{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:56Z","timestamp":1790805956779,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Commission","doi-asserted-by":"publisher","award":["20241029Y164"],"award-info":[{"award-number":["20241029Y164"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cellsig.2026.112535","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T22:20:55Z","timestamp":1776637255000},"page":"112535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["IL-6 as a key regulator of ferroptosis in diabetic nephropathy: From molecular mechanisms to therapeutic implications"],"prefix":"10.1016","volume":"144","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0005","article-title":"Dietary non-starch plant polysaccharides: multi-mechanisms for managing diabetic microvascular complications","volume":"368","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0010","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s11033-023-08249-z","article-title":"Expression of pro-inflammatory cytokines (IL-6 & IL-18) exacerbate the risk of diabetic nephropathy in the pakistani population","volume":"50","author":"Maqsood","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112535_bb0015","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i10.109782","article-title":"Nicotinamide mononucleotide protects against diabetic nephropathy via IL-6\/Rab5-mediated crosstalk between proximal tubular epithelial cells and podocytes","volume":"16","author":"Zha","year":"2025","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.cellsig.2026.112535_bb0020","article-title":"Renoprotective effect of the recombinant anti-IL-6R fusion proteins by inhibiting JAK2\/STAT3 signaling pathway in diabetic nephropathy","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112535_bb0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1159\/000545387","article-title":"Pathogenesis mechanism of ferroptosis and pharmacotherapy in kidney diseases: a review","volume":"149","author":"Li","year":"2025","journal-title":"Nephron"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0030","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2498629","article-title":"Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets","volume":"47","author":"Lyu","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.cellsig.2026.112535_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.945976","article-title":"Research progress on ferroptosis in diabetic kidney disease","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112535_bb0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41419-021-03452-x","article-title":"Characterization of ferroptosis in kidney tubular cell death under diabetic conditions","volume":"12","author":"Kim","year":"2021","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112535_bb0045","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf042","article-title":"Ferroptosis activation contributes to kidney aging in mice by promoting tubular cell senescence","volume":"80","author":"Wang","year":"2025","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41420-022-00931-8","article-title":"Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5\/6 nephrectomy-induced CKD rat model","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112535_bb0055","article-title":"Iron-immune crosstalk at the maternal-Fetal interface: emerging mechanisms in the pathogenesis of preeclampsia","volume":"14","author":"Zhong","year":"2025","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.cellsig.2026.112535_bb0060","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.2147\/DMSO.S524983","article-title":"A network pharmacology-based investigation into the mechanism of quercetin combined with rosuvastatin in delaying diabetic nephropathy via inhibiting NRK-52E cell ferroptosis","volume":"18","author":"Gan","year":"2025","journal-title":"Diabetes Metab. Syndr. Obes."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0065","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2019.03.027","article-title":"Pleiotropy and specificity: insights from the interleukin 6 family of cytokines","volume":"50","author":"Murakami","year":"2019","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112535_bb0070","doi-asserted-by":"crossref","DOI":"10.4110\/in.2025.25.e22","article-title":"The diverse function of IL-6 in biological processes and the advancement of cancer","volume":"25","author":"Zhou","year":"2025","journal-title":"Immune Netw."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0075","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40164-024-00527-1","article-title":"The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases","volume":"13","author":"Wang","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112535_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103826","article-title":"Interleukin-6 in neuroimmunological disorders: pathophysiology and therapeutic advances with satralizumab","volume":"24","author":"Li","year":"2025","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0085","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/med.22022","article-title":"Natural products as IL-6 inhibitors for inflammatory diseases: synthetic and SAR perspective","volume":"44","author":"Harmalkar","year":"2024","journal-title":"Med. Res. Rev."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112535_bb0090","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"824","key":"10.1016\/j.cellsig.2026.112535_bb0095","doi-asserted-by":"crossref","first-page":"eadc9662","DOI":"10.1126\/scisignal.adc9662","article-title":"Activation of gp130 signaling in t cells drives TH17-mediated multi-organ autoimmunity","volume":"17","author":"Baumgartner","year":"2024","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cellsig.2026.112535_bb0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cytogfr.2023.12.007","article-title":"Navigating IL-6: from molecular mechanisms to therapeutic breakthroughs","volume":"76","author":"Swaroop","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119143","article-title":"Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease","volume":"1869","author":"Schumertl","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266632","article-title":"Structure-based 3D-pharmacophore modeling to discover novel interleukin 6 inhibitors: an in silico screening, molecular dynamics simulations and binding free energy calculations","volume":"17","author":"Tran","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0115","first-page":"1180","article-title":"Interleukin 6: friend or foe in diabetic nephropathy?","volume":"21","author":"Alhamawi","year":"2025","journal-title":"Arch. Med. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112535_bb0120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.amjms.2019.07.011","article-title":"Association between IL-6 polymorphisms and diabetic nephropathy risk: a meta-analysis","volume":"358","author":"Chen","year":"2019","journal-title":"Am. J. Med. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112535_bb0125","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jimmun\/vkae024","article-title":"Effects of PARP1 inhibitor PJ-34 on TGF\u03b1, IL-6, and IL-1\u03b2 levels in diabetic nephropathy","volume":"214","author":"Ke","year":"2025","journal-title":"J. Immunol."},{"key":"10.1016\/j.cellsig.2026.112535_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4428484","article-title":"Prognostic value of serum interleukin-6, NF-\u03baB plus MCP-1 assay in patients with diabetic nephropathy","volume":"2022","author":"An","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cellsig.2026.112535_bb0135","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbpb.2019.01.004","article-title":"Molecular cloning of IL-6, IL-10, IL-11, IFN-\u0264 and modulation of pro- and anti-inflammatory cytokines in cobia (rachycentron canadum) after photobacterium damselae subsp. piscicida infection","volume":"230","author":"Tran","year":"2019","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112535_bb0140","article-title":"Higher hepcidin levels in adolescents with obesity are associated with metabolic syndrome dyslipidemia and visceral fat","volume":"10","author":"Rodr\u00edguez-Mortera","year":"2021","journal-title":"Antioxidants (Basel)."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0145","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/s41598-019-38811-4","article-title":"Interleukin 17A promotes diabetic kidney injury","volume":"9","author":"Ma","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0150","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12882-025-04358-y","article-title":"Association between high-sensitivity c-reactive protein and diabetic nephropathy: a systematic review and meta-analysis","volume":"26","author":"Bassami","year":"2025","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cellsig.2026.112535_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.abb.2019.01.001","article-title":"Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18","volume":"663","author":"Nariai","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2026.112535_bb0160","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbrc.2023.10.010","article-title":"Biophysical insight into protein-protein interactions in the Interleukin-11\/interleukin-11R\u03b1\/glycoprotein 130 signaling complex","volume":"682","author":"Mori","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112535_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136372","article-title":"Inflammation and cognition in bipolar disorder: diverging paths of interleukin-6 and outcomes","volume":"26","author":"R\u00edos","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112535_bb0170","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1248\/bpb.b23-00482","article-title":"Arid5a\/IL-6\/PAI-1 signaling is involved in the pathogenesis of lipopolysaccharide-induced kidney injury","volume":"46","author":"Tanaka","year":"2023","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0175","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1681\/ASN.2020050595","article-title":"Ziltivekimab for treatment of anemia of inflammation in patients on hemodialysis: results from a phase 1\/2 multicenter, randomized, double-blind, Placebo-Controlled Trial","volume":"32","author":"Pergola","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112535_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfad062","article-title":"Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting m1 polarization","volume":"15","author":"Tang","year":"2023","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112535_bb0185","first-page":"99","article-title":"Ferroptosis: regulated cell death","volume":"71","author":"\u010cepelak","year":"2020","journal-title":"Arh. Hig. Rada Toksikol."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112535_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112535_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2023.100243","article-title":"Ferroptosis in diabetic nephropathy: mechanisms and therapeutic implications","volume":"18","author":"Mengstie","year":"2023","journal-title":"Metabol. Open."},{"key":"10.1016\/j.cellsig.2026.112535_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108373","article-title":"Molecular mechanisms of ferroptosis and their involvement in brain diseases","volume":"244","author":"Costa","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112535_bb0205","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfac034","article-title":"ZIP14 is involved in iron deposition and triggers ferroptosis in diabetic nephropathy","volume":"14","author":"Wu","year":"2022","journal-title":"Metallomics"},{"key":"10.1016\/j.cellsig.2026.112535_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173574","article-title":"Ferroptosis involves in renal tubular cell death in diabetic nephropathy","volume":"888","author":"Wang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112535_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1516466","article-title":"Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy","volume":"16","author":"Wei","year":"2025","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112535_bb0220","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2026.112535_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175787","article-title":"Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis","volume":"951","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0230","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2024.2346543","article-title":"Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy","volume":"56","author":"Wu","year":"2024","journal-title":"Ann. Med."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112535_bb0235","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1021\/acs.chemrestox.4c00263","article-title":"Berberine inhibits KLF4 promoter methylation and ferroptosis to ameliorate diabetic nephropathy in mice","volume":"37","author":"Cai","year":"2024","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cellsig.2026.112535_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1294317","article-title":"Ferroptosis: an important player in the inflammatory response in diabetic nephropathy","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112535_bb0245","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1113\/EP091520","article-title":"SRS 16-86 promotes diabetic nephropathy recovery by regulating ferroptosis","volume":"109","author":"Qiao","year":"2024","journal-title":"Exp. Physiol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112535_bb0250","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41418-024-01357-8","article-title":"The PRMT6\/STAT1\/ACSL1 axis promotes ferroptosis in diabetic nephropathy","volume":"31","author":"Hong","year":"2024","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112535_bb0255","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1002\/ptr.70083","article-title":"Natural products targeting ferroptosis in type 2 diabetes mellitus and its complications","volume":"39","author":"Niazpour","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.cellsig.2026.112535_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113953","article-title":"Ginkgolide b alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy","volume":"156","author":"Chen","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"28","key":"10.1016\/j.cellsig.2026.112535_bb0265","article-title":"SELENOI functions as a key modulator of ferroptosis pathway in colitis and colorectal cancer","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci. (Weinh)."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0270","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41420-022-01212-0","article-title":"GPX4-independent ferroptosis-a new strategy in disease\u2019s therapy","volume":"8","author":"Ma","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0275","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2529618","article-title":"ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1\/Nrf2 signaling","volume":"30","author":"Liu","year":"2025","journal-title":"Redox Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112535_bb0280","first-page":"708","article-title":"Roles of ferroptosis in the development of diabetic nephropathy","volume":"53","author":"Liu","year":"2024","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.cellsig.2026.112535_bb0285","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-025-02195-w","article-title":"Intermodulation of endoplasmic reticulum stress and ferroptosis in diabetic nephropathy: molecular mechanisms and therapeutic potentials","author":"Wang","year":"2025","journal-title":"Apoptosis"},{"key":"10.1016\/j.cellsig.2026.112535_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127259","article-title":"Chronic intermittent hypobaric hypoxia improves iron metabolism disorders via the IL-6\/JAK2\/STAT3 and Epo\/STAT5\/ERFE signaling pathways in metabolic syndrome rats","volume":"79","author":"Cui","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0295","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12950-020-00265-1","article-title":"Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity","volume":"17","author":"Cui","year":"2020","journal-title":"J. Inflamm. (Lond)."},{"key":"10.1016\/j.cellsig.2026.112535_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114862","article-title":"Iron deposition participates in LPS-induced cognitive impairment by promoting neuroinflammation and ferroptosis in mice","volume":"379","author":"Li","year":"2024","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112535_bb0305","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.3168\/jds.2024-25557","article-title":"Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet","volume":"108","author":"Zhang","year":"2025","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112535_bb0310","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13578","article-title":"A high-fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism","volume":"45","author":"Wang","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.cellsig.2026.112535_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157269","article-title":"Artesunate triggers ferroptosis in ovarian cancer via GP130-mediated IL-6\/STAT3\/OTUB1\/SLC7A11 axis disruption","volume":"148","author":"Nie","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112535_bb0320","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2021.12.011","article-title":"Interleukin-6 facilitates tumor progression by inducing ferroptosis resistance in head and neck squamous cell carcinoma","volume":"527","author":"Li","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112535_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118487","article-title":"Tocilizumab mimotope alleviates kidney injury and fibrosis by inhibiting IL-6 signaling and ferroptosis in UUO model","volume":"261","author":"Yang","year":"2020","journal-title":"Life Sci."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826001877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:51:08Z","timestamp":1781794268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826001877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":65,"alternative-id":["S0898656826001877"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112535","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-6 as a key regulator of ferroptosis in diabetic nephropathy: From molecular mechanisms to therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112535"}}