{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:38:37Z","timestamp":1790948317942,"version":"4.1.0"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["20PJ056"],"award-info":[{"award-number":["20PJ056"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["Z2018B20"],"award-info":[{"award-number":["Z2018B20"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014901","name":"Hubei University of Arts and Science","doi-asserted-by":"publisher","award":["2059345"],"award-info":[{"award-number":["2059345"]}],"id":[{"id":"10.13039\/501100014901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0122"],"award-info":[{"award-number":["2021YFS0122"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802210"],"award-info":[{"award-number":["81802210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cellsig.2026.112545","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:58:28Z","timestamp":1776754708000},"page":"112545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Reactivating mitochondrial quality control via the Nrf2 pathway to combat metabolic stress in diabetic osteoarthritis"],"prefix":"10.1016","volume":"144","author":[{"given":"Yang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bo","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112545_bb0005","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2024.7","article-title":"Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers","volume":"26","author":"Seow","year":"2024","journal-title":"Expert Rev. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00590-025-04231-6","article-title":"Association of type 2 diabetes and osteoarthritis: an umbrella review of systematic reviews and meta-analyses","volume":"35","author":"Vaishya","year":"2025","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0015","first-page":"15","article-title":"Mesenchymal stem cells attenuate diabetic lung fibrosis via adjusting Sirt3-mediated stress responses in rats","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s10020-024-00824-9","article-title":"An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory","volume":"30","author":"Yang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112545_bb0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41584-025-01223-y","article-title":"The role of the immune system in osteoarthritis: mechanisms, challenges and future directions","volume":"21","author":"Moulin","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijsu.2020.01.017","article-title":"The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: a systematic review and meta-analysis","volume":"75","author":"Ma","year":"2020","journal-title":"Int. J. Surg."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0040","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.joca.2024.07.014","article-title":"Osteoarthritis year in review 2024: epidemiology and therapy","volume":"32","author":"Courties","year":"2024","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0045","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/acr.24173","article-title":"Impact of diabetes mellitus on knee osteoarthritis pain and physical and mental status: data from the osteoarthritis initiative","volume":"73","author":"Eitner","year":"2021","journal-title":"Arthritis Care Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12081630","article-title":"Diabetes and osteoarthritis: exploring the interactions and therapeutic implications of insulin, metformin, and GLP-1-based interventions","volume":"12","author":"Halabitska","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0055","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000077","article-title":"Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis","volume":"1","author":"Louati","year":"2015","journal-title":"RMD Open"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0060","article-title":"Osteoarthritis and diabetes: where are we and where should we go?","volume":"13","author":"Alenazi","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0065","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/1756-185X.12712","article-title":"Musculoskeletal manifestations in diabetic versus prediabetic patients","volume":"18","author":"Fatemi","year":"2015","journal-title":"Int. J. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000441418","article-title":"Knee osteoarthritis in Type 2 diabetes mellitus: does insulin therapy retard osteophyte formation?","volume":"25","author":"Al-Jarallah","year":"2016","journal-title":"Med. Princ. Pract."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.rehab.2016.04.002","article-title":"Osteoarthritis, obesity and type 2 diabetes: the weight of waist circumference","volume":"59","author":"Duclos","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/RHU.0b013e31827cd578","article-title":"Association of hand or knee osteoarthritis with diabetes mellitus in a population of Hispanics from Puerto Rico","volume":"19","author":"Nieves-Plaza","year":"2013","journal-title":"J. Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0085","doi-asserted-by":"crossref","DOI":"10.4103\/ijam.ijam_115_21","article-title":"The proportion of hand and knee osteoarthritis and its associated risk factors among an urban diabetic population","volume":"8","author":"Pathak","year":"2022","journal-title":"Int. J. Acad. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0090","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/03009742.2018.1459831","article-title":"Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study","volume":"48","author":"Marshall","year":"2019","journal-title":"Scand. J. Rheumatol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10626","article-title":"Interactions between diabetes mellitus and osteoarthritis: from animal studies to clinical data","volume":"6","author":"Rios-Arce","year":"2022","journal-title":"JBMR Plus"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3254","article-title":"Osteoarthritis and type 2 diabetes: from pathogenetic factors to therapeutic intervention","volume":"36","author":"Cannata","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0105","article-title":"The association between diabetes mellitus and osteoarthritis: does diabetes mellitus play a role in the severity of pain in osteoarthritis?","volume":"14","author":"Chowdhury","year":"2022","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0110","article-title":"Targeting YAP1-regulated glycolysis in fibroblast-like synoviocytes impairs macrophage infiltration to ameliorate diabetic osteoarthritis progression","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.cellsig.2026.112545_bb0115","article-title":"Micro-223 promotes diabetic osteoarthritis progression by regulating cartilage degeneration and subchondral bone remodeling","author":"Li","year":"2023","journal-title":"Cartilage"},{"key":"10.1016\/j.cellsig.2026.112545_bb0120","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/IJGM.S418520","article-title":"Correlation between glycemic variability and diabetic complications: a narrative review","volume":"16","author":"Huang","year":"2023","journal-title":"Int. J. Gen. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119352","article-title":"Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections","volume":"24","author":"Gonz\u00e1lez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112545_bb0130","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.diabres.2016.10.021","article-title":"Osteoarthritis and type 2 diabetes mellitus: what are the links?","volume":"122","author":"Courties","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.cellsig.2026.112545_bb0135","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnmol.2017.00349","article-title":"Mechanisms of osteoarthritic pain. studies in humans and experimental models","volume":"10","author":"Eitner","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0140","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/acr.25464","article-title":"National institute of health and care excellence clinical criteria for the diagnosis of knee osteoarthritis: a prospective diagnostic accuracy study in individuals with Type 2 diabetes","volume":"77","author":"King","year":"2025","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.cellsig.2026.112545_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105497","article-title":"Mechanistic insights into AMPK-SIRT3 positive feedback loop-mediated chondrocyte mitochondrial quality control in osteoarthritis pathogenesis","volume":"166","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0150","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.joca.2021.10.009","article-title":"Mitochondrial quality control in cartilage damage and osteoarthritis: new insights and potential therapeutic targets","volume":"30","author":"Liu","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0155","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.joca.2015.01.013","article-title":"Diabetes is a risk factor for knee osteoarthritis progression","volume":"23","author":"Eymard","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cellsig.2026.112545_bb0160","doi-asserted-by":"crossref","first-page":"6324348","DOI":"10.1155\/2019\/6324348","article-title":"Diabetes is associated with musculoskeletal pain, osteoarthritis, osteoporosis, and rheumatoid arthritis","volume":"2019","author":"Rehling","year":"2019","journal-title":"J. Diabetes Res."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0165","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.joca.2018.03.010","article-title":"Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative","volume":"26","author":"Neumann","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0170","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/acr.24872","article-title":"Association of diabetes mellitus status and hyperglycemia with symptomatic knee osteoarthritis","volume":"75","author":"Zheng","year":"2023","journal-title":"Arthritis Care Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0175","doi-asserted-by":"crossref","first-page":"496","DOI":"10.23736\/S1973-9087.24.08034-1","article-title":"Diabetes is associated with longitudinal declined physical performance measures in persons with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative","volume":"60","author":"Alenazi","year":"2024","journal-title":"Eur. J. Phys. Rehabil. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0180","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s13018-023-03982-4","article-title":"Does diabetes mellitus impair the clinical results of total knee arthroplasty under enhanced recovery after surgery?","volume":"18","author":"Li","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112545_bb0185","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1016\/j.arth.2018.06.021","article-title":"The impact of diabetes on patient outcomes after total knee arthroplasty in an asian population","volume":"33","author":"Teo","year":"2018","journal-title":"J. Arthroplast."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0190","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/ptj\/pzaa144","article-title":"The association of diabetes with knee pain locations, pain while walking, and walking speed: data from the osteoarthritis initiative","volume":"100","author":"Alenazi","year":"2020","journal-title":"Phys. Ther."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0195","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1210\/clinem\/dgaa912","article-title":"Reduced muscle strength is associated with insulin resistance in Type 2 diabetes patients with osteoarthritis","volume":"106","author":"Zaharia","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0200","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/pm\/pnz299","article-title":"Type 2 diabetes affects joint pain severity in people with localized osteoarthritis: a retrospective study","volume":"21","author":"Alenazi","year":"2020","journal-title":"Pain Med."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0205","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00256-018-3088-0","article-title":"Diabetics show accelerated progression of knee cartilage and meniscal lesions: data from the osteoarthritis initiative","volume":"48","author":"Neumann","year":"2019","journal-title":"Skeletal Radiol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112545_bb0210","doi-asserted-by":"crossref","first-page":"768","DOI":"10.21037\/atm-20-6797","article-title":"Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0215","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1080\/13813455.2020.1771378","article-title":"Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress","volume":"128","author":"Ebrahim","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0220","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13018-021-02208-9","article-title":"Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model","volume":"16","author":"Luo","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.cellsig.2026.112545_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111354","article-title":"Effect of type II diabetes-induced osteoarthritis on articular cartilage aging in rats: a study in vivo and in vitro","volume":"150","author":"Wang","year":"2021","journal-title":"Exp. Gerontol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112545_bb0230","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.tem.2024.12.006","article-title":"The growing range of complications of diabetes mellitus","volume":"36","author":"Hamblin","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0235","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s12020-022-03125-5","article-title":"Type-2 diabetes mellitus (T2DM): spatial-temporal patterns of incidence, mortality and attributable risk factors from 1990 to 2019 among 21 world regions","volume":"77","author":"Nanda","year":"2022","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0240","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i7.105233","article-title":"Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications","volume":"16","author":"Aktas","year":"2025","journal-title":"World J. Diabetes"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13098-025-01748-y","article-title":"Genetics of diabetes and its complications: a comprehensive review","volume":"17","author":"Sami","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0250","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12933-024-02145-x","article-title":"Double diabetes-when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition","volume":"23","author":"Bielka","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115707","article-title":"Targeting regulated chondrocyte death in osteoarthritis therapy","volume":"215","author":"Zhu","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120555","article-title":"The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration","volume":"268","author":"Peng","year":"2021","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0265","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41584-021-00724-w","article-title":"Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis","volume":"18","author":"Hodgkinson","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0275","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s13300-024-01532-7","article-title":"A narrative review of diabetic macroangiopathy: from molecular mechanism to therapeutic approaches","volume":"15","author":"Yin","year":"2024","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.cellsig.2026.112545_bb0280","doi-asserted-by":"crossref","first-page":"1001212","DOI":"10.3389\/fmolb.2022.1001212","article-title":"The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0285","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s11658-023-00489-y","article-title":"Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review","volume":"28","author":"Riegger","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112545_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11123176","article-title":"Anti-osteoarthritis mechanism of the Nrf2 signaling pathway","volume":"11","author":"Saha","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2026.112545_bb0295","doi-asserted-by":"crossref","first-page":"16","DOI":"10.22203\/eCM.v054a02","article-title":"Irisin liposomes inhibit ferroptosis and improve atherosclerosis in mouse models via the NRF2\/HO-1 signaling pathway","volume":"54","author":"Han","year":"2025","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.cellsig.2026.112545_bb0300","article-title":"Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0305","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.joca.2022.11.004","article-title":"Dysregulated energy metabolism impairs chondrocyte function in osteoarthritis","volume":"31","author":"Wu","year":"2023","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0310","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3892\/etm.2023.12086","article-title":"Effects of glucose concentration and oxygen partial pressure on the respiratory metabolism of sheep temporomandibular joint disc cells","volume":"26","author":"Dong","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cellsig.2026.112545_bb0315","article-title":"The role and intervention of mitochondrial metabolism in osteoarthritis","author":"Qi","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"35","key":"10.1016\/j.cellsig.2026.112545_bb0320","doi-asserted-by":"crossref","first-page":"14505","DOI":"10.1074\/jbc.M117.802157","article-title":"The nuclear factor-erythroid 2-related factor\/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis","volume":"292","author":"Vaamonde-Garcia","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0325","article-title":"Reduced levels of H(2)S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2\/HO-1 signalling downregulation and chondrocyte dysfunction","volume":"11","author":"Pi\u00f1eiro-Ramil","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0330","doi-asserted-by":"crossref","first-page":"483","DOI":"10.14336\/AD.2018.0616","article-title":"Adipose-derived stem cells attenuates diabetic osteoarthritis via inhibition of glycation-mediated inflammatory cascade","volume":"10","author":"Dubey","year":"2019","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0335","first-page":"2855","article-title":"SIRT2 inhibits oxidative stress and inflammatory response in diabetic osteoarthritis","volume":"24","author":"Qu","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0340","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/art.39561","article-title":"Suppressive effects of insulin on tumor necrosis factor-dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus","volume":"68","author":"Hamada","year":"2016","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0345","doi-asserted-by":"crossref","first-page":"13177","DOI":"10.1002\/jcb.28592","article-title":"Elevated expression of ICAM-1 in synovium is associated with early inflammatory response for cartilage degeneration in type 2 diabetes mellitus","volume":"120","author":"Gui","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0350","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s10067-024-07042-y","article-title":"Inflammation as a therapeutic target for osteoarthritis: a literature review of clinical trials","volume":"43","author":"Zhu","year":"2024","journal-title":"Clin. Rheumatol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0355","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0360","article-title":"Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years","author":"van den Bosch","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cellsig.2026.112545_bb0365","doi-asserted-by":"crossref","first-page":"8293921","DOI":"10.1155\/2020\/8293921","article-title":"The role of inflammation in the pathogenesis of osteoarthritis","volume":"2020","author":"Chow","year":"2020","journal-title":"Mediat. Inflamm."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28041683","article-title":"Connection between osteoarthritis and nitric oxide: from pathophysiology to therapeutic target","volume":"28","author":"Jiang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.cellsig.2026.112545_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110452","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"Suppl A","key":"10.1016\/j.cellsig.2026.112545_bb0380","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.joca.2003.09.016","article-title":"Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis","volume":"12","author":"Burr","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.cellsig.2026.112545_bb0385","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.omtm.2018.02.006","article-title":"Isoliquiritigenin inhibits IL-1\u03b2-induced production of matrix metalloproteinase in articular chondrocytes","volume":"9","author":"Zhang","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0390","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s12276-021-00697-6","article-title":"Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis","volume":"53","author":"Li","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112545_bb0395","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.joca.2015.04.026","article-title":"Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis","volume":"23","author":"Laiguillon","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0400","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jor.22770","article-title":"PPAR\u03b3 is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages","volume":"33","author":"Chen","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cellsig.2026.112545_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.etap.2018.05.009","article-title":"Diabetes escalates knee osteoarthritis in rats: evidence of adaptive mechanism","volume":"61","author":"Adeyemi","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107282","article-title":"Activation and modulation of the AGEs-RAGE axis: Implications for inflammatory pathologies and therapeutic interventions - a review","volume":"206","author":"Zhou","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus: mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112545_bb0420","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18147236","article-title":"Advanced glycation end products: new clinical and molecular perspectives","volume":"18","author":"Salazar","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0425","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3892\/br.2021.1422","article-title":"Toxicity of advanced glycation end products (Review)","volume":"14","author":"Kuzan","year":"2021","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.cellsig.2026.112545_bb0430","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ymeth.2020.09.012","article-title":"Advanced glycation end products in musculoskeletal system and disorders","volume":"203","author":"Suzuki","year":"2022","journal-title":"Methods"},{"key":"10.1016\/j.cellsig.2026.112545_bb0435","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fcvm.2020.00037","article-title":"Receptor for advanced glycation end products (RAGE) and mechanisms and therapeutic opportunities in diabetes and cardiovascular disease: insights from human subjects and animal models","volume":"7","author":"Ega\u00f1a-Gorro\u00f1o","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0440","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1302\/2046-3758.115.BJR-2021-0334.R1","article-title":"The role of AGEs in pathogenesis of cartilage destruction in osteoarthritis","volume":"11","author":"He","year":"2022","journal-title":"Bone Joint Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0445","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1002\/art.21199","article-title":"Articular chondrocytes express the receptor for advanced glycation end products: potential role in osteoarthritis","volume":"52","author":"Loeser","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"Pt 2","key":"10.1016\/j.cellsig.2026.112545_bb0450","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/bj3500381","article-title":"Age-related accumulation of Maillard reaction products in human articular cartilage collagen","volume":"350","author":"Verzijl","year":"2000","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0455","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P","article-title":"Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis","volume":"46","author":"Verzijl","year":"2002","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0460","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.coph.2004.01.007","article-title":"The AGE of the matrix: chemistry, consequence and cure","volume":"4","author":"DeGroot","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0465","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.joca.2012.03.012","article-title":"Enhanced levels of non-enzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression","volume":"20","author":"Willett","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112545_bb0470","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1007\/s10495-016-1280-z","article-title":"Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-\u03baB","volume":"21","author":"Zhang","year":"2016","journal-title":"Apoptosis"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125776","article-title":"The role of PPAR\u03b3 in advanced glycation end products-induced inflammatory response in human chondrocytes","volume":"10","author":"Ma","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0480","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1248\/bpb.b19-00036","article-title":"The function of PPAR\u03b3\/AMPK\/SIRT-1 pathway in inflammatory response of human articular chondrocytes stimulated by advanced glycation end products","volume":"42","author":"Huang","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.cellsig.2026.112545_bb0485","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.biopha.2017.04.054","article-title":"Memantine inhibits degradation of the articular cartilage extracellular matrix induced by advanced glycation end products (AGEs)","volume":"91","author":"Zhao","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0490","article-title":"Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-\u03b1, nuclear factor-\u03ba B and reactive oxygen species","volume":"11","author":"Sun","year":"2018","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.cellsig.2026.112545_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106530","article-title":"\u03b1-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis","volume":"84","author":"Xu","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0500","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1039\/C9FO01089K","article-title":"Troxerutin suppresses the inflammatory response in advanced glycation end-product-administered chondrocytes and attenuates mouse osteoarthritis development","volume":"10","author":"Xue","year":"2019","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0505","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.157","article-title":"Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes","volume":"49","author":"Ly","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0510","article-title":"The implication of reactive oxygen species and antioxidants in knee osteoarthritis","volume":"10","author":"Tudorachi","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112545_bb0515","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103021","article-title":"Correlation between diabetes mellitus and knee osteoarthritis: a dry-to-wet lab approach","volume":"19","author":"Dubey","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112545_bb0520","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184105","article-title":"Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112545_bb0525","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1007\/s11033-023-08861-z","article-title":"Intra-articular site-specific distribution of advanced glycation end products in the shoulder of patients with diabetes mellitus having rotator cuff tears","volume":"50","author":"Kato","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0530","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2024.09.015","article-title":"Autophagy, aging, and age-related neurodegeneration","volume":"113","author":"Palmer","year":"2025","journal-title":"Neuron"},{"issue":"19","key":"10.1016\/j.cellsig.2026.112545_bb0535","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2026.112545_bb0540","doi-asserted-by":"crossref","first-page":"1228045","DOI":"10.3389\/fendo.2023.1228045","article-title":"The role of autophagy in the treatment of type II diabetes and its complications: a review","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0545","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052700","article-title":"Control of the autophagy pathway in osteoarthritis: key regulators, therapeutic targets and therapeutic strategies","volume":"22","author":"Valenti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0550","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10495-010-0458-z","article-title":"Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model","volume":"15","author":"Almonte-Becerril","year":"2010","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0555","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/art.34323","article-title":"Autophagy modulates osteoarthritis-related gene expression in human chondrocytes","volume":"64","author":"Sasaki","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0560","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.maturitas.2014.12.003","article-title":"Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis","volume":"80","author":"Mobasheri","year":"2015","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0565","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.27305","article-title":"Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis","volume":"62","author":"Caram\u00e9s","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0570","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1136\/annrheumdis-2013-204599","article-title":"Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis","volume":"74","author":"Zhang","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0575","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.joca.2015.10.017","article-title":"Insulin decreases autophagy and leads to cartilage degradation","volume":"24","author":"Ribeiro","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0580","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41419-021-03791-9","article-title":"High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0585","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0590","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70319","article-title":"Mitochondrial quality control in health and disease","volume":"6","author":"Ye","year":"2025","journal-title":"MedComm"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0595","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.devcel.2021.02.009","article-title":"Quality control of the mitochondrion","volume":"56","author":"Ng","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cellsig.2026.112545_bb0600","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2022.07.013","article-title":"Nrf2 as a regulator of mitochondrial function: energy metabolism and beyond","volume":"189","author":"Esteras","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0605","article-title":"The roles of NFR2-regulated oxidative stress and mitochondrial quality control in chronic liver diseases","volume":"12","author":"Park","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0610","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","article-title":"Thirty years of NRF2: advances and therapeutic challenges","volume":"24","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0615","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10110847","article-title":"p62-Nrf2-p62 mitophagy regulatory loop as a target for preventive therapy of neurodegenerative diseases","volume":"10","author":"Gureev","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.cellsig.2026.112545_bb0620","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fgene.2019.00435","article-title":"Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1\u03b1 signaling pathways","volume":"10","author":"Gureev","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.cellsig.2026.112545_bb0625","doi-asserted-by":"crossref","first-page":"1452696","DOI":"10.1155\/2020\/1452696","article-title":"PGC-1\u03b1, inflammation, and oxidative stress: an integrative view in metabolism","volume":"2020","author":"Rius-P\u00e9rez","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112545_bb0630","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2016.6855","article-title":"The Keap1-Nrf2 stress response pathway promotes mitochondrial hyperfusion through degradation of the mitochondrial fission protein Drp1","volume":"27","author":"Sabouny","year":"2017","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103827","article-title":"Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response","volume":"25","author":"Ryan","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.cellsig.2026.112545_bb0640","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2021.01.045","article-title":"MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2\/Drp1 pathway","volume":"165","author":"Hou","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0645","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/med.21714","article-title":"Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson\u2019s disease","volume":"41","author":"Bento-Pereira","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cellsig.2026.112545_bb0650","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.freeradbiomed.2021.12.001","article-title":"Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury","volume":"179","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cellsig.2026.112545_bb0655","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221124920","article-title":"Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis","volume":"18","author":"Gao","year":"2022","journal-title":"Mol. Pain"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112545_bb0660","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1007\/s13577-023-00959-7","article-title":"Intermittent cyclic mechanical compression promotes endplate chondrocytes degeneration by disturbing Nrf2\/PINK1 signaling pathway-dependent mitophagy","volume":"36","author":"Zheng","year":"2023","journal-title":"Hum. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0665","doi-asserted-by":"crossref","first-page":"20230711","DOI":"10.1515\/med-2023-0711","article-title":"Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission","volume":"18","author":"Wang","year":"2023","journal-title":"Open Med. (Wars.)"},{"key":"10.1016\/j.cellsig.2026.112545_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176042","article-title":"Sulforaphane ameliorated podocyte injury according to regulation of the Nrf2\/PINK1 pathway for mitophagy in diabetic kidney disease","volume":"958","author":"Wang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115618","article-title":"Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3","volume":"167","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0680","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101470R","article-title":"NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury","volume":"36","author":"Kim","year":"2022","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112545_bb0685","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1021\/acs.jproteome.2c00167","article-title":"Nicotinamide mononucleotide administration restores redox homeostasis via the Sirt3-Nrf2 axis and protects aged mice from oxidative stress-induced liver injury","volume":"21","author":"Luo","year":"2022","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0690","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbrc.2014.10.005","article-title":"Dimethyl fumarate protection against collagen II degradation","volume":"454","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2026.112545_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174044","article-title":"Activation of the Nrf2\/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund\u2019s adjuvant-induced arthritis in rats","volume":"899","author":"Lal","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0700","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.2147\/JIR.S311924","article-title":"Quercetin alleviates osteoarthritis progression in rats by suppressing inflammation and apoptosis via inhibition of IRAK1\/NLRP3 signaling","volume":"14","author":"Li","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cellsig.2026.112545_bb0705","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats","volume":"103","author":"Qiu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112545_bb0710","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.09.024","article-title":"Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages","volume":"145","author":"Hu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0715","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12251","article-title":"Sulforaphane protects against oxidative stress-induced apoptosis via activating SIRT1 in mouse osteoarthritis","volume":"24","author":"Chen","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112545_bb0720","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/art.38133","article-title":"Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo","volume":"65","author":"Davidson","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0725","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028514","article-title":"Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial","volume":"10","author":"Zolnourian","year":"2020","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0730","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tips.2022.12.003","article-title":"Advances and challenges in therapeutic targeting of NRF2","volume":"44","author":"Dinkova-Kostova","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112545_bb0735","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1158\/0008-5472.CAN-16-3538","article-title":"Nrf2 mutagenic activation drives hepatocarcinogenesis","volume":"77","author":"Ngo","year":"2017","journal-title":"Cancer Res."},{"issue":"15","key":"10.1016\/j.cellsig.2026.112545_bb0740","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155378","article-title":"Molecular mechanisms underlying hepatocellular carcinoma induction by aberrant NRF2 activation-mediated transcription networks: interaction of NRF2-KEAP1 controls the fate of hepatocarcinogenesis","volume":"21","author":"Haque","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0745","article-title":"Oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging","volume":"12","author":"Mladenov","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112545_bb0750","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s11033-022-08126-1","article-title":"Dual role of Nrf2 in cancer: molecular mechanisms, cellular functions and therapeutic interventions","volume":"50","author":"Poornashree","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112545_bb0755","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/ptr.70008","article-title":"Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products","volume":"39","author":"Chang","year":"2025","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0760","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0765","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jare.2024.10.030","article-title":"Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy","volume":"75","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101034","article-title":"Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury","volume":"14","author":"Yang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.cellsig.2026.112545_bb0775","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0780","doi-asserted-by":"crossref","first-page":"1539566","DOI":"10.3389\/fbioe.2025.1539566","article-title":"Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy","volume":"13","author":"Xu","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0785","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-life.2025.100160","article-title":"Cartilage-targeted drug delivery in osteoarthritis: Redefining local therapy with intelligent hydrogel microspheres","volume":"3","author":"Liu","year":"2025","journal-title":"Innov. Life"},{"key":"10.1016\/j.cellsig.2026.112545_bb0790","doi-asserted-by":"crossref","first-page":"1728679","DOI":"10.3389\/fcell.2026.1728679","article-title":"The Nrf2\/HO-1 signaling pathway in arthritis: from molecular mechanisms to therapeutic potential","volume":"14","author":"Zhang","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112545_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112545_bb0800","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10625","article-title":"Preexisting Type 1 diabetes mellitus blunts the development of posttraumatic osteoarthritis","volume":"6","author":"Rios-Arce","year":"2022","journal-title":"JBMR Plus"},{"key":"10.1016\/j.cellsig.2026.112545_bb0805","doi-asserted-by":"crossref","first-page":"1536341","DOI":"10.3389\/fendo.2025.1536341","article-title":"Effect of diabetes mellitus on physical function in patients with osteoarthritis: a cross-sectional observational study","volume":"16","author":"Que","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"43","key":"10.1016\/j.cellsig.2026.112545_bb0810","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000039996","article-title":"The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: a life-guiding review","volume":"103","author":"Chang","year":"2024","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0815","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cellsig.2026.112545_bb0820","doi-asserted-by":"crossref","first-page":"1422686","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112545_bb0825","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.joca.2023.11.019","article-title":"Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies","volume":"32","author":"Rai","year":"2024","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0830","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13075-025-03563-2","article-title":"Recent advances in omics and the integration of multi-omics in osteoarthritis research","volume":"27","author":"Liu","year":"2025","journal-title":"Arthrit. Res. Ther."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112545_bb0835","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.7150\/ijbs.95853","article-title":"Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia\/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"14","key":"10.1016\/j.cellsig.2026.112545_bb0840","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112545_bb0845","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13578-024-01259-9","article-title":"Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders","volume":"14","author":"Wu","year":"2024","journal-title":"Cell Biosci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112545_bb0850","first-page":"311","article-title":"Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-\u03b2-tubulin mediated synergistic mechanism of \u201cmitophagy-unfolded protein response\u201d and mitophagy","volume":"23","author":"Chang","year":"2025","journal-title":"Chin. J. Nat. Med."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682600197X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089865682600197X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:09:51Z","timestamp":1783116591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089865682600197X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":170,"alternative-id":["S089865682600197X"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112545","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactivating mitochondrial quality control via the Nrf2 pathway to combat metabolic stress in diabetic osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112545"}}