191","author":"Zhang","year":"2025","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0185","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12967-025-07604-x","article-title":"Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances","volume":"24","author":"Liao","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/diseases13020060","article-title":"TREM2 alleviates neuroinflammation by maintaining cellular metabolic homeostasis and mitophagy activity during early inflammation","volume":"13","author":"Hu","year":"2025","journal-title":"Diseases"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112485_bb0195","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jnutbio.2012.04.017","article-title":"TRAF6 is functional in inhibition of TLR4-mediated NF-\u03baB activation by resveratrol","volume":"24","author":"Jakus","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cellsig.2026.112485_bb0200","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.expneurol.2018.01.016","article-title":"TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson\u2019s disease","volume":"302","author":"Ren","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cellsig.2026.112485_bb0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-3-031-27681-1_46","article-title":"Role of TFEB in diseases associated with lysosomal dysfunction","volume":"1415","author":"Pan","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112485_bb0210","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1007\/s12035-020-01934-1","article-title":"Ferulic acid ameliorates MPP+\/MPTP-induced oxidative stress via ERK1\/2-dependent Nrf2 activation: translational implications for Parkinson disease treatment","volume":"57","author":"Li","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0215","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200527","article-title":"Decoding TREM2 signaling pathways: linking macrophage glycolysis to inflammatory diseases in the CNS","volume":"13","author":"Che","year":"2026","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112485_bb0220","article-title":"Microglia process \u03b1-Synuclein fibrils and enhance their pathogenicity in a TREM2-dependent manner","volume":"12","author":"Xiong","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112485_bb0225","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.immuni.2025.04.022","article-title":"Microglial and TREM2 dialogues in the developing brain","volume":"58","author":"Morini","year":"2025","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112485_bb0230","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.1096\/fj.201900992R","article-title":"TREM2 deficiency aggravates \u03b1-synuclein-induced neurodegeneration and neuroinflammation in Parkinson\u2019s disease models","volume":"33","author":"Guo","year":"2019","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0235","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12031-019-01424-7","article-title":"Analysis of cerebrospinal fluid soluble TREM2 and polymorphisms in sporadic Parkinson\u2019s disease in a Chinese population","volume":"70","author":"Peng","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.cellsig.2026.112485_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137277","article-title":"Effects of soluble TREM2 on motor progression in Parkinson\u2019s disease","volume":"807","author":"Zhang","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cellsig.2026.112485_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111445","article-title":"TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance","volume":"127","author":"Meng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2026.112485_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103787","article-title":"Decoding Parkinson\u2019s disease: the interplay of cell death pathways, oxidative stress, and therapeutic innovations","volume":"85","author":"Liu","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-019-1430-7","article-title":"Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro","volume":"16","author":"Yauger","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"122","key":"10.1016\/j.cellsig.2026.112485_bb0260","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000500","article-title":"TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1","volume":"3","author":"Peng","year":"2010","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0265","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s10020-025-01208-3","article-title":"The interplay of iron, oxidative stress, and \u03b1-synuclein in Parkinson\u2019s disease progression","volume":"31","author":"Chen","year":"2025","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0270","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/s41467-026-68706-8","article-title":"TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism","volume":"17","author":"Feiten","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112485_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113506","article-title":"TREM2 overexpression rescues cognitive deficits in APP\/PS1 transgenic mice by reducing neuroinflammation via the JAK\/STAT\/SOCS signaling pathway","volume":"336","author":"Ruganzu","year":"2021","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0280","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14394","article-title":"Iron overload suppresses hippocampal neurogenesis in adult mice: implication for iron dysregulation-linked neurological diseases","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0285","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41531-022-00361-4","article-title":"Harmol promotes \u03b1-synuclein degradation and improves motor impairment in Parkinson\u2019s models via regulating autophagy-lysosome pathway","volume":"8","author":"Xu","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0290","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI43366","article-title":"\u03b1-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells","volume":"121","author":"Hansen","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2026.112485_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102077","article-title":"Ferroptosis in Parkinson\u2019s disease: molecular mechanisms and therapeutic potential","volume":"91","author":"Ding","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cellsig.2026.112485_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102032","article-title":"Metabolic reprogramming and polarization of microglia in Parkinson\u2019s disease: role of inflammasome and iron","volume":"90","author":"Yu","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0305","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41531-024-00640-2","article-title":"Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson\u2019s disease mouse model","volume":"10","author":"Thi Lai","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0310","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/brain\/awx339","article-title":"Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration","volume":"141","author":"Scott","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.cellsig.2026.112485_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0320","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12035-025-05449-5","article-title":"TREM2 alleviates Neuroinflammation and improves neurogenesis in ApoE\u2212\/\u2212 mice by regulating M1\/M2 microglial polarization","volume":"63","author":"Peng","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112485_bb0325","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.3390\/jcm10132909","article-title":"Impaired Iron homeostasis and Haematopoiesis impacts inflammation in the ageing process in down syndrome dementia","volume":"10","author":"Raha-Chowdhury","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0330","doi-asserted-by":"crossref","first-page":"24968","DOI":"10.1038\/s41598-025-09563-1","article-title":"Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer\u2019s disease by activating the Wnt\/\u03b2-catenin signaling","volume":"15","author":"Zhu","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0335","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbrc.2018.03.226","article-title":"TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson\u2019s disease","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0340","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cbin.10975","article-title":"TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K\/NF-\u03baB signaling","volume":"43","author":"Li","year":"2019","journal-title":"Cell Biol. Int."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112485_bb0345","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/hmg\/ddaa209","article-title":"Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions","volume":"29","author":"Liu","year":"2020","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0350","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"issue":"2023","key":"10.1016\/j.cellsig.2026.112485_bb0355","article-title":"Regulatory mechanism of M1\/M2 macrophage polarization in the development of autoimmune diseases","author":"Peng","year":"2023","journal-title":"Mediat. Inflamm."},{"issue":"257","key":"10.1016\/j.cellsig.2026.112485_bb0360","article-title":"Microglia and TREM2","author":"Pocock","year":"2024","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0365","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1080\/02648725.2023.2204719","article-title":"Regulation of TREM2 on BV2 inflammation through PI3K\/AKT\/mTOR pathway","volume":"40","author":"Li","year":"2024","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"10.1016\/j.cellsig.2026.112485_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115547","article-title":"Role of TREM2 in neuroinflammation","volume":"396","author":"Abdulkhaliq","year":"2026","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0375","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jnr.24185","article-title":"Updates on immunity and inflammation in Parkinson disease pathology","volume":"96","author":"Joshi","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0380","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14630","article-title":"TREM2 gene induces differentiation of induced pluripotent stem cells into dopaminergic neurons and promotes neuronal repair via TGF-\u03b2 activation in 6-OHDA-lesioned mouse model of Parkinson\u2019s disease","volume":"30","author":"Liang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112485_bb0385","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S1474-4422(10)70212-X","article-title":"Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson\u2019s disease","volume":"9","author":"Kehagia","year":"2010","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0390","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/brain\/awaa021","article-title":"Soluble TREM2 is elevated in Parkinson\u2019s disease subgroups with increased CSF tau","volume":"143","author":"Wilson","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.cellsig.2026.112485_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.892493","article-title":"The association of CSF sTREM2 with cognitive decline and its dynamic change in Parkinson\u2019s disease: analysis of the PPMI cohort","volume":"14","author":"Qin","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0400","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5507\/bp.2025.021","article-title":"Diagnostics of olfactory dysfunction in Parkinson\u2019s disease - a literature overview and case series","volume":"170","author":"Vasina","year":"2026","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0405","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11481-023-10081-y","article-title":"Curcumin-activated olfactory Ensheathing cells improve functional recovery after spinal cord injury by modulating microglia polarization through APOE\/TREM2\/NF-\u03baB signaling pathway","volume":"18","author":"Jiang","year":"2023","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112485_bb0410","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s10753-024-02029-y","article-title":"STING agonist cGAMP attenuates sleep deprivation-induced Neuroinflammation and cognitive deficits via TREM2 up-regulation","volume":"47","author":"Wang","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.cellsig.2026.112485_bb0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.753210","article-title":"Soluble triggering receptor expressed on myeloid cells 2 from cerebrospinal fluid in sleep disorders related to Parkinson\u2019s disease","volume":"13","author":"Mo","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2026.112485_bb0420","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1468-1331.2008.02056.x","article-title":"Non-motor symptoms in Parkinson\u2019s disease","volume":"15","author":"Poewe","year":"2008","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0425","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41531-025-01247-x","article-title":"Parkinson\u2019s disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses","volume":"12","author":"Hou","year":"2026","journal-title":"NPJ Parkinsons Dis."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0430","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","article-title":"Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice","volume":"23","author":"Challis","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0435","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00011-025-02155-9","article-title":"TREM2-driven peripheral macrophage regulation in inflammatory diseases: implications extending beyond neurological disorders","volume":"75","author":"Zhou","year":"2025","journal-title":"Inflamm. Res."},{"issue":"15","key":"10.1016\/j.cellsig.2026.112485_bb0440","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.3390\/ijms26157057","article-title":"TREM2 in neurodegenerative disorders: mutation Spectrum, pathophysiology, and therapeutic targeting","volume":"26","author":"Yang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0445","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40035-025-00531-3","article-title":"Microglia in the crosstalk between peripheral and central nervous systems in Parkinson\u2019s disease","volume":"14","author":"Li","year":"2025","journal-title":"Transl. Neurodegener."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0450","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/brainsci15040379","article-title":"TREM 2 in Parkinson\u2019s disease: a promising candidate gene for disease susceptibility and progression","volume":"15","author":"Alonge","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.cellsig.2026.112485_bb0455","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2022.10.008","article-title":"Nobiletin protects enteric nerves and ameliorates disordered bowel motility in diet-induced obese mice via increasing Trem2 expression","volume":"635","author":"Pang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112485_bb0460","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1007\/s00415-012-6736-7","article-title":"Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management","volume":"260","author":"Metzler","year":"2013","journal-title":"J. Neurol."},{"key":"10.1016\/j.cellsig.2026.112485_bb0465","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson\u2019s disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112485_bb0470","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/00207454.2020.1750388","article-title":"Assessment of TREM2 rs75932628 variant\u2019s association with Parkinson\u2019s disease in a Greek population and Meta-analysis of current data","volume":"131","author":"Dardiotis","year":"2021","journal-title":"Int. J. Neurosci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112485_bb0475","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000085","article-title":"TREM2 p.R47H substitution is not associated with dementia with Lewy bodies","volume":"2","author":"Walton","year":"2016","journal-title":"Neurol. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0480","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab009","article-title":"The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles","volume":"3","author":"Mallach","year":"2021","journal-title":"Brain Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0485","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3233\/JAD-181038","article-title":"TREM2 variants and neurodegenerative diseases: a systematic review and meta-analysis","volume":"68","author":"Zhou","year":"2019","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.cellsig.2026.112485_bb0490","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neulet.2015.12.029","article-title":"Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson\u2019s disease","volume":"612","author":"Tan","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cellsig.2026.112485_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuro.2025.103343","article-title":"DDT exposure induces microglial activation and disease-associated microglial signatures: relevance to mechanisms of Alzheimer\u2019s disease","volume":"111","author":"Mhatre-Winters","year":"2025","journal-title":"Neurotoxicology"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112485_bb0500","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13094","article-title":"Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson\u2019s disease","volume":"54","author":"Li","year":"2021","journal-title":"Cell Prolif."},{"issue":"585","key":"10.1016\/j.cellsig.2026.112485_bb0505","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2025.08.063","article-title":"TREM2 mediates parkinsonism-like neurodegeneration in carbon disulfide-induced neurotoxicity","author":"Zhidan","year":"2025","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112485_bb0510","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3390\/nu12061860","article-title":"The effect of caffeine on the risk and progression of Parkinson\u2019s disease: a meta-analysis","volume":"12","author":"Hong","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0515","doi-asserted-by":"crossref","first-page":"13414","DOI":"10.1038\/s41598-020-69660-1","article-title":"Neuronal adenosine A2A receptors signal ergogenic effects of caffeine","volume":"10","author":"Aguiar","year":"2020","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.cellsig.2026.112485_bb0520","article-title":"Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases","author":"Romero Garavito","year":"2025","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0525","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12974-023-02741-w","article-title":"TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair","volume":"20","author":"Xu","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"Pt 2","key":"10.1016\/j.cellsig.2026.112485_bb0530","article-title":"Exendin-4 prevents oxLDL-induced upregulation of TREM2 and attenuates foam cell formation and inflammation in macrophages","volume":"242","author":"Wang","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112485_bb0535","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1002\/alz.13828","article-title":"Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer\u2019s disease independent of amyloid and tau pathology","volume":"20","author":"Kotredes","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112485_bb0540","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.gendis.2020.05.005","article-title":"Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia","volume":"9","author":"Wu","year":"2020","journal-title":"Genes Dis."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112485_bb0545","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1007\/s12035-022-02873-9","article-title":"Cyanidin-3-O-glucoside regulates the M1\/M2 polarization of microglia via PPAR\u03b3 and A\u03b242 phagocytosis through TREM2 in an Alzheimer\u2019s disease model","volume":"59","author":"Sanjay","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"24","key":"10.1016\/j.cellsig.2026.112485_bb0550","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1039\/D5FO03220B","article-title":"Acer truncatum Bunge seed oil ameliorates cuprizone-induced cognitive decline and brain white matter impairment by improving sphingomyelin metabolism and neuroinflammation via activation of the TREM2 signaling pathway","volume":"16","author":"Ju","year":"2025","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112485_bb0555","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(23)00247-8","article-title":"Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer\u2019s disease","volume":"22","author":"Schlepckow","year":"2023","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112485_bb0560","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1152\/ajpendo.00124.2025","article-title":"Synergistic potential of TREM2 agonists and exercise training in Alzheimer\u2019s disease","volume":"330","author":"Zhang","year":"2026","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112485_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115777","article-title":"Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures","volume":"44","author":"Lish","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2026.112485_bb0570","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molimm.2019.09.020","article-title":"Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2\/ TLR4\/ NF-\u03baB pathways in BV2 cells","volume":"116","author":"Zhang","year":"2019","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112485_bb0575","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.3390\/ijms26115044","article-title":"Resveratrol attenuates CSF markers of neurodegeneration and Neuroinflammation in individuals with Alzheimer\u2019s disease","volume":"26","author":"Liu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0580","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12974-020-01853-x","article-title":"TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K\/Akt pathway after intracerebral hemorrhage in mice","volume":"17","author":"Chen","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0585","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13024-018-0262-8","article-title":"The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer\u2019s disease","volume":"13","author":"Cheng-Hathaway","year":"2018","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112485_bb0590","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13024-023-00599-3","article-title":"Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology","volume":"18","author":"Qiao","year":"2023","journal-title":"Mol. Neurodegener."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:15:34Z","timestamp":1776140134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826001361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":118,"alternative-id":["S0898656826001361"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112485","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting TREM2 to disentangle neuroinflammation and \u03b1-Syn pathological propagation in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112485"}}