{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:21:31Z","timestamp":1787066491440,"version":"build-2736575974"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cellsig.2026.112549","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T14:42:54Z","timestamp":1777214574000},"page":"112549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nobiletin reprograms cancer cell fate signaling: PI3K\/Akt\/mTOR\u2013MAPK crosstalk, NF-kB\/STAT3 inhibition and chemosensitization"],"prefix":"10.1016","volume":"144","author":[{"given":"Adithya Jayaprakash","family":"Kamath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Syam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraswathy","family":"Renjini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balachandran S.","family":"Vinod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devarajan Baby Sulekha Ambili","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekshmi R.","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Calina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112549_bb0005","series-title":"Angiogenesis","author":"Adair","year":"2010"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112549_bb0010","doi-asserted-by":"crossref","first-page":"11542","DOI":"10.1002\/cam4.5577","article-title":"Autophagy: a challengeable paradox in cancer treatment","volume":"12","author":"Ahmadi-Dehlaghi","year":"2023","journal-title":"Cancer Med."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9110258","article-title":"A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery","volume":"9","author":"Anand","year":"2019","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8050110","article-title":"Nobiletin in cancer therapy: how this plant derived-natural compound targets various oncogene and onco-suppressor pathways","volume":"8","author":"Ashrafizadeh","year":"2020","journal-title":"Biomedicines"},{"issue":"24","key":"10.1016\/j.cellsig.2026.112549_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14246203","article-title":"Natural products\/bioactive compounds as a source of anticancer drugs","volume":"14","author":"Asma","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cellsig.2026.112549_bb0030","series-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","author":"Bray","year":"2022"},{"key":"10.1016\/j.cellsig.2026.112549_bb0035","series-title":"Identifying Novel Causes of Cancers to Enhance Cancer Prevention: New Strategies Are Needed","author":"Brennan","year":"2022"},{"key":"10.1016\/j.cellsig.2026.112549_bb0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/2050-6511-15-59","article-title":"Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells","volume":"15","author":"Chen","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0045","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.3892\/ijo.2015.2946","article-title":"The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the akt pathway","volume":"46","author":"Chen","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.20892\/j.issn.2095-3941.2020.0186","article-title":"Nobiletin downregulates the SKP2-p21\/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma","volume":"18","author":"Chen","year":"2021","journal-title":"Cancer Biol. Med."},{"issue":"23","key":"10.1016\/j.cellsig.2026.112549_bb0055","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1080\/10408398.2022.2030297","article-title":"Nobiletin as a chemopreventive natural product against cancer, a comprehensive review","volume":"63","author":"Chen","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.cellsig.2026.112549_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155360","article-title":"Nobiletin targets SREBP1\/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K\/Akt\/mTOR signaling pathway","volume":"128","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112549_bb0065","series-title":"5-Demethylnobiletin more potently inhibits colon cancer cell growth than nobiletin in vitro and in vivo","author":"Chiou","year":"2018"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbcan.2016.11.003","article-title":"Molecular interplay between mutant p53 proteins and autophagy in cancer cells","volume":"1867","author":"Cordani","year":"2017","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"9\u201310","key":"10.1016\/j.cellsig.2026.112549_bb0075","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10495-021-01687-9","article-title":"Mechanism of interaction between autophagy and apoptosis in cancer","volume":"26","author":"Das","year":"2021","journal-title":"Apoptosis"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0080","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0278-6915(02)00007-8","article-title":"Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones","volume":"40","author":"Delaney","year":"2002","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112549_bb0085","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tcb.2015.06.002","article-title":"Regulation of mTORC1 by PI3K signaling","volume":"25","author":"Dibble","year":"2015","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112549_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0245-z","article-title":"Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1\/FOXO3a-mediated autophagy and mitochondrial biogenesis","volume":"51","author":"Dusabimana","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/biof.5520310201","article-title":"Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells","volume":"31","author":"Eguchi","year":"2007","journal-title":"Biofactors"},{"issue":"6835","key":"10.1016\/j.cellsig.2026.112549_bb0100","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112549_bb0105","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41565-025-01979-0","article-title":"Annexin a1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages","volume":"20","author":"Fang","year":"2025","journal-title":"Nat. Nanotechnol."},{"issue":"Suppl(Suppl)","key":"10.1016\/j.cellsig.2026.112549_bb0110","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.semcancer.2015.02.006","article-title":"Sustained proliferation in cancer: mechanisms and novel therapeutic targets","volume":"35","author":"Feitelson","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cellsig.2026.112549_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153141","article-title":"Nobiletin potentiates paclitaxel anticancer efficacy in A549\/T xenograft model: pharmacokinetic and pharmacological study","volume":"67","author":"Feng","year":"2020","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112549_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrclinonc.2016.183","article-title":"Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy","volume":"14","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112549_bb0125","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/s41401-020-0400-z","article-title":"Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy","volume":"41","author":"Gao","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"38","key":"10.1016\/j.cellsig.2026.112549_bb0130","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2024.100030","article-title":"Cell cycle dysregulation in cancer","volume":"77","author":"Glaviano","year":"2025","journal-title":"Pharmacol. Rev."},{"issue":"16","key":"10.1016\/j.cellsig.2026.112549_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24162881","article-title":"Involvement of mitochondrial dysfunction, endoplasmic reticulum stress, and the PI3K\/AKT\/mTOR pathway in nobiletin-induced apoptosis of human bladder cancer cells","volume":"24","author":"Goan","year":"2019","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11060867","article-title":"Nobiletin and derivatives: functional compounds from citrus fruit peel for colon cancer chemoprevention","volume":"11","author":"Goh","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s43556-024-00239-2","article-title":"Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer","volume":"6","author":"Gu","year":"2025","journal-title":"Mol. Biomed."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0155","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1038\/s41598-020-60921-7","article-title":"Author correction: transdermal delivery of nobiletin using ionic liquids","volume":"10","author":"Hattori","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112549_bb0160","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ctrv.2012.04.006","article-title":"Role of angiogenesis in the pathogenesis of cancer","volume":"38","author":"Hoff","year":"2012","journal-title":"Cancer Treat. Rev."},{"issue":"5\u20136","key":"10.1016\/j.cellsig.2026.112549_bb0165","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10495-022-01721-4","article-title":"Nobiletin as an inducer of programmed cell death in cancer: a review","volume":"27","author":"Huang","year":"2022","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0170","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2741\/4847","article-title":"Epigenetic alterations in cancer","volume":"25","author":"Ilango","year":"2020","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051405","article-title":"Autophagic regulation of p62 is critical for cancer therapy","volume":"19","author":"Islam","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0180","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3892\/ol.2013.1245","article-title":"The synergistic effects of traditional chinese herbs and radiotherapy for cancer treatment","volume":"5","author":"Jia","year":"2013","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0185","first-page":"1070","article-title":"Nobiletin flavone inhibits the growth and metastasis of human pancreatic cancer cells via induction of autophagy, G0\/G1 cell cycle arrest and inhibition of NF-kB signalling pathway","volume":"25","author":"Jiang","year":"2020","journal-title":"J. BUON"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/genes8060151","article-title":"MYC deregulation in primary human cancers","volume":"8","author":"Kalkat","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.cellsig.2026.112549_bb0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/bs.apcsb.2021.01.003","article-title":"Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis","volume":"125","author":"Kashyap","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/jf9805101","article-title":"HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices","volume":"47","author":"Kawaii","year":"1999","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0205","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1208\/s12249-020-01767-0","article-title":"Nobiletin as a molecule for formulation development: an overview of advanced formulation and nanotechnology-based strategies of nobiletin","volume":"21","author":"Kesharwani","year":"2020","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0210","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1038\/s41598-019-48262-6","article-title":"Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis","volume":"9","author":"Keshtkar","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0215","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12964-023-01302-1","article-title":"Unveiling the mechanisms and challenges of cancer drug resistance","volume":"22","author":"Khan","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0220","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3109\/00498254.2011.593208","article-title":"In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome p450","volume":"41","author":"Koga","year":"2011","journal-title":"Xenobiotica"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112549_bb0225","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0024-3205(01)01169-9","article-title":"Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats","volume":"69","author":"Kohno","year":"2001","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112549_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11041166","article-title":"Pathogenesis of hepatocellular carcinoma: the interplay of apoptosis and autophagy","volume":"11","author":"Kouroumalis","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0235","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13167-025-00407-6","article-title":"Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients","volume":"16","author":"Kubatka","year":"2025","journal-title":"EPMA J."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0240","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/j.1349-7006.2010.01668.x","article-title":"Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo","volume":"101","author":"Kunimasa","year":"2010","journal-title":"Cancer Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9111651","article-title":"The emerging roles of autophagy in human diseases","volume":"9","author":"Lei","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26444\/aaem\/94299","article-title":"Environmental risk factors for cancer - review paper","volume":"26","author":"Lewandowska","year":"2019","journal-title":"Ann. Agric. Environ. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0255","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2741\/4719","article-title":"Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K\/Akt\/MTOR pathway","volume":"24","author":"Li","year":"2019","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"19","key":"10.1016\/j.cellsig.2026.112549_bb0260","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401409R","article-title":"Advances in natural products modulating autophagy influenced by cellular stress conditions and their anticancer roles in the treatment of ovarian cancer","volume":"38","author":"Li","year":"2024","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0265","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ptr.5517","article-title":"Nobiletin, a polymethoxylated flavone, inhibits glioma cell growth and migration via arresting cell cycle and suppressing MAPK and akt pathways","volume":"30","author":"Lien","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.cellsig.2026.112549_bb0270","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2147\/DDDT.S126464","article-title":"Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells","volume":"11","author":"Lin","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0275","doi-asserted-by":"crossref","first-page":"19055","DOI":"10.1038\/s41598-023-45774-0","article-title":"MAPK signaling pathway-based glioma subtypes, machine-learning risk model, and key hub proteins identification","volume":"13","author":"Liu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112549_bb0280","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v62.1323","article-title":"Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-kappaB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells","volume":"62","author":"Liu","year":"2018","journal-title":"Food Nutr. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0285","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2026.112549_bb0290","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cancergen.2025.06.008","article-title":"TRIM29 promotes glioblastoma progression via ubiquitinating NEFL and activating the PI3K\/AKT signaling pathway","volume":"296-297","author":"Liu","year":"2025","journal-title":"Cancer Gene Ther."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0295","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/BCJ20210854","article-title":"The concept of intrinsic versus extrinsic apoptosis","volume":"479","author":"Lossi","year":"2022","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112549_bb0300","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0305","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4161\/cbt.7.6.5967","article-title":"Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line a549 in vitro and in vivo","volume":"7","author":"Luo","year":"2008","journal-title":"Cancer Biol. Ther."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112549_bb0310","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ptr.5024","article-title":"Inhibitory effects of nobiletin on hepatocellular carcinoma in vitro and in vivo","volume":"28","author":"Ma","year":"2014","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0315","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","article-title":"Cell cycle control in cancer","volume":"23","author":"Matthews","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112549_bb0320","series-title":"Angiogenesis in Disease","author":"Mendola","year":"2022"},{"issue":"22","key":"10.1016\/j.cellsig.2026.112549_bb0325","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.2174\/1381612829666230426115424","article-title":"Nobiletin in cancer therapy; mechanisms and therapy perspectives","volume":"29","author":"Moazamiyanfar","year":"2023","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0330","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/01635581.2013.756529","article-title":"Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells","volume":"65","author":"Moon","year":"2013","journal-title":"Nutr. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112549_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21070914","article-title":"Nobiletin induces protective autophagy accompanied by ER-stress mediated apoptosis in human gastric cancer SNU-16 cells","volume":"21","author":"Moon","year":"2016","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031328","article-title":"The apoptosis paradox in cancer","volume":"23","author":"Morana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0345","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tibs.2012.02.008","article-title":"P62: a versatile multitasker takes on cancer","volume":"37","author":"Moscat","year":"2012","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0350","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pathmechdis-051222-115023","article-title":"Apoptosis in cancer biology and therapy","volume":"20","author":"Moyer","year":"2025","journal-title":"Annu. Rev. Pathol."},{"issue":"23","key":"10.1016\/j.cellsig.2026.112549_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112549_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143380","article-title":"Potential benefits of nobiletin, a citrus flavonoid, against alzheimer\u2019s disease and parkinson\u2019s disease","volume":"20","author":"Nakajima","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112549_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104670","article-title":"An evaluation of the genotoxicity and subchronic toxicity of the peel extract of ponkan cultivar \u2018ohta ponkan\u2019 (citrus reticulata Blanco) that is rich in nobiletin and tangeretin with anti-dementia activity","volume":"114","author":"Nakajima","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112549_bb0370","series-title":"IAP Antagonists Potentiate TNF\u03b1-Triggered Apoptosis but Selectively Eliminate Senescent Tumor Cells Independently of TNF\u03b1","author":"Ochiiwa","year":"2025"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112549_bb0375","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ejps.2013.05.014","article-title":"Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects","volume":"49","author":"Onoue","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.cellsig.2026.112549_bb0380","article-title":"An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway","volume":"15","author":"Pandey","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0385","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112549_bb0390","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020448","article-title":"Apoptosis: a target for anticancer therapy","volume":"19","author":"Pfeffer","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112549_bb0395","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1158\/1535-7163.MCT-09-0280","article-title":"Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts","volume":"8","author":"Roland","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cellsig.2026.112549_bb0400","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.biopha.2018.05.007","article-title":"Autophagy in health and disease: a comprehensive review","volume":"104","author":"Saha","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112549_bb0405","series-title":"Nobiletin a Biologically Active Phytoconstituent: Systematic Review","author":"Singh","year":"2021"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0410","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050935","article-title":"Nobiletin inhibits angiogenesis by regulating Src\/FAK\/STAT3-mediated signaling through PXN in ER(+) breast cancer cells","volume":"18","author":"Sp","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112549_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189843","article-title":"Mechanistic insights of anti-immune evasion by nobiletin through regulating miR-197\/STAT3\/PD-L1 signaling in non-small cell lung cancer (NSCLC) cells","volume":"22","author":"Sp","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112549_bb0420","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112549_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114005","article-title":"Induction of autophagy via the PI3K\/Akt\/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice","volume":"157","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112549_bb0430","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tiv.2018.04.001","article-title":"Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1\/CYP1B1 enzyme induction and CYP1A1\/CYP1B1-mediated metabolism to the product 4\u2032 hydroxy tangeretin","volume":"50","author":"Surichan","year":"2018","journal-title":"Toxicol. in Vitro"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0435","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2174\/0109298665350654250111144722","article-title":"Anti-Cancer bioactive peptide induces apoptosis in gastric cancer cells through TP53 signaling cascade","volume":"32","author":"Suyila","year":"2025","journal-title":"Protein Pept. Lett."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0440","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrgastro.2016.185","article-title":"Autophagy in the liver: functions inhealth and disease","volume":"14","author":"Ueno","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112549_bb0445","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1055\/s-0034-1368321","article-title":"Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from citrus depressa on non-small-cell lung cancer cell lines","volume":"80","author":"Uesato","year":"2014","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0450","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbagrm.2014.07.004","article-title":"Impact of MYC in regulation of tumor cell metabolism","volume":"1849","author":"Wahlstrom","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112549_bb0455","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nm0997-1034","article-title":"Cell-cycle arrest versus cell death in cancer therapy","volume":"3","author":"Waldman","year":"1997","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112549_bb0460","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123327","article-title":"Regulation of cell cycle progression by growth factor-induced cell signaling","volume":"10","author":"Wang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112549_bb0465","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-2736-5_1","article-title":"Cell cycle progression and synchronization: an overview","volume":"2579","author":"Wang","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0470","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/bmc.686","article-title":"Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases","volume":"20","author":"Wang","year":"2006","journal-title":"Biomed. Chromatogr."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112549_bb0475","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29071570","article-title":"Flavonoids with anti-angiogenesis function in cancer","volume":"29","author":"Wei","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.cellsig.2026.112549_bb0480","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fphar.2019.00690","article-title":"Nobiletin inhibits cell viability via the SRC\/AKT\/STAT3\/YY1AP1 pathway in human renal carcinoma cells","volume":"10","author":"Wei","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112549_bb0485","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cancergen.2025.07.009","article-title":"The mechanism of lncRNA SSTR5-AS1 promoting ferroptosis resistance and immune escape in ovarian cancer cells by recruiting STAT3 to regulate SLC7A11 expression","volume":"296-297","author":"Wei","year":"2025","journal-title":"Cancer Gene Ther."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112549_bb0490","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/mnfr.201500378","article-title":"Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis","volume":"59","author":"Wu","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.cellsig.2026.112549_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108691","article-title":"Plant exine capsules based encapsulation strategy: a high loading and long-term effective delivery system for nobiletin","volume":"127","author":"Wu","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.cellsig.2026.112549_bb0500","article-title":"The application of citrus folium in breast cancer and the mechanism of its main component nobiletin: A systematic review","volume":"2021","author":"Wu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0505","doi-asserted-by":"crossref","first-page":"199","DOI":"10.14715\/cmb\/2020.66.5.33","article-title":"Nobiletin inhibits viability of human renal carcinoma cells via the JAK2\/STAT3 and PI3K\/Akt pathway","volume":"66","author":"Xu","year":"2020","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118573","article-title":"Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer","volume":"1867","author":"Yadav","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0515","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1272\/jnms.JNMS.2024_91-102","article-title":"Molecular mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy","volume":"91","author":"Yamamoto","year":"2024","journal-title":"J. Nippon Med. Sch."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112549_bb0520","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010341","article-title":"Nobiletin delays aging and enhances stress resistance of caenorhabditis elegans","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112549_bb0525","doi-asserted-by":"crossref","first-page":"22","DOI":"10.18433\/J3MS3M","article-title":"Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats","volume":"11","author":"Yao","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112549_bb0530","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.3892\/or.2017.5522","article-title":"Nobiletin inhibits invasion via inhibiting AKT\/GSK3beta\/beta-catenin signaling pathway in slug-expressing glioma cells","volume":"37","author":"Zhang","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellsig.2026.112549_bb0535","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.intimp.2019.04.060","article-title":"Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K\/AKT signal pathway","volume":"73","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"52","key":"10.1016\/j.cellsig.2026.112549_bb0540","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.1073\/pnas.1521919112","article-title":"MTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy","volume":"112","author":"Zhao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2026.112549_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112549_bb0550","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/mnfr.201300211","article-title":"Identification of novel bioactive metabolites of 5-demethylnobiletin in mice","volume":"57","author":"Zheng","year":"2013","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:52:23Z","timestamp":1781794343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":110,"alternative-id":["S0898656826002019"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112549","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nobiletin reprograms cancer cell fate signaling: PI3K\/Akt\/mTOR\u2013MAPK crosstalk, NF-kB\/STAT3 inhibition and chemosensitization","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112549"}}