{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:37:55Z","timestamp":1787510275071,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1078"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1078"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cellsig.2026.112514","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:55:07Z","timestamp":1775181307000},"page":"112514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A novel diagnostic and prognostic biomarker FSD1L facilitates EMT and Lenvatinib resistance via the WNT\/\u03b2-catenin pathway in hepatocellular carcinoma"],"prefix":"10.1016","volume":"144","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112514_bb0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cytogfr.2024.08.006","article-title":"Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis","volume":"79","author":"Yu","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.cellsig.2026.112514_bb0010","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","article-title":"Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial","volume":"391","author":"Kudo","year":"2018","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.cellsig.2026.112514_bb0015","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-024-07054-3","article-title":"Deep whole-genome analysis of 494 hepatocellular carcinomas","volume":"627","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112514_bb0020","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112514_bb0025","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.386","article-title":"Meta-analysis of genome-wide association data identifies two loci influencing age at menarche","volume":"41","author":"Perry","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cellsig.2026.112514_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/mi\/8833556","article-title":"Exploring the relationship between immune cells and scoliosis by mendelian randomization, colocalization analysis, and SMR","volume":"2025","author":"Qin","year":"2025","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.cellsig.2026.112514_bb0035","article-title":"The first pituitary proteome landscape from matched anterior and posterior lobes for a better understanding of the pituitary gland","volume":"22","author":"Banerjee","year":"2022","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cellsig.2026.112514_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-023-01524-7","article-title":"Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age","volume":"15","author":"Taschereau","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.cellsig.2026.112514_bb0045","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1093\/eurheartj\/ehac431","article-title":"Exerkine fibronectin type-III domain-containing protein 5\/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability","volume":"43","author":"Chi","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cellsig.2026.112514_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2023.08.012","article-title":"Irisin reduces amyloid-\u03b2 by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling","volume":"111","author":"Kim","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.cellsig.2026.112514_bb0055","first-page":"34","article-title":"TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability","volume":"42","author":"Chen","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.cellsig.2026.112514_bb0060","article-title":"A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets","volume":"71","author":"Juan","year":"2019"},{"key":"10.1016\/j.cellsig.2026.112514_bb0065","article-title":"Identification and validation of a prognostic model based on three MVI-related genes in hepatocellular carcinoma","volume":"18","author":"Yongchang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2026.112514_bb0070","article-title":"Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma","volume":"13","author":"Suk Mei","year":"2007","journal-title":"HJCCR"},{"key":"10.1016\/j.cellsig.2026.112514_bb0075","article-title":"Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. results from a prospective study","volume":"65","author":"Erica","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.cellsig.2026.112514_bb0080","article-title":"Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer","volume":"8","author":"Hyun Goo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112514_bb0085","article-title":"Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma","volume":"12","author":"Oleg V","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112514_bb0090","article-title":"Prediction of disease-free survival in hepatocellular carcinoma by gene expression profiling","volume":"20","author":"Ho-Yeong","year":"2013","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.cellsig.2026.112514_bb0095","article-title":"Lymphoid enhancer factor 1 contributes to hepatocellular carcinoma progression through transcriptional regulation of epithelial-mesenchymal transition regulators and stemness genes","volume":"2","author":"Chih-Li","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.cellsig.2026.112514_bb0100","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/hep4.1928","article-title":"Integrin subunit beta 8 contributes to lenvatinib resistance in HCC","volume":"6","author":"Hou","year":"2022","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.cellsig.2026.112514_bb0105","article-title":"A cell cycle-related 13-mRNA signature to predict prognosis in hepatocellular carcinoma","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cellsig.2026.112514_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-025-00721-x","article-title":"Maff alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1\/STAT3 signaling pathway","volume":"30","author":"Lei","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.cellsig.2026.112514_bb0115","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.18632\/oncotarget.6573","article-title":"AEG-1 activates Wnt\/PCP signaling to promote metastasis in tongue squamous cell carcinoma","volume":"7","author":"Pan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2026.112514_bb0120","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cellsig.2011.04.001","article-title":"Cdc42 in oncogenic transformation, invasion, and tumorigenesis","volume":"23","author":"Stengel","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2026.112514_bb0125","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cellsig.2026.112514_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116685","article-title":"Wnt\/\u03b2-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells","volume":"175","author":"Sun","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112514_bb0135","article-title":"Yes-associated protein indispensably mediates hirsutine-induced inhibition on cell growth and wnt\/\u03b2-catenin signaling in colorectal cancer","volume":"135","author":"Ren","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.cellsig.2026.112514_bb0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12943-024-02101-z","article-title":"Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma","volume":"23","author":"Chan","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2026.112514_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/genes12050768","article-title":"Meta-analysis of heifer traits identified reproductive pathways in bos indicus cattle","volume":"12","author":"Tahir","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.cellsig.2026.112514_bb0150","article-title":"A novel prognostic model for identifying the risk of hepatocellular carcinoma based on angiogenesis factors","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.cellsig.2026.112514_bb0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/CBM-220227","article-title":"Construction and validation of a prognostic model based on ten signature cell cycle-related genes for early-stage lung squamous cell carcinoma","volume":"36","author":"Zhang","year":"2023","journal-title":"Cancer Biomarkers\u202f: Sect. A Dis. Markers"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682600166X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682600166X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:51:00Z","timestamp":1781794260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865682600166X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"alternative-id":["S089865682600166X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112514","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel diagnostic and prognostic biomarker FSD1L facilitates EMT and Lenvatinib resistance via the WNT\/\u03b2-catenin pathway in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112514"}}