{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:17:43Z","timestamp":1783192663693,"version":"3.54.6"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202601ZYTS721"],"award-info":[{"award-number":["YDZJ202601ZYTS721"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160695"],"award-info":[{"award-number":["82160695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cellsig.2026.112625","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:29:06Z","timestamp":1780118946000},"page":"112625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["miR-494-3p\/G6PC\/FOXO1 signaling axis drives autophagy-mediated breast cancer progression and predicts poor prognosis"],"prefix":"10.1016","volume":"145","author":[{"given":"Kun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1470-2045(17)30904-X","article-title":"Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy","volume":"19","author":"Denkert","year":"2018","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast Cancer treatment: a review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112625_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082179","article-title":"The biology of exosomes in breast cancer progression: dissemination, immune evasion and metastatic colonization","volume":"12","author":"Giordano","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-023-01805-y","article-title":"Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer","volume":"22","author":"Ye","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11033-023-09096-8","article-title":"Revolutionizing cancer care strategies: immunotherapy, gene therapy, and molecular targeted therapy","volume":"51","author":"Zafar","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112625_bb0035","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/jamaoncol.2024.0194","article-title":"Clinical value of molecular targets and FDA-approved genome-targeted cancer therapies","volume":"10","author":"Tibau","year":"2024","journal-title":"JAMA Oncol."},{"issue":"5133","key":"10.1016\/j.cellsig.2026.112625_bb0040","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.8211187","article-title":"Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a","volume":"262","author":"Lei","year":"1993","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112625_bb0045","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/humu.20772","article-title":"Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease","volume":"29","author":"Chou","year":"2008","journal-title":"Hum. Mutat."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ymgme.2017.01.003","article-title":"Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-\u03b1 activity restored are at risk of developing hepatic tumors","volume":"120","author":"Kim","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cellsig.2026.112625_bb0055","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1038\/cddiscovery.2015.16","article-title":"mTORC2 controls cancer cell survival by modulating gluconeogenesis","volume":"1","author":"Khan","year":"2015","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13046-023-02718-w","article-title":"MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma","volume":"42","author":"Bergamini","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112625_bb0065","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1038\/ncomms3508","article-title":"Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma","volume":"4","author":"Ma","year":"2013","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112625_bb0070","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1158\/1541-7786.MCR-14-0106-T","article-title":"Glucose-6-phosphatase is a key metabolic regulator of glioblastoma invasion","volume":"12","author":"Abbadi","year":"2014","journal-title":"Mol. Cancer Res."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112625_bb0075","doi-asserted-by":"crossref","first-page":"7649","DOI":"10.1007\/s13277-015-3463-6","article-title":"Genetic and molecular analyses reveal G6PC as a key element connecting glucose metabolism and cell cycle control in ovarian cancer","volume":"36","author":"Guo","year":"2015","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0080","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12958-022-00921-6","article-title":"G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo","volume":"20","author":"Zhu","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112625_bb0085","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/mc.23681","article-title":"The FOXO1\/G6PC axis promotes gastric cancer progression and mediates 5-fluorouracil resistance by targeting the PI3K\/AKT\/mTOR signaling pathway","volume":"63","author":"Han","year":"2024","journal-title":"Mol. Carcinog."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112625_bb0095","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cmet.2017.04.004","article-title":"Autophagy and tumor metabolism","volume":"25","author":"Kimmelman","year":"2017","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112625_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.398","article-title":"Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance","volume":"8","author":"Bingel","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/1878-0261.12017","article-title":"Epithelial-mesenchymal transition in tumor metastasis","volume":"11","author":"Yeung","year":"2017","journal-title":"Mol. Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030326","article-title":"Role of miRNAs in melanoma metastasis","volume":"11","author":"Gajos-Michniewicz","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112625_bb0115","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.18632\/oncotarget.13933","article-title":"miR-494-3p is a novel tumor driver of lung carcinogenesis","volume":"8","author":"Faversani","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0120","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1016\/j.bbagen.2012.12.013","article-title":"Multiple roles of glucose-6-phosphatases in pathophysiology: state of the art and future trends","volume":"1830","author":"Marcolongo","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.cellsig.2026.112625_bb0125","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1111\/jcmm.15536","article-title":"Large-scale transcriptome profiles reveal robust 20-signatures metabolic prediction models and novel role of G6PC in clear cell renal cell carcinoma","volume":"24","author":"Xu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112625_bb0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-015-0447-5","article-title":"Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation","volume":"14","author":"Song","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2026.112625_bb0135","first-page":"1","article-title":"The evolving, multifaceted roles of autophagy in Cancer","volume":"130","author":"Liu","year":"2016","journal-title":"Adv. Cancer Res."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112625_bb0140","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/15548627.2015.1023981","article-title":"Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways","volume":"11","author":"Zhang","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112625_bb0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41416-019-0641-0","article-title":"Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS\/FoxO1-mediated autophagic response","volume":"122","author":"Ciccarone","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112625_bb0150","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/jcmm.17258","article-title":"Downregulation of MEG3 and upregulation of EZH2 cooperatively promote neuroblastoma progression","volume":"26","author":"Ye","year":"2022","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41392-025-02245-4","article-title":"Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk","volume":"10","author":"Ma","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112625_bb0160","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.7150\/jca.111680","article-title":"The dual roles of circular RNAs in breast Cancer distant metastasis and their clinical applications","volume":"16","author":"Bao","year":"2025","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1515\/jtim-2025-0029","article-title":"CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer","volume":"13","author":"Dai","year":"2025","journal-title":"J Transl Int Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-026-02568-y","article-title":"PiR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer","volume":"25","author":"Luo","year":"2026","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112625_bb0175","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.3390\/ijms26073449","article-title":"MicroRNAs as endocrine modulators of breast Cancer","volume":"26","author":"Richard","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112625_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112625_bb0185","first-page":"241","article-title":"miR-634 decreases the Radioresistance of human breast Cancer cells by targeting STAT3","volume":"35","author":"Yang","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0190","doi-asserted-by":"crossref","first-page":"e2529","DOI":"10.1038\/cddis.2016.440","article-title":"MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1","volume":"8","author":"Zhan","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112625_bb0195","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3892\/or.2015.3965","article-title":"miR-494 suppresses the progression of breast cancer in vitro by targeting CXCR4 through the Wnt\/\u03b2-catenin signaling pathway","volume":"34","author":"Song","year":"2015","journal-title":"Oncol. Rep."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:13:39Z","timestamp":1783192419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"alternative-id":["S0898656826002780"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112625","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-494-3p\/G6PC\/FOXO1 signaling axis drives autophagy-mediated breast cancer progression and predicts poor prognosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112625"}}