{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:23:34Z","timestamp":1783117414927,"version":"3.54.6"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2025QNB47"],"award-info":[{"award-number":["YG2025QNB47"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472666"],"award-info":[{"award-number":["82472666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073098"],"award-info":[{"award-number":["82073098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272994"],"award-info":[{"award-number":["82272994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cellsig.2026.112563","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:43:03Z","timestamp":1777560183000},"page":"112563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NSUN5\u2013CBX8 m5C axis promotes gastric tumorigenesis by activating JAK\u2013STAT3 signaling"],"prefix":"10.1016","volume":"145","author":[{"given":"Jingyi","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.cellsig.2026.112563_bb0005","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41568-020-0253-2","article-title":"Role of RNA modifications in cancer","volume":"20","author":"Barbieri","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112563_bb0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41575-023-00884-y","article-title":"RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives","volume":"21","author":"Lin","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01485-z","article-title":"Role of N6-methyladenosine RNA modification in gastric cancer","volume":"9","author":"Ding","year":"2023","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112563_bb0020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41571-023-00774-x","article-title":"The roles and implications of RNA m6A modification in cancer","volume":"20","author":"Deng","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112563_bb0025","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41585-023-00851-x","article-title":"RNA N6-methyladenosine modifications in urological cancers: from mechanism to application","volume":"21","author":"Yang","year":"2024","journal-title":"Nat. Rev. Urol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0030","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-020-01263-w","article-title":"The role of m(6)a, m(5)C and psi RNA modifications in cancer: novel therapeutic opportunities","volume":"20","author":"Nombela","year":"2021","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-018-0590-8","article-title":"Multiple functions of m6A RNA methylation in cancer","volume":"11","author":"Pan","year":"2018","journal-title":"J. Hematol. Oncol."},{"issue":"7860","key":"10.1016\/j.cellsig.2026.112563_bb0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","article-title":"Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112563_bb0050","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat. Med."},{"issue":"7683","key":"10.1016\/j.cellsig.2026.112563_bb0055","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-1119-7","article-title":"m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112563_bb0065","first-page":"6084","article-title":"m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation","volume":"11","author":"Jie Li","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.cellsig.2026.112563_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2017.11.018","article-title":"HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g","volume":"415","author":"Cai","year":"2018","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112563_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.10.004","article-title":"YTHDF3 induces the translation of m6A-enriched gene transcripts to promote breast cancer brain metastasis","volume":"38","author":"Chang","year":"2020","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112563_bb0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1602883113","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cellsig.2026.112563_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217416","article-title":"NSUN2-mediated R-loop stabilization as a key driver of bladder cancer progression and cisplatin sensitivity","volume":"611","author":"Wu","year":"2025","journal-title":"Cancer Lett."},{"issue":"28","key":"10.1016\/j.cellsig.2026.112563_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309840","article-title":"Metabolic recoding of NSUN2-mediated m5C modification promotes the progression of colorectal cancer via the NSUN2\/YBX1\/m5C-ENO1 positive feedback loop","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112563_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05661-y","article-title":"M5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6\/TK1 mRNAs splicing and stabilization","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12943-023-01785-z","article-title":"Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer","volume":"22","author":"Ortiz-Barahona","year":"2023","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112563_bb0110","article-title":"NSUN5 facilitates hepatocellular carcinoma progression by increasing SMAD3 expression","volume":"12","author":"Han","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112563_bb0115","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41388-023-02931-z","article-title":"RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism","volume":"43","author":"Gu","year":"2024","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112563_bb0120","first-page":"3858","article-title":"High expression of NSUN5 promotes cell proliferation via cell cycle regulation in colorectal cancer","volume":"12","author":"Jiang","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"15","key":"10.1016\/j.cellsig.2026.112563_bb0125","doi-asserted-by":"crossref","first-page":"13446","DOI":"10.1021\/acs.jmedchem.4c01323","article-title":"Bipyridine derivatives as NOP2\/Sun RNA methyltransferase 3 inhibitors for the treatment of colorectal cancer","volume":"67","author":"Tang","year":"2024","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0130","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41419-023-06241-w","article-title":"m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112563_bb0135","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/cac2.12443","article-title":"N6-methyladenosine modification of CENPF mRNA facilitates gastric cancer metastasis via regulating FAK nuclear export","volume":"43","author":"Xu","year":"2023","journal-title":"Cancer Commun."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112563_bb0140","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1136\/gutjnl-2019-319639","article-title":"METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112563_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04127-3","article-title":"NSUN2 modified by SUMO-2\/3 promotes gastric cancer progression and regulates mRNA m5C methylation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112563_bb0150","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41419-023-06049-8","article-title":"m5C-methylated lncRNA NR_033928 promotes gastric cancer proliferation by stabilizing GLS mRNA to promote glutamine metabolism reprogramming","volume":"14","author":"Fang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112563_bb0155","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12013-023-01152-1","article-title":"NSUN5-FTH1 Axis inhibits ferroptosis to promote the growth of gastric cancer cells","volume":"81","author":"Su","year":"2023","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2026.112563_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111475","article-title":"NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer","volume":"124","author":"Liu","year":"2024","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0165","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-024-03260-z","article-title":"NONO regulates m(5)C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression","volume":"44","author":"Zhao","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112563_bb0170","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41419-023-05781-5","article-title":"Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0175","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1038\/s41418-023-01223-z","article-title":"CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA","volume":"30","author":"Zhang","year":"2023","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12943-024-02055-2","article-title":"NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer","volume":"23","author":"Yu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-024-01847-0","article-title":"NSUN2\/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation","volume":"26","author":"Zhang","year":"2024","journal-title":"Breast Cancer Res."},{"issue":"39","key":"10.1016\/j.cellsig.2026.112563_bb0190","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1038\/s41388-021-01978-0","article-title":"NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization","volume":"40","author":"Su","year":"2021","journal-title":"Oncogene"},{"issue":"22","key":"10.1016\/j.cellsig.2026.112563_bb0195","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1038\/s41388-022-02325-7","article-title":"RNA bisulfite sequencing reveals NSUN2-mediated suppression of epithelial differentiation in pancreatic cancer","volume":"41","author":"Chen","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2026.112563_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217266","article-title":"NSUN4-mediated m5C modification of circERI3 promotes lung cancer development by altering mitochondrial energy metabolism","volume":"605","author":"Wu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112563_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217059","article-title":"NSUN4 mediated RNA 5-methylcytosine promotes the malignant progression of glioma through improving the CDC42 mRNA stabilization","volume":"597","author":"Zhao","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112563_bb0210","article-title":"NSUN5\/TET2-\u00addirected chromatin-\u00adassociated RNA modification of 5-\u00admethylcytosine to 5-\u00adhydroxymethylcytosine governs glioma immune evasion","volume":"121","author":"Wu","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7158","article-title":"Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan","volume":"6","author":"Schosserer","year":"2015","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.cellsig.2026.112563_bb0220","doi-asserted-by":"crossref","first-page":"11807","DOI":"10.1093\/nar\/gkz1043","article-title":"Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth","volume":"47","author":"Heissenberger","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112563_bb0225","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00401-019-02062-4","article-title":"Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program","volume":"138","author":"Janin","year":"2019","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1137","article-title":"RNA-methyltransferase Nsun5 controls the maternal-to-zygotic transition by regulating maternal mRNA stability","volume":"12","author":"Ding","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112563_bb0235","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41591-018-0022-x","article-title":"Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition","volume":"24","author":"Wong","year":"2018","journal-title":"Nat. Med."},{"issue":"7517","key":"10.1016\/j.cellsig.2026.112563_bb0240","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0245","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/s41556-021-00793-9","article-title":"A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers","volume":"23","author":"Fatehullah","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0250","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pharmthera.2016.09.003","article-title":"KRAS-related proteins in pancreatic cancer","volume":"168","author":"Mann","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112563_bb0255","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153470","article-title":"Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47","volume":"133","author":"Hu","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0260","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nrd4281","article-title":"Targeting RAS\u2013ERK signalling in cancer: promises and challenges","volume":"13","author":"Samatar","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7918","key":"10.1016\/j.cellsig.2026.112563_bb0265","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-022-04847-2","article-title":"cGAS\u2013STING drives the IL-6-dependent survival of chromosomally instable cancers","volume":"607","author":"Hong","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112563_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106311","article-title":"STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response","volume":"182","author":"Sadrkhanloo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2026.112563_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2026.151403","article-title":"STAT3-driven EMT in cancer metastasis and chemoresistance: a review","volume":"357","author":"Tian","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0280","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1158\/0008-5472.CAN-17-0700","article-title":"CBX8 exhibits oncogenic activity via AKT\/beta-catenin activation in hepatocellular carcinoma","volume":"78","author":"Zhang","year":"2018","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0285","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12967-021-02709-5","article-title":"KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1\/c-FOS pathway","volume":"19","author":"Zeng","year":"2021","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112563_bb0290","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41419-018-1288-0","article-title":"CBX8 exhibits oncogenic properties and serves as a prognostic factor in hepatocellular carcinoma","volume":"10","author":"Tang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112563_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111852","article-title":"High expression of a cancer stemness-related gene, Chromobox 8 (CBX8), in normal tissue adjacent to the tumor (NAT) is associated with poor prognosis of colorectal cancer patients","volume":"11","author":"Ng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112563_bb0300","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.omto.2020.09.012","article-title":"Upregulated CBX8 promotes cancer metastasis via the WNK2\/MMP2 pathway","volume":"19","author":"Jia","year":"2020","journal-title":"Mol. Ther, Oncol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112563_bb0305","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41556-019-0361-y","article-title":"5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs","volume":"21","author":"Chen","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112563_bb0310","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41580-023-00622-x","article-title":"Regulation and functions of non-m(6)a mRNA modifications","volume":"24","author":"Sun","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112563_bb0315","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105937","article-title":"RNA methylation and cancer treatment","volume":"174","author":"Yang","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112563_bb0325","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.stem.2023.05.012","article-title":"Organoid cultures for cancer modeling","volume":"30","author":"Yan","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0330","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcmgh.2021.09.005","article-title":"Gastric organoids: progress and remaining challenges","volume":"13","author":"Pang","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0335","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ccell.2022.11.015","article-title":"KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition","volume":"41","author":"Pan","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2026.112563_bb0340","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41594-024-01457-6","article-title":"Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates","volume":"32","author":"Uckelmann","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112563_bb0345","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41594-021-00661-y","article-title":"PRC1 drives polycomb-mediated gene repression by controlling transcription initiation and burst frequency","volume":"28","author":"Dobrinic","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112563_bb0350","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.it.2003.10.008","article-title":"Regulation of cytokine signaling by SOCS family molecules","volume":"24","author":"Fujimoto","year":"2003","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112563_bb0355","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tips.2019.03.001","article-title":"Targeting SOCS proteins to control JAK-STAT signalling in disease","volume":"40","author":"Durham","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2026.112563_bb0360","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/43206","article-title":"A family of cytokine-inducible inhibitors of signalling","volume":"387","author":"Starr","year":"1997","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.cellsig.2026.112563_bb0365","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/sj.onc.1209993","article-title":"Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals","volume":"26","author":"Evans","year":"2006","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0370","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1158\/1078-0432.CCR-11-1889","article-title":"STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma","volume":"18","author":"Sen","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112563_bb0375","doi-asserted-by":"crossref","DOI":"10.5847\/wjem.j.1920-8642.2022.089","article-title":"Hepatocellular carcinoma-derived exosomal miRNA-761 regulates the tumor microenvironment by targeting the SOCS2\/JAK2\/STAT3 pathway","volume":"13","author":"Zhou","year":"2022","journal-title":"World J Emerg Med"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0380","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01332-w","article-title":"Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression","volume":"20","author":"Xian","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0385","first-page":"11","article-title":"Tripartite motif protein 6 promotes colorectal cancer cell migration and metastasis via SOCS2-STAT3 signaling","author":"Zhao","year":"2021","journal-title":"Front. Oncol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112563_bb0390","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081758","article-title":"The RNA methyltransferase NSUN2 and its potential roles in cancer","volume":"9","author":"Chellamuthu","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0395","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00895-1","article-title":"Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer","volume":"13","author":"Wang","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112563_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00951-w","article-title":"Roles of METTL3 in cancer: mechanisms and therapeutic targeting","volume":"13","author":"Zeng","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217064","article-title":"YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification","volume":"597","author":"Meng","year":"2024","journal-title":"Cancer Lett."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112563_bb0410","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-06008-3","article-title":"THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification","volume":"14","author":"Yu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112563_bb0415","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.canlet.2020.07.006","article-title":"YB-1: the key to personalised prostate cancer management?","volume":"490","author":"Bates","year":"2020","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112563_bb0420","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142376","article-title":"A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg Balance","volume":"6","author":"Aqel","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2026.112563_bb0425","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi2952","article-title":"Tumor-\u00adassociated NK cells drive MDSC-\u00admediated tumor immune tolerance through the IL-\u00ad6\/STAT3 axis","volume":"16","author":"Neo","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112563_bb0430","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230683","article-title":"TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation","volume":"221","author":"Qin","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cellsig.2026.112563_bb0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1512353","article-title":"m5C methylation modification may be an accomplice in colorectal cancer escaping from anti-tumor effects of innate immunity-type I\/III interferon","volume":"15","author":"Sun","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1380697","article-title":"RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis","volume":"15","author":"Xiong","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112563_bb0445","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2015.08.051","article-title":"N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice","volume":"217","author":"Andries","year":"2015","journal-title":"J. Control. Release"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:09:52Z","timestamp":1783116592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":89,"alternative-id":["S0898656826002160"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112563","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NSUN5\u2013CBX8 m5C axis promotes gastric tumorigenesis by activating JAK\u2013STAT3 signaling","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112563"}}