{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:07:51Z","timestamp":1792195671168,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PWXx2025-04"],"award-info":[{"award-number":["PWXx2025-04"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PDZY-2024-0713"],"award-info":[{"award-number":["PDZY-2024-0713"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cellsig.2026.112621","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:11:30Z","timestamp":1779725490000},"page":"112621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Grape-derived exosome-like nanoparticles suppress nasopharyngeal carcinoma progression by targeting the FASN\/MAPK axis"],"prefix":"10.1016","volume":"145","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuixian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112621_bb0005","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.7150\/ijbs.59688","article-title":"The role of exosomes in the pathogenesis of nasopharyngeal carcinoma and the involved clinical application","volume":"17","author":"Luo","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2026.112621_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12951-025-03315-z","article-title":"PTEN as a prognostic factor for radiotherapy plus immunotherapy response in nasopharyngeal carcinoma","volume":"23","author":"Guo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0015","first-page":"612","article-title":"Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2","volume":"24","author":"Yang","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cellsig.2026.112621_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122638","article-title":"An exosomal approach for oral delivery of resveratrol: implications for inflammatory bowel disease treatment in rat model","volume":"346","author":"Esfahani","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112621_bb0025","first-page":"281","article-title":"Exosomes: small vesicles with big roles in cancer, vaccine development, and therapeutics","volume":"10","author":"Thakur","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.cellsig.2026.112621_bb0030","article-title":"Combination therapy with resveratrol and celastrol using folic acid-functionalized exosomes enhances the therapeutic efficacy of sepsis","volume":"12","author":"Zheng","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.cellsig.2026.112621_bb0035","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1021\/acs.jafc.1c07306","article-title":"Characterization of the MicroRNA profile of ginger exosome-like nanoparticles and their anti-inflammatory effects in intestinal Caco-2 cells","volume":"70","author":"Yin","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cellsig.2026.112621_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107071","article-title":"peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron","volume":"200","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2026.112621_bb0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12951-023-02286-3","article-title":"Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route","volume":"22","author":"Gao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0050","doi-asserted-by":"crossref","first-page":"11941","DOI":"10.2147\/IJN.S483091","article-title":"Therapeutic potential of ginger exosome-like nanoparticles for alleviating periodontitis-induced tissue damage","volume":"19","author":"Xie","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellsig.2026.112621_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110853","article-title":"MicroRNAs as regulators of ERK\/MAPK pathway: a comprehensive review","volume":"132","author":"Safa","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112621_bb0060","first-page":"251","article-title":"Study on content and extraction process of resveratrol in different parts of grape","author":"Mei-ling","year":"2017","journal-title":"Mod. Agric. Sci. Technol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0065","first-page":"318","article-title":"Determination of trans-resveratrol and its glucoside content in pulp of five grape varieties in Guangxi using HPLC","volume":"43","author":"Yang","year":"2012","journal-title":"J. South. Agric."},{"key":"10.1016\/j.cellsig.2026.112621_bb0070","article-title":"Vitis vinifera Kyoho-derived exosome-like nanoparticles-based drug delivery and therapeutic modalities for breast cancer therapy","volume":"91","author":"Farheen","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0075","first-page":"7228","article-title":"Garlic-derived exosome-like nanoparticles enhance gut homeostasis in stressed piglets: involvement of Lactobacillus reuteri modulation and Indole-3-propionic acid induction","volume":"73","author":"Liu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cellsig.2026.112621_bb0080","doi-asserted-by":"crossref","first-page":"12793","DOI":"10.2147\/IJN.S496664","article-title":"Engineering strategies of plant-derived exosome-like nanovesicles: current knowledge and future perspectives","volume":"19","author":"Li","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellsig.2026.112621_bb0085","doi-asserted-by":"crossref","first-page":"1500998","DOI":"10.3389\/fimmu.2024.1500998","article-title":"Effects of resveratrol-loaded dendrimer nanomedicine on hepatocellular carcinoma cells","volume":"15","author":"Qu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0090","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1829346","article-title":"Resveratrol exerts antitumor effects by downregulating CD8(+)CD122(+) Tregs in murine hepatocellular carcinoma","volume":"9","author":"Zhang","year":"2020","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cellsig.2026.112621_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2024.102840","article-title":"Advances and challenges in immunotherapy for locally advanced nasopharyngeal carcinoma","volume":"131","author":"Cai","year":"2024","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.cellsig.2026.112621_bb0100","article-title":"Enhancing efficacy and reducing toxicity: therapeutic optimization in locoregionally advanced nasopharyngeal carcinoma","volume":"5","author":"Jiang","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cellsig.2026.112621_bb0105","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1186\/s12935-021-02280-5","article-title":"Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation","volume":"21","author":"Alavi","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2026.112621_bb0110","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.2147\/IJN.S540094","article-title":"Exosomes in disease therapy: plant-derived exosome-like nanoparticles current status, challenges, and future prospects","volume":"20","author":"Song","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellsig.2026.112621_bb0115","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.2147\/IJN.S526287","article-title":"Medicinal plant-derived exosome-like nanovesicles as regulatory mediators in microenvironment for disease treatment","volume":"20","author":"Feng","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellsig.2026.112621_bb0120","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.2147\/IJN.S370784","article-title":"Extracellular vesicles: the next generation theranostic nanomedicine for inflammatory bowel disease","volume":"17","author":"Li","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.cellsig.2026.112621_bb0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13045-023-01498-2","article-title":"Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics","volume":"16","author":"Jin","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0130","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41419-022-04926-2","article-title":"FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis","volume":"13","author":"Du","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112621_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104910","article-title":"Targeting cancer metabolism: therapeutic potential of the fatty acid synthase (FASN) inhibitors","volume":"214","author":"Nuzzo","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.cellsig.2026.112621_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106398","article-title":"A renewed concept on the MAPK signaling pathway in cancers: polyphenols as a choice of therapeutics","volume":"184","author":"Anjum","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2026.112621_bb0145","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13046-020-01763-z","article-title":"Therapeutic evaluation of palbociclib and its compatibility with other chemotherapies for primary and recurrent nasopharyngeal carcinoma","volume":"39","author":"Xue","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112621_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113629","article-title":"Selenium regulates the mitogen-activated protein kinase pathway to protect broilers from hexavalent chromium-induced kidney dysfunction and apoptosis","volume":"239","author":"Zhao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cellsig.2026.112621_bb0155","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jgr.2023.05.002","article-title":"Phenolic acids in Panax ginseng inhibit melanin production through bidirectional regulation of melanin synthase transcription via different signaling pathways","volume":"47","author":"Liu","year":"2023","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.cellsig.2026.112621_bb0160","doi-asserted-by":"crossref","first-page":"740","DOI":"10.20892\/j.issn.2095-3941.2020.0219","article-title":"Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10","volume":"17","author":"Chen","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.cellsig.2026.112621_bb0165","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/path.5130","article-title":"Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma","volume":"246","author":"Lo","year":"2018","journal-title":"J. Pathol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:59:18Z","timestamp":1783169958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S0898656826002743"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112621","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grape-derived exosome-like nanoparticles suppress nasopharyngeal carcinoma progression by targeting the FASN\/MAPK axis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112621"}}