{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:23:17Z","timestamp":1791487397213,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013103","name":"Shanghai General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cellsig.2026.112515","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:08:34Z","timestamp":1775099314000},"page":"112515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Bone marrow mesenchymal stem cell-derived exosomes enhance tendon regeneration and promote TDSC migration and differentiation"],"prefix":"10.1016","volume":"144","author":[{"given":"Jian","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cellsig.2026.112515_bb0005","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/14712598.2020.1786532","article-title":"Progress with stem cell therapies for tendon tissue regeneration","volume":"20","author":"Migliorini","year":"2020","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112515_bb0010","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2023.5324","article-title":"Bone marrow mesenchymal stem cell-derived exosomes: a novel therapeutic agent for tendon-bone healing (review)","volume":"52","author":"Zhu","year":"2023","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10439-020-02635-5","article-title":"Techniques for in vivo measurement of ligament and tendon strain: a review","volume":"49","author":"Zhang","year":"2021","journal-title":"Ann. Biomed. Eng."},{"issue":"5\u20136","key":"10.1016\/j.cellsig.2026.112515_bb0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1089\/ten.tea.2022.0183","article-title":"Tendon stem\/progenitor cell-laden nanofiber hydrogel enhanced functional repair of patellar tendon","volume":"29","author":"Zhang","year":"2023","journal-title":"Tissue Eng. Part A"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0025","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s13287-022-03113-6","article-title":"Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside","volume":"13","author":"Chen","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.cellsig.2026.112515_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113393","article-title":"The regulation of tendon stem cell distribution, morphology, and gene expression by the modulus of microfibers","volume":"228","author":"Ye","year":"2023","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.cellsig.2026.112515_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111506","article-title":"Tenogenic adipose-derived stem cell sheets with nanoyarn scaffolds for tendon regeneration","volume":"119","author":"Chen","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s13258-023-01447-w","article-title":"HPF1 regulates tendon stem\/progenitor cell senescence and tendon repair via PARP1-mediated poly-ADP ribosylation of HuR","volume":"46","author":"Han","year":"2024","journal-title":"Genes Genom."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13062-024-00581-z","article-title":"Integrative in-silico and in-vitro analysis of taurine and vitamin b12 in modulating PPAR\u03b3 and Wnt signaling in hyperhomocysteinemia-induced osteoporosis","volume":"19","author":"Adhish","year":"2024","journal-title":"Biol. Direct"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112515_bb0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrendo.2010.155","article-title":"PPAR\u03b3: a circadian transcription factor in adipogenesis and osteogenesis","volume":"6","author":"Kawai","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112515_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12122791","article-title":"Nano-delivery revolution: harnessing mesenchymal stem cell-derived exosomes\u2019 potential for wound healing","volume":"12","author":"Raghav","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2026.112515_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119465","article-title":"Cancer stem cells targets and combined therapies to prevent cancer recurrence","volume":"277","author":"Raghav","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112515_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174657","article-title":"Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine","volume":"918","author":"Raghav","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"22","key":"10.1016\/j.cellsig.2026.112515_bb0070","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.2217\/nnm-2021-0121","article-title":"Graphene nanofiber composites for enhanced neuronal differentiation of human mesenchymal stem cells","volume":"16","author":"Rawat","year":"2021","journal-title":"Nanomedicine (London)"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112515_bb0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3727\/096368912X655118","article-title":"Stem cell therapy for tendon injury","volume":"22","author":"Chen","year":"2013","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0080","first-page":"187","article-title":"Tendon injury and tendinopathy: healing and repair","volume":"87","author":"Sharma","year":"2005","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.cellsig.2026.112515_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.121998","article-title":"Bioactive glass-elicited stem cell-derived extracellular vesicles regulate m2 macrophage polarization and angiogenesis to improve tendon regeneration and functional recovery","volume":"294","author":"Xu","year":"2023","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112515_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/cells10081959","article-title":"Mesenchymal stem cell-derived exosomes: applications in regenerative medicine","volume":"10","author":"Hade","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112515_bb0095","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.actbio.2020.01.051","article-title":"Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem\/progenitor cells","volume":"106","author":"Yu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cellsig.2026.112515_bb0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jot.2024.07.009","article-title":"Exosomes derived from bone marrow mesenchymal stem cell preconditioned by low-intensity pulsed ultrasound stimulation promote bone-tendon interface fibrocartilage regeneration and ameliorate rotator cuff fatty infiltration","volume":"48","author":"Wu","year":"2024","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.cellsig.2026.112515_bb0105","article-title":"Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p\/SMAD7 pathway","volume":"15","author":"Wu","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12967-024-06029-2","article-title":"Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears","volume":"23","author":"Chen","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13287-022-02975-0","article-title":"BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1\/M2 macrophage polarization in rats","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0120","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s13287-022-03212-4","article-title":"Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors","volume":"13","author":"Ghasempour","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112515_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103119","article-title":"Exosomes secreted from induced pluripotent stem cell-derived mesenchymal stem cells accelerate skin cell proliferation","volume":"19","author":"Kim","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1067-2516(97)80006-3","article-title":"Extensor hallucis longus tendon injury: an in-depth analysis and treatment protocol","volume":"36","author":"Kass","year":"1997","journal-title":"J. Foot Ankle Surg."},{"key":"10.1016\/j.cellsig.2026.112515_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113211","article-title":"Mesenchymal stromal\/stem cells spheroid culture effect on the therapeutic efficacy of these cells and their exosomes: a new strategy to overcome cell therapy limitations","volume":"152","author":"Hazrati","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"30","key":"10.1016\/j.cellsig.2026.112515_bb0140","article-title":"Adipose-derived mesenchymal stem cell-derived exosomes biopotentiated extracellular matrix hydrogels accelerate diabetic wound healing and skin regeneration","volume":"10","author":"Song","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.cellsig.2026.112515_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112171","article-title":"Mesenchymal stem cell-derived exosomes for management of prostate cancer: an updated view","volume":"134","author":"Lavi Arab","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112515_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073571","article-title":"Roles of oxidative stress in acute tendon injury and degenerative tendinopathy-a target for intervention","volume":"23","author":"Lui","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112515_bb0155","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/jor.22806","article-title":"Mechanisms of tendon injury and repair","volume":"33","author":"Thomopoulos","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112515_bb0160","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00441-023-03748-8","article-title":"Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins","volume":"392","author":"Fang","year":"2023","journal-title":"Cell Tissue Res."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112515_bb0165","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/dev.128.19.3855","article-title":"Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments","volume":"128","author":"Schweitzer","year":"2001","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ydbio.2006.06.036","article-title":"Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes","volume":"298","author":"Shukunami","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112515_bb0175","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1128\/MCB.00207-10","article-title":"The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis","volume":"30","author":"Liu","year":"2010","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0180","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00776-013-0485-z","article-title":"The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates","volume":"19","author":"Onizuka","year":"2014","journal-title":"J. Orthop. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112515_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059944","article-title":"The paratenon contributes to Scleraxis-expressing cells during patellar tendon healing","volume":"8","author":"Dyment","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.cellsig.2026.112515_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26157516","article-title":"When bone forms where it shouldn\u2019t: heterotopic ossification in muscle injury and disease","volume":"26","author":"Facchin","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112515_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.actbio.2018.01.032","article-title":"Enhanced tendon-to-bone repair through adhesive films","volume":"70","author":"Linderman","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cellsig.2026.112515_bb0200","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.actbio.2022.09.007","article-title":"Scavenging of reactive oxygen species can adjust the differentiation of tendon stem cells and progenitor cells and prevent ectopic calcification in tendinopathy","volume":"152","author":"Shen","year":"2022","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112515_bb0205","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1021\/acsbiomaterials.4c00935","article-title":"Elemental and structural characterization of heterotopic ossification during Achilles tendon healing provides new insights on the formation process","volume":"10","author":"Sharma","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.cellsig.2026.112515_bb0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jot.2021.03.004","article-title":"Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the \u03b2-catenin signaling pathway","volume":"29","author":"Wang","year":"2021","journal-title":"J. Orthopaed. Transl."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112515_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14060299","article-title":"Therapeutic potential of exosomes in tendon and tendon\u2013bone healing: a systematic review of preclinical studies","volume":"14","author":"Zou","year":"2023","journal-title":"J. Funct. Biomater."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13578-024-01277-7","article-title":"Signaling pathways activated and regulated by stem cell-derived exosome therapy","volume":"14","author":"Li","year":"2024","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0225","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13287-023-03431-3","article-title":"Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy","volume":"14","author":"Zhang","year":"2023","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112515_bb0230","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12951-023-01778-6","article-title":"Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon\u2013bone healing","volume":"21","author":"Zou","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112515_bb0235","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s12276-024-01201-6","article-title":"Recent advances in extracellular vesicles for therapeutic cargo delivery","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:51:49Z","timestamp":1781794309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826001671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":47,"alternative-id":["S0898656826001671"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112515","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone marrow mesenchymal stem cell-derived exosomes enhance tendon regeneration and promote TDSC migration and differentiation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112515"}}