{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:26:12Z","timestamp":1783117572651,"version":"3.54.6"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["R1025"],"award-info":[{"award-number":["R1025"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cellsig.2026.112579","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:32:12Z","timestamp":1778340732000},"page":"112579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omics identifies RNF149 as a key molecular marker mediating neuron-glia interaction in temporal lobe epilepsy"],"prefix":"10.1016","volume":"145","author":[{"given":"Bi","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Running","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.cellsig.2026.112579_bb0005","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1212\/WNL.0000000000001005","article-title":"Epilepsy-related clinical characteristics and mortality: a systematic review and meta-analysis","volume":"83","author":"Nevalainen","year":"2014","journal-title":"Neurology"},{"issue":"10172","key":"10.1016\/j.cellsig.2026.112579_bb0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"17","key":"10.1016\/j.cellsig.2026.112579_bb0015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0000000000011839","article-title":"Incidence and prevalence of drug-resistant epilepsy: a systematic review and meta-analysis","volume":"96","author":"Sultana","year":"2021","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112579_bb0020","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5694\/mja17.00951","article-title":"The management of epilepsy in children and adults","volume":"208","author":"Perucca","year":"2018","journal-title":"Med. J. Aust."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112579_bb0025","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/ana.26644","article-title":"Selective neuronal knockout of STAT3 function inhibits epilepsy progression, improves cognition, and restores dysregulated gene networks in a temporal lobe epilepsy model","volume":"94","author":"Tipton","year":"2023","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112579_bb0035","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1093\/brain\/awaf209","article-title":"Twins with temporal lobe epilepsy: genetic contributions to hippocampal sclerosis and other subtypes","volume":"148","author":"Dang","year":"2025","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112579_bb0040","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1111\/epi.17757","article-title":"Postoperative seizure and memory outcome of temporal lobe epilepsy with hippocampal sclerosis: a systematic review","volume":"64","author":"Li","year":"2023","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0045","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1124\/pr.120.019539","article-title":"Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options","volume":"72","author":"L\u00f6scher","year":"2020","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0050","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-med-050522-034458","article-title":"Advances in therapy for refractory epilepsy","volume":"76","author":"Jehi","year":"2025","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13195-021-00814-7","article-title":"An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer\u2019s disease","volume":"13","author":"Clark","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.cellsig.2026.112579_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107385","article-title":"Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease","volume":"208","author":"Huang","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ymthe.2024.11.025","article-title":"Long-read RNA sequencing: a transformative technology for exploring transcriptome complexity in human diseases","volume":"33","author":"Ament","year":"2025","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12943-022-01526-8","article-title":"Proteomics technologies for cancer liquid biopsies","volume":"21","author":"Ding","year":"2022","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032943","article-title":"The evolution of single-cell RNA sequencing technology and application: progress and perspectives","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112579_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107066","article-title":"Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels T cell-related prognostic risk model and tumor immune microenvironment modulation in triple-negative breast cancer","volume":"161","author":"Guo","year":"2023","journal-title":"Comput. Biol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0085","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41467-021-21407-w","article-title":"Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages","volume":"12","author":"Ochocka","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0090","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12975-024-01255-8","article-title":"Integrating bulk RNA and single-cell sequencing data unveils efferocytosis patterns and ceRNA network in ischemic stroke","volume":"16","author":"Yuan","year":"2025","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.cellsig.2026.112579_bb0095","doi-asserted-by":"crossref","first-page":"1454486","DOI":"10.3389\/fgene.2024.1454486","article-title":"Identification of potential therapeutic targets for systemic lupus erythematosus based on GEO database analysis and Mendelian randomization analysis","volume":"15","author":"Apaer","year":"2024","journal-title":"Front. Genet."},{"key":"10.1016\/j.cellsig.2026.112579_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.896507","article-title":"Role of the ubiquitin ligase RNF149 in the development of rat neonatal gonocytes","volume":"13","author":"Manku","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cellsig.2026.112579_bb0105","article-title":"Eupalinolide B targets DEK and PANoptosis through E3 ubiquitin ligases RNF149 and RNF170 to negatively regulate asthma","volume":"141","author":"Bai","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0110","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s42003-023-04763-9","article-title":"The role of RNF149 in the pre-emptive quality control substrate ubiquitination","volume":"6","author":"Legesse","year":"2023","journal-title":"Commun. Biol."},{"issue":"21","key":"10.1016\/j.cellsig.2026.112579_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15215203","article-title":"RNF149 promotes HCC progression through its E3 ubiquitin ligase activity","volume":"15","author":"Guo","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.cellsig.2026.112579_bb0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.freeradbiomed.2016.03.004","article-title":"NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy","volume":"94","author":"Zhu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112579_bb0125","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1097\/TP.0000000000004514","article-title":"Renal ischemia-reperfusion injury attenuated by exosomes extracted from splenic ischemic preconditioning models","volume":"107","author":"Liu","year":"2023","journal-title":"Transplantation"},{"issue":"20","key":"10.1016\/j.cellsig.2026.112579_bb0130","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.7150\/thno.33872","article-title":"Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice","volume":"9","author":"Xian","year":"2019","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112579_bb0135","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0920-1211(01)00272-8","article-title":"Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy","volume":"46","author":"Glien","year":"2001","journal-title":"Epilepsy Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0140","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13046-016-0468-y","article-title":"Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer","volume":"35","author":"Wang","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0145","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41467-025-56853-3","article-title":"Human and mouse proteomics reveals the shared pathways in Alzheimer\u2019s disease and delayed protein turnover in the amyloidome","volume":"16","author":"Yarbro","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0150","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41587-023-01782-z","article-title":"Comparative analysis of cell-cell communication at single-cell resolution","volume":"42","author":"Wilk","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112579_bb0155","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s00415-024-12352-x","article-title":"Channelopathies in epilepsy: an overview of clinical presentations, pathogenic mechanisms, and therapeutic insights","volume":"271","author":"Ng","year":"2024","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0160","article-title":"Machine learning and multi-omics in precision medicine for ME\/CFS","volume":"23","author":"Huang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40364-025-00798-8","article-title":"Multi-omics: a bridge connecting genotype and phenotype for epilepsy?","volume":"13","author":"Wang","year":"2025","journal-title":"Biomark. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0170","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1186\/s12967-023-04579-5","article-title":"Spatiotemporal evolution of AML immune microenvironment remodeling and RNF149-driven drug resistance through single-cell multidimensional analysis","volume":"21","author":"Wu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112579_bb0175","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCRESAHA.123.324023","article-title":"RNF149 destabilizes IFNGR1 in macrophages to favor postinfarction cardiac repair","volume":"135","author":"Huang","year":"2024","journal-title":"Circ. Res."},{"issue":"28","key":"10.1016\/j.cellsig.2026.112579_bb0180","doi-asserted-by":"crossref","first-page":"24017","DOI":"10.1074\/jbc.M111.319822","article-title":"Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF)","volume":"287","author":"Hong","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112579_bb0185","article-title":"RNF149 confers cisplatin resistance in esophageal squamous cell carcinoma via destabilization of PHLPP2 and activating PI3K\/AKT signalling","volume":"40","author":"Zhu","year":"2023","journal-title":"Med. Oncol. (Northwood, London, England)"},{"key":"10.1016\/j.cellsig.2026.112579_bb0190","doi-asserted-by":"crossref","DOI":"10.2174\/0109298673378818250610053439","article-title":"A ubiquitination-related gene prognostic signature and the oncogenic role of RNF149 in nasopharyngeal carcinoma: scRNAseq-based bioinformatics and experimental validation","author":"Deng","year":"2025","journal-title":"Curr. Med. Chem."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112579_bb0195","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.tibs.2024.06.011","article-title":"Ubiquitin system mutations in neurological diseases","volume":"49","author":"Zenge","year":"2024","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/glia.23006","article-title":"Microglia-neuron communication in epilepsy","volume":"65","author":"Eyo","year":"2017","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112579_bb0205","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1111\/epi.18413","article-title":"Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics","volume":"66","author":"Galv\u00e3o","year":"2025","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0210","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1007\/s12035-024-04428-6","article-title":"Single-nucleus landscape of glial cells and neurons in Alzheimer\u2019s disease","volume":"62","author":"Lu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112579_bb0215","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/STROKEAHA.124.049265","article-title":"Enhancing neuron activity promotes functional recovery by inhibiting microglia-mediated synapse elimination after stroke","volume":"56","author":"Sun","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.cellsig.2026.112579_bb0220","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.semcdb.2019.05.017","article-title":"Microglia-neuron crosstalk: signaling mechanism and control of synaptic transmission","volume":"94","author":"Marinelli","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112579_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108882","article-title":"Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes","volume":"34","author":"Baxter","year":"2021","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112579_bb0230","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13195-020-00655-w","article-title":"CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer\u2019s disease","volume":"12","author":"Mouton-Liger","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112579_bb0235","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nn.3006","article-title":"Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy","volume":"15","author":"Li","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"9\u201310","key":"10.1016\/j.cellsig.2026.112579_bb0240","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1101\/gad.310490.117","article-title":"Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells","volume":"32","author":"Kim","year":"2018","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112579_bb0245","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/glia.23264","article-title":"Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord","volume":"66","author":"Kataria","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.cellsig.2026.112579_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106881","article-title":"Microglia sense and suppress epileptic neuronal hyperexcitability","volume":"195","author":"Hu","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112579_bb0255","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70072","article-title":"Excitatory neurons and oligodendrocyte precursor cells are vulnerable to focal cortical dysplasia type IIIa as suggested by single-nucleus multiomics","volume":"14","author":"Liu","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112579_bb0260","article-title":"NgR1 knockout increased neuronal excitability and altered seizure pattern in traumatic brain injury mice brain after PTZ-induced seizure","volume":"20","author":"Zhang","year":"2025","journal-title":"PloS One"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:10:26Z","timestamp":1783116626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"alternative-id":["S0898656826002329"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112579","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics identifies RNF149 as a key molecular marker mediating neuron-glia interaction in temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112579","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112579"}}